期刊：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2019年141(15):6167-6172 ISSN：0002-7863
通讯作者：
Lu, Liang-Qiu;Xiao, Wen-Jing;Lan, Yu
作者机构：
[Lu, Fu-Dong; Lu, LQ; Xiao, WJ; Lu, Liang-Qiu; Xiao, Wen-Jing; Zhou, Quan-Quan; Wei, Yi; Liu, Dan] Cent China Normal Univ, CCNU uOttawa Joint Res Ctr, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;[Zhu, Lei; Lan, Yu] Chongqing Univ, Sch Chem & Chem Engn, Chongqing 400030, Peoples R China.;[Yang, Qian] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, 1037 Luoyu Rd, Wuhan 430074, Hubei, Peoples R China.;[Xiao, Wen-Jing] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China.
通讯机构：
[Lu, LQ; Xiao, WJ; Lan, Yu; Xiao, Wen-Jing] C;Cent China Normal Univ, CCNU uOttawa Joint Res Ctr, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;Chongqing Univ, Sch Chem & Chem Engn, Chongqing 400030, Peoples R China.;Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China.
摘要：
The first asymmetric propargylic radical cyanation was realized through a dual photoredox and copper catalysis. An organic photocatalyst serves to both generate propargyl radicals and oxidize Cu(I) species to Cu(II) species. A chiral Cu complex functions as an efficient organometallic catalyst to resemble the propargyl radical and cyanide in an enantio-controlled manner. Thus, a diverse range of optically active propargyl cyanides were produced with high reaction efficiency and enantioselectivities (28 examples, 57-97% yields and 83-98% ee). Moreover, mechanistic investigations including experiments and density functional theory calculations were performed to illustrate on the reaction pathway and stereochemical results.
期刊：
Proceedings of the National Academy of Sciences of the United States of America,2019年116(6):1968-1973 ISSN：0027-8424
通讯作者：
Li, Haibing;Yang, Guangfu;Sun, Yao;Stang, Peter J.
作者机构：
[Xu, Yuling; Sun, Yue; Yang, Guangfu; Li, Haibing; Yang, GF; Sun, Y; Sun, Yao; Li, Chonglu; Ding, Feng] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Xu, Yuling; Sun, Yue; Yang, Guangfu; Li, Haibing; Yang, GF; Sun, Y; Sun, Yao; Li, Chonglu; Ding, Feng] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Chem Biol Ctr, Wuhan 430079, Hubei, Peoples R China.;[Sun, Yue; Stang, Peter J.; Zhou, Zhixuan] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA.;[Pu, Maoping] Rheinisch Westfalische Tech Hsch Aachen Univ, Inst Organ Chem, D-52074 Aachen, Germany.;[Lu, Xiaoju; Zhan, Yibei] Hubei Polytech Univ, Sch Chem & Chem Engn, Huangshi 435003, Peoples R China.
通讯机构：
[Li, HB; Yang, GF; Sun, Y] C;[Stang, Peter J.] U;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Chem Biol Ctr, Wuhan 430079, Hubei, Peoples R China.;Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA.
期刊：
CHEMICAL SOCIETY REVIEWS,2019年48(12):3181-3192 ISSN：0306-0012
通讯作者：
Lin, Yuehe;Zhu, Chengzhou
作者机构：
[Du, Dan; Lin, Yuehe; Shi, Qiurong] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Zhu, Chengzhou] Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Lin, Yuehe] W;[Zhu, Chengzhou] C;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.
摘要：
In recent years, visible light-driven organic photochemical synthesis has attracted wide research interest from academic and industrial communities due to its features of green and sustainable chemistry. In this flourishing area, Chinese chemists have devoted great efforts to different aspects of synthetic chemistry. This review will summarize their representative work according to the following categories: C–H functionalization, synthesis of aromatic aza-heterocycles, asymmetric organic photochemical synthesis, transformations of small molecules and biomolecule-compatible reactions.
作者机构：
[Xiao, Wen-Jing; Chen, Jia-Rong; Wang, Peng-Zi] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Chen, Jia-Rong] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
摘要：
Hantzsch esters were often previously used as reductants in thermal catalytic hydrogenation reactions. Over the last few decades, Hantzsch esters have proven to be a useful class of electron donors and proton sources in photoredox catalyzed processes. Moreover, under photoredox catalytic conditions, alkyl-1,4-dihydropyridines can serve as versatile types of alkylation reagents via oxidative fragmentation mechanisms. This minireview highlights the recent advances in the chemistry of Hantzsch esters in photoredox catalyzed organic synthesis, with particular emphasis placed on reaction mechanisms. We hope that this review will inspire further new reaction design and developments with such a class of readily accessible reagents.
作者：
Wu, Hao;Li, Zhen;Clarke, Keith C.;Shi, Wenzhong;Fang, Linchuan*;...
期刊：
International Journal of Geographical Information Science,2019年33(5):1040-1061 ISSN：1365-8816
通讯作者：
Fang, Linchuan
作者机构：
[Zhou, Jie; Wu, Hao; Lin, Anqi] Cent China Normal Univ, Coll Urban & Environm Sci, Wuhan, Hubei, Peoples R China.;[Zhou, Jie; Wu, Hao; Lin, Anqi] Cent China Normal Univ, Hubei Prov Key Lab Geog Proc Anal & Simulat, Wuhan, Hubei, Peoples R China.;[Li, Zhen] Wuhan Univ Technol, Sch Resources & Environm Engn, Wuhan, Hubei, Peoples R China.;[Clarke, Keith C.] Univ Calif Santa Barbara, Dept Geog, Santa Barbara, CA 93106 USA.;[Shi, Wenzhong] Hong Kong Polytech Univ, Dept Land Surveying & Geoinformat, Kowloon, Hong Kong, Peoples R China.
