期刊：
CHEMICAL SOCIETY REVIEWS,2024年53(1):137-162 ISSN：0306-0012
通讯作者：
Zhu, CZ;Lin, YH
作者机构：
[Xu, Weiqing; Zhu, Chengzhou; Wu, Yu; Zhu, CZ; Gu, Wenling] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Lin, YH; Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Lin, YH ] W;[Zhu, CZ ] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
摘要：
Natural metalloenzymes with astonishing reaction activity and specificity underpin essential life transformations. Nevertheless, enzymes only operate under mild conditions to keep sophisticated structures active, limiting their potential applications. Artificial metalloenzymes that recapitulate the catalytic activity of enzymes can not only circumvent the enzymatic fragility but also bring versatile functions into practice. Among them, metal-organic frameworks (MOFs) featuring diverse and site-isolated metal sites and supramolecular structures have emerged as promising candidates for metalloenzymes to move toward unparalleled properties and behaviour of enzymes. In this review, we systematically summarize the significant advances in MOF-based metalloenzyme mimics with a special emphasis on active pocket engineering at the atomic level, including primary catalytic sites and secondary coordination spheres. Then, the deep understanding of catalytic mechanisms and their advanced applications are discussed. Finally, a perspective on this emerging frontier research is provided to advance bioinspired catalysis. This review systematically summarizes the significant advances in MOF-based metalloenzyme mimics for bioinspired catalysis with a special emphasis on active pocket engineering at the atomic level.
摘要：
Food safety has garnered global concern. The food production chain, “from harvest to table”, provides multiple opportunities for contact with hazardous substances. Thus, detection, removal, and control of risks from the food production chain are necessary. Single-atom materials (SAMs), in which the atomically dispersed and catalytically active metal atoms are stabilized by surrounding atoms, possess the maximum usage efficiency of active metal sites. Benefiting from their unique structures and catalytical properties distinct from the traditional nanomaterials, SAMs have emerged as the frontier of research field in food safety. In this review, we briefly summarize recent advances in the synthesis, characterization and properties of SAMs. Following that, the applications of SAMs in food safety are highlighted, such as food detection, food preservation, food packaging and food cleaning. Specifically, the advantage of SAMs in food safety and their structure-performance are highlighted. Finally, we present current challenges and provide possible approaches for the future development of SAMs towards food safety.
作者机构：
[Tang, Yinjun; Qin, Ying; Zhu, Chengzhou; Jiao, Lei; Gu, Wenling; Xu, Weiqing; Wu, Yu; Su, Rina; Zhu, CZ; Wang, Hengjia] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Zheng, Lirong; Cui, Xiaowen] Chinese Acad Sci, Beijing Synchrotron Radiat Facil, Beijing 100049, Peoples R China.;[Wang, Canglong] Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China.;[Hu, Liuyong] Wuhan Inst Technol, Hubei Engn Technol Res Ctr Optoelect & New Energy, Hubei Key Lab Plasma Chem & Adv Mat, Wuhan 430205, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Zhu, CZ ] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
摘要：
Various applications lead to the requirement of nanozymes with either specific activity or multiple enzyme-like activities. To this end, intelligent nanozymes with freely switching specificity abilities hold great promise to adapt to complicated and changeable practical conditions. Herein, a nitrogen-doped carbon-supported copper single-atom nanozyme (named Cu SA/NC) with switchable specificity is reported. Atomically dispersed active sites endow Cu SA/NC with specific peroxidase-like activity at room temperature. Furthermore, the intrinsic photothermal conversion ability of Cu SA/NC enables the specificity switch by additional laser irradiation, where photothermal-induced temperature elevation triggers the expression of oxidase-like and catalase-like activity of Cu SA/NC. For further applications in practice, a pretreatment-and-sensing integration kit (PSIK) is constructed, where Cu SA/NC can successively achieve sample pretreatment and sensitive detection by switching from multi-activity mode to specific-activity mode. This study sets the foundation for nanozymes with switchable specificity and broadens the application scope in point-of-care testing.
