2-芳氧基-3-对氯苯基-3,5,6,7-四氢-4H-环戊二烯并[4,5]噻吩并[2,3-d]-嘧啶-4-酮衍生物的合成及其抑菌活性
作者：
廖全斌;陈百玲;刘明国;丁明武
作者机构：
[廖全斌; 陈百玲; 刘明国; 丁明武] 天然产物研究与利用湖北省重点实验室;[廖全斌; 陈百玲; 刘明国; 丁明武] 三峡大学化学与生命科学学院;[廖全斌; 陈百玲; 刘明国; 丁明武] 湖北省宜昌市大学路8号;[廖全斌; 陈百玲; 刘明国; 丁明武] 443002;[廖全斌; 陈百玲; 刘明国; 丁明武] 华中师范大学化学学院
会议名称：
中国化学会第六届有机化学学术会议
会议时间：
2009-8-1
会议地点：
西安
会议主办单位：
中国化学会
会议论文集名称：
中国化学会第六届有机化学学术会议论文集
语种：
中文
展开
连续的Ugi/Staudinger/aza-Wittig反应合成3,4-二氢喹唑啉
作者：
钟莹;丁明武
作者机构：
[钟莹; 丁明武] 华中师范大学教育部农药与化学生物学重点实验室 湖北省武汉市珞喻路152号 430079
会议名称：
中国化学会第六届有机化学学术会议
会议时间：
2009-8-1
会议地点：
西安
会议主办单位：
中国化学会
会议论文集名称：
中国化学会第六届有机化学学术会议论文集
语种：
中文
展开
Efficient synthesis and fungicidal activities of 2-alkylamino-3-aryl- 6-(1H,2,4-triazol-1-yl)-thieno[2,3-d]pyrimidin-4(3H)-ones
作者：
Sun, Yong;Wu, Jing;Feng, Ling-Ling
* （ ;Ding, Ming-Wu
期刊：
ARKIVOC ,2009年2009(7):111-118 ISSN：1551-7004
通讯作者：
Feng, Ling-Ling
（ 作者机构：
[Feng, Ling-Ling; Wu, Jing; Sun, Yong; Ding, Ming-Wu] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Sun, Yong] Yunyang Teachers Coll, Dept Chem, Danjiangkou Hubei 442700, Peoples R China.
通讯机构：
[Feng, Ling-Ling] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
关键词：
1,2,4-triazole;Aza-Wittig reaction;Fungicidal activity;Isocyanate;Thieno[2,3-d]pyrimidin-4(3H)-one
摘要：
The carbodiimides 4, obtained from an aza-Wittig reactions of iminophosphorane 3 with aromatic isocyanates, reacted with primary amines in the presence of catalytic amounts of sodium alkoxide to give selectively 2-alkylamino-3-aryl-6-(1H-1,2,4-triazol-1-yl)-thieno[2,3-d]- pyrimidin-4(3H)-ones 6 in good yields. Compounds 6 exhibit fungicidal activity; e.g., compound 6h showing the best inhibitive activity (92%) against Colletotrichum gossypii in 50 mg/L. © ARKAT USA, Inc.
语种：
英文
展开
对称二噻吩并嘧啶酮基取代的苯衍生物的合成及性质研究
作者：
喻飞;胡海军;陈剑锋;廖全斌;丁明武;...
作者机构：
[喻飞; 胡海军; 陈剑锋; 廖全斌; 刘明国] 天然产物研究与利用湖北省重点实验室 三峡大学化学与生命科学学院 湖北省宜昌市大学路8号 443002;[丁明武] 华中师范大学化学学院 教育部农药与化学生物学重点实验室 湖北省武汉市珞喻路152号 430079
会议名称：
中国化学会第六届有机化学学术会议
会议时间：
2009-8-1
会议地点：
西安
会议主办单位：
中国化学会
会议论文集名称：
中国化学会第六届有机化学学术会议论文集
语种：
中文
展开
Efficient Synthesis and Fungicidal Activities of 3,5,6,8-Tetrahydro-4H-thiopyrano[4',3':4,5]thieno[2,3-d]pyrimidin-4-ones
作者：
Xie, Hai* ;Huang, Nian-Yu;Ding, Ming-Wu
期刊：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS ,2009年184(2):480-491 ISSN：1042-6507
通讯作者：
Xie, Hai
作者机构：
[Xie, Hai] Shanxi Datong Univ, Coll Chem & Chem Engn, Datong 037009, Shanxi, Peoples R China.;[Xie, Hai; Huang, Nian-Yu; Ding, Ming-Wu] Cent China Normal Univ, Key Lab Pesticide Chem Biol Minist Educ, Wuhan, Peoples R China.
