作者机构：
[Li, Qian; Yan, Qiang; Yan, Q; Li, Yuntao] Zhejiang Univ, Huzhou Cent Hosp, Affiliated Huzhou Hosp, Dept Gen Surg,Sch Med, Huzhou 313000, Peoples R China.;[Li, Qian; Sun, Yao; Zhao, Fang] Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Ye, Huan] Guangxi Univ, Sch Light Ind & Food Engn, Nanning 530004, Peoples R China.;[Zhang, ZP; Zhang, Zhipeng] Hubei Univ Sci & Technol, Xianning Med Coll, Coll Pharm, Xianning 437100, Peoples R China.
通讯机构：
[Zhang, ZP ] H;[Sun, Y ] C;[Yan, Q ] Z;Zhejiang Univ, Huzhou Cent Hosp, Affiliated Huzhou Hosp, Dept Gen Surg,Sch Med, Huzhou 313000, Peoples R China.;Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
摘要：
Bacterial infections can lead to the development of large-scale outbreaks of diseases that pose a serious threat to human life and health. Also, conventional antibiotics are prone to producing resistance and allergic reactions, and their therapeutic effect is dramatically diminished when bacterial communities form biofilms. Fortunately, well-designed supramolecular coordination complexes (SCCs) have been used as antibacterials or anti-biofilms in recent years. SCCs can kill bacteria by directly engaging with the bacterial surface through electrostatic interactions or by penetrating the bacterial membrane through the auxiliary effect of cell-penetrating peptides. Furthermore, scientists have engineered fluorescent SCCs that can produce reactive oxygen species (ROS) to eliminate bacteria when exposed to laser irradiation, and they also demonstrate outstanding performance in in vivo imaging, enabling integrated diagnosis and treatment. In this review, we summarize the design strategy and applications of SCCs in antibacterials or anti-biofilms and provide an outlook on future research.
摘要：
Immune checkpoint inhibitors (ICIs) therapy targeting programmed cell death ligand 1 (PD-L1) and programmed death protein 1 (PD-1) had exhibited significant clinical benefits for cancer treatment such as triple negative breast cancer (TNBC). However, the relatively low anti-tumor immune response rate and ICIs drug resistance highlight the necessity of developing ICIs combination therapy strategies to improve the anti-tumor effect of immunotherapy. Herein, the immunomodulator epigallocatechin gallate palmitate (PEGCG) and the immunoadjuvant metformin (MET) self-assembled into tumor-targeted micelles via hydrogen bond and electrostatic interaction, which encapsulated the therapeutic agents doxorubicin (DOX)loaded PEGCG-MET micelles (PMD) and combined with ICIs (anti-PD-1 antibody) as therapeutic strategy to reduce the endogenous expression of PD-L1 and improve the tumor immunosuppressive microenvironment. The results presented that PMD integrated chemotherapy and immunotherapy to enhance antitumor efficacy in vitro and in vivo , compared with DOX or anti-PD-1 antibody for the therapy of TNBC. PMD micelles might be a potential candidate, which could remedy the shortcomings of antibody-based ICIs and provide synergistic effect to enhance the antitumor effects of ICIs in tumor therapy.(c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
摘要：
Pyroptosis has garnered significant interest due to its involvement in cancer progression and potential to trigger inflammation and host immune responses. While many efforts have been made to induce pyroptosis using chemotherapeutic agents, these approaches often result in off-target effects, drug resistance, and unwanted systemic toxicity. Furthermore, the non-specific activation of pyroptosis could lead to pro-inflammatory death, creating a microenvironment that potentially heightens the chances of cancer proliferation and metastasis. To solve these limitations, photon-evoking pyroptosis engineering has emerged as a promising approach due to its precise spatiotemporal control, non-invasiveness, and reduced side effects. In this context, this work provides an overview of recent advancements in the molecular mechanisms of pyroptosis, and explore various effective strategies associated with different mode of photon-evoked pyroptosis based on the pyroptosis pathway. Thereafter, we put forth our perspectives on the challenges and prospects of utilizing photon-evoked pyroptosis in anticancer therapy.
