期刊：
CHEMICAL SOCIETY REVIEWS,2021年50(2):750-765 ISSN：0306-0012
通讯作者：
Zhu, Chengzhou(czzhu@mail.ccnu.edu.cn)
作者机构：
[Xu, Weiqing; Zhu, Chengzhou; Yan, Hongye; Wu, Yu; Jiao, Lei; Gu, Wenling] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Jiao, Lei] K;[Du, Dan] S;Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China.;School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA. yuehe.
作者机构：
[Cai, Xiaoli; Du, Dan; Song, Yang; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Cai, Xiaoli] Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, Wuhan 430079, Peoples R China.;[Ostermeyer, Grayson] Washington State Univ, Sch Biol Sci, Pullman, WA 99164 USA.;[Yu, Jierui] Southern Illinois Univ, Dept Chem & Biochem, Carbondale, IL 62901 USA.;[Song, Yang] Evergreen Syst Inc, Immuno Diagnost Div, Seattle, WA 98105 USA.
通讯机构：
[Song, Yang] W;[Song, Yang] E;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Evergreen Syst Inc, Immuno Diagnost Div, Seattle, WA 98105 USA.;Evergreen Syst Inc, Biomonitoring, Seattle, WA 98105 USA.
关键词：
in vitro diagnostics;allochroic nanoparticles;oxidation activity;lateral flow assay;cardiac biomarker
摘要：
Paper-based rapid diagnostic tests, such as immunochromatographic assays, namely lateral flow immunoassay (LFA), are valuable alternatives for biomarker detection compared to traditional laboratory-based tests, but these assays need further refinement to consolidate their biosensing capabilities. Nanozyme integration into LFA systems may provide a reliable means of improving the analytic sensitivity of LFA tests. Due to the involvement of multiple liquid-handling steps, the quantitative accuracy is compromised, hence hindering the use of untrained personnel point-of-care use. Self-assembling allochroic nanocatalyst (SAN) assemblies satisfy these LFA quality measures by optimizing analyte-antibody reporting performance and by intrinsically catalyzing chromogen activation, thereby reducing the number of liquid handling steps involved during sample analysis. In SANs, the hydrophobic chromogens serve as peroxidase substrates that self-assemble into nanoparticles at high loading fractions. These features demonstrate the potential for SAN-LFAs to be a valuable patient point-of-care (POC) test. Herein, we describe the SAN fabrication process and employ SAN-LFAs to detect cardiac troponin I-troponin C (cTnI-TnC) and myoglobin (Myo) levels present in plasma samples. Using SAN-LFAs, the limits of detection for cTnI-TnC and Myo were 0.012 ng/mL and 0.2 ng/mL respectively. We also demonstrate SAN compatibility with blood samples and stability under long-term storage conditions. The successful utlization of SANs in LFA-based biomarker detection may inspire these nanocatalysts to be integrated into similar immunochromatographic testing methods.
作者机构：
[Fang, Qie; Zhu, Chengzhou; Gu, Wenling; Wang, Hengjia] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Zhu, Chengzhou] C;[Lin, Yuehe] W;Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
摘要：
In traditional luminol-H2O2 electrochemiluminescence (ECL) sensing platform, H2O2 suffers from the self-decomposition of at room temperature, inevitably leading to the difficulty for quantitative analysis. In this work, we first adopt iron single-atom catalysts (Fe-N-C SACs) as an advanced coreactant accelerator to directly reduce the dissolved oxygen (O2) into reactive oxygen species (ROS). Owing to the unique electronic structure and catalytic activity of Fe-N-C SACs, a large amount of ROS could be efficiently produced, which will react with the luminol anion radical and significantly amplify the luminol ECL emission. Under the optimal conditions, a Fe-N-C SACs-luminol ECL sensor for antioxidant capacity measurement was developed with a good linear relationship ranged from 0.8 muM to 1.0 mM of Trolox. This typical single-atom catalyst sheds light on boosting the ECL emission of the luminol-dissolved O2 sensing platform, providing a new pathway for further research of a luminol-based ECL system.
作者机构：
[Zhu, Chengzhou; Yan, Hongye; Wu, Yu; Jiao, Lei; Gu, Wenling] Cent China Normal Univ Wuhan, Key Lab Pesticide & Chem Biol, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Coll Chem, Wuhan 430079, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Zhu, Chengzhou] C;[Lin, Yuehe] W;Cent China Normal Univ Wuhan, Key Lab Pesticide & Chem Biol, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Coll Chem, Wuhan 430079, Peoples R China.;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
期刊：
Chemical Communications,2019年55(66):9865-9868 ISSN：1359-7345
通讯作者：
Zhu, Chengzhou
作者机构：
[Xu, Weiqing; Zhu, Chengzhou; Yan, Hongye; Wu, Yu; Jiao, Lei; Gu, Wenling] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China.;[Li, He] Chengdu Univ Informat Technol, Coll Optoelect Technol, Chengdu 610225, Sichuan, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Zhu, Chengzhou] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China.