期刊：
Trends in Chemistry,2023年5(4):324-335 ISSN：2589-5974
通讯作者：
Zhu, CZ;Lin, YH
作者机构：
[Xiao, Runshi; Hu, Liuyong] Wuhan Inst Technol, Hubei Engn Technol Res Ctr Optoelect & New Energy, Hubei Key Lab Plasma Chem & Adv Mat, Wuhan 430205, Peoples R China.;[Zhu, Chengzhou; Xiao, Runshi; Zhu, CZ] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.;[Lin, YH; Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Lin, YH ] W;[Zhu, CZ ] C;Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
摘要：
The proton exchange membrane water electrolyzer (PEMWE) has attracted signifi-cant attention as a promising technology for large-scale hydrogen production. However, the challenge in developing stable and active catalysts for acidic oxygen evolution reaction (OER) restricts the overall water splitting efficiency. Recently, metal-organic framework (MOF)-based materials have been widely explored as electrocatalysts for acidic OER due to their intrinsically porous structures and excellent tunability. In this review article, the acidic OER mechanism and advanced strategies for designing efficient MOF-based acidic OER electrocatalysts are highlighted. Finally, the challenges and perspectives for the exploration of robust MOF-based OER electrocatalysts in acidic media are discussed.
作者机构：
[Xu, Weiqing; Zhu, Chengzhou; Wu, Yu; Jiao, Lei; Gu, Wenling] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Hu, Liuyong] Wuhan Inst Technol, Hubei Engn Technol Res Ctr Optoelect & New Energy, Hubei Key Lab Plasma Chem & Adv Mat, Wuhan 430205, Peoples R China.
通讯机构：
[Yuehe Lin] S;[Chengzhou Zhu] K;School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA<&wdkj&>Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
作者机构：
[Yinjun Tang; Yu Wu; Weiqing Xu; Lei Jiao; Wenling Gu; Chengzhou Zhu] Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China;[Dan Du; Yuehe Lin] School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164, United States
关键词：
Nanozymes;Food safety;Sensing;Biocatalysis
摘要：
Food safety has become a subject of major concern in controlling food contamination and supervision. Effective detection and analysis methods need to be urgently exploited to cope with this grand global challenge. Among conventional methods for food safety analysis, enzyme-based biosensing methods serve a critical role in the monitoring of food safety. However, some long-lasting challenges, like high cost and low stability, hinder enzyme-based biosensing systems. In this regard, nanozymes with superior enzyme-like activity and special physical and chemical characteristics gradually emerge as excellent tools for quality and safety analysis in agricultural fields. In this review, recent advances made in the food safety analysis based on nanozymes are summarized. Firstly, an introduction of nanozymes containing their definition, classification, and modulation is provided. Subsequently, four main sensing modes used in nanozyme-based biosensing are discussed in detail. Taking advantage of nanozyme-based biosensing platforms, great achievements made in food safety are highlighted, where biological hazards, heavy metal ions, antibiotics, pesticide residues, and additives are involved. At last, personal views of the progress and perspective in this evolving field are proposed. This review not only shows great reference significance for the construction and application of nanozyme-based analysis methods but also promotes solutions to some challenges existing in food safety.
期刊：
CURRENT ANALYTICAL CHEMISTRY,2022年18(6):739-752 ISSN：1573-4110
通讯作者：
Lin, Y.;Zhu, C.
作者机构：
[Xu, Weiqing; Zhu, Chengzhou; Wu, Yu; Jiao, Lei; Gu, Wenling] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr ForIntelligent Biosensing Techn, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Lin, Y.] S;[Zhu, C.] K;School of Mechanical and Materials Engineering, United States;Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, China
期刊：
CHEMICAL SOCIETY REVIEWS,2021年50(2):750-765 ISSN：0306-0012
通讯作者：
Zhu, Chengzhou(czzhu@mail.ccnu.edu.cn)
作者机构：
[Xu, Weiqing; Zhu, Chengzhou; Yan, Hongye; Wu, Yu; Jiao, Lei; Gu, Wenling] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Jiao, Lei] K;[Du, Dan] S;Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China.;School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA. yuehe.
