Synthesis of Tetrasubstituted Unsymmetrical 1,4-Enediones via Copper-Promoted Autotandem Catalysis and Air As the Oxidant
作者：
Yang, Yan;Ni, Fan;Shu, Wen-Ming;Yu, Shang-Bo;Gao, Meng;...
期刊：
JOURNAL OF ORGANIC CHEMISTRY ,2013年78(11):5418-5426 ISSN：0022-3263
作者机构：
[Wu, An-Xin; Yu, Shang-Bo; Gao, Meng; Yang, Yan; Ni, Fan; Shu, Wen-Ming] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Wu, An-Xin] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
An efficient procedure has been developed for the preparation of tetrasubstituted unsymmetrical 1,4-enediones via copper-promoted autotandem catalysis and air as the oxidant. Various N-nucleophiles are compatible with this reaction, such as morpholine, piperidine, pyrrolidine, arylamines, pyrazole, imidazole, benzimidazole, and benzotriazole. This reaction also has significant advantages in easily available substrates, atom economy, bond-forming efficiency, and environmental benignity.
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英文
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A cascade coupling strategy for one-pot total synthesis of β-carboline and isoquinoline-containing natural products and derivatives
作者：
Zhu, Yan-Ping;Liu, Mei-Cai;Cai, Qun;Jia, Feng-Cheng;Wu, An-Xin
* （ 期刊：
CHEMISTRY-A EUROPEAN JOURNAL ,2013年19(31):10132-10137 ISSN：0947-6539
作者机构：
[Wu, An-Xin; Jia, Feng-Cheng; Cai, Qun; Liu, Mei-Cai; Zhu, Yan-Ping] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan, Peoples R China.
通讯机构：
[Wu, An-Xin] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan, Peoples R China.
关键词：
carboline;cascade reactions;C? H coupling;isoquinoline;natural products
摘要：
Multi-birds with one stone: A cascade coupling strategy was developed for the synthesis of β-carbolines. The method can direct the synthesis of β-carboline and isoquinoline-containing natural products with high yields. Moreover, this protocol can also be further applied towards the total synthesis of natural products fascaplysin and papaverin (see scheme). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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英文
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A new selective pyrazoline-based fluorescent chemosensor for Cu 2+ in aqueous solution
作者：
Shengli Hu;Shushu Zhang;Yang Hu;Qing Tao;Anxin Wu
（ 期刊：
Dyes and Pigments ,2013年96(2):509-515 ISSN：0143-7208
通讯作者：
Hu, Shengli
作者机构：
[Shushu Zhang; Yang Hu; Shengli Hu; Qing Tao] Hubei Normal Univ, Dept Chem & Environm Engn, Hubei Key Lab Pollutant Anal & Reuse Technol, Huangshi 435002, Peoples R China.;[Anxin Wu] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Hu, Shengli] H;Hubei Normal Univ, Dept Chem & Environm Engn, Hubei Key Lab Pollutant Anal & Reuse Technol, Huangshi 435002, Peoples R China.
关键词：
Copper ion detection;Fluorescent sensor;Pyrazoline;Selective
摘要：
A new pyrazoline derivate was designed and synthesized. The structure of the pyrazoline was confirmed by single crystal X-ray diffraction and its photophysical properties were studied by absorption and fluorescence spectra. This compound can be used to determine Cu2+ ion with high selectivity and sensitivity among a series of cations in aqueous tetrahydrofuran. This sensor forms a 1:1 complex with Cu2+ and displays fluorescent quenching. © 2012 Elsevier Ltd. All rights reserved.
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英文
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A benzimidazole-based ratiometric fluorescent sensor for Cr3+ and Fe3+ in aqueous solution
作者：
Meng Wang;Jungang Wang;Weijian Xue;Anxin Wu
（ 期刊：
Dyes and Pigments ,2013年97(3):475-480 ISSN：0143-7208
通讯作者：
Wu, Anxin
作者机构：
[Anxin Wu; Weijian Xue; Meng Wang; Jungang Wang] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Anxin Wu] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构：
[Wu, Anxin] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
关键词：
Aqueous solution;Benzimidazole;Cr3+;Fe 3+;Fluorescent sensor;Ratiometric
摘要：
A novel ratiometric fluorescent sensor bearing two benzimidazole groups has been synthesized. The sensor showed a ratiometric fluorescence response with an enhancement of the ratios of emission intensities at 443 and 378 nm from 0.17 to 3.21 for Cr3+. The ratios of emission intensities at 443 and 380 nm were enhanced from 0.40 to 2.09 for Fe3+. Fe3+ revealed significant adsorption in the UV-vis region, which can be used to discriminate Cr3+ and Fe3+. Detection limits of the method for Cr 3+ and Fe3+ were 25 μM and 2 μM, respectively. In addition, the sensor showed good selectivity to Cr3+ and Fe 3+ over other metal ions. © 2013 Elsevier Ltd. All rights reserved.
