摘要：
RNA regulates various biological processes, such as gene regulation, RNA splicing, and intracellular signal transduction. RNA's conformational dynamics play crucial roles in performing its diverse functions. Thus, it is essential to explore the flexibility characteristics of RNA, especially pocket flexibility. Here, we propose a computational approach, RPflex, to analyze pocket flexibility using the coarse-grained network model. We first clustered 3154 pockets into 297 groups by similarity calculation based on the coarse-grained lattice model. Then, we introduced the flexibility score to quantify the flexibility by global pocket features. The results show strong correlations between the flexibility scores and root-mean-square fluctuation (RMSF) values, with Pearson correlation coefficients of 0.60, 0.76, and 0.53 in Testing Sets I-III. Considering both flexibility score and network calculations, the Pearson correlation coefficient was increased to 0.71 in flexible pockets on Testing Set IV. The network calculations reveal that the long-range interaction changes contributed most to flexibility. In addition, the hydrogen bonds in the base-base interactions greatly stabilize the RNA structure, while backbone interactions determine RNA folding. The computational analysis of pocket flexibility could facilitate RNA engineering for biological or medical applications.
摘要：
With the ever-changing social environment, individual creativity is facing a severe challenge induced by stress. However, little is known regarding the underlying mechanisms by which acute stress affects creative cognitive processing. The current research explored the impacts of the neuroendocrine response on creativity under stress and its underlying cognitive flexibility mechanisms. The enzyme-linked immuno sorbent assay was employed to assess salivary cortisol, which acted as a marker of stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis. Eye blink rate (EBR) and pupil diameter were measured as respective indicators of dopamine and noradrenaline released by the activation of the sympathetic-adrenal-medullary (SAM) axis. The Wisconsin card task (WCST) measured cognitive flexibility, while the alternative uses task (AUT) and the remote association task (RAT) measured separately divergent and convergent thinking in creativity. Results showed higher cortisol increments following acute stress induction in the stress group than control group. Ocular results showed that the stress manipulation significantly increased EBR and pupil diameter compared to controls, reflecting increased SAM activity. Further analysis revealed that stress-released cortisol impaired the originality component of the AUT, reducing cognitive flexibility as measured by perseverative errors on the WCST task. Serial mediation analyses showed that both EBR and pupil diameter were also associated with increased perseverative errors leading to poor originality on the AUT. These findings confirm that physiological arousal under stress can impair divergent thinking through the regulation of different neuroendocrine pathways, in which the deterioration of flexible switching plays an important mediating role. The current research is the first attempt to uncover the potential cognitive and neurophysiological mechanisms underlying creative processing under acute stress, providing a novel route to reducing stress and stress-related physiology. Moreover, the Dual Pathway to Creativity Model has been corroborated and extended for application in stressful situations.
期刊：
Journal of Research on Adolescence,2023年33(3):828-840 ISSN：1050-8392
通讯作者：
Jianzhong Hong
作者机构：
[Bao, Guanghua; Xie, Han; Hong, Jianzhong; Zhang, Rui; Gao, Fangfang] Cent China Normal Univ, Sch Psychol, Key Lab Adolescent Cyberpsychol & Behav, Minist Educ, Wuhan, Peoples R China.;[Bao, Guanghua] Guangxi Univ Finance & Econ, Sch Finance & Insurance, Nanning, Peoples R China.;[Gao, Fangfang] Changzhi Univ, Dept Educ, Changzhi, Peoples R China.;[Hong, Jianzhong] Cent China Normal Univ, Sch Psychol, 152 Luo Yu Rd, Wuhan 430079, Peoples R China.