作者机构：
[Yan, Hongye; Cai, Xiaoli; Wu, Yu; Gu, Wenling; Jiao, Lei; Zhu, Chengzhou] Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, China;[Du, Dan; Lin, Yuehe] School of Mechanical and Materials Engineering, Washington State University Pullman, Washington, 99164, United States
通讯机构：
[Yuehe Lin] S;[Chengzhou Zhu] K;School of Mechanical and Materials Engineering, Washington State University Pullman, Washington 99164, USA<&wdkj&>Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, PR China
作者机构：
[Cai, Xiaoli; Du, Dan; Song, Yang; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Cai, Xiaoli] Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, Wuhan 430079, Peoples R China.;[Ostermeyer, Grayson] Washington State Univ, Sch Biol Sci, Pullman, WA 99164 USA.;[Yu, Jierui] Southern Illinois Univ, Dept Chem & Biochem, Carbondale, IL 62901 USA.;[Song, Yang] Evergreen Syst Inc, Immuno Diagnost Div, Seattle, WA 98105 USA.
通讯机构：
[Song, Yang] W;[Song, Yang] E;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Evergreen Syst Inc, Immuno Diagnost Div, Seattle, WA 98105 USA.;Evergreen Syst Inc, Biomonitoring, Seattle, WA 98105 USA.
关键词：
in vitro diagnostics;allochroic nanoparticles;oxidation activity;lateral flow assay;cardiac biomarker
摘要：
Paper-based rapid diagnostic tests, such as immunochromatographic assays, namely lateral flow immunoassay (LFA), are valuable alternatives for biomarker detection compared to traditional laboratory-based tests, but these assays need further refinement to consolidate their biosensing capabilities. Nanozyme integration into LFA systems may provide a reliable means of improving the analytic sensitivity of LFA tests. Due to the involvement of multiple liquid-handling steps, the quantitative accuracy is compromised, hence hindering the use of untrained personnel point-of-care use. Self-assembling allochroic nanocatalyst (SAN) assemblies satisfy these LFA quality measures by optimizing analyte-antibody reporting performance and by intrinsically catalyzing chromogen activation, thereby reducing the number of liquid handling steps involved during sample analysis. In SANs, the hydrophobic chromogens serve as peroxidase substrates that self-assemble into nanoparticles at high loading fractions. These features demonstrate the potential for SAN-LFAs to be a valuable patient point-of-care (POC) test. Herein, we describe the SAN fabrication process and employ SAN-LFAs to detect cardiac troponin I-troponin C (cTnI-TnC) and myoglobin (Myo) levels present in plasma samples. Using SAN-LFAs, the limits of detection for cTnI-TnC and Myo were 0.012 ng/mL and 0.2 ng/mL respectively. We also demonstrate SAN compatibility with blood samples and stability under long-term storage conditions. The successful utlization of SANs in LFA-based biomarker detection may inspire these nanocatalysts to be integrated into similar immunochromatographic testing methods.
作者机构：
[Gu, Wenling; Wang, Hengjia; Jiao, Lei; Wu, Yu; Chen, Yuxin; Gong, Jingming; Zhu, Chengzhou] Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan;430079, China;[Hu, Liuyong] School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan;430205, China;[Du, Dan] School of Mechanical and Materials Engineering, Washington State University, Pullman
期刊：
re:search: das Forschungsmagazin,2020年2020(2):415-425 ISSN：2568-8103
通讯作者：
Weiyu Song<&wdkj&>Chengzhou Zhu
作者机构：
Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, China;State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Beijing, 102249, China;School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, United States;[Hongye Yan; Weiqing Xu; Yu Wu; Chengzhou Zhu; Yifeng Chen; Lei Jiao; Wenling Gu] 华中师范大学;[Linzhe Wang; Weiyu Song] 中国石油大学（北京）
通讯机构：
State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Beijing, China
作者机构：
[Fang, Qie; Zhu, Chengzhou; Gu, Wenling; Wang, Hengjia] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Zhu, Chengzhou] C;[Lin, Yuehe] W;Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
作者机构：
[Zhu, Chengzhou; Yan, Hongye; Wu, Yu; Jiao, Lei; Gu, Wenling] Cent China Normal Univ Wuhan, Key Lab Pesticide & Chem Biol, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Coll Chem, Wuhan 430079, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Zhu, Chengzhou] C;[Lin, Yuehe] W;Cent China Normal Univ Wuhan, Key Lab Pesticide & Chem Biol, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Coll Chem, Wuhan 430079, Peoples R China.;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