期刊：
CHEMISTRY-AN ASIAN JOURNAL,2024年19(2):e202300860- ISSN：1861-4728
通讯作者：
Liu, SH;Hartl, F
作者机构：
[Yang, Xiao Fei; Liu, Sheng Hua; Liu, SH; Zhang, Ming-Xing] Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Zhang, Ming-Xing] Hubei Univ Educ, Coll Chem & Life Sci, Hubei Key Lab Purificat & Applicat Plant Anticanc, Wuhan 430205, Peoples R China.;[Hartl, Frantisek; Hartl, F] Univ Reading, Dept Chem, Reading RG6 6DX, England.
通讯机构：
[Liu, SH ] C;[Hartl, F ] U;Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;Univ Reading, Dept Chem, Reading RG6 6DX, England.
摘要：
The reviewed literature documents that certain metallaaromatics with unconventional photophysical properties, redox and electronic transport properties and magnetism, have potential to be widely used in diverse practical applications, with selected examples of amino acid identification, photothermal effects, functional materials, photodynamic therapy (PDT) in biomedicine, single‐molecule junction conductors, and electron‐transport layer materials (ETLs) in solar cells. Abstract In recent years, the field of organometallic chemistry has made a great progress and diverse types of metallaaromatics have successively been reported. In those studies, incorporation of ligated osmium centers into metallaaromatic systems played a prominent role. The reviewed literature documents that certain metallaaromatics with unconventional photophysical properties, redox and electronic transport properties and magnetism, have potential to be widely used in diverse practical applications, with selected examples of amino acid and fluoride anion identification, photothermal effects, functional materials, photodynamic therapy (PDT) in biomedicine, single‐molecule junction conductors, and electron‐transport layer materials (ETLs) in solar cells.
作者机构：
[Yin, Ya; Chen, Zhao; Deng, Dian-Dian] Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, People's Republic of China;[Guan, Qichen] State Key Laboratory of Separation Membrane and Membrane Process, School of Chemistry, Tiangong University, Tianjin 300387, People's Republic of China;[Liu, Sheng Hua; Liu, Shanting] Xi'an Key Laboratory of Functional Organic Porous Materials, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an 710129, People's Republic of China;[Sun, Yue] National Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan 430079, People's Republic of China
摘要：
Achieving high-contrast tricolor emissive regulation of a single-component molecule using a single type of external stimulus is highly desirable but challenging. In the present study, we report a symmetric acceptor-donor-acceptor (A-D-A)-type aggregation-induced emission-active luminogen, which displays a sequential high-contrast fluorescence switching just by anisotropic mechanical grinding. Specifically, upon light grinding, an orange-yellow-to-blue hypsochromic mechanofluorochromic response with a distinct color contrast (change in the maximum emission wavelength, Δλ(em,max) = 122 nm) is noticed, and the slightly ground solid exhibits a blue-to-red high-contrast (Δλ(em,max) = 185 nm) bathochromic mechanofluorochromic conversion upon vigorous grinding. Thus, using a single luminogen developed here, we can realize wide-range (Δλ(em,max) > 100 nm) hypso- and bathochromic fluorescence mechanochromisms simultaneously. The tricolored mechanofluorochromic phenomenon is attributed to two different morphological transitions involving crystalline-to-crystalline and crystalline-to-amorphous states. Furthermore, three information anticounterfeiting systems are developed using the luminogen presented here.
摘要：
Particulate matter, represented by soot particles, poses a significant global environmental threat, necessitating efficient control technology. Here, we innovatively designed and elaborately fabricated ordered hierarchical macroporous catalysts of Ce(0.8)Zr(0.2)O(2) (OM CZO) integrated on a catalyzed diesel particulate filter (CDPF) using the self-assembly method. An oxygen-vacancy-enriched ordered macroporous Ce(0.8)Zr(0.2)O(2) catalyst (V(O)-OM CZO) integrated CDPF was synthesized by subsequent NaBH(4) reduction. The V(O)-OM CZO integrated CDPF exhibited a markedly enhanced soot oxidation activity compared to OM CZO and powder CZO coated CDPFs (T(50): 430 vs 490 and 545 °C, respectively). The well-defined OM structure of the V(O)-OM CZO catalysts effectively improves the contact efficiency between soot and the catalysts. Meanwhile, oxygen vacancies trigger the formation of a large amount of highly reactive peroxide species (O(2)(2-)) from molecular oxygen (O(2)) through electron abstraction from the three adjacent Ce(3+) (3Ce(3+) + Vö + O(2) → 3Ce(4+) + O(2)(2-)), contributing to the efficient soot oxidation. This work demonstrates the fabrication of the ordered macroporous CZO integrated CDPF and reveals the importance of structure and surface engineering in soot oxidation, which sheds light on the design of highly efficient PM capture and removal devices.