通讯机构：
[Jianzhong Hong] K;Key Laboratory of Adolescent Cyberpsychology and Behavior (Ministry of Education), School of Psychology, Central China Normal University, Wuhan, China
关键词：
Chinese emerging adults;conceptions of adulthood;parenting
摘要：
Framed through family life course theory, two studies were conducted to examine the relationship between parenting and Chinese emerging adults' conceptions of adulthood. Study 1 identified five important adult criteria among 763 participants (M(age) =23.13; 54.8% girls) through exploratory factor analysis. In Study 2, 616 participants (M(age) =22.51; 71.6% girls) completed measures of parental autonomy support (PAS) and psychological control (PPC), subjective adult status, and adult criteria. Results showed that PAS was positively associated with subjective adult status and endorsement of almost all adult criteria, whereas PPC was both positively and negatively associated with different adult criteria. Findings reveal the influence of family factors on youth transition to adulthood in the Chinese context and may have implications for family based interventions.
期刊：
OMEGA - Journal of Death and Dying,2023年:302228231221844 ISSN：0030-2228
通讯作者：
Zhu, X
作者机构：
[Wu, Caizhi; Zhu, Xu; Huang, Tingting; Bai, Xin] Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;[Wu, Caizhi; Zhu, Xu; Huang, Tingting; Bai, Xin] Key Lab Human Dev & Mental Hlth Hubei Prov, Wuhan, Peoples R China.;[Wu, Caizhi; Zhu, Xu; Huang, Tingting; Bai, Xin] Minist Educ, Key Lab Adolescent Cyber Psychol & Behav, Wuhan, Peoples R China.;[Peng, Xueyu] Wuhan 1 High Sch, Wuhan, Peoples R China.;[Huang, Tingting] Ocean Univ China, Educ & Counseling Cent Mental Hlth, Qingdao, Peoples R China.
通讯机构：
[Zhu, X ] C;Cent China Normal Univ, Sch Psychol, Wuhan 430079, Peoples R China.
关键词：
college students;coping strategies;depressive symptoms;fatalism;suicidal behaviors
摘要：
The aim of this study was to investigate the relationship between fatalism and suicidal behaviors, the mediating role of depressive symptoms, and the moderating effect of coping strategies on the mediating process. A total of 519 participants completed the Multidimensional Fatalism Scale for General Life Events, the Center for Epidemiologic Studies-Depression scale, the Simplified Coping Style Questionnaire, and the Suicidal Behaviors Questionnaire-Revised. Results suggest that depressive symptoms partially mediated the relationship between fatalism and suicidal behaviors. Active coping moderated the mediating effect of depressive symptoms. The higher the active coping level, the weaker the mediating effect. The findings revealed that the mechanism of fatalism affecting suicidal behaviors, and had theoretical and empirical value for the prevention and intervention of suicide among college students.
作者机构：
[Yang, Qi] Tongji Univ, Sch Humanities, Shanghai 200092, Peoples R China.;[Zhang, Wenyu] Zhejiang Gongshang Univ, Sch Marxism, Hangzhou 310018, Peoples R China.;[Wu, Huan] Guangzhou Coll Commerce, Mental Hlth Educ & Counselling Ctr, Guangzhou 511363, Peoples R China.;[Huang, Baozhen] Ningde Normal Univ, Coll Educ & Arts, Ningde 352100, Peoples R China.;[Zhang, Chenyan] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China.
通讯机构：
[Niu, GF ] M;Minist Educ, Key Lab Adolescent Cyberpsychol & Behav CCNU, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Sch Psychol, Key Lab Human Dev & Mental Hlth Hubei Prov, Wuhan 430079, Peoples R China.
关键词：
adolescents;depression;parent–child attachment;perceived family financial stress;suicidal ideation
摘要：
Nowadays, suicide (especially adolescents' suicide) has been an increasingly prominent social problem worldwide; suicide ideation, as an important predictor, has been the focus of relevant studies and practices. Against this background, the present study aimed to examine the association between perceived family financial stress and adolescents' suicidal ideation, as well as the potential roles of depression and parent-child attachment. A sample of 526 junior middle school students was recruited voluntarily to participate in this cross-sectional study, and the results indicated that the prevalence of suicidal ideation among junior high school students was 15.45%; perceived family financial stress was positively associated with suicidal ideation, and depression could significantly mediate this relation; parent-child attachment significantly moderated the mediating effect of depression (in particular, the relation between depression and suicidal ideation); specifically, this relation was stronger among adolescents with lower values of parent-child attachment. These findings could deepen our understanding of the influences of perceived family financial condition and the risky factors of adolescents' suicidal ideation, which could provide guidance for the prevention and intervention of adolescents' depression and suicidal ideation.
