作者机构：
[李中强; 汪正祥; 谭庆; 余曼] College of Resources and Environment, Hubei University, Wuhan 430062, China;[雷耘] College of Life Science, Central China Normal University, Wuhan 430079, China
通讯机构：
[Tan, Q.] C;College of Resources and Environment, Hubei University, China
作者机构：
College of Life Science, Central China Normal University, Wuhan 430079
会议名称：
第十届室内空气品质和质量国际学术会议(Proceedings of the 10th International Conference on Indoor Air Quality and Climate)
会议时间：
2005-09-04
会议地点：
北京
会议论文集名称：
第十届室内空气品质和质量国际学术会议
关键词：
Formaldehyde;Toxicological study;Physiological study
摘要：
This paper is a review on recent developments of the toxicological and physiological studies on formaldehyde.Hotspots involved in this topic include: (1) Formaldehyde-induced gene expression; (2) Formaldehyde-induced asthma; (3) Airway neurogenic inflammation (4) formaldehyde working as signaling molecule in body;, (5)Epigenesis: methylation of DNA and proteins; (6) DNA-protein crosslink; (7) Lysine-DPC repair enzyme; (8)Formaldehyde-induced Apoptosis.
摘要：
Tobacco hydroxyproline-rich glycopeptide systemin precursor A (TobpreproHypSys-A), from which TobHypSys I and II are released, plays a crucial role in defense responses. Here, we investigated the expression of TobpreproHypSys-A and the activity of defense proteins in tobacco organs during wounding. Expression was induced more rapidly in upper, non-wounded leaves than in lower, wounded leaves. At 24 h after mechanical wounding, expression was low in the roots, but increased in the stems and flowers, although to a lesser extent than in the leaves. At 3 or 10 d after insect-wounding, expression did not differ among organs, suggesting that TobpreproHypSys-A could be induced globally and continuously throughout such stress. During that period, the activity of two defense proteins -- PPO and PI -- was consistent with the expression of TobpreproHypSys-A in various organs. This indicates that those proteins also could be regulated by TobHypSys, both globally and continuously.
作者机构：
College of Life Science, Central China Normal University, Wuhan 430079, China;College of Life Science, Central China Normal University, Wuhan 430079, China Key Laboratory of Pest;Key Laboratory of Pesticide & Chemical Biology (CCNU) of Ministry of Education, Wuhan 430079, China
会议名称：
The 2nd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2008)(第二届生物信息与生物医学工程国际会议)
会议时间：
2008-05-16
会议地点：
上海
会议论文集名称：
The 2nd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2008)(第二届生物信息与生物医学工程国际会议)论文集
摘要：
Streptococcus pneumoniae is the major causative organisms of meningitis, bacteremia, and pneumonia. The drug resistance of S.pneumoniae to antibiotics showed ascending tendency. The present study cloned the full-length HMG-CoA reductase (HMGR) gene of S.pneumoniae and expressed in E.coli BL21 (DE3). The His-tag containing recombinant protein was purified by Ni-NTA affinity chromatography. Statins represent a kind of excellent competing inhibitor targeted for the class Ι HMG-CoA reductase, but were relatively poor to the class II enzyme of important bacterial pathogens. In order to develop new inhibitors with more specific and stronger function targeted for the class II HMG-CoA reductase, the 3D model of S.pneumoniae HMG-CoAR was built based on structure template of HMGR of Pseudomonas mevalonii by homology modeling using composer module of SYBYL7.0 program.
作者机构：
[Yang, Jiao-Yan] Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.;[Lu, Liang-Qiu; Ming, Zhi-Hui; An, Jing; Hua, Qiu-Lin] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Lu, Liang-Qiu] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
The crystal structure of the title compound, C14H11NO4, is influenced by N - H⋯O and O - H⋯O hydrogen bonds, linking mol-ecules into one-dimensional tapes running along the [010] direction.