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英文
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Synthesis of functionalized 2-aryl-4-(indol-3-yl)-4H-chromenes via iodine-catalyzed domino Michael addition-intramolecular cyclization reaction
作者：
Yin, Guodong* ;Fan, Ling;Ren, Tianbing;Zheng, Chunyang;Tao, Qing;...
期刊：
Organic & Biomolecular Chemistry ,2012年10(44):8877-8883 ISSN：1477-0520
作者机构：
[Yin, Guodong; Ren, Tianbing; Zheng, Chunyang; Fan, Ling; Tao, Qing] Hubei Normal Univ, Coll Chem & Environm Engn, Hubei Key Lab Pollutant Anal & Reuse Technol, Huangshi 435002, Peoples R China.;[She, Nengfang; Wu, Anxin] Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticides & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Yin, Guodong] H;Hubei Normal Univ, Coll Chem & Environm Engn, Hubei Key Lab Pollutant Anal & Reuse Technol, Huangshi 435002, Peoples R China.
摘要：
An efficient synthesis of novel functionalized 2-aryl-4-(indol-3-yl)-4H-chromenes has been developed, in the presence of a catalytic amount of iodine, from easily available starting materials, 2-hydroxychalcone derivatives. Indole, substituted indoles and 7-azaindole are suitable for this transformation. The possible domino Michael addition-intramolecular cyclization reaction mechanism is proposed.
语种：
英文
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Novel furo[2,3-d] pyrimidine derivative as fluorescent chemosensor for HSO4-
作者：
Xue, Weijian;Li, Lin;Li, Qi;Wu, Anxin
* （ 期刊：
Talanta ,2012年88:734-738 ISSN：0039-9140
作者机构：
[Wu, Anxin; Xue, Weijian; Li, Lin; Li, Qi] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Wu, Anxin] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构：
[Wu, Anxin] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
关键词：
Fluorescent chemosensor;HSO4- ion;Selectivity;Sonogashira reaction
摘要：
A class of novel heterocyclic compounds 1a-1c has been designed and synthesized. And our initial discovery is that these compounds can effectively recognize HSO<inf>4</inf><sup>-</sup>. With the addition of HSO<inf>4</inf> <sup>-</sup>, a new energy band appears at 360-390 nm in the absorption spectra. The emission spectrum (λ<inf>ex</inf> = 328 nm) undergoes an important change in its fluorescent effect in the presence of HSO<inf>4</inf><sup>-</sup>. All available data (absorption and emission) strongly support the formation of hydrogen-bonded complexes between 1a and 1c and HSO<inf>4</inf><sup>-</sup>. ©2011 Elsevier B.V. All rights reserved.
语种：
英文
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Unexpected C-C bond cleavage: A route to 3,6-diarylpyridazines and 6-arylpyridazin-3-ones from 1,3-dicarbonyl compounds and methyl ketones
作者：
Gao, Qinghe;Zhu, Yanping;Lian, Mi;Liu, Meicai;Yuan, Jingjing;...
期刊：
JOURNAL OF ORGANIC CHEMISTRY ,2012年77(21):9865-9870 ISSN：0022-3263
通讯作者：
Yin, Guodong
作者机构：
[Wu, Anxin; Zhu, Yanping; Lian, Mi; Gao, Qinghe; Yuan, Jingjing; Liu, Meicai] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Yin, Guodong] Hubei Normal Univ, Coll Chem & Environm Engn, Hubei Key Lab Pollutant Anal & Reuse Technol, Huangshi 435002, Peoples R China.
通讯机构：
[Yin, Guodong] H;Hubei Normal Univ, Coll Chem & Environm Engn, Hubei Key Lab Pollutant Anal & Reuse Technol, Huangshi 435002, Peoples R China.
