作者机构：
[王宏青; 丁明武; 刘钊杰] College of Chemistry,Centre China Normal University,Wuhan,China,430079
会议名称：
第六届全国磷化学化工学术讨论会
会议时间：
2003-09
会议地点：
中国湖北武汉
摘要：
<正> Compounds containing a pyrazolopyrimidinone ring play a very important part in the biochemistry of the living cell. Many potential drugs have been modeled on the compound. In recent years, α-hydroxyalkylphosphonates and its derivatives are of increasing interest. Many studies make clear that they are inhibitors of rennin, EPSP synthetase, pyruvatedehydrogenase and they
摘要：
2-Dialkylamino-4H-imidazolin-4-ones 6 were rapidly synthesized by a solution-phase parallel synthetic method, which includes Aza-Wittig reaction of iminophosphorane 3 with aromatic isocynate to give carbodiimide 4 and subsequent reaction of 4 with various aliphatic secondary amine in a parallel fashion.
作者机构：
Institute of Organic Synthesis, Central China Normal University, Wuhan, P.R.China
摘要：
The carbodiimides 2, obtained form aza-Wittig reactions of iminophosphorane 1 with aromatic isocyanates, reacted with aliphatic primary amines to give mainly 2-alkylamino-4(3H)-quinoazolines 4 with unusualy selectivity.
摘要：
The title compounds 2-(8-quinolinoxy)-4H-imidazolin-4-ones(4) were synthesized by means of base catalytic reactions of 8-hydroxyquinoline with each of carbodiimides 2, which were obtained via aza-Wittig reactions of iminophosphoranes 1 with the corresponding aromatic isocyanates.
摘要：
2-Alkylthio-5-phenylmethylidene-4H-imidazolin-4-ones 5 were synthesized by S-alkylation of thioimidazolinones 4, which were obtained via cyclization of carbodiimides 2 with Na2S/HOAc. The direct reaction of carbodiimides 2 with butylthiol could not give 2-butylthio-4H-imidazolin-4-ones 3.
作者机构：
[王宏青; 杨风岭; 曹宏; 丁明武; 刘钊杰] College of Chemistry,Centre China Normal University,Wuhan,China,430079
会议名称：
第六届全国磷化学化工学术讨论会
会议时间：
2003-09
会议地点：
中国湖北武汉
摘要：
<正> Fused pyrimidine derivatives are of increasing interest due to that they are potent and selective inhibitors of cyclic guanosine 3’,5’-monophosphate specific phosphodiesterase （cGMP specific PDE）, adenosine, DNA potymerase Ⅲand methionyl t-RNA synthetase, having utility in a variety of therapeutic areas. We have developed a facile fused pyrimidine annulation process, which takes place under
作者机构：
[Liu, ZJ; Sun, Y; Ding, MW; Liu, XP] Cent China Normal Univ, Inst Organ Synth, Wuhan 430079, Peoples R China.
通讯机构：
[Ding, MW] C;Cent China Normal Univ, Inst Organ Synth, Wuhan 430079, Peoples R China.
摘要：
2-Alkoxy-4H-imidazol-4-ones 4 were synthesized by aza-Wittig reaction of iminophosphorane 1 with phenyl isocynate to give carbodiimide 2 and subsequent reaction of 2 with ROH in the presence of catalytic RO-Na +.
摘要：
2-Alkylthio-5-phenylmethylidene-4H-imidazol-4-ones 4-were synthesized by S-alkylation of 2-thioxo-3-alkyl(aryl)-4-imidazolidinones 3, which were obtained via cyclization of isothiocyanates 2 with aliphatic (aromatic) primary amines. (C) 2003 Wiley, Periodicals, Inc.
摘要：
ABSTRACT The reaction of 1,2,4-triazole with functionalized carbodiimide 2 or 6 under solid K2CO3 provide a convenient and regiospecific route to 1-(2-imidazolonyl)-1,2,4-triazole 4 or 1-(2-quinazolonyl)-1,2,4-triazole 8.
