作者机构：
[Zhang, Jing; Liu, Sheng Hua; Wang, Xiao-Yan; Yin, Jun] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Zhang, Jing; Tang, Ben Zhong] Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Dept Chem & Biol Engn, Inst Adv Study,Dept Chem,Kowloon, Clear Water Bay, Hong Kong, Peoples R China.;[Zhang, Jing; Tang, Ben Zhong] Hong Kong Univ Sci & Technol, Inst Mol Funct Mat, Kowloon, Clear Water Bay, Hong Kong, Peoples R China.
通讯机构：
[Liu, Sheng Hua] C;[Tang, Ben Zhong] H;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Dept Chem & Biol Engn, Inst Adv Study,Dept Chem,Kowloon, Clear Water Bay, Hong Kong, Peoples R China.;Hong Kong Univ Sci & Technol, Inst Mol Funct Mat, Kowloon, Clear Water Bay, Hong Kong, Peoples R China.
作者机构：
[Liu, Sheng Hua; Yin, Jun; He, Yongxin] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ,Hubei I, Wuhan 430079, Peoples R China.;[Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 120750, South Korea.
通讯机构：
[Yin, Jun] C;[Yoon, Juyoung] E;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ,Hubei I, Wuhan 430079, Peoples R China.;Ewha Womans Univ, Dept Chem & Nanosci, Seoul 120750, South Korea.
摘要：
Reactive oxygen species (ROS) are a type of active species in body, and can participate in the process of tumor development under the condition of oxidative stress, which can lead to the apoptosis of cancer cells through a variety of different mechanisms. Photodynamic therapy (PDT) is a novel method of treating tumor with photosensitive drugs and laser activation. However, PDT suffers from the poor penetrating depth of tissue of excitation light. By comparison, sonodynamic therapy (SDT) adopts high-penetrating sound waves to trigger the ultrasound-responsive materials called sonosensitizers for the treatment of cancer by different mechanisms such as ROS, ultrasound response cavitation, and thermal effects. The efficiency of SDT is bound up with molecular structures and performances of sonosensitizers, which has promoted the design of sonosensitive agents and their development in various biological fields. In clinical treatment, regulating the tumor microenvironment offers a door and new ideas for effective tumor treatment. For tumor microenvironment (TME) involving pH values, excessive production of hydrogen peroxide, scientists have designed and synthesized many nanomaterials to produce hydroxyl radicals (center dot OH) for tumor chemodynamic therapy (CDT) through Fenton and Fenton-like reactions. Many studies have indicated that its therapeutic efficiency is associated with the increase of center dot OH production in situ of the tumor. Many approaches based on Fenton reaction have been used to improve the production of center dot OH, including the choice of nanomaterials and the adjustment of the microenvironment. In view of the above two new treatment methods, this article summarizes, discusses and enlightens the SDT-related sonosensitizers and CDT-related nanomaterials in recent years, and discusses their applications and potential challenges. (C) 2020 Elsevier B.V. All rights reserved.
作者机构：
[Yin, Jun] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensing Technol, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
通讯机构：
[Yin, Jun] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
关键词：
Alkali metal ions;Bioimaging application;Fluorescent dyes;Fluorescent probes;pH
摘要：
The homeostasis of acid/base and alkali metal played critical roles in life process. To get insight into their functional mechanism, a large amount of detectors, especially based on organic fluorescent probes have been largely developed and used to monitor the dynamic changes of pH and alkali metal ions. Importantly, fluorescent probes provide a portable means to carry out a real-time determination and even a clinical diagnosis for abnormal pathological states. Over the past decades, numerous fluorescent probes for the pH and alkali metals analytes have been extensively developed and applied in living systems. In this review, we outlined the recent advances on fluorescent probes for pH and alkali metal ions containing their sensing mechanism, binding modes and application. (C) 2020 Elsevier B.V. All rights reserved.
摘要：
The different oxidation states of sulphur atom play a significant role on functional materials. In this work, a aryl-thioether and its sulphone substituted benzo[c][1,2,5]oxadiazole dyes were synthesized and utilized to determine thiol-containing amino acids. The result of selectivity experiments showed they detected the cysteine and homocysteine under physiological condition with negligible interference from other amino acids. In comparison to the thioether dye, the sulphone-based dye exhibited much faster response time for Cys and Hcy. However, the sulphone restricted its thiol-reactivity and bioimaging performance in living cells. By reducing the oxidation state of sulphur atom, we amazedly found that the sulfoxide-based dye still maintained high selectivity ultrafast response time for Cys/Hcy under physiological condition. It was worth mentioning that it also had high reactivity and good bioimaging performance that sulfone compounds did not have.