摘要：
An unexpected C-C bond cleavage has been revealed in the absence of metal. This observation has been exploited to develop an efficient approach toward 3,6-diarylpyridazines and 6-arylpyridazin-3-ones from simple and commercially available 1,3-dicarbonyl compounds and methyl ketones. ©2012 American Chemical Society.
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英文
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Novel Fluorescent Molecular Clips: Selective Recognition Towards Fe3+ in Aqueous Solution
作者：
Li, Lin;She, Neng-fang
（ ;Fei, Zhuan;So, Pui-kin;Wang, Yu-zhou;...
期刊：
Journal of Fluorescence ,2011年21(3):1103-1110 ISSN：1053-0509
作者机构：
[She, Neng-fang; Wu, An-xin; Li, Lin; Fei, Zhuan; Cao, Li-ping; Wang, Yu-zhou] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Yao, Zhong-ping; So, Pui-kin] Hong Kong Polytech Univ, State Key Lab Chirosci, Kowloon, Hong Kong, Peoples R China.;[Yao, Zhong-ping; So, Pui-kin] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China.
通讯机构：
[Wu, An-xin] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
关键词：
Chemosensor;Fluorescence quenching;Fe3+;Diethoxycarbonyl glycoluril derivative
摘要：
In this paper, we report the synthesis, characterization and Fe <sup>3+</sup>-sensing properties of a series of new artificial fluorescent molecular clips, and structure of clip 1 is confirmed by X-ray crystallography. All these molecular clips had the ability to bind and sense Fe<sup>3+</sup> selectively through decrease fluorescence responses in THF-MeOH-Water. Fluorimetric titration experiment indicated that the quenching of these compounds' fluorescence upon Fe<sup>3+</sup> probably arises from the electron/energy transfer between Fe<sup>3+</sup> and the excited chemosensors. The limit of detection, linear concentration range and selectivity of the fluorescent molecular clips were evaluated in this study as well. ©Springer Science+Business Media, LLC 2011.
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英文
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New fluorescent probes based on supramolecular diastereomers for the detection of 2-nitrophenol
作者：
Li, Lin;Sun, Yichong;Wang, Shuai;Qiu, Mingqiang;Wu, Anxin
* （ 期刊：
Talanta ,2010年81(4-5):1643-1649 ISSN：0039-9140
通讯作者：
Wu, Anxin
作者机构：
[Wu, Anxin; Li, Lin; Sun, Yichong; Qiu, Mingqiang] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Sun, Yichong] ZhongShan 1 Middle Sch, Zhongshan 528403, Peoples R China.
通讯机构：
[Wu, Anxin] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
关键词：
Fluorescent probes;2-nitrophenol;Diethoxycarbonyl glycoluril;Supramolecular diastereomers
摘要：
A couple of new fluorescent probes, based on diethoxycarbonyl glycoluril, were synthesized and characterized by <sup>1</sup>H NMR, X-ray crystal structure. The probes were found to be relatively highly fluorescence with quantum yields of 0.20 and 0.18, respectively, at room temperature in THF solution. Both of the proposed probes were tested using different phenolic compounds, showing very high selectivity and sensitivity for 2-nitrophenol by forming a 1:1 complex in THF-MeOH (9:1, v/v). Additionally, the sensors could be used for the qualitative analysis of 2-nitrophenol in real water samples. ©2010 Elsevier B.V. All rights reserved.
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英文
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Supramolecular rhombic grids formed from bimolecular building blocks
作者：
She, Neng-Fang
（ ;Gao, Meng;Meng, Xiang-Gao;Yang, Guang-Fu
（ ;Elemans, Johannes A A W;...
期刊：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY ,2009年131(33):11695-11697 ISSN：0002-7863
作者机构：
[She, Neng-Fang; Yang, Guang-Fu; Wu, An-Xin; Gao, Meng; Meng, Xiang-Gao] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Elemans, Johannes A A W] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 ED Nijmegen, Netherlands.;[Isaacs, Lyle] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA.
通讯机构：
[Wu, An-Xin] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
(Figure Presented) A programmed assembly process produces rhombic grid networks from compounds L1-L4 in the crystal by π-π stacking interactions that generate a bimolecular grid synthon, which undergoes further NH⋯N hydrogen-bond-mediated assembly. © 2009 American Chemical Society.
语种：
英文
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An Efficient Method for the Selective Iodination of alpha,beta-Unsaturated Ketones
作者：
Wang, Zihua;Yin, Guodong;Qin, Jing;Gao, Meng;Cao, Liping;...
