通讯机构：
[Yin, Jun] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
摘要：
A photoactivatable benzo[c][1,2,5]oxadiazole-dressing tetraphenyl-ethylene (TPE) was developed. The optical performance results indicate that UV-irradiation can lead to remarkable emission enhancement in solution states due to the cyclization of the TPE component. Application in the solid state confirmed that it has a potential to serve as a photoactivatable visualized material.
作者机构：
[Wang, Yangyang; Li, Ziyong; Guo, Hui; Li, Mengna; Li, ZY; Ya, Huiyuan; Zhang, Haining] Luoyang Normal Univ, Coll Food & Drug, Key Lab Organ Funct Mol, Luoyang 471934, Peoples R China.;[Li, Ziyong; Li, ZY; Yin, Jun] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Li, ZY; Ya, HY] L;[Li, ZY; Yin, J] C;Luoyang Normal Univ, Coll Food & Drug, Key Lab Organ Funct Mol, Luoyang 471934, Peoples R China.;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
摘要：
Photopharmacology involving azobenzene has offered a viable alternative for combating bacterial resistance. However, the degradation and potential toxicity of azobenzene limit its further study in vivo. Therefore, searching for an appropriate photoswitch for further clinical application is highly desirable. Herein a series of dithienylethene-functionalized switchable antibacterial agents have been designed and prepared by the introduction of the dithienylethene scaffold into fluoroquinolones. And it was found that these switchable antibacterial agents displayed good photochromism and fluorescence switching behaviors upon irradiation with UV/Vis light in DMSO. Surprisingly, methoxy-substituted dithienylethenes 3a and 3b exhibited fluorescence turn-on behavior. Furthermore, it was found that all of the open-isomers showed partial antibacterial activity on E. coli and S. aureus compared with the native drugs. Apart from 2a and 2b, the other switchable antibacterial agents showed a large difference in antibacterial activity on Gram-negative E. coli between the open and closed forms, in which the antimicrobial activity of the ring-closed isomers for 1b and 3b was 16 times that of the corresponding ring-open isomers. DFT calculations showed that the ring-closed isomers of 1b and 3b presented a rigid "S-type" conformation, which may be conducive to forming more stable complexes with the DNA gyrase of E. coli.
摘要：
A new ratiometric fluorescent probe based on a hemicyanine dye was synthesized. Investigation on the response behavior towards amino acids showed that the probe had a capability of rapidly and selectively detecting cysteine over other biothiols such as glutathione and homocysteine with similar structure and reactivity, and it also displayed a high selectivity and rapid response. Moreover, the probe had good water solubility, which authorized it could be applied in fluorescent bioimaging. The laser confocal fluorescence images indicated that the probe could visualize the intracellular cysteine. This work suggested that it could be utilized as a fluorescent indicator to discriminate the endogenous cysteine in living cells.
摘要：
Developing the novel fluorescent dyes with a larger Stokes shift is still a challenge in the research of fluorescence probes. In this work, a naphthalimide-modified near-infrared cyanine dye with an emission at 785 nm has been synthesized for lysosome-targeting imaging. This fluorescent dye showed a large Stokes shift (up to 165 nm) and favorable lysosome-targeting property, which facilitated it to be a potential candidate for studying of lysosomal functions. The result also indicated that the probe is a promising contrast agent for in vivo imaging in mouse models.
摘要：
Formaldehyde, as one of the simplest reactive carbonyl species (RCS), is regarded as a potential carcinogen and a sick house syndrome gas. Recent studies have shown that abnormally high levels of formaldehyde may result in cognitive decline and spatial memory deficits, asthmatic symptoms, Alzheimer's disease, and cancer. Due to the harmfulness of high levels of formaldehyde in nature and humans, it is of great significance to further elucidate the roles and functions of formaldehyde by a noninvasive detection approach. Fluorescence imaging has become a powerful and popular tool in monitoring bio-species owing to their high sensitivity and selectivity, excellent spatiotemporal resolution and non-invasion nature. Therefore, fluorescent probes are widely applied to track and detect formaldehyde in vitro and in vivo which have attracted more and more interest recently. This review focuses on various strategies to design the fluorescent probes for detecting formaldehyde based on different recognition groups.