期刊：
Building and Environment,2023年244:110800 ISSN：0360-1323
通讯作者：
Lu, C
作者机构：
[Lu, Chan; Lan, Mengju] Cent South Univ, XiangYa Sch Publ Hlth, Changsha, Peoples R China.;[Yang, Wenhui] Hunan Prov Maternal & Child Hlth Care Hosp, Changsha, Peoples R China.;[Li, Bin] Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;[Wang, Faming] Katholieke Univ Leuven, Dept Biosyst, Div Anim & Human Hlth Engn, Leuven, Belgium.
通讯机构：
[Lu, C ] C;Cent South Univ, XiangYa Sch Publ Hlth, Changsha, Peoples R China.
关键词：
Childhood pneumonia;Pregnancy;Postnatal;Meteorological factors;Environmental temperature;Diurnal temperature variation
摘要：
Background: Childhood pneumonia remains a major public health concern worldwide, but the critical meteorological factors that contribute to it are unknown. Objective: To investigate the relationship between childhood pneumonia and prenatal and postnatal exposure to meteorological factors to identify the critical factors and vulnerable timing windows. Methods: We conducted a retrospective cohort study of 8689 preschoolers in China. We gathered information on personal factors, health status, and indoor environment through questionnaires. We considered meteorological factors including temperature (mean, maximum, minimum), diurnal temperature variation (DTV), relative humidity, wind speed, rainfall, pressure and sunshine during early life. Using multiple logistic regression models, we investigated the links between childhood pneumonia and early life exposure to meteorological factors. Results: Exposure to mean, maximum, and minimum temperatures was associated with childhood pneumonia in the first month and first trimester, with ORs (95% CI) of 1.32 (1.07-1.62), 1.26 (1.04-1.52) and 1.33 (1.08-1.64) in the first month, and 1.42 (1.12-1.81), 1.36 (1.08-1.71) and 1.47 (1.15-1.88) in the first trimester for per IQR increase in each meteorological factor exposure. Wind speed, rainfall, and sunshine exhibited significant associations with pneumonia during the first, second, and third trimesters, respectively. Exposure to various temperatures, DTV, relative humidity, rainfall, air pressure, and sunshine were linked to childhood pneumonia in the postnatal period, particularly in the previous year. The sensitivity analysis revealed that boys are more vulnerable to meteorological factors. Keeping dogs or plants may offer protection against the pneumonia risk of prenatal and postnatal meteorological exposure. Conclusion: Exposure to meteorological factors during both the prenatal and postnatal periods, especially in early pregnancy, was found to elevate the risk of childhood pneumonia.
期刊：
FRONTIERS IN PSYCHIATRY,2023年14:1258673 ISSN：1664-0640
通讯作者：
Ye, JM;Zhao, X
作者机构：
[Wang, Weijun; Ye, Jianmei; Huang, Dawei] Minist Educ, Key Lab Adolescent Cyberpsychol & Behav, Wuhan, Hubei, Peoples R China.;[Wang, Weijun; Ye, Jianmei; Zhu, Yimeng; Huang, Dawei] Cent China Normal Univ, Sch Psychol, Wuhan, Hubei, Peoples R China.;[Wang, Weijun] Wuhan Technol & Business Univ, Inst Digital Commerce, Wuhan, Peoples R China.;[Zhu, Yimeng] Key Lab Human Dev & Mental Hlth Hubei Prov, Wuhan, Peoples R China.;[Zhao, X; Zhao, Xin] Univ Sheffield, Informat Sch, Sheffield, England.