期刊：
SYNTHESIS-STUTTGART ,2008年2008(22):3675-3681 ISSN：0039-7881
作者机构：
[Wu, Anxin; Yin, Guodong; Cao, Liping; Gao, Meng; Qin, Jing; Wang, Zihua] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Wu, Anxin] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
关键词：
iodination;alpha,beta-unsaturated ketones;alpha,beta-unsaturated alpha '-iodo ketones;self-sorting
摘要：
An efficient approach to alpha,beta-unsaturated alpha'-iodo ketones directly from alpha,beta-unsaturated ketones by selective iodination at the alpha'-position, without effect on the double bond and the activated benzene ring, in the presence of copper(II) oxide/iodine is described. The present method has the advantages of high yields, short reaction times, inexpensive reagents, mild reaction conditions, ease of manipulation, and the formation of cleaner products.
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英文
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Direct conversion of aromatic ketones to arenecarboxylic esters via carbon-carbon bond-cleavage reactions
作者：
Yin, Guodong;Gao, Meng;Wang, Zihua;Wu, Yandong;Wu, Anxin
* （ 期刊：
Bulletin of the Chemical Society of Japan ,2008年81(3):369-372 ISSN：0009-2673
通讯作者：
Wu, Anxin
作者机构：
[Wu, Anxin; Yin, Guodong; Gao, Meng; Wang, Zihua] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Wu, Yandong] Xiangtan Univ, Coll Chem, Xiangtan 411105, Peoples R China.
通讯机构：
[Wu, Anxin] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
Aromatic methyl ketones, ß-keto esters, and trifluoromethyl-l,3- diketones can be directly converted to arene-carboxylic esters via carbon-carbon bond cleavage of pyridinium iodide intermediates in the presence of copper(II) oxide, iodine, pyridine, and potassium carbonate in alcoholic media. The advantages of the present method in terms of good yields, mild reaction conditions, and inexpensive reagents should make this protocol a valuable alternative to the existing methods. © 2008 The Chemical Society of Japan.
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英文
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Self-sorting molecular clips
作者：
Ghosh, Soumyadip;Wu, Anxin
* （ ;Fettinger, James C.;Zavalij, Peter Y.;Isaacs, Lyle
期刊：
JOURNAL OF ORGANIC CHEMISTRY ,2008年73(15):5915-5925 ISSN：0022-3263
作者机构：
[Ghosh, Soumyadip; Fettinger, James C.; Isaacs, Lyle; Zavalij, Peter Y.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA.;[Wu, Anxin] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Wu, Anxin] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
(Figure Presented) We report the synthesis and characterization of 12 C-shaped methylene-bridged glycoluril dimers (1-12) bearing H-bonding groups on their aromatic rings. Compounds 1, 2, (±)-4a, (±)-5, (±)-7, and 8 form tightly associated homodimers in CDCl<inf>3</inf>, due to the combined driving force of π,πand H-bonding interactions. Compounds 2, (±)-5, and 8, having disparate spatial distribution of their H-bonding groups, display the ability to efficiently distinguish between self and nonself even within three-component mixtures in CDCl<inf>3</inf>. When the spatial distributions of the H-bonding groups of the molecular clips are similar (e.g., 1 and 2), a mixture of homodimers and heterodimers is formed. The effect of various structural modifications (e.g., chirality, side chain steric bulk, number and pattern of H-bonds) on the strength of self-assembly and the fidelity of self-sorting are presented. On the basis of these results we prepared self-sorting systems comprising three (e.g., 1, (±)-5, and (±)-7) and even four (2, (±)-5, 9, and 10) components. The potential of molecular clips 1-12 as robust, functionalizable, self-sorting modules to control the noncovalent interaction network in systems chemistry studies is described. ©2008 American Chemical Society.
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英文
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Synthesis, X-ray structure, and binding properties of a new fluorescent molecular clip derived from diethoxycarbonyl glycoluril
作者：
Hu, Sheng-Li
* ;Yin, Guo-Dong;Wang, Yu-Zhou;Wu, An-Xin
（ 期刊：
CANADIAN JOURNAL OF CHEMISTRY ,2008年86(7):691-694 ISSN：0008-4042
作者机构：
[Wu, An-Xin; Hu, Sheng-Li; Wang, Yu-Zhou; Yin, Guo-Dong] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Hu, Sheng-Li] Hubei Normal Univ, Hubei Key Lab Bioanalyt Tech, Huangshi 435002, Peoples R China.