通讯机构：
[Xie, Hai] S;Shanxi Datong Univ, Coll Chem & Chem Engn, Datong 037009, Shanxi, Peoples R China.
关键词：
Aza-Wittig reaction;carbodiimide;fungicidal activity;iminophosphorane;thiopyrano[4',3':4,5]thieno[2,3-d]pyrimidin-4-one
摘要：
The carbodiimides 4, obtained from reactions of iminophosphorane 3 with aromatic isocyanates, reacted with amines, phenols, or ROH to give 2-substituted 3,5,6,8-tetrahydro-4H-thiopyrano[4',3' :4,5]thieno [2,3-d]pyrimidin-4-ones 6 in the presence of a catalytic amount of sodium alkoxide or solid potassium carbonate in satisfactory yields. Compounds 6 exhibited fungicidal activity. For example, compounds 6e, 6m, and 6s showed 70% inhibition activities against Dothiorella gregaria in 100 mg/L.
语种：
英文
展开
Efficient synthesis and fungicidal activities of 2-alkylamino-3-aryl- 6-(1H,2,4-triazol-1-yl)-thieno[2,3-d]pyrimidin-4(3H)-ones
作者：
Yong Sun;Jing Wu;L.-L. Feng
（ ;M.-W. Ding
期刊：
ARKIVOC ,2009年2009(7):111-118 ISSN：1551-7004
通讯作者：
Feng, L.-L.
作者机构：
Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Central China Normal University, Wuhan 430079, China;Department of Chemistry, Yunyang Teachers College, Danjiangkou Hubei, 442700, China
通讯机构：
Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Central China Normal University, China
关键词：
1,2,4-triazole;Aza-Wittig reaction;Fungicidal activity;Isocyanate;Thieno[2,3-d]pyrimidin-4(3H)-one
摘要：
The carbodiimides 4, obtained from an aza-Wittig reactions of iminophosphorane 3 with aromatic isocyanates, reacted with primary amines in the presence of catalytic amounts of sodium alkoxide to give selectively 2-alkylamino-3-aryl-6-(1H-1,2,4-triazol-1-yl)-thieno[2,3-d]- pyrimidin-4(3H)-ones 6 in good yields. Compounds 6 exhibit fungicidal activity; e.g., compound 6h showing the best inhibitive activity (92%) against Colletotrichum gossypii in 50 mg/L. © ARKAT USA, Inc.
语种：
英文
展开
New efficient synthesis of imidazo[2,1-b]quinazoline-2,5(1H,3H)-diones by a consecutive aza-Wittig/heterocumulene-mediated annulation
作者：
Xie, Chang;Huang, Nian-Yu;Ding, Ming-Wu*
期刊：
ARKIVOC ,2009年2009(10):220-232 ISSN：1551-7004
通讯作者：
Ding, Ming-Wu
作者机构：
[Xie, Chang; Huang, Nian-Yu; Ding, Ming-Wu] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Ding, Ming-Wu] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
关键词：
1-b]quinazoline-2;3H)-dione;5(1H;Aza-Wittig reaction;Carbodiimide;Imidazo[2;Iminophosphorane;Quinazolinone
摘要：
The carbodiimide 2, obtained from aza-Wittig reaction of iminophosphorane 1 with aromatic isocyanate, reacted with α-amino ester in the presence of triethylamine to give imidazo[2,1-b]quinazoline-2,5(1H,3H)-diones 5 (when R 2 is H) or quinazolinones 6 (when R2 is not H). Imidazo[2,1-b]quinazoline-2,5(1H,3H)-diones 5 were prepared more generally by another route, using a consecutive aza-Wittig / heterocumulene-mediated annulation of iminophosphoranes 9 with isocyanates and catalytic sodium ethoxide.