通讯机构：
[Zhao, X ] U;[Ye, JM ] M;Minist Educ, Key Lab Adolescent Cyberpsychol & Behav, Wuhan, Hubei, Peoples R China.;Cent China Normal Univ, Sch Psychol, Wuhan, Hubei, Peoples R China.;Univ Sheffield, Informat Sch, Sheffield, England.
关键词：
problematic internet use;Internet Self-Control;meaning in life;Cross-lagged panel model;Longitudinal mediation model;adolescents
摘要：
Introduction: While studies indicate that high self-control may serve as a safeguard against problematic internet use, there's evidence suggesting that problematic internet use can, in turn, diminish self-control. This study aimed to elucidate the longitudinal interplay between internet self-control and problematic internet use in adolescents, employing cross-lagged panel modeling. Furthermore, drawing from a positive psychology perspective, we examined the potential role of 'meaning in life' as a protective mediator within this longitudinal relationship. We then constructed a mediation model to explore protective factors against problematic internet use.Methods: Through a questionnaire, we tracked 659 adolescents (331 males and 328 females; mean age=13.61) in a longitudinal design across two time points, spaced at five-month intervals, to assess their internet self-control, problematic internet use, and meaning in life.Results: Results of the cross-lagged panel models showed that: Internet self-control had a significant negative impact on problematic internet use after five months (beta = -0.094, p < 0.01). Conversely, problematic internet use had a significant negative impact on internet self-control after five months (beta = -0.099, p < 0.05). Results from the longitudinal mediation model showed that: Meaning in life mediated the effect of internet self-control on problematic internet use after five months (beta(internet self-control(T1)-meaning in life(T2)) = 0.142, p < 0.01; beta(meaning in life(T1)-problematic internet use (T2)) = -0.075, p < 0.05).Conclusion: Our study uncovers a reciprocal predictive relationship between internet self-control and problematic internet use, while highlighting the mediating role of meaning in life within this relationship. These findings suggest that fostering internet self-control and cultivating a sense of meaning in life among adolescents can serve as effective prevention and intervention strategies for addressing the issue of problematic internet use.
期刊：
Frontiers in Digital Health,2023年5:1208116 ISSN：2673-253X
通讯作者：
Li, A.
作者机构：
[Li, Ang] Department of Psychology, Beijing Forestry University, Beijing, China;[Liu, Xingyun] Institute of Psychology, Chinese Academy of Sciences, Beijing, China;[Liu, Xingyun] School of Psychology, Central China Normal University, Wuhan, China
通讯机构：
[Li, A.] D;Department of Psychology, China
关键词：
digital mental health;Technology innovation;health technology implementation;Barrier;solution
作者机构：
[Liu, Jingjing; Sun, Xiaojun; Sun, XJ; Duan, Changying; Bai, Xuqing] Cent China Normal Univ, Sch Psychol, Wuhan 430079, Peoples R China.;[Liu, Jingjing] Yancheng Teachers Univ, Dept Students Affairs, Yancheng 224007, Peoples R China.;[Liu, Jingjing; Sun, Xiaojun; Sun, XJ; Duan, Changying; Bai, Xuqing] Minist Educ, Key Lab Adolescent Cyberpsychol & Behav CCNU, Wuhan 430079, Peoples R China.;[Wu, Li] Cent China Normal Univ, Sch Educ, Wuhan 430079, Peoples R China.;[Sun, Xiaojun; Wu, Li; Sun, XJ] Beijing Normal Univ Collaborat Innovat Ctr, Cent China Normal Univ Branch, Wuhan 430079, Peoples R China.
通讯机构：
[Sun, XJ ] C;Cent China Normal Univ, Sch Psychol, Wuhan 430079, Peoples R China.;Minist Educ, Key Lab Adolescent Cyberpsychol & Behav CCNU, Wuhan 430079, Peoples R China.;Beijing Normal Univ Collaborat Innovat Ctr, Cent China Normal Univ Branch, Wuhan 430079, Peoples R China.