通讯机构：
[Hu, Sheng-Li] H;Hubei Normal Univ, Hubei Key Lab Bioanalyt Tech, Huangshi 435002, Peoples R China.
关键词：
Diethoxycarbonyl glycoluril;Fe(III);Fluorescence;Molecular clip
摘要：
A new fluorescent molecule clip derived from diethoxycarbonyl glycoluril with two 2,5-diphenyl-furan side-walls was designed and synthesized. Its structure and conformation was confirmed by single-crystal X-ray diffraction. Its binding properties, investigated by fluorescence spectroscopey, showed that it can selectively bind Fe3+ with fluorescence quenching. © 2008 NRC Canada.
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英文
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A new facile approach to the synthesis of 3-methylthio-substituted furans, pyrroles, thiophenes, and related derivatives
作者：
Yin, Guodong;Wang, Zihua;Chen, Aihua;Gao, Meng;Wu, Anxin
* （ ;...
期刊：
JOURNAL OF ORGANIC CHEMISTRY ,2008年73(9):3377-3383 ISSN：0022-3263
通讯作者：
Wu, Anxin
作者机构：
[Wu, Anxin; Yin, Guodong; Gao, Meng; Wang, Zihua; Chen, Aihua] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Pan, Yuanjiang] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China.
通讯机构：
[Wu, Anxin] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
(Chemical Equation Presented) 2-(Methylthio)-1,4-diaryl-2-butene-1,4-dione (3) are prepared from readily available aryl methyl ketones in the presence of copper(II) oxide, iodine, and dimethyl sulfoxide. The success of the cross-coupling reaction of 4-chloroacetophenone with 2-acetylthiophene confirms a proposed self-sorting tandem reaction mechanism. Both Z- and E-isomers of compound 3 are readily converted into the corresponding 3-methylthio 2,5-diaryl furan 7 in good yield through a domino process involving the reduction of the double bond followed by the Paal-Knorr furan synthesis. Meanwhile, 4-bromo-3-methylthio 2,5-diaryl furan 10 is obtained either by the treatment of furan 7 with molecular bromine or by the treatment of diketone 3 with 30% hydrogen bromide in acetic acid solution in one pot. Removal of the methylthio group is accomplished by the treatment of 7 with Raney Ni in ethanol, which affords the diaryl-substituted furan 11 in excellent isolated yield. Selective reduction of the double bond of compound 3 leads to the formation of the saturated 1,4-diketone 13, which is easily converted to the corresponding 3-methylthio-2,5-diaryl-substituted pyrrole 14 and thiophene 15 via the Paal-Knorr cyclization reaction. ©2008 American Chemical Society.
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英文
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Highly efficient and clean method for direct alpha-iodination of aromatic ketones
作者：
Yin, Guodong;Gao, Meng;She, Nengfang
（ ;Hu, Shengli;Wu, Anxin
* （ ;...
期刊：
SYNTHESIS-STUTTGART ,2007年2007(20):3113-3116 ISSN：0039-7881
作者机构：
[Wu, Anxin] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 460079, Peoples R China.;Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China.
通讯机构：
[Wu, Anxin] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 460079, Peoples R China.
关键词：
aromatic ketones;iodine;iodo ketones;multifunctional reagent;self;sorting
摘要：
Under neutral reaction conditions, aromatic ketones were transformed into the corresponding a.-iodo ketones in high yields by the combination of copper(II) oxide and iodine. The reaction mechanism showed that copper(II) oxide played multiple roles through random self-sorting.
语种：
英文
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One-pot synthesis of novel molecular clips and macrocyclic polyamines derived from bis(ethoxycarbonyl)glycoluril
作者：
Li, Yitao;Yin, Guodong;Guo, Huizhen;Zhou, Baohan;Wu, Anxin
* （ 期刊：
SYNTHESIS-STUTTGART ,2006年2006(17):2897-2902 ISSN：0039-7881
作者机构：
[Wu, Anxin; Li, Yitao; Yin, Guodong; Guo, Huizhen; Zhou, Baohan] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Wu, Anxin] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
关键词：
amines;polyamines;macrocycles;molecular clips;glycoluril
摘要：
A new class of molecular clips and two novel macrocyclic polyamines were synthesized in one-pot procedures from aliphatic amines, formaldehyde, and rigid bis(ethoxycarbonyl)glycoluril. Apart from characterization of all reaction products by <sup>1</sup>H NMR, <sup>13</sup>C NMR, mass, and IR spectroscopy, a clip molecule and two macrocyclic cycloadducts were also studied by X-ray crystallography. ©Georg Thieme Verlag Stuttgart.