语种：
英文
展开
Efficient synthesis and biological evaluation of 1,2,9-trisubstituted 1,9-dihydro-6H-purin-6-ones
作者：
Huang, Nian-Yu;Liang, Yong-Ju;Ding, Ming-Wu* ;Fu, Li-Wu;He, Hong-Wu
期刊：
Bioorganic & Medicinal Chemistry Letters ,2009年19(3):831-833 ISSN：0960-894X
通讯作者：
Ding, Ming-Wu
作者机构：
[He, Hong-Wu; Huang, Nian-Yu; Ding, Ming-Wu] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Fu, Li-Wu; Liang, Yong-Ju] Sun Yat Sen Univ, Ctr Canc, Inst Canc, Guangzhou 510060, Guangdong, Peoples R China.
通讯机构：
[Ding, Ming-Wu] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
关键词：
1,9-Dihydro-purin-6-one;Iminophosphorane;Carbodiimide;Aza-Wittig reaction;Antitumor activity
摘要：
The carbodiimides 4, obtained from aza-Wittig reactions of iminophosphorane 3 with aromatic isocyanates, reacted with amines in the presence of a catalytic amount of RO-Na+ to give the 1,2,9-trisubstituted 1,9-dihydro-6H-purin-6-ones 6 in good yields. Compound 6 exhibited cytotoxicity against various cancer cells. For example, compounds 6b showed the best inhibition activities against KB, HepG2 and OVCAR3 with IC50 9.5, 20.4 and 10.0 μM. © 2008 Elsevier Ltd. All rights reserved.
语种：
英文
展开
2-芳氧基-3-对氟苯基-3,5,6,7-四氢-4H-环戊二烯并[4,5]噻吩并[2,3-d]-嘧啶-4-酮衍生物的合成及其抑菌活性
作者：
Liao Quanbin* ;Liu Mingguo;Yu Lan;Zhu Min;Ding Mingwu
期刊：
有机化学 ,2009年29(10):1582-1586 ISSN：0253-2786
通讯作者：
Liao Quanbin
作者机构：
[Zhu Min; Yu Lan; Liao Quanbin; Liu Mingguo] China Three Gorges Univ, Coll Chem & Life Sci, Hubei Prov Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China.;[Ding Mingwu] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Liao Quanbin] C;China Three Gorges Univ, Coll Chem & Life Sci, Hubei Prov Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China.
关键词：
噻吩并嘧啶酮;氮杂Wittig反应;合成;抑菌活性
摘要：
利用三组分氮杂Wittig反应,以三氢环戊二烯并噻吩基三苯基膦亚胺、对氟苯基异氰酸酯和酚,合成了13个未见文献报道的2-芳氧基-3-对氟苯基-3,5,6,7-四氢-4H环戊二烯并[4,5]噻吩并[2,3-d]-嘧啶-4-酮衍生物,产率58%～73%.通过IR,1H NMR,MS和元素分析对目标化合物的结构进行了表征,初步探讨了所合成化合物的抑菌活性,结果显示所合成的化合物对真菌(桔青霉菌)的抑制活性优于对细菌的抑制活性.
语种：
中文
展开
Efficient synthesis of 5,6-dihydrothieno[3',2':4,5]-thieno[2,3-d]pyrimidin-4(3H)-ones via an iminophosphorane
作者：
Chen, Yu Lu;Nie, Yi Bo;Ding, Ming Wu*
期刊：
中国化学快报：英文版 ,2009年20(9):1055-1058 ISSN：1001-8417
通讯作者：
Ding, Ming Wu
作者机构：
[Chen, Yu Lu; Nie, Yi Bo; Ding, Ming Wu] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Chen, Yu Lu] Xianning Vocat & Tech Coll, Dept Biol, Xianning 437100, Peoples R China.
通讯机构：
[Ding, Ming Wu] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
关键词：
5,6-Dihydrothieno[3 ',2 ':4,5]thieno[2,3-d]pyrimidin-4(3H)-one;Iminophosphorane;Aza-Wittig reaction;Carbodiimide;Isocyanate
摘要：
5,6-Dihydrothieno[3′,2′:4,5]thieno[2,3-d]pyrimidin-4(3H)-ones 6 were synthesized in yields of 71–87% by a consecutive method, which includes aza-Wittig reaction of iminophosphorane 3 with aromatic isocynate to give carbodiimide 4 and subsequent reaction of 4 with various amines, phenols or alcohols in the presence of catalytic amount of sodium ethoxide or solid potassium carbonate.