期刊：
Journal of Carbohydrate Chemistry,2024年 ISSN：0732-8303
通讯作者：
Guo, J
作者机构：
[Zhang, Ru-Yan; Liu, Yan-Ling; Ding, Dong; Guo, J; Wen, Yu; Guo, Jun; Zhou, Shi-Hao; Zou, Yong-Ke] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
通讯机构：
[Guo, J ] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
关键词：
Cancer vaccine;c-GAMP;MUC1;MUC1 glycopeptide;poly(I:C);ternary adjuvant system
摘要：
The highly glycosylated mucin 1 (MUC1) serves as a promising target for cancer vaccines. However, the weak immunogenicity of MUC1 greatly impedes its application. Here, we covalently linked a MUC1 glycopeptide to carrier protein bovine serum albumin (BSA), and the resulting BSA-MUC1 conjugate was integrated with a ternary adjuvant system comprising TLR3 agonist poly(I:C), STING agonist c-GAMP, and Alum adjuvant. Compared to adjuvant-free and Alum-adjuvanted groups, the ternary adjuvant group induced 18.3- and 10.9-fold increases in MUC1-specific IgG titers, and effectively suppressed tumor growth. These findings may propose a straightforward yet highly effective strategy for designing vaccines, offering promising prospects in cancer treatment.
摘要：
Engineering isolated metal sites resembling the primary coordination sphere of metallocofactors enables atomically dispersed materials as promising nanozymes. However, most existing nanozymes primarily focus on replicating specific metallocofactors while neglecting other supporting cofactors within active pockets, leading to reduced electron transfer (ET) efficiency and thus inferior catalytic performances. Herein, we report a metal–organic framework UiO-67 nanozyme with atomically dispersed iron sites, which involves multiple tailored enzyme-like nanocofactors that synergistically drive the ET process for enhanced peroxidase-like catalysis. Among them, the linker-coupled atomic iron site plays a critical role in substrate activation, while bare linkers and zirconia nodes facilitate the ET efficiency of intermediates. The synergy of three nanocofactors results in a 4.29-fold enhancement compared with the single effort of isolated metal site-based nanocofactor, holding promise in immunoassay for sensitive detection of chlorpyrifos. This finding opens a new way for designing high-performance nanozymes by harmonizing various nanocofactors at the atomic and molecular scale.
摘要：
Cancer cells need a greater supply of glucose mainly due to their aerobic glycolysis, known as the Warburg effect. Glucose transport by glucose transporter 1 (GLUT1) is the rate-limiting step for glucose uptake, making it a potential cancer therapeutic target. However, GLUT1 is widely expressed and performs crucial functions in a variety of cells, and its indiscriminate inhibition will cause serious side effects. In this study, we designed and synthesized a photocaged GLUT1 inhibitor WZB117-PPG to suppress the growth of cancer cells in a spatiotemporally controllable manner. WZB117-PPG exhibited remarkable photolysis efficiency and substantial cytotoxicity toward cancer cells under visible light illumination with minimal side effects, ensuring its safety as a potential cancer therapy. Furthermore, our quantitative proteomics data delineated a comprehensive portrait of responses in cancer cells under glucose deprivation, underlining the mechanism of cell death via necrosis rather than apoptosis. We reason that our study provides a potentially reliable cancer treatment strategy and can be used as a spatiotemporally controllable trigger for studying nutrient deprivation-related stress responses.
作者机构：
[Li, Guang; Xu, Weiwei; Hameed, Muhammad Salman; Yang, Qinglin; Li, Haibing; Qu, Haonan] Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Quan, Jiaxin; Quan, JX] Hanjiang Normal Univ, Dept Chem Biol & Environm Engn, Shiyan 442000, Peoples R China.;[Zhang, J; Zhang, Jin] Yunnan Normal Univ, Coll Chem & Chem Engn, Kunming 650092, Peoples R China.;[Sun, Zhongyue] Hubei Univ Chinese Med, Sch Lab Med, Wuhan 430065, Peoples R China.