关键词：
PIU;adolescents;hiding online behavior;parental active mediation;parent–child relationship
摘要：
In today's information society, with the growing integration of the Internet into individuals' lives, problematic Internet use (PIU) among adolescents has become more prevalent. Therefore, we conducted this study to investigate the correlation between active parental mediation and PIU in adolescents, as well as the potential mediating roles of parent-child relationship and adolescents' hiding online behavior. A total of 539 middle school students (mean age = 13.384) were recruited for this study and participated by completing a series of paper-and-pencil questionnaires. The findings indicated a significant negative relationship between active parental mediation and PIU. Furthermore, both the mediating role of the parent-child relationship and the role of hiding online behavior were found to be significant. Specifically, the mediating role is comprised of two paths: the independent mediating role of the parent-child relationship, and the sequential mediating role involving both the parent-child relationship and hiding online behavior. The study contributes an innovative theoretical perspective to deepen the understanding of the formation mechanism of PIU. Moreover, it offers practical empirical insights for the prevention and intervention of PIU among adolescents.
期刊：
Psychology of Popular Media,2023年 ISSN：2689-6567
通讯作者：
Sun, XJ
作者机构：
[Sun, Xiaojun; Chen, Bizhong; Yao, Liangshuang] Minist Educ, Key Lab Adolescent Cyberpsychol & Behav CCNU, Wuhan, Peoples R China.;[Sun, Xiaojun; Chen, Bizhong; Yao, Liangshuang] Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;[Zhang, Qilin] Guangdong Ocean Univ, Mental Hlth Educat & Consultat Ctr, Zhanjiang, Peoples R China.;[Sun, Xiaojun; Sun, XJ] Cent China Normal Univ CCNU, Sch Psychol, 382 Xiongchu Rd, Wuhan 430079, Peoples R China.
通讯机构：
[Sun, XJ ] C;Cent China Normal Univ CCNU, Sch Psychol, 382 Xiongchu Rd, Wuhan 430079, Peoples R China.
关键词：
social media;discontinuous use;general use;problematic use;social media fatigue
摘要：
As users' psychological involvement with social media enters a bottleneck, social media fatigue (SMF) is silently growing. Numerous studies investigating the relationship between social media use and SMF have shown disparate results, leading to substantial uncertainty of SMF in relation to different types of social media use. To clarify this controversy, this study used the three-level meta-analytic method to quantitatively synthesize 121 studies with 213 effect sizes (N = 55,896). No significant publication bias was detected. Results showed that SMF was highly positively related to both discontinuous use (r = .46) and problematic use (r = .43), but negligibly related to general use (r = .09). Moderator analyses indicated that the age of the sample, assessment mode, and type of social media moderated the relationship between SMF and social media use. These findings suggest a widespread "SMF paradox" among social media users, in which they have a negative attitude toward social media but still rely heavily on it and do not significantly reduce the intensity of their use. Instead, they may tend to engage in passive use. We attempted to explain this phenomenon from the three-dimensional perspective of social media use.
摘要：
Anxiety and depression have been shown to negatively influence the processing of emotional information in working memory. However, most studies have examined anxiety-related or depression-related working memory deficits independently, without considering their high co-morbidity. We tested the effects of emotional valence on working memory performance among healthy young adults with varying levels of anxiety and depressive symptoms. Ninety young adults aged between 18-24 (51 female) completed an emotional 2-back task in which positive, negative, and neutral images were presented. Multi-level modeling was used to examine anxiety and depressive symptoms as predictors of response accuracy and latency across the three emotional valence conditions. The results showed that participants responded to negative images with the highest accuracy and to positive images with the lowest accuracy. Both negative and positive images elicited slower responses than neutral images. Importantly, we found that more severe anxiety symptoms predicted a smaller difference in response accuracy between negative and neutral stimuli, whereas more severe depressive symptoms predicted a larger updating reaction time difference between positive and neutral stimuli. These findings demonstrated the uniquely anxiety-related deficits in processing negative contents and the uniquely depression-related deficits in updating positive contents in working memory, thus highlighting the necessity of novel cognitive bias modification interventions targeting the anxiety-specific and depression-specific deficits in working memory.