语种：
英文
展开
Efficient regioselective synthesis of indole N-carboximidamides and N-carboximidoates by a sequential aza-wittig/Ag(I)-catalyzed cyclization
作者：
Huang, Nian-Yu;Liu, Ming-Guo;Ding, Ming-Wu*
期刊：
JOURNAL OF ORGANIC CHEMISTRY ,2009年74(17):6874-6877 ISSN：0022-3263
通讯作者：
Ding, Ming-Wu
作者机构：
[Huang, Nian-Yu; Ding, Ming-Wu] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Liu, Ming-Guo; Huang, Nian-Yu] China Three Gorges Univ, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China.
通讯机构：
[Ding, Ming-Wu] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
An efficient Ag(I)-catalyzed regioselective cyclization of (2-alkynylphenyl)guanidine or (2-alkynylphenyl)isourea to indole N-carboximidamides or N-carboximidoates has been developed. The approach has the advantages of high regioselectivity, mild reaction conditions, easily accessible starting materials, and good yields.
语种：
英文
展开
3,4-二氢-2,3,4-三取代喹唑啉的合成新方法
作者：
和平;丁明武
作者机构：
[和平; 丁明武] 华中师范大学教育部农药与化学生物学重点实验室 湖北省武汉市珞喻路152号 430079
会议名称：
中国化学会第六届有机化学学术会议
会议时间：
2009-8-1
会议地点：
西安
会议主办单位：
中国化学会
会议论文集名称：
中国化学会第六届有机化学学术会议论文集
语种：
中文
展开
Efficient Synthesis of Benzothieno[3,2-d]-1,2,4-triazolo [1,5-a]pyrimidin-5(1H)-ones via a Tandem aza-Wittig/Heterocumulene-Mediated Annulation
作者：
Xu, Sheng-Zhen;Cao, Min-Hui;Chen, Chang-Shui;Ding, Ming-Wu*
期刊：
Journal of Heterocyclic Chemistry ,2009年46(5):903-908 ISSN：0022-152X
通讯作者：
Ding, Ming-Wu
作者机构：
[Xu, Sheng-Zhen; Ding, Ming-Wu] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Chen, Chang-Shui; Xu, Sheng-Zhen; Cao, Min-Hui] HuaZhong Agr Univ, Coll Basic Sci, Wuhan 430070, Peoples R China.
通讯机构：
[Ding, Ming-Wu] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
(Chemical Equation Presented) The carbodiimides 2, obtained from reactions of iminophosphorane 1 with isocyanates, reacted with hydrazine to give selectively 3-amino-2-arylaminobenzothieno[3,2-d]pyrimidin-4(3H)-ones 4. Reactions of 4 with triphenylphosphine, hexachloroethane, and Et3N produced iminophosphoranes 5. A tandem aza-Wittig reaction of iminophosphorane 5 with isocyanate, acyl chloride generated benzothieno[3,2-d]-1,2,4-triazolo[1,5- a]pyrimidin-5(1H)-ones 7 and 9 in satisfactory yields. The effects of the nucleophiles on cyclization have been investigated. © 2009 HeteroCorporation.
语种：
英文
展开
OG-PP34:Synthesis of substituted indolo[1,2-c]quinazolins by sequential Ugi and aza-Wittig reaction
作者：
HE Ping;DING Ming-Wu
作者机构：
[HE Ping; DING Ming-Wu] Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Central China Normal University, Wuhan, 430079, P.R.China
会议名称：
第13届亚洲化学大会(13th Asian Chemical Congress)
会议时间：
2009-9-13
会议地点：
上海
会议主办单位：
亚洲化学联合会;中国化学会
会议论文集名称：
第13届亚洲化学大会(13th Asian Chemical Congress)论文集
关键词：
Ugi reaction;aza-Wittig reaction;indolo[1,2-c]quinazolin;synthesis
语种：
英文
展开
Synthesis and Crystal Structure of Ethyl3-(4-Chlorophenyl)-3,4-dihydro-6-methyl-4-oxo-2-(pyrrolidin- 1-yl) furo [2,3-d] pyrimidine-5-carboxylate
作者：
Hu Yang-Gen* ;Xu Jing;Ding Ming-Wu
期刊：
Chinese Journal of Structural Chemistry ,2009年28(6):689-692 ISSN：0254-5861
通讯作者：
Hu Yang-Gen
作者机构：
[Xu Jing; Hu Yang-Gen] Yunyang Med Coll, Dept Med Chem, Shiyan 442000, Peoples R China.;[Ding Ming-Wu] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Coll Chem, Wuhan 430079, Peoples R China.
通讯机构：
[Hu Yang-Gen] Y;Yunyang Med Coll, Dept Med Chem, Shiyan 442000, Peoples R China.
关键词：
crystal structure;ethyl 3-(4-ehlorophenyl)-3,4-dihydro-6-methyl-4-oxo-2-(pyrrolidin-1-yl)furo[2,3-d]pyrimidine-5-carboxylate;aza-Wittig reaction;synthesis
摘要：
The crystal structure of the title compound ethyl 3-(4-chlorophenyl)-3,4-dihydro-6- methyl-4-oxo-2-(pyrrolidin-1-yl)furo[2,3-d]pyrimidine-5-earboxylate (C_(20)H_(20)ClN_3O_4, M_r= 401.84) has been prepared and determined by single-crystal X-ray diffraction. The crystal is of monoelinic, space group P2_1/n with a = 20.6215(9), b = 8.5311(4), c = 21.6886(9) (A), β = 91.607(1)°, V = 3814.0(3) (A)3, Z = 8, D_c = 1.400 g/cm~3, F(000) = 1680,μ = 0.233 mm~(-1), R = 0.0718 and wR = 0.1545 for 6717 observed reflections with I > 2σ(I). X-ray diffraction analysis reveals two crystallographically independent molecules in the asymmetric unit.
语种：
英文
展开
Efficient synthesis of 2-substituted thieno[2,3-d]pyrimidin-4(3H)-ones via an iminophosphorane
作者：
Fang, Zheng-Dong;Hu, Yang-Gen;Ding, Ming-Wu*
期刊：
Heteroatom Chemistry ,2008年19(3):266-270 ISSN：1042-7163
通讯作者：
Ding, Ming-Wu
作者机构：
[Fang, Zheng-Dong; Hu, Yang-Gen; Ding, Ming-Wu] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Fang, Zheng-Dong] Hubei Normal Univ, Dept Chem, Huangshi 435002, Peoples R China.
通讯机构：
[Ding, Ming-Wu] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
摘要：
The carbodiimides 4, obtained from reactions of iminophosphorane 3 with aromatic isocyanates, were reacted with secondary amines to give 2‐dialkylamino‐5‐ethyl‐6‐methyl‐thieno[2,3‐d]pyrimidin‐4(3H)‐ones 6 in the presence of catalytic amount of EtONa. Reactions of 4 with phenols or ROH in the presence of the catalytic amount of K2CO3 or RONa gave 2‐aryloxy‐ or 2‐alkoxy‐5‐ethyl‐6‐methyl‐thieno[2,3‐d]pyrimidin‐4(3H)‐ones 6 in satisfactory yields. The effects of the nucleophiles on cyclization have been investigated. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:266–270, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20424
语种：
英文
展开
Efficient synthesis of 4(3H)-quinazolinones using a soluble polymeric support
作者：
Xie, Chang;Li, Hong Xia;Liu, Ming Guo;Ding, Ming Wu
期刊：
中国化学快报：英文版 ,2008年19(5):505-508 ISSN：1001-8417
通讯作者：
Ding, MW
作者机构：
[Xie, Chang; Li, Hong Xia; Liu, Ming Guo; Ding, Ming Wu] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Ding, MW ] ;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
关键词：
4(3H)-quinazolinone;poly(ethylene glycol) supported;aza-Wittig;reaction;carbodiimide;iminophosphorane
摘要：
4(3H)-Quinazolinones have been synthesized from poly(ethylene glycol) (PEG) supported aza-Wittig reaction. 2-Dialkylamino-4(3H)-quinazolinones 6 were synthesized efficiently by reaction of secondary amine with PEG-supported carbodiimides 4, which were obtained from aza-Wittig reaction of PEG-supported iminophosphoranes 3 with isocyanates. © 2008 Ming Wu Ding.