作者机构：
[Xu, Weiqing; Jiao, Lei; Yan, Hongye; Wu, Yu; Gu, Wenling; Zhu, Chengzhou] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China;[Chen, Lijuan] Zhengzhou Univ, Henan Prov Peoples Hosp, Henan Key Lab Neurol Imaging, Dept Radiol, Zhengzhou 450003, Henan, Peoples R China;[Chen, Lijuan] Zhengzhou Univ, Peoples Hosp, Zhengzhou 450003, Henan, Peoples R China;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA
通讯机构：
[Zhu, Chengzhou] C;[Lin, Yuehe] W;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China. Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
摘要：
Electrochromic windows (ECWs) become an appealing concept for green buildings. However, conventional ECWs need external biases to operate causing energy consumption and are usually restricted by monotonous color. Recently, electrochromic energy storage windows (EESWs) integrating the functions of electrochromism and energy storage in one device have attracted particular attention in various fields, such as self-powered addressable displays, human-readable batteries, and most importantly energy-efficient smart windows. Herein, a color-tunable (nonemissive-red-yellow-green) self-powered EESW is initially presented utilizing Prussian blue (PB) as a controller of the fluorescent component of CdSe quantum dots. The key design feature is that without any external stimuli, the EESW can be powered by a rechargeable "perpetual" battery, which is composed of two half-cell couples of Fe/PB and Prussian white (PW)/Pt. This technique allows to achieve only by switching the connection status of the two half-cells, the fast discharging and self-charging process of the EESWs with high and sustainable charge-storage capacity. Remarkably, the fabricated self-powered EESWs exhibit quick response ("off" 7 s, "on" 50 s), large transmittance spectra contrast, and high fluorescent contrast modulation (60-86%) over a wide optical range, and great reproducibility (only 3% of the modulation ratio decreased after 30 cycles), which is comparable to ECWs powered by an electrochemical potentiostat.
作者机构：
[Zhu, Peiyuan; Belfiore, Laurence A.; Li, Zhenhua; Mao, Sui; Tang, Jianguo; Zhai, Yanling; Zhu, Zhijun] Qingdao Univ, Natl Ctr Int Res Hybrid Mat Technol, Natl Base Int Sci & Technol Cooperat, Inst Hybrid Mat,Coll Mat Sci & Engn, Qingdao 266071, Shandong, Peoples R China.;[Zhu, Chengzhou] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Coll Chem, Wuhan 430079, Hubei, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Belfiore, Laurence A.] Colorado State Univ, Chem & Biol Engn, Ft Collins, CO 80523 USA.
通讯机构：
[Zhai, YL; Tang, JG] Q;[Zhu, Chengzhou] C;[Lin, Yuehe] W;Qingdao Univ, Natl Ctr Int Res Hybrid Mat Technol, Natl Base Int Sci & Technol Cooperat, Inst Hybrid Mat,Coll Mat Sci & Engn, Qingdao 266071, Shandong, Peoples R China.;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Coll Chem, Wuhan 430079, Hubei, Peoples R China.
摘要：
Recent years have witnessed a rapid development of the fluorescent carbon dots (CDs), due to their distinctive advantages of straightforward synthesis, excellent biocompatibility, low cost, and tunable optical properties. However, the widespread applications of CDs in biomedical theranostics, light harvesting, and photocatalysis are limited by the lack of emission and/or excitation in the red/near-infrared (NIR) region. Extensive explorations have been conducted to synthesize CDs with intensive red/NIR emission/excitation (red CDs) by rational design and ingenious synthesis to broaden their applications. This review emphasizes the most recent efforts in the development of CDs with intensive emission at a long wavelength, with a focus on the regulation methods for the optical properties of CDs, including particle size, surface state, and heteroatom doping. Key factors in processing red CDs, such as reaction solvent and precursors, are demonstrated. More importantly, employing polyaromatic and dye molecules as carbon sources is highlighted, which could further expand emission/excitation to the NIR region. The boosting applications of red CDs in white light-emitting diodes (WLEDs), biosensing, bioimaging, theranostics, and photocatalysis are demonstrated. Finally, the challenges and perspectives of red CDs are also discussed.