作者机构：
[Lu, Chan] XiangYa School of Public Health, Central South University, Changsha, China. Electronic address: chanlu@csu.edu.cn;[Wang, Faming] Division of Animal and Human Health Engineering, Department of Biosystems, KU Leuven, Leuven, Belgium;[Liu, Zijing; Yang, Wenhui; Liao, Hongsen] XiangYa School of Public Health, Central South University, Changsha, China;[Li, Bin] School of Psychology, Central China Normal University, Wuhan, China
通讯机构：
[Lu, C.] X;XiangYa School of Public Health, China
关键词：
Childhood allergic rhinitis;Early life exposure;Particulate matters;Pregnancy;TRAP
摘要：
BACKGROUND: Despite mounting evidence linking allergic rhinitis (AR) to air pollution, it remains unclear which major air pollutant(s) and critical window(s) of exposure play important roles in children's AR. OBJECTIVE: To examine the effects of intrauterine and early postnatal exposure to outdoor air pollution on children with doctor-diagnosed allergic rhinitis (DDAR). METHODS: A retrospective cohort study involving 8689 kindergarten children was conducted in Changsha, China, from 2019 to 2020. A questionnaire survey was conducted to collect information on the health status of children and their family members, as well as their living habits and home environment. Personal exposure to daily outdoor air pollutants (PM(2.5), PM(2.5-10), PM(10), SO(2), NO(2), and CO) was estimated during 40 gestational weeks, three trimesters, the entire pregnancy, and the first year after birth. Multiple logistic regression models were used to assess the associations between air pollution and children's DDAR. RESULTS: Children's DDAR was associated with intrauterine CO exposure, with adjusted ORs (95% CI) of 1.18 (1.03-1.34) for each IQR increase in CO exposure. The second and third trimesters were critical windows for PM(2.5) and CO exposure in relation to DDAR. Furthermore, early postnatal exposure to PM(2.5-10) and PM(10) in first year of life was associated with DDAR development, with adjusted ORs (95% CI) of 1.11 (1.01-1.22) and 1.27 (1.09, 1.47). The entire pregnancy and the first year of life were critical windows for CO and PM(10) exposure. Some children were predisposed to DDAR risk due to exposure to traffic-related air pollution (TRAP). CONCLUSION: Our findings support the hypothesis of "fetal origin of allergic rhinitis" by demonstrating that intrauterine and early postnatal exposure to air pollution plays an important role in children's DDAR.
期刊：
Scientific Studies of Reading,2023年27(5):393-407 ISSN：1088-8438
通讯作者：
Siyun Liu
作者机构：
[Jin, Jian] Anhui Normal Univ, Sch Educ Sci, Wuhu, Anhui, Peoples R China.;[Jin, Jian; Liu, Siyun] Cent China Normal Univ, Sch Psychol, Wuhan, Peoples R China.;[Liu, Siyun] Cent China Normal Univ, Key Lab Adolescent Cyberpsychol & Behav, Minist Educ, Wuhan, Peoples R China.;[Liu, Siyun] Cent China Normal Univ, Key Lab Human Dev & Mental Hlth Hubei Prov, Wuhan, Peoples R China.;[Liu, Siyun] Cent China Normal Univ, Sch Psychol, 152 Luo Yu Rd, Wuhan 430079, Peoples R China.
通讯机构：
[Siyun Liu] S;School of Psychology, Central China Normal University, Wuhan, China<&wdkj&>Ministry of Education, Key Laboratory of Adolescent Cyberpsychology and Behavior (Central China Normal University), Wuhan, China<&wdkj&>Key Laboratory of Human Development and Mental Health of Hubei Province, Central China Normal University, Wuhan, China
摘要：
PurposeThe use of attentional resources is an important cognitive indicator of reading engagement but it is unknown how this is influenced by linguistic cues. We designed two experiments to investigate whether shifts in narrative perspectives occupy more of the attention of readers and engage them more in the text.MethodsExperiment 1 employed a dual-task paradigm to explore how shifts in narrative perspective influence the attention that readers allocate to the text. Experiment 2 used the same methods but replaced sentences with whole chapters to examine the effects of shifted perspectives on readers' ability to allocate attention and engage in reading.ResultsExperiment 1 found that shifts in perspective delayed the participants' responses to the tones. Experiment 2 found that perspective shifts enhanced the participants' self-reported attentional focus and overall reading engagement. The results of Experiment 1 were not replicated by Experiment 2 but both experiments found that attentional engagement was deeper at the initial than the later stage of reading.ConclusionPerspective shifts in novels constitute valid language cues that can fully utilize readers' attentional resources and improve their engagement in reading. Attentional resources play a more important role when readers initially process texts than at later stages.
关键词：
Sense of control;Experiential avoidance;Problematic mobile phone use;Self-concept clarity
摘要：
Problematic mobile phone use (PMPU) has been revealed to be shaped by multiple factors. Nevertheless, limited studies have focused on sense of control, an intrinsic human motive, and investigated its impact on PMPU and the mechanisms of this influence. On the grounds of the Interaction of Person-Affect-Cognition-Execution model, the present study tested experiential avoidance as a possible mediator and self-concept clarity as a possible moderator in the connection linking sense of control and PMPU. Undergraduate students (N = 1,093; Mage = 18.95, SD = 1.10; 53.2% women) recruited through convenience sampling completed questionnaires in their classrooms. The mediation analysis revealed a significant mediating effect of experiential avoidance on the negative link between sense of control and PMPU. The moderated mediation analysis demonstrated a significant moderating effect of self-concept clarity, which attenuated both the direct path linking sense of control and PMPU and the mediating path through experiential avoidance. The findings contribute to elucidating whether, how, and under what conditions sense of control is connected with PMPU, and offer insights for developing practical intervention strategies to address PMPU.
作者机构：
[Zeng, Chengwei; Zhao, Yunjie] Cent China Normal Univ, Inst Biophys, Wuhan 430079, Peoples R China.;[Zeng, Chengwei; Zhao, Yunjie] Cent China Normal Univ, Dept Phys, Wuhan 430079, Peoples R China.;[Jian, Yiren; Vosoughi, Soroush] Dartmouth Coll, Dept Comp Sci, Hanover, NH 03755 USA.;[Zeng, Chen] George Washington Univ, Dept Phys, Washington, DC 20052 USA.
通讯机构：
[Zhao, Yunjie] I;Institute of Biophysics and Department of Physics, Central China Normal University, Wuhan, China
摘要：
RNA-protein complexes underlie numerous cellular processes, including basic translation and gene regulation. The high-resolution structure determination of the RNA-protein complexes is essential for elucidating their functions. Therefore, computational methods capable of identifying the native-like RNA-protein structures are needed. To address this challenge, we thus develop DRPScore, a deep-learning-based approach for identifying native-like RNA-protein structures. DRPScore is tested on representative sets of RNA-protein complexes with various degrees of binding-induced conformation change ranging from fully rigid docking (bound-bound) to fully flexible docking (unbound-unbound). Out of the top 20 predictions, DRPScore selects native-like structures with a success rate of 91.67% on the testing set of bound RNA-protein complexes and 56.14% on the unbound complexes. DRPScore consistently outperforms existing methods with a roughly 10.53–15.79% improvement, even for the most difficult unbound cases. Furthermore, DRPScore significantly improves the accuracy of the native interface interaction predictions. DRPScore should be broadly useful for modeling and designing RNA-protein complexes. RNA-protein docking is a very challenging area. Here, the authors develop a deep-learning based method, DRPScore, to evaluate RNA-protein complexes. DRPScore is robust and consistently performs better than existing methods on representative testing sets.