摘要：
Au hydrogel with a well-defined nanowire network was rationally designed through one-step dopamine-induced self-assembly. Due to the porous nanostructure along with the polydopamine induced accumulation and interfacial electron transfer effects, the resulting Au hydrogel nanozyme exhibits enhanced glucose oxidase-like activity and peroxidase-like activity, with a biomimetic cascade catalysis.
作者机构：
[Zhu, Peiyuan; Belfiore, Laurence A.; Li, Zhenhua; Mao, Sui; Tang, Jianguo; Zhai, Yanling; Zhu, Zhijun] Qingdao Univ, Natl Ctr Int Res Hybrid Mat Technol, Natl Base Int Sci & Technol Cooperat, Inst Hybrid Mat,Coll Mat Sci & Engn, Qingdao 266071, Shandong, Peoples R China.;[Zhu, Chengzhou] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Coll Chem, Wuhan 430079, Hubei, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Belfiore, Laurence A.] Colorado State Univ, Chem & Biol Engn, Ft Collins, CO 80523 USA.
通讯机构：
[Zhai, YL; Tang, JG] Q;[Zhu, Chengzhou] C;[Lin, Yuehe] W;Qingdao Univ, Natl Ctr Int Res Hybrid Mat Technol, Natl Base Int Sci & Technol Cooperat, Inst Hybrid Mat,Coll Mat Sci & Engn, Qingdao 266071, Shandong, Peoples R China.;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Coll Chem, Wuhan 430079, Hubei, Peoples R China.
摘要：
Recent years have witnessed a rapid development of the fluorescent carbon dots (CDs), due to their distinctive advantages of straightforward synthesis, excellent biocompatibility, low cost, and tunable optical properties. However, the widespread applications of CDs in biomedical theranostics, light harvesting, and photocatalysis are limited by the lack of emission and/or excitation in the red/near-infrared (NIR) region. Extensive explorations have been conducted to synthesize CDs with intensive red/NIR emission/excitation (red CDs) by rational design and ingenious synthesis to broaden their applications. This review emphasizes the most recent efforts in the development of CDs with intensive emission at a long wavelength, with a focus on the regulation methods for the optical properties of CDs, including particle size, surface state, and heteroatom doping. Key factors in processing red CDs, such as reaction solvent and precursors, are demonstrated. More importantly, employing polyaromatic and dye molecules as carbon sources is highlighted, which could further expand emission/excitation to the NIR region. The boosting applications of red CDs in white light-emitting diodes (WLEDs), biosensing, bioimaging, theranostics, and photocatalysis are demonstrated. Finally, the challenges and perspectives of red CDs are also discussed.
作者机构：
[Xu, Weiqing; Jiao, Lei; Yan, Hongye; Wu, Yu; Gu, Wenling; Zhu, Chengzhou] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China;[Chen, Lijuan] Zhengzhou Univ, Henan Prov Peoples Hosp, Henan Key Lab Neurol Imaging, Dept Radiol, Zhengzhou 450003, Henan, Peoples R China;[Chen, Lijuan] Zhengzhou Univ, Peoples Hosp, Zhengzhou 450003, Henan, Peoples R China;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA
通讯机构：
[Zhu, Chengzhou] C;[Lin, Yuehe] W;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China. Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
摘要：
Electrochromic windows (ECWs) become an appealing concept for green buildings. However, conventional ECWs need external biases to operate causing energy consumption and are usually restricted by monotonous color. Recently, electrochromic energy storage windows (EESWs) integrating the functions of electrochromism and energy storage in one device have attracted particular attention in various fields, such as self-powered addressable displays, human-readable batteries, and most importantly energy-efficient smart windows. Herein, a color-tunable (nonemissive-red-yellow-green) self-powered EESW is initially presented utilizing Prussian blue (PB) as a controller of the fluorescent component of CdSe quantum dots. The key design feature is that without any external stimuli, the EESW can be powered by a rechargeable "perpetual" battery, which is composed of two half-cell couples of Fe/PB and Prussian white (PW)/Pt. This technique allows to achieve only by switching the connection status of the two half-cells, the fast discharging and self-charging process of the EESWs with high and sustainable charge-storage capacity. Remarkably, the fabricated self-powered EESWs exhibit quick response ("off" 7 s, "on" 50 s), large transmittance spectra contrast, and high fluorescent contrast modulation (60-86%) over a wide optical range, and great reproducibility (only 3% of the modulation ratio decreased after 30 cycles), which is comparable to ECWs powered by an electrochemical potentiostat.