摘要：
Molecular recognition based on hydrogen bond interaction plays a significant role in supramolecular self-assembly. In this work, we successfully developed a class of novel frameworks containing a urea in the recognition site and a carboxylate anion in the guest unit. The self-recognition model based on the interaction between urea and carboxylate anion could induce the molecules to assemble into a highly organized form. The crystal structures showed that they assembled in highly ordered two-dimensional architectures. The optical properties showed that the position of carboxylate anion on the diphenylacetylene backbone had an obvious influence on optical properties. The self-recognition strategy is useful for the construction of highly ordered self-assembled architectures. (C) 2017 Elsevier Ltd. All rights reserved.
作者机构：
[Xie Han; Zhiqiang Xu; Sheng Hua Liu; Jun Yin] Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, Hubei 430079 China;College of Food and Drug, Luoyang Normal University, Luoyang, Henan 471022 China;[Zhiyong Zhao] College of Chemical Engineering and Technology, Wuhan University of Science and Technology, Wuhan, Hubei 430081, China;[Ziyong Li] Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, Hubei 430079 China<&wdkj&>College of Food and Drug, Luoyang Normal University, Luoyang, Henan 471022 China
通讯机构：
[Zhiyong Zhao] C;[Jun Yin] K;Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, Hubei 430079 China<&wdkj&>College of Chemical Engineering and Technology, Wuhan University of Science and Technology, Wuhan, Hubei 430081, China
摘要：
The cover picture shows shows the construction of crown etherstoppering [3]rotaxanes based on N‐hetero crown ether host. Usually, crown ethers play the role of host macrocycles to combine with the guest molecules in the construction of rotaxanes. Based on the fact that crown ethers have large dimension, two [3]rotaxanes containing four crown ether units were designed and synthesized, of which, two N‐hetero crown ether components were employed as the macrocyclic hosts to assemble the mechanically interlocked framework by using a template‐directed clipping reaction while bis (metaphenylene‐26‐crown‐8) located on two sides of template diammonium acting as the stoppering groups of [3]rotaxanes. More details are discussed in the article by Yin et al. on page 1050–1056.
期刊：
Sensors and Actuators B-Chemical,2017年246:570-577 ISSN：0925-4005
通讯作者：
Yin, Jun;Liu, Sheng-Hua
作者机构：
[Guo, Shen-Zhen; Zhang, Jing; Wang, Xiao-Yan; Yin, Jun; Dong, Yu-Sao; Yu, Guang-Ao; Liu, Sheng-Hua] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Chen, Zhao] Jiangxi Sci & Technol Normal Univ, Jiangxi Key Lab Organ Chem, Nanchang 330013, Jiangxi, Peoples R China.
通讯机构：
[Yin, J; Liu, SH] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
关键词：
Indolo[3,2-b]carbazole;Electrochromism;Electroluminochromism;Aggregation-induced fluorescence change;Density functional theory
摘要：
A new indolo[3,2-b]carbazole-based compound (1) has been developed by linking two redox-active diphenylamine moieties to the rigid pi-conjugated indolo[3,2-b]carbazole core. Its first two completely reversible oxidation steps are mainly related to the two terminal amine centers, and a moderate electron coupling between these amine centers has been determined. The associated oxidized species 1(+) and 1(2+) both exhibited strong NIR absorptions, and a completely reversible conversion among three different colors (light-yellow, red, and blue, corresponding to neutral, monocationic and dicationic states, respectively) could be realized. In addition, reversible switching between turn-off and turn-on of its fluorescence could be accomplished by electrochemical oxidation and reduction, respectively. Compound 1 also exhibited obvious fluorescence color changes during its aggregate-forming process, and its solid showed bright-yellow fluorescence with a high emission quantum yield of 30%. (C) 2017 Elsevier B.V. All rights reserved.