通讯机构：
[Quan, JX ; Sun, ZY ] H;[Li, HB ] C;[Zhang, J ] Y;Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;Hanjiang Normal Univ, Dept Chem Biol & Environm Engn, Shiyan 442000, Peoples R China.
关键词：
arginine;biomimetic;mimic Cyt C transport;nanochannel;pH
摘要：
Proteins are vital components in cells, biological tissues, and organs, playing a pivotal role in growth and developmental processes in living organisms. Cytochrome C (Cyt C) is a class of heme proteins found in almost all life and is involved in cellular energy metabolic processes such as respiration, mainly as electron carriers or terminal reductases. It binds cardiolipin in the inner mitochondrial membrane, leading to apoptosis. It is a challenge to design a simple and effective artificial system to mimic the complex Cyt C biological transport process. In this paper, an asymmetric biomimetic pH-driven protein gate is described by introducing arginine (Arg) at one end of an hourglass-shaped nanochannel. The nanochannel shows a sensitive protonation-driven protein gate that can be "off" at pH = 7 and "on" at pH = 2. Further studies show that differences in the binding of Arg and Cyt C at different levels of protonation lead to different switching behaviors within the nanochannels, which in turn lead to different surface charges within the nanochannels. It can be used for detecting Cyt C and as an excellent and robust gate for developing integrated circuits and nanoelectronic logic devices.
摘要：
Fosmidomycin (FOS) is a natural product inhibiting the DXR enzyme in the MEP pathway and has stimulated interest for finding more suitable FOS analogues. Herein, two series of FOS analogue hydroxamate-containing bisphosphonates as proherbicides were designed, with bisphosphonate replacing the phosphonic unit in FOS while retaining the hydroxamate (BPF series) or replacing it with retro-hydroxamate (BPRF series). The BPF series were synthesized through a three-step reaction sequence including Michael addition of vinylidenebisphosphonate, N-acylation, and deprotection, and the BPRF series were synthesized with a retro-Claisen condensation incorporated into the reaction sequence. Evaluation on model plants demonstrated several compounds having considerable herbicidal activities, and in particular, compound 8m exhibited multifold activity enhancement as compared to the control FOS. The proherbicide properties were comparatively validated. Furthermore, DXR enzyme assay, dimethylallyl pyrophosphate rescue, and molecular docking verified 8m to be a promising proherbicide candidate targeting the DXR enzyme. In addition, 8m also displayed good antimalarial activities.
作者机构：
[Wang, Dong; Wang, D; Cao, Dandan] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;[Yang, Yongqing] Chongqing Normal Univ, Coll Life Sci, Chongqing 401331, Peoples R China.;[Wang, Dong; Wang, D] Shaanxi Univ Technol, Bioresources Key Lab Shaanxi Prov, Hanzhong 723001, Shaanxi, Peoples R China.
通讯机构：
[Wang, D ] C;Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;Shaanxi Univ Technol, Bioresources Key Lab Shaanxi Prov, Hanzhong 723001, Shaanxi, Peoples R China.
摘要：
Invasive plants have been shown to alter ecosystem functions. However, there is limited information available on the effect of the invasive species litter input on native litter decomposition and home-field advantage (HFA, increased decomposition at a home environment compared to a guest environment). To investigate this, we conducted a field experiment using leaves of native Trapa natans and Typha orientalis with and without invasive species Alternanthera philoxeroides and then incubated them at T. natans and T. orientalis habitats in a eutrophic lake for 50 days. In control and treatment, the decomposition and N release rate of T. natans were significantly higher than that in T. orientalis species litter at two habitats, indicating no HFA occurrence. A. philoxeroides litter input promoted the decomposition and N decay rate of T. orientalis, not T. natans. The mean decomposition rate of T. orientalis in control and treatment were 0.0138 and 0.0342 day-1; for T. natans, it was 0.0703 and 0.0754 day-1, respectively. The mean N decay rate of T. orientalis in control and treatment were 0.0235 and 0.0468 day-1; for T. natans, it was 0.0511 and 0.0544 day-1, respectively. Invasive species presence increased microbial respiration rate of T. orientalis, but not for T. natans species litter in two habitats. These results suggested that A. philoxeroides litter input accelerated low quality litter decomposition though increased microbial activity. However, it did not influence the HFA performance, which may be closely related to the lake eutrophication.
摘要：
BACKGROUNDS AND AIMS: The hypothesis that plants evolve features that protect accessible pollen from consumption by flower visitors remains poorly understood. METHODS: To explore potential chemical defenses against pollen consumption, we examined the pollinator assemblage, foraging behaviour, visitation frequency and pollen transfer efficiency in Rhododendron molle, a highly toxic shrub containing Rhodojaponin III. Nutrient (protein and lipid) and toxic components in pollen and other tissues were measured. KEY RESULTS: Overall in the five populations, floral visits by butterflies and bumblebees were relatively more frequent than visits by honeybees. All foraged for nectar but not pollen. Butterflies did not differ from bumblebees in the amount of pollen removed per visit, but deposited more pollen per visit. Pollination experiments indicated that R. molle was self-compatible, but both fruit and seed production were pollen limited. Our analysis indicated that the pollen was not protein-poor and had a higher concentration of the toxic compound Rhodojaponin III than petals and leaves, which compound was undetectable in nectar. CONCLUSION: Pollen toxicity in Rhododendron flowers may discourage pollen robbers (bees) from taking the freely accessible pollen grains, while the toxin-free nectar rewards effective pollinators, promoting pollen transfer. This preliminary study supports the hypothesis that chemical defense in pollen would be likely to evolve in species without physical protection from pollinivores.
摘要：
During field work on mutualisms between oil bees and Cucurbitaceae in Yunnan, China, we discovered a new species of Thladiantha that we here describe and illustrate. It is overall similar to T. globicarpa A.M.Lu & Zhi Y.Zhang from Guangxi, but differs in the shape of its fruits. DNA sequences of the new species analyzed in the context of a densely sampled phylogeny of Thladiantha confirm its distinctness from all other species. The molecular data also revealed another collection of the new species made in Guangxi in 1937. Like all Thladiantha, the new species offers oil in glandular hairs on its petals and is pollinated by oil -collecting Ctenoplectra bees.
期刊：
International Journal of Biological Macromolecules,2024年267(Pt 1):131459 ISSN：0141-8130
通讯作者：
Liu, Leilei
作者机构：
[Liu, Leilei] Center of Applied Biotechnology, School of Life Sciences and Technology, Wuhan University of Bioengineering, Wuhan, Hubei, China. Electronic address: liulei@mails.ccnu.edu.cn;[Wang, Jintao; Xu, Peiwen; Wei, Wei; He, Wenfeng] Center of Applied Biotechnology, School of Life Sciences and Technology, Wuhan University of Bioengineering, Wuhan, Hubei, China;[Xu, Peiwen; He, Wenfeng] College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China;[Liu, Kaiyu] School of Life Sciences, Central China Normal University, Wuhan, Hubei, China
通讯机构：
[Liu, Leilei] C;Center of Applied Biotechnology, School of Life Sciences and Technology, Wuhan University of Bioengineering, Wuhan, Hubei, China. Electronic address:
摘要：
Insect resistance evolution poses a significant threat to the advantages of biopesticides and transgenic crops utilizing insecticidal Cry-toxins from Bacillus thuringiensis (Bt). However, there is limited research on the relationship between transcriptional regulation of specific toxin receptors in lepidopteran insects and their resistance to Bt toxins. Here, we report the positive regulatory role of the SfGATAe transcription factor on the expression of the ABCC2 gene in Spodoptera frugiperda. DNA regions in the SfABCC2 promoter that are vital for regulation by SfGATAe, utilizing DAP-seq technology and promoter deletion mapping. Through yeast one-hybrid assays, DNA pull-down experiments, and site-directed mutagenesis, we confirmed that the transcription factor SfGATAe regulates the core control site PBS2 in the ABCC2 target gene. Tissue-specific expression analysis has revealed that SfGATAe is involved in the regulation and expression of midgut cells in the fall armyworm. Silencing SfGATAe in fall armyworm larvae resulted in reduced expression of SfABCC2 and decreased sensitivity to Cry1Ac toxin. Overall, this study elucidated the regulatory mechanism of the transcription factor SfGATAe on the expression of the toxin receptor gene SfABCC2 and this transcriptional control mechanism impacts the resistance of the fall armyworm to Bt toxins.
摘要：
Accurate wind speed forecasting is capable of increasing the stability of wind power system. Notably, there are numerous factors affecting wind speed, thus causing wind speed forecasting to be difficult. To address the above -mentioned challenge, a novel hybrid model integrating genetic algorithm (GA), variational mode decomposition (VMD), improved dung beetle optimization algorithm (IDBO), and Bidirectional long short-term memory network based on attention mechanism (BiLSTM-A) is proposed in this study to achieve satisfactory forecasting performance. In the proposed model, GA is adopted to optimize the VMD to eliminate noise and extract original series attributes. And the IDBO is adopted for hyperparameters selection for the BiLSTM-A. The proposed GA-VMD-IDBO-BiLSTM-A is compared with nine established comparable models, with the aim of verifying its forecasting performance. A series of experiments on four 1 -hour real wind series in Stratford are performed to assess the performance of the model. The MAPE of the four datasets forecasting results reached 1.4%, 2.4%, 3.5%, 2.4%. As indicated by the experimental results, GA-VMD can better process the data and improve the forecasting accuracy. IDBO can optimize the parameters of BiLSTM model and improve the forecasting performance. The dual -optimization wind speed forecasting model can obtain high accuracy and strong stability.
作者机构：
[Zhang, Wei; Ju, Changting; Xue, Jinfeng] Cent China Normal Univ, Sch Psychol, 152 Luoyu St, Wuhan 430079, Hubei, Peoples R China.;[Ju, Changting] Anyang Inst Technol, Mental Hlth Educ Ctr, Zhumadian, Henan, Peoples R China.;[Mo, Ning] Anyang Univ, Mental Hlth Educ Ctr, Zhumadian, Henan, Peoples R China.;[Jiang, Xu] Temple Univ, Dept Psychol Studies Educ, 1301 Cecil B Moore Ave, Philadelphia, PA 19122 USA.;[Xue, Jinfeng] Hunan Univ Chinese Med, Sch Nursing, Changsha, Hunan, Peoples R China.
通讯机构：
[Zhang, W ] C;[Jiang, X ] T;Cent China Normal Univ, Sch Psychol, 152 Luoyu St, Wuhan 430079, Hubei, Peoples R China.;Temple Univ, Dept Psychol Studies Educ, 1301 Cecil B Moore Ave, Philadelphia, PA 19122 USA.
关键词：
Mindful Self-Care Scale;MSCS;Brief-MSCS;Chinese college students;Validity;Reliability
摘要：
ObjectivesMindful self-care is a way of embodied self-regulation that can safeguard and enhance psychological well-being. This study aimed to test the reliability and validity of the Chinese version of the Mindful Self-Care Scale (MSCS) among college students.MethodA total of 1486 college students (Mage = 19.36, SD = 1.16) from four different universities participated in this study. All participants completed a series of online surveys, including the MSCS, the Self-Compassion Scale-Short Form, the Body Appreciation Scale-2, and the Satisfaction With Life Scale. Confirmatory factor analysis was used to evaluate the validity of the MSCS, and the R package measureQ was utilized to calculate the reliability. Additionally, we conducted comparative analyses involving the MSCS (33 items), its brief version (Brief-MSCS, 24 items), and previous relevant research.ResultsThe MSCS and Brief-MSCS demonstrated an acceptable factor structure, while the Brief-MSCS exhibited a more robust structure. Notably, the bifactor model adequately fitted the data for both versions. In bifactor model, each item not only belonged to its own group of factors but also belonged to a general factor. Both versions displayed satisfactory convergent validity, discriminant validity, concurrent validity, and robust composite reliability. Furthermore, Chinese college students exhibited a higher level of mindful self-care than Chinese medical professionals and a Western community sample.ConclusionsThe MSCS and Brief-MSCS have been found to be reliable and valid tools for assessing the levels of mindful self-care among college students, with the brief version showing superior performance. The robust fit of the bifactor model suggests that there is an overarching structure of mindful self-care that can be used to assess an individual's level through the total score. Moreover, there are differences in the level of mindful self-care among different groups, which need further verification.PreregistrationThis study is not preregistered.