语种：
英文
展开
Reaction of Functionalized Carbodiimide with -Amino Ester: A Selective Synthesis of 2,3,5-Trisubstituted Imidazol-4-ones
作者：
Li, Hong-Xia;Sun, Yong;Ding, Ming-Wu*
期刊：
Synthetic Communications ,2008年38(24):4328-4336 ISSN：0039-7911
通讯作者：
Ding, Ming-Wu
作者机构：
[Li, Hong-Xia] Naval Univ Engn, Coll Sci, Wuhan, Peoples R China.;[Sun, Yong; Ding, Ming-Wu] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Ding, Ming-Wu] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
关键词：
-Amino ester;aza-Wittig reaction;carbodiimide;imidazolin-4-one;ylides;AZA-WITTIG REACTION;FACILE SYNTHESIS;HETEROCYCLIC SYNTHESIS;MEDIATED ANNULATION;EFFICIENT SYNTHESIS;DERIVATIVES;ALKALOIDS
摘要：
Abstract 3-(Ethoxycarbonylmethylene)-2-(arylimino)-imidazol-4-ones 5 were synthesized selectively by reaction of α-amino ester with carbodiimides 4, which were obtained from aza-Wittig reaction of iminophosphoranes 2 with aromatic isocyanates.
语种：
英文
展开
A facile synthesis and fungicidal activities of 2-(alkylamino)-5,6- dimethylthieno[2,3-d]pyrimidin-4(3H)-ones
作者：
Hu, Yang-Gen;Zheng, Ai-Hua;Ruan, Xu-Zhi;Ding, Ming-Wu
期刊：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY ,2008年4(1):49 ISSN：1860-5397
通讯作者：
Hu, YG
作者机构：
[Hu, Yang-Gen; Zheng, Ai-Hua; Ruan, Xu-Zhi] Yunyang Med Coll, Dept Med Chem, Shiyan 442000, Peoples R China.;[Ruan, Xu-Zhi] Affiliated Taihe Hosp, Yunyang Med Coll, Inst Life Sci, Shiyan 442000, Peoples R China.;[Ding, Ming-Wu] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Hu, YG ] ;Yunyang Med Coll, Dept Med Chem, Shiyan 442000, Peoples R China.
关键词：
2-(alkylamino)-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one;aza-Wittig reaction;fungicidal activity;synthesis
摘要：
The aza-Wittig reactions of iminophosphorane 3 with aromatic isocyanates generated carbodiimides 4, which were reacted with alkylamines under mild conditions to give a series of 2-(alkylamino)-5,6-dimethylthieno[2,3-d] pyrimidin-4(3H)-ones 6 and 8 in satisfactory yield. Their structures were confirmed by 1H NMR, EI-MS, IR and elementary analysis, and compound 8c was further analyzed by single-crystal X-ray diffraction. The preliminary bioassays indicated that these compounds showed excellent fungicidal activities against six kinds of fungi. © 2008 Hu et al; licensee Beilstein-Institut.
语种：
英文
展开
以D1蛋白酶为靶标的双酰肼类化合物的合成及除草活性
作者：
蔡昌权;胡扬根;丁明武
作者机构：
华中师范大学教育部农药与化学生物学重点实验室
会议名称：
中国化工学会农药专业委员会第十三届年会
会议时间：
2008-05-12
会议地点：
井冈山
会议论文集名称：
中国化工学会农药专业委员会第十三届年会论文集
关键词：
D1蛋白酶;虚拟筛选;双酰肼;除草活性;化学合成
摘要：
基于菠菜D1蛋白酶的三维结构模型，通过虚拟筛选，得到D1蛋白酶抑制剂杂环先导化合物。通过优化筛选所得化合物结构，设计合成了两类共十三个新型双酰肼类化合物。其中一些化合物表现出了很好的除草活性。其结构经质谱、红外和1HNMR等得到证实。
语种：
中文
展开
