作者机构：
College of Life Science, Central China Normal University, Wuhan 430079, China;Nanyang Technological;Institute for Environmental Health, Chinese Center for Disease Control and Prevention;Nanyang Technological University, Nanyang Avenue, 639798, Singapore
会议名称：
第十届室内空气品质和质量国际学术会议(Proceedings of the 10th International Conference on Indoor Air Quality and Climate)
会议时间：
2005-09-04
会议地点：
北京
会议论文集名称：
第十届室内空气品质和质量国际学术会议
关键词：
IAQ;Formaldehyde;Neurotoxicity;Morris water maze
摘要：
Purpose: To find out if any neurotoxicity effect exists in the mice that exposed to low-level formaldehyde.Approach: After exposed to the gaseous formaldehyde at 0mg/m3, 1.0mg/m3 and 3.0mg/m3 levels, the mice were tested in Morris water maze. Findings: Results demonstrated that there were significant differences on water maze performances between 0mg/m3 and 3.0mg/m3 formaldehyde inhaled groups (p＜0.01) but little between 0mg/m3 and 1.0mg/m3 groups. Conclusions: These findings indicated that the neurotoxicity effect of formaldehyde assuredly existed, and it may occur only at middle-level (3.0mg/m3) gaseous formaldehyde but not do at low-levels.
期刊：
INDOOR AIR 2005: PROCEEDINGS OF THE 10TH INTERNATIONAL CONFERENCE ON INDOOR AIR QUALITY AND CLIMATE, VOLS 1-5,2005年15:3805-3809 ISSN：0908-5920
通讯作者：
Yang, X
作者机构：
[Qiao, Y; Lu, ZS; Yan, Y; Li, CM; Yang, X; Qi, QP] Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
通讯机构：
[Yang, X] C;Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
会议名称：
10th International Conference on Indoor Air Quality and Climate (Indoor Air 2005)
会议时间：
SEP 04-09, 2005
会议地点：
Beijing, PEOPLES R CHINA
会议主办单位：
Cent China Normal Univ, Coll Life Sci, Wuhan 430079, Peoples R China.
关键词：
IAQ;formaldehyde;neurotoxicity;Morris water maze
摘要：
Purpose: To find out if any neurotoxicity effect exists in the mice that exposed to low-level formaldehyde. Approach: After exposed to the gaseous formaldehyde at 0 mg/m3, 1.0 mg/m3 and 3.0 mg/m3 levels, the mice were tested in Morris water maze. Findings: Results demonstrated that there were significant differences on water maze performances between 0 mg/m3 and 3.0 mg/m3 formaldehyde inhaled groups (p<0.01) but little between 0 mg/m3 and 1.0 mg/m3 groups. Conclusions: These findings indicated that the neurotoxicity effect of formaldehyde assuredly existed, and it may occur only at middle-level (3.0 mg/m3) gaseous formaldehyde but not do at low-levels.
作者机构：
Wuhan University of Science and Technology, Wuhan 430080, PR China;School of Life Science, Central China Normal University, Wuhan 430079, PR China
会议名称：
第十届室内空气品质和质量国际学术会议(Proceedings of the 10th International Conference on Indoor Air Quality and Climate)
摘要：
Objective: To study the effect of formaldehyde on DNA-protein crosslinks (DPC) in buccal cells in students who were taking anatomy course. Methods: The modified KCl-SDS precipitation assay was applied. This method has been used to explore DPC induced by different pollutants in laboratory studies. Results: 37 students in medical school and 40 in school of sciences were studied. The frequency of exposure to formaldehyde was 6 h per week in exposed group. Concentrations of formaldehyde in anatomy laboratory ranged from 0.42 to 1.57 mg/m. Exposure to formaldehyde resulted in an increase of DNA-protein crosslinