摘要：
The production of Υ mesons in pp collisions at
$$ \sqrt{s}=7 $$
and 8 TeV is studied with the LHCb detector using data samples corresponding to an integrated luminosity of 1 fb−1 and 2 fb−1 respectively. The production cross-sections and ratios of cross-sections are measured as functions of the meson transverse momentum p and rapidity y, for p < 30 GeV/c and 2.0 < y < 4.5.
摘要：
We consider m integral vectors X1,…,Xm∈Zs located in a half-space of Rs ( m≥s≥1) and study the structure of the additive semi-group X1N+⋯+XmN. We introduce and study maximal saturated cone and directional growth function which describe some aspects of the structure of the semi-group. When the vectors X1,⋯,Xm are located in a fixed hyperplane, we obtain an explicit formula for the directional growth function and we show that this function completely characterizes the defining data (X1,⋯,Xm) of the semi-group. The last result will be applied to the study of Lipschitz equivalence of Cantor sets (see [11]).
On considére m vecteurs X1,…,Xm∈Zs localisés dans un demi-espace de Rs ( m≥s≥1) et on étudie la structure du semi-groupe additif X1N+⋯+XmN. Dans cet article on introduit et on étudie la notion de cône saturé maximal et celle de la fonction de croissance directionnelle, qui permettent de décrire certains aspects de la structure du semi-groupe. Lorsque les vecteurs X1,⋯,Xm sont localisés dans un hyperplane fixe, on obtient une formule explicite pour la fonction de croissance directionnelle et on montre que cette fonction caractérise complètement la donnée (X1,⋯,Xm) qui définit le semi-groupe. Ce dernier résultat sera appliqué à l'étude de l'équivalence lipschitzienne d'ensembles de Cantors (voir [11]).
期刊：
INTERNATIONAL JOURNAL OF BIOSTATISTICS,2015年12(2):1-17 ISSN：2194-573X
通讯作者：
Yuan, Ao
作者机构：
[Yuan, Ao; Tan, Ming T.] Georgetown Univ, Dept Biostat Bioinformat & Biomath, Washington, DC 20057 USA.;[Li, Qizhai] Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China.;[Xiong, Ming] Cent China Normal Univ, Sch Math & Stat, Wuhan 430079, Peoples R China.
通讯机构：
[Yuan, Ao] G;Georgetown Univ, Dept Biostat Bioinformat & Biomath, Washington, DC 20057 USA.
摘要：
In phase II and/or III clinical trial study, there are several competing treatments, the goal is to assess the performances of the treatments at the end of the study, the trial design aims to minimize risks to the patients in the trial, according to some given allocation optimality criterion. Recently, a new type of clinical trial, the staggered-start trial has been proposed in some studies, in which different treatments enter the same trial at different times. Some basic questions for this trial are whether optimality can still be kept? under what conditions? and if so how to allocate the the coming patients to treatments to achieve such optimality? Here we propose and study a class of adaptive designs of staggered-start clinical trials, in which for given optimality criterion object, we show that as long as the initial sizes at the beginning of the successive trials are not too large relative to the total sample size, the proposed design can still achieve optimality criterion asymptotically for the allocation proportions as the ordinary trials; if these initial sample sizes have about the same magnitude as the total sample size, full optimality cannot be achieved. The proposed method is simple to use and is illustrated with several examples and a simulation study.
期刊：
Genetics and Molecular Research,2015年14(1):1155-1168 ISSN：1676-5680
通讯作者：
Huang, Q.
作者机构：
[Han, L.; Wu, G.; Huang, Q.; Liu, Y.; Zhao, K.] Cent China Normal Univ, Coll Life Sci, Wuhan, Peoples R China.;[Qu, Y.] Wuhan Ctr Med Therapeut, Wuhan, Peoples R China.;[Xu, A.] Univ Hong Kong, Dept Pharmacol & Pharm, Hong Kong, Hong Kong, Peoples R China.
通讯机构：
[Huang, Q.] C;Cent China Normal Univ, Coll Life Sci, Wuhan, Peoples R China.
摘要：
Previous studies have reported associations between the functional FABP2 Ala54Thr (rs1799883) polymorphism and type 2 diabetes mellitus (T2DM), obesity, and metabolic syndrome in different populations with conflicting results. We investigated the association between the FABP2 Ala54Thr polymorphism and T2DM (235 cases, 431 controls), obesity (377 cases, 431 controls), and metabolic syndrome (315 cases, 323 controls) by logistic regression analysis in a Chinese study cohort recruited from Yichang, Hubei Province. We then comprehensively reviewed the association of the FABP2 Ala54Thr polymorphism with T2DM, obesity, and metabolic syndrome via meta-analysis. The strength of association was assessed by odds ratios (ORs) with 95% confidence intervals (CIs). The FABP2 Ala54Thr polymorphism was significantly associated with obesity (AT vs AA: OR = 2.633, 95%CI = 1.065-6.663, P = 0.036; TT vs AA: OR = 4.160, 95%CI = 1.609-10.757, P = 0.003) and metabolic syndrome (TT vs AA: OR = 2.273, 95%CI = 1.242-4.156, P = 0.008) by logistic regression with adjustment for covariates. However, no significant association was found between T2DM and the FABP2 Ala54Thr polymorphism. We identified 24 studies on T2DM (4517 cases, 5224 controls), 9 studies on obesity (949 cases, 2002 controls), and 6 studies on metabolic syndrome (2194 cases, 3282 controls) by literature search. The meta-analyses revealed significant associations for metabolic syndrome (T allele: OR = 1.179, 95%CI = 1.015-1.362, P = 0.031) and T2DM (T allele: OR = 1.160, 95%CI = 1.08-1.24, P < 0.001), but no association for obesity (T allele: OR = 1.069, 95%CI = 0.925-1.235, P = 0.367).
关键词：
Collective flow;Heavy Ions;Particle correlations and fluctuations
摘要：
The elliptic flow coefficient (v
2) of identified particles in Pb-Pb collisions at
$$ \sqrt{s_{\mathrm{NN}}}=2.76 $$
TeV was measured with the ALICE detector at the Large Hadron Collider (LHC). The results were obtained with the Scalar Product method, a two-particle correlation technique, using a pseudo-rapidity gap of |Δη| > 0.9 between the identified hadron under study and the reference particles. The v
2 is reported for π
±, K±, K
S
0
,
$$ \mathrm{p}+\overline{\mathrm{p}} $$
, ϕ,
$$ \Lambda +\overline{\Lambda} $$
,
$$ {\Xi}^{-}+{\overline{\Xi}}^{+} $$
and
$$ {\Omega}^{-}+{\overline{\Omega}}^{+} $$
in several collision centralities. In the low transverse momentum (p
T) region, p
T
< 3 GeV/c, v
2(p
T) exhibits a particle mass dependence consistent with elliptic flow accompanied by the transverse radial expansion of the system with a common velocity field. The experimental data for π
± and the combined K± and K
S
0
results, are described fairly well by hydrodynamic calculations coupled to a hadronic cascade model (VISHNU) for central collisions. However, the same calculations fail to reproduce the v
2(p
T) for
$$ \mathrm{p}+\overline{\mathrm{p}} $$
, ϕ,
$$ \Lambda +\overline{\Lambda} $$
and
$$ {\Xi}^{-}+{\overline{\Xi}}^{+} $$
. For transverse momentum values larger than about 3 GeV/c, particles tend to group according to their type, i.e. mesons and baryons. The present measurements exhibit deviations from the number of constituent quark (NCQ) scaling at the level of ±20% for p
T
> 3 GeV/c.
摘要：
Using a dataset corresponding to an integrated luminosity of 3.0 fb−1 collected in pp collisions at centre-of-mass energies of 7 and 8 TeV, the B
0
→ ϕϕ branching fraction is measured to be
$$ \mathrm{\mathcal{B}}\left({B}_s^0\to \phi \phi \right)=\left(1.84\pm 0.05\left(\mathrm{stat}\right)\pm 0.07\left(\mathrm{syst}\right)\pm 0.11\left({f}_s/{f}_d\right)\pm 0.12\left(\mathrm{norm}\right)\right)\times 1{0}^{-5}, $$
where f
s
/f
d
represents the ratio of the B
0
to B
0 production cross-sections, and the B
0 → ϕK
*(892)0 decay mode is used for normalization. This is the most precise measurement of this branching fraction to date, representing a factor five reduction in the statistical uncertainty compared with the previous best measurement. A search for the decay B
0 → ϕϕ is also made. No signal is observed, and an upper limit on the branching fraction is set as
$$ \mathrm{\mathcal{B}}\left({B}^0\to \phi \phi \right)<2.8\times 1{0}^{-8} $$
at 90% confidence level. This is a factor of seven improvement compared to the previous best limit.
通讯机构：
[Wang Dawei] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
关键词：
对羟苯基丙酮酸双氧化酶;抑制剂;喹唑啉二酮;除草剂;先导化合物
摘要：
对羟苯基丙酮酸双氧化酶(EC 1.13.11.27,HPPD)是一个重要的除草剂作用靶标.为了寻找具有高效除草活性的新型HPPD抑制剂,在前期研究的基础上设计合成了24个含有喹唑啉二酮结构的三酮类化合物9a~9x.所合成的化合物均经过~1H NMR,~(13)C NMR和HRMS的表征.以来源于拟南芥的HPPD(At HPPD)为测试对象进行酶抑制活性筛选,结果表明所合成的大部分化合物对At HPPD均表现出了较好的抑制效果,其中化合物9i的K_i值为0.005μmol/L,显著优于商品化对照药剂硝磺草酮(K_i=0.013μmol/L).进一步温室盆栽筛选结果表明,多数化合物在150 g ai/ha的剂量下对六种供试杂草中的至少一种表现出80%以上的防效,特别是化合物9g在37.5 g ai/ha的低剂量下对所测试的六种杂草中的四种仍表现出了大于85%的抑制效果,同时9g在150 g ai/ha的剂量下对水稻和小麦均表现出了很好的作物安全性,可以作为先导化合物供进一步深入研究.
作者机构：
[Feng, Guoqiang; Wu, Fengxu; Huang, Feihu; Hao, Gefei] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Feng, Guoqiang] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构：
[Feng, Guoqiang] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
摘要：
An anthracene-bridged dinuclear zinc(II)-dipicolylamine complex was found to show high selectivity for ADP with a significant fluorescence enhancement over ATP, PPi and other common analytes in 100% aqueous solution. This complex can be used for fluorescence detection of ADP in living cells and for monitoring the activity of kinases.
作者机构：
[Wu, An-Xin; Jia, Feng-Cheng; Zhou, Zhi-Wen; Xu, Cheng; Cai, Qun; Li, Deng-Kui] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Wu, An-Xin] Lanzhou Univ, Dept Chem, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.
通讯机构：
[Wu, An-Xin] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
A copper-catalyzed domino protocol for the synthesis of 2-(1,3,4-oxadiazol-2-yl)aniline derivatives has been developed from simple and available isatins and hydrazides. This domino process integrated consecutive condensation, base-promoted ring-opening and the key copper-catalyzed decarboxylative coupling for intramolecular C-O bond formation.
通讯机构：
[Li, Gao-xiang] H;Huazhong Normal Univ, Dept Phys, Wuhan 430079, Peoples R China.
关键词：
Cold ions;Electromagnetically induced transparency;Optical networks;Quantum dots;Quantum information processing;Quantum state engineering
摘要：
We propose a scheme for generation of the stationary continuous-variable entanglement and Einstein-Podolsky-Rosen (EPR) steering between an optical cavity mode and a nanomechanical resonator (NMR) mode. The cavity and the NMR are commonly coupled with two separated quantum dots (QDs), where the two QDs are driven simultaneously by a strong laser field. By adjusting the frequency of the strong laser field, the two QDs are nearly trapped on different dressed states, which is helpful to generate the entanglement between the cavity mode and the NMR mode. Due to the combined resonant interaction of the two QDs with the NMR-cavity subsystem, the photon and the phonon created and (or) annihilated are correlated. In this regime, the optimal entanglement of the two modes is obtained and the purity of the state of the NMR-cavity subsystem is near to 1. Furthermore, the coupling strength between the cavity and two QDs is different from the dot-NMR coupling strength, which leads to the different mean occupation numbers of the cavity and the NMR. In this case, one-way EPR steering is observed. In addition, through analyzing the purity, we find the conditions of the existence for the different types of EPR steering.
摘要：
Hydrogen sulfide (H2S) is considered as the third signaling molecule in vivo and it plays an important role in various physiological processes and pathological processes in vivo, such as vasodilation, apoptosis, neurotransmission, ischemia/reperfusion-induced injury, insulin secretion and inflammation. Developing a highly selective and sensitive method that can detect H2S in the biological system is very important. In this work, a colorimetric and “turn-on” fluorescent probe is developed. Furthermore, this probe displays a highly selective response to H2S in aqueous solution and possesses good capability for bioimaging H2S without interference in living cells. The results suggest that a H2S-selective probe has good water-solubility, biocompatibility and cell-penetrability and can serve as an efficient tool for probing H2S in the cell level.