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英文
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Substituent effects control the self-association of molecular clips in the crystalline state
作者：
Wang, Zhi-Guo;Zhou, Bao-Han;Chen, Yun-Feng;Yin, Guo-Dong;Li, Yi-Tao;...
期刊：
JOURNAL OF ORGANIC CHEMISTRY ,2006年71(12):4502-4508 ISSN：0022-3263
作者机构：
[Wu, An-Xin] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA.
通讯机构：
[Wu, An-Xin] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
We report the X-ray crystal structure of 11 molecular clips and analyze the influence of substituents ( e. g., OMe, Me, and NO2) and their location on the observed crystal packing. Molecular clips 3a and 3b form tapelike structures in the crystal due to pi-pi interactions between the aromatic walls. Compounds 3d, 3eC, and 3fC form dimers driven by critical C-H center dot center dot center dot O interactions and then form tapes driven by pi-pi interactions in the crystal. These two building motifs, pi-pi and C-H center dot center dot center dot O interactions, can be used to rationalize the enantio- and diastereoselectivity observed in the X-ray crystal structures of the remaining five molecular clips. For example, the C-H center dot center dot center dot O interactions are found to dictate the formation of homochiral dimers in the structures of (+/-)-3eT and (+/-)-3fT and to control the diastereoselective formation of 6a(2)-6c(2) dimeric motifs with internal p-dimethoxy-o-xylylene walls. Overall, the results suggest that substituent effects that induce even weak intermolecular interactions ( e. g., C-H center dot center dot center dot O) can be used to reliably control crystal packing within glycoluril-based systems.
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英文
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The absolute configuration of a nitroxide spin labeled derivative of podophyllotoxin determined by the crystal structure
作者：
Zhou, Baohan;Yin, Guodong;Meng, Xianggao;Li, Yitao;Wu, Anxin
* （ 期刊：
CANADIAN JOURNAL OF CHEMISTRY ,2006年84(12):1603-1606 ISSN：0008-4042
作者机构：
[Wu, Anxin; Meng, Xianggao; Li, Yitao; Yin, Guodong; Zhou, Baohan] Cent China Normal Univ, Coll Chem, Minist Educ, Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Wu, Anxin] C;Cent China Normal Univ, Coll Chem, Minist Educ, Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
关键词：
Crystal structure;Nitroxyl radical;Podophyllotoxin;Synthesis
摘要：
The crystal structure of the nitroxide spin labeled derivative of podophyllotoxin was first reported. X-ray analysis demonstrated that four contiguous chiral centers in the molecule, C1, C2, C3, and C4, adopt cis- (1:2), trans-(2:3), and cis- (3:4) arrangement. ©2006 NRC.
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Molecular clips form isostructural dimeric aggregates from benzene to water
作者：
Wu, AX
（ ;Mukhopadhyay, P;Chakraborty, A;Fettinger, JC;Isaacs, L
* 期刊：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY ,2004年126(32):10035-10043 ISSN：0002-7863
通讯作者：
Isaacs, L
作者机构：
[Isaacs, L] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA.;Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
通讯机构：
[Isaacs, L] U;Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA.
摘要：
We report the synthesis and characterization of eight C-shaped methylene-bridged glycoluril dimers (1-8) bearing hydrogen-bonding amide groups on their aromatic rings. Compounds 1-6 undergo tight dimerization in CDCl <inf>3</inf> solution (K<inf>s</inf> >9 ×10<sup>5</sup> M <sup>-1</sup>);binary mixtures of 1-7 form mixtures of homodimers and heterodimers in moderately selective dimerization processes (0.23 &le K <inf>eq</inf> &le 768;0.253 &le χAB <0.933). The high affinity formation of 1·1-6·6 is due to the commensurate nature of the geometrical constraints imposed by the π-πinteractions and only two hydrogen bonds. The differential response of the strengths of the π-πinteractions and H-bonds of 2·2 to changes in solvent polarity-from C<inf>6</inf>D<inf>6</inf> to D<inf>2</inf>O-results in the formation of a solvent-independent isostructural aggregate that exhibits high affinity dimerization across the full range of solvents.
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