摘要：
Novel classes of contorted hexabenzocoronenes (c-HBCs) which exhibit a doubly concave configuration were synthesized by using hexabenzocoronene as bridge ligand and diphenylamine/triphenylamine as the redox-active termini. Although the analysis of the crystal structures of tri-di(4-methoxyphenyl) amino-substituted HBC (1), trimethoxy-substituted HBC (3) and tri(triphenylamine)-substituted HBC (4) show that the peripheral modified arylamine groups have a certain influence on the interaction force between molecules, the results of UV-vis absorption and fluorescence emission spectra indicate that these arylamine-modified hexabenzocoronenes have similar photophysical properties, which are primarily regulated by the c-HBC center. Subsequent electrochemical tests found that these compounds have multi-step redox process, and there is a certain degree of overlap between the arylamine and arylamine or between the arylamine and the bridge (c-HBC) during the oxidation process. Combining the UV-vis-NIR spectroelectrochemistry with the density functional theory (DFT) calculations, we further explored the electronic characters of the neutral and one-electron oxidation states of tri-di(4-methoxyphenyl)amino-substituted HBC (1), trimethoxy-substituted HBC (3) and tri(triphenylamine)substituted HBC (4). (C) 2020 Elsevier Ltd. All rights reserved.
作者机构：
[Zhang, Chen; Tan, Ying; Zhang, Jiewen; Liu, Feng; Zang, Kun] Tsinghua Univ, State Key Lab Chem Oncogen, Key Lab Chem Biol, Tsinghua Shenzhen Int Grad Sch, Shenzhen 518055, Peoples R China.;[Xu, Zhiqiang; Yin, Jun] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Jiang, Yuyang] Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China.
通讯机构：
[Tan, Ying] T;[Yin, Jun] C;Tsinghua Univ, State Key Lab Chem Oncogen, Key Lab Chem Biol, Tsinghua Shenzhen Int Grad Sch, Shenzhen 518055, Peoples R China.;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
摘要：
Hydrogen sulfide (H2S), a well-known signaling molecule, exerts significant regulatory effects on the cardiovascular and nervous systems. Therefore, monitoring the metabolism of H2S offers a potential mechanism to detect various diseases. In addition, biotin is significantly used as a targeting group to detect cancer cells exclusively. In this work, a biotin-guided benzoxadizole-based fluorescent probe, NP-biotin, was developed for H2S detection and evaluated in normal liver cell (LO2) and liver cancer cell (HepG2) lines. Results reveal that NP-biotin can detect cellular H2S with high sensitivity and selectivity. Moreover, NP-biotin has been confirmed to possess the ability to target cancer cells under the guidance of the biotin group.
摘要：
IR780 as a commercially available dye with near-infrared emission has been extensively applied in fluorescent probes and bioimaging. In this work, to further intensify the optical behavior, a tetrahydropyridine ring was used to replace the cyclohexene ring at the center of IR780, forming a cyanine dye Cy-NH with near-infrared emission. Photophysical properties demonstrated that Cy-NH exhibits good optical performance. In particular, Cy-NH contains two functional reaction sites (e.g. Cl and NH sites on the tetrahydropyridine ring) and can be used to construct functional cyanine dyes. Investigation on imaging showed that these cyanines can be used as near-infrared fluorescent imaging agents in living cells and in vivo.
作者机构：
[Yin, Jun] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensing Technol, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
通讯机构：
[Yin, Jun] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
Heptamethine cyanine dyes (Cy7) have attracted much attention in the field of biological application due to their unique structure and attractive near infrared (NIR) photophysical properties. In this review, the influences of different modification sites on the absorption characteristics, photostability, Stokes shift, fluorescence characteristics, water solubility, and singlet oxygen generation efficiency of this class of dyes are summarized, and the application development of the corresponding dyes in the field of biological application is introduced, which will provide a reference for the optimization and improvement of heptamethine cyanine dyes in the future.
