摘要：
2,3,4,5-Tetrasubstituted 4,5-dihydro-3H-1,4-benzodiazepines were synthesized in one-pot by a new sequential Ugi 4CC/Staudinger/aza-Wittig reaction, starting from easily accessible o-azidobenzaldehyde, alpha-amino ketone hydrochloride, isocyanide and carboxylic acid. (C) 2013 Elsevier Ltd. All rights reserved.
摘要：
Azides obtained from Baylis–Hillman adducts were treated with triphenylphosphine to give the corresponding iminophosphoranes that underwent aza-Wittig reactions with aryl isocyanates and then reacted with amines, alcohol, or phenols in the presence of catalytic amounts of sodium alkoxide or potassium carbonate to give the corresponding 2,3,5-trisubstituted pyrimidin-4(3H)-ones directly in good yields.
作者机构：
[Nie, Yi-Bo; Duan, Zhuan; Ding, Ming-Wu] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Ding, Ming-Wu] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, LuoYu Rd 100, Wuhan 430079, Peoples R China.
通讯机构：
[Ding, Ming-Wu] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, LuoYu Rd 100, Wuhan 430079, Peoples R China.
摘要：
A series of 1,2,4-trisubstituted imidazoles 5 were synthesized efficiently by a tandem aza-Wittig/1,5-electrocyclic ring-closure reaction of vinyliminophosphoranes 3 with aldehydes. Reactions of 5s,t with triphenylphosphine produced iminophosphoranes 7. A tandem aza-Wittig reaction of iminophosphorane 7 with isocyanate generated imidazo[1,2-c]quinazolines 9 in high yields. (C) 2011 Elsevier Ltd. All rights reserved.
期刊：
JOURNAL OF ORGANIC CHEMISTRY,2012年77(1):696-700 ISSN：0022-3263
通讯作者：
Ding, Ming-Wu
作者机构：
[Nie, Yi-Bo; Wang, Long; Ding, Ming-Wu] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Ding, Ming-Wu] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
摘要：
Carbodiimides 4, obtained from aza-Wittig reactions of iminophosphorane 3 with aryl isocyanates, reacted with secondary amines in the presence of a catalytic amount of sodium alkoxide to give 1,2,4,5-tetrasubstituted imidazoles 7 in good yields. However, 4-acylimidazoles 11 were obtained, as phenols were used in the presence of a catalytic amount of potassium carbonate due to further air oxidation of the expected products 10.
摘要：
Isothiocyanate 6, obtained from vinyliminophosphorane 4 with CS2, reacted with various aliphatic primary amines to afford directly the 1,4,5-trisubstituted imidazolidine-2-thiones 5. However, the reaction of isothiocyanate 6 with aliphatic secondary amines provided 2,4,5-trisubstituted thiazoles 10 in good yields.
摘要：
1H-Pyrazolo[1,5-b]indazoles were prepared via a domino Staudinger–aza-Wittig cyclization in one-pot fashion, starting from easily accessible azides and triphenylphosphine.
期刊：
JOURNAL OF ORGANIC CHEMISTRY,2012年77(6):2954-2958 ISSN：0022-3263
通讯作者：
Ding, Ming-Wu
作者机构：
[Xie, Hai; Ding, Ming-Wu; Yuan, Ding] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Xie, Hai] Shanxi Datong Univ, Coll Chem & Chem Engn, Datong 037009, Shanxi, Peoples R China.
通讯机构：
[Ding, Ming-Wu] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
2,4,5-Trisubstituted oxazoles 6 were unexpectedly prepared from a tandem reaction of vinyliminophosphorane 3 with various acyl chlorides in a one-pot fashion.
摘要：
3-Iodoindole N-carboximidamides and N-carboximidoates 4 were prepared regioselectively via a sequential aza-Wittig/iodine induced cyclization, starting from easily accessible 2-alkynylphenyl iminophosphorane, isocyanates, various nucleophiles and iodine.
摘要：
The crystal structure of the title compound 1-(4-fluorophenyl)-2-hexylthio-benzo [4,5]furo[3,2-d]-1,2,4-triazolo[1,5-a]pyrimidin-5(1H)-one(C23H_21FN4O2S, Mr=436.5)has been prepared and determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/n with a=13.9854(3),b=17.2678(4),c=18.1828(5)A,β=99.364(2)°,V=4332.58(18) A~ 3,Z=4, Dc=1.338,F(000)=1824,μ=0.185 mm~(-1), MoKa radiation(λ=0.71073),R=0.0538 and wR=0.1162 for 4728 observed reflections with I>2σ(I).X-ray diffraction analysis reveals the fused rings of benzo[4,5]furo[3,2-d]-1,2,4-triazolo[1,5-a]pyrimidin-5(1H)-one system are nearly coplanar. The crystal packing is mainly stabilized by weak intermolecular C-H…O hydrogen bond andπ-πinteractions
作者机构：
[Wang, Long; Zhong, Ying; Ding, Ming-Wu] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Ding, Ming-Wu] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
A series of 2,3,4-trisubstituted 3,4-dihydroquinazoline 3 was prepared by intramolecular aza-Wittig reaction of amide carbonyl groups with methyldiphenyl iminophosphorane, which was obtained from a Ugi 4CC/Staudinger sequence. Further intramolecular Heck reaction of 3d'-g' in the presence of catalytic amount of Pd(OAc)(2) gave 6,12-dihydroindolo[2,1-b]quinazolines 4a-d in good yields. (C) 2011 Elsevier Ltd. All rights reserved.
摘要：
The title compound (C20H18FN3O2, Mr = 351.37) is prepared and its crystal structure is determined by single crystal X-ray diffraction. The crystal is tetragonal, the P-42(1)c space group with a = 11.0922(6) Å, b = 11.0922(6) Å, c = 28.6271(15) Å, V = 3522.2(3) Å3, Z = 8, d
x
= 1.325 g/cm3, F(000) = 1472, μ = 0.095 mm−1, MoK
α radiation (λ = 0.71073), R = 0.0505, wR = 0.1090 for 2433 observed reflections with I > 2σ(I). The X-ray diffraction analysis reveals that all ring atoms in the benzo[4,5]furo[3,2-d]pyrimidinone moieties are almost coplanar.