作者机构：
[Zhu, Chengzhou; Luo, Yanan] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Zhu, Chengzhou] C;[Lin, Yuehe] W;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China.;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
摘要：
It has become increasingly crucial to implement the precise determination of hydrogen sulfide (H2S) in biosystems since the abnormal level of H2S may induce various diseases. However, due to the high volatility and fast catabolism of H2S, traditional H2S detection methods are confronted with great challenges. Fortunately, the development of optical nanotechnology sheds new light on the real-time and sensitive detection of intracellular or subcellular H2S. Nanomaterials emerged as potential candidates for the optical detection of biomolecule analytes due to their excellent properties, such as easy preparation and modification, tunable optical characteristics and high photostability. Recently, many probes based on nanomaterials, ranging from inorganic nanostructures to organic polymers, have been demonstrated to exhibit high sensitive and selective detection toward H2S both in vitro and in vivo. Different from the previous review articles, we mainly summarize the advancements of optical probes, including fluorescence and non-fluorescence probes, for endogenous H2S detection based on nanomaterials in recent five years.
期刊：
CHEMICAL SOCIETY REVIEWS,2019年48(12):3181-3192 ISSN：0306-0012
通讯作者：
Lin, Yuehe;Zhu, Chengzhou
作者机构：
[Du, Dan; Lin, Yuehe; Shi, Qiurong] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Zhu, Chengzhou] Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Lin, Yuehe] W;[Zhu, Chengzhou] C;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.
摘要：
Ternary PtRuCu aerogels are facilely synthesized by one-step in situ reduction. The formation of ternary PtRuCu aerogels can be completed within 2 hours owing to the accelerated gelation kinetics. Because of the unique porous architectures and synergistic effect, the optimized Pt4Ru1Cu5 aerogels exhibited good electrochemical performance for methanol oxidation reaction.
摘要：
Single-atom catalysts (SACs) have attracted extensive attention in the catalysis field because of their remarkable catalytic activity, gratifying stability, excellent selectivity, and 100% atom utilization. With atomically dispersed metal active sites, Fe-N-C SACs can mimic oxidase by activating O-2 into reactive oxygen species, O-2(-)center dot radicals. Taking advantages of this property, single-atom nanozymes (SAzymes) can become a great impetus to develop novel biosensors. Herein, the performance of Fe-N-C SACs as oxidase-like nanozymes is explored. Besides, the Fe-N-C SAzymes are applied in biosensor areas to evaluate the activity of acetylcholinesterase based on the inhibition toward nanozyme activity by thiols. Moreover, this SAzymes-based biosensor is further used for monitoring the amounts of organophosphorus compounds.
作者机构：
[Xu, Weiqing; Zhu, Chengzhou; Wu, Yu; Jiao, Lei; Gu, Wenling] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Zhu, Chengzhou] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
关键词：
biosensors;electrocatalysis;enzyme immobilization;noble metal hydrogels;organophosphorus pesticides detection
摘要：
Noble metal hydrogels/aerogels with macroscopic nanoassemblies characterized by ultralow density, profuse continuous porosity, and extremely large surface area have gained abundant interest due to not only their tunable physicochemical properties, but also promising applications in catalysis and sensing. Coupling the increased reaction temperature with dopamine-induced effect, herein, a one-step synthetic approach with accelerated gelation kinetics is reported for the synthesis of polydopamine-capped bimetallic AuPt hydrogels. 3D porous nanowire networks with surface functionalization of polydopamine make them a promising biocompatible microenvironment for immobilizing acetylcholinesterase (AChE) and constructing enzyme-based biosensors for sensitive detection of organophosphorus compounds. Taking advantage of their favorable structure and composition, the optimized product exhibits superior electrochemical activity toward thiocholine produced by AChE-catalyzed hydrolysis of acetylthiocholine. Based on the inhibition of organophosphorus pesticide on the enzymatic activity of AChE, the inhibition mode for the detection of paraoxon-ethyl is established, displaying linear regions over the range of 0.5-1000 ng L(-1) with a low detection limit of 0.185 ng L(-1) .
作者机构：
[Zhu, Chengzhou; Yan, Hongye; Wu, Yu; Jiao, Lei; Luo, Xin] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Du, Dan] Washington State Univ, Sch Mech & Mat Engn, POB 642920, Pullman, WA 99164 USA.
通讯机构：
[Zhu, Chengzhou] C;[Du, Dan] W;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;Washington State Univ, Sch Mech & Mat Engn, POB 642920, Pullman, WA 99164 USA.
摘要：
Herein, tuning polyelectrolyte-graphene interaction was demonstrated to enhance electrocatalytic activity for non-enzymatic hydrogen peroxide detection. The introduction of positively charged poly(diallyldimethylammonium chloride) (PDDA) onto graphene surface not only prevent the aggregation of graphene sheets through electrostatic repulsion but also create net positive charge on adjacent carbon atoms in the graphene due to the occurrence of the intermolecular charge transfer by virtue of the robust electron-withdrawing ability of PDDA. Notably, we revealed the influence of the adsorbed polyelectrolytes on the redox of H2O2 and the related mechanism was discussed in detail. In a word, the catalytic activities of the graphene could be effectively tuned via the induction of the polyelectrolytes with different attributes. It was expected that this finding could be favorable for the tuning graphene electronic structure and further developing the novel graphene-based electrochemical sensing platforms.