摘要：
<jats:title>Abstract</jats:title><jats:p>Four cyclometalated diiridium complexes, with IrCp*Cl (Cp*=η<jats:sup>5</jats:sup>‐C<jats:sub>5</jats:sub>Me<jats:sub>5</jats:sub><jats:sup>−</jats:sup>) termini bridged by 1,4‐ and 1,3‐bis(<jats:italic>p</jats:italic>‐tolyliminoethyl)benzene (<jats:bold>1</jats:bold>, <jats:bold>2</jats:bold>), or 1,4‐ and 1,3‐bis(2‐pyridyl)benzene (<jats:bold>3</jats:bold>, <jats:bold>4</jats:bold>), were prepared and characterized by nuclear magnetic resonance (NMR) spectroscopy and single‐crystal X‐ray diffraction (complexes <jats:bold>1</jats:bold>, <jats:bold>2</jats:bold>, and <jats:bold>4</jats:bold>). The two iridium centers in complexes <jats:bold>1</jats:bold> and <jats:bold>3</jats:bold> are thus bound at the central benzene ring in the <jats:italic>para</jats:italic>‐position (<jats:italic>trans</jats:italic>‐Ir2), whereas those in complexes <jats:bold>2</jats:bold> and <jats:bold>4</jats:bold> are in the <jats:italic>meta</jats:italic>‐position (<jats:italic>cis</jats:italic>‐Ir2). Cyclic voltammograms of all four complexes show two consecutive one‐electron oxidations. The potential difference between the two anodic steps in <jats:bold>1</jats:bold> and <jats:bold>3</jats:bold> is distinctly larger than that for <jats:bold>2</jats:bold> and <jats:bold>4</jats:bold>. The visible–near‐infrared (NIR)–short‐wave infrared (SWIR) absorption spectra of <jats:italic>trans</jats:italic>‐Ir2 monocations <jats:bold>1</jats:bold><jats:sup>+</jats:sup> and <jats:bold>3</jats:bold><jats:sup>+</jats:sup> are markedly different from those of <jats:italic>cis</jats:italic>‐Ir2 monocations <jats:bold>2</jats:bold><jats:sup>+</jats:sup> and <jats:bold>4</jats:bold><jats:sup>+</jats:sup>. Notably, strong near‐infrared electronic absorption appears only in the spectra of <jats:bold>1</jats:bold><jats:sup>+</jats:sup> and <jats:bold>3</jats:bold><jats:sup>+</jats:sup> whereas <jats:bold>2</jats:bold><jats:sup>+</jats:sup> and <jats:bold>4</jats:bold><jats:sup>+</jats:sup> absorb only weakly in the NIR‐SWIR region. Combined DFT and TD‐DFT calculations have revealed that (a) <jats:bold>1</jats:bold><jats:sup>+</jats:sup> and <jats:bold>3</jats:bold><jats:sup>+</jats:sup> (the diiridium‐benzene <jats:italic>trans</jats:italic>‐isomers) display the highest occupied spin‐orbitals (HOSO) and the lowest unoccupied spin‐orbital (LUSO) evenly delocalized over both molecule halves, and (b) their electronic absorptions in the NIR‐SWIR region are attributed to mixed metal‐to‐ligand and ligand‐to‐ligand charge transfers (MLCT and LLCT). In contrast, <jats:italic>cis</jats:italic>‐isomers <jats:bold>2</jats:bold><jats:sup>+</jats:sup> and <jats:bold>4</jats:bold><jats:sup>+</jats:sup> do not feature this stabilizing π‐delocalization but a localized mixed‐valence state showing a weak intervalence charge‐transfer (IVCT) absorption in the SWIR region.</jats:p>
期刊：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,2020年239:118465 ISSN：1386-1425
通讯作者：
Yin, Jun
作者机构：
[Liu, Sheng Hua; Guan, Yihan; Yin, Jun; Ye, Fengying; Li, Guangjin] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ,Hubei I, Wuhan 430079, Peoples R China.
通讯机构：
[Yin, Jun] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ,Hubei I, Wuhan 430079, Peoples R China.
摘要：
A commercial cyanine dye IR-780 and a thioether-containing dicarboxylic acid ligand were used to construct the near-infrared fluorescent probe, which was used as a near-infrared fluorescent indicator for the determination of mercury ions in water and in living cells. This indicator displayed high specificity towards Hg(2+) without any interference from other detecting species. Especially, the emission at 790nm dramatically increased more than 25 times after interacting with Hg(2+). The binding experiment showed that the indicator formed 1:1 complex with Hg(2+). More, this indicator could be applied in the visualization of Hg(2+) in living cells and measuring the Hg(2+) concentration of tap-water sample.