通讯机构：
[Fang, Linchuan] N;Northwest A&F Univ, State Key Lab Soil Eros & Dryland Farming Loess P, Yangling, Shaanxi, Peoples R China.
关键词：
Land use change simulation;Markov chain;cellular automata;response surface method;spatial scale sensitivity
摘要：
Understanding the spatial scale sensitivity of cellular automata is crucial for improving the accuracy of land use change simulation. We propose a framework based on a response surface method to comprehensively explore spatial scale sensitivity of the cellular automata Markov chain (CA-Markov) model, and present a hybrid evaluation model for expressing simulation accuracy that merges the strengths of the Kappa coefficient and of Contagion index. Three Landsat-Thematic Mapper remote sensing images of Wuhan in 1987, 1996, and 2005 were used to extract land use information. The results demonstrate that the spatial scale sensitivity of the CA-Markov model resulting from individual components and their combinations are both worthy of attention. The utility of our proposed hybrid evaluation model and response surface method to investigate the sensitivity has proven to be more accurate than the single Kappa coefficient method and more efficient than traditional methods. The findings also show that the CA-Markov model is more sensitive to neighborhood size than to cell size or neighborhood type considering individual component effects. Particularly, the bilateral and trilateral interactions between neighborhood and cell size result in a more remarkable scale effect than that of a single cell size.
作者：
Tang, Xinfeng;Tang, Suqin;Ren, Zhihong;Wong, Daniel Fu Keung*
期刊：
Journal of Affective Disorders,2019年245:498-507 ISSN：0165-0327
通讯作者：
Wong, Daniel Fu Keung
作者机构：
[Tang, Xinfeng; Wong, Daniel Fu Keung; Tang, Suqin] Univ Hong Kong, Dept Social Work & Social Adm, Hong Kong, Peoples R China.;[Tang, Suqin] Shenzhen Univ, Coll Psychol & Sociol, Shenzhen, Peoples R China.;[Ren, Zhihong] Cent China Normal Univ, Sch Psychol, Wuhan 430079, Hubei, Peoples R China.;[Ren, Zhihong] Minist Educ, Key Lab Adolescent Cyberpsychol & Behav CCNU, Wuhan 430079, Hubei, Peoples R China.;[Ren, Zhihong] Key Lab Human Dev & Mental Hlth Hubei Prov, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Wong, Daniel Fu Keung] U;Univ Hong Kong, Dept Social Work & Social Adm, Hong Kong, Peoples R China.
摘要：
BACKGROUND: The objective of the study reported here is to systematically estimate the prevalence of depressive symptoms among adolescents in secondary schools in mainland China. METHOD: Literature searches were conducted in both English and Chinese databases from database inception to January 2018. This meta-analysis used a random-effects model to estimate the prevalence of depressive symptoms. RESULTS: Fifty-one eligible studies (n=144,060) using probability sampling were identified. The results revealed a pooled prevalence of depressive symptoms of 24.3% (95% CI, 21.3%-27.6%), with high between-studies heterogeneity (Q=9909, I(2)=99.5%, p<0.001). The prevalence estimates reported by the individual studies ranged from 6.2% to 64.8%. There was an increased prevalence with increasing grades from year 1 in junior secondary school (24.5%; 95% CI, 17.8%-32.8%) to year 3 in senior secondary school (40.1%; 95% CI, 29.4%-51.9%) (Q=7.1, p<0.01). Potential sources of high heterogeneity of prevalence among studies can be accounted for by screening instruments with different cutoffs. Further analysis stratified by gender, grade, household registration (hukou) and number of children in the household were performed. LIMITATIONS: Limitations include the high level of heterogeneity between studies (mainly from the heterogeneity of measurement tools) and stringent inclusion and exclusion criteria. CONCLUSIONS: This study suggests that depressive symptoms are common among Chinese secondary school students. Further research is needed to identify the risk factors and effective strategies for preventing and treating depression among adolescents in secondary schools.
摘要：
The cancer transcriptome is remarkably complex, including low-abundance transcripts, many not polyadenylated. To fully characterize the transcriptome of localized prostate cancer, we performed ultra-deep total RNA-seq on 144 tumors with rich clinical annotation. This revealed a linear transcriptomic subtype associated with the aggressive intraductal carcinoma sub-histology and a fusion profile that differentiates localized from metastatic disease. Analysis of back-splicing events showed widespread RNA circularization, with the average tumor expressing 7,232 circular RNAs (circRNAs). The degree of circRNA production was correlated to disease progression in multiple patient cohorts. Loss-of-function screening identified 11.3% of highly abundant circRNAs as essential for cell proliferation; for approximately 90% of these, their parental linear transcripts were not essential. Individual circRNAs can have distinct functions, with circCSNK1G3 promoting cell growth by interacting with miR-181. These data advocate for adoption of ultra-deep RNA-seq without poly-A selection to interrogate both linear and circular transcriptomes.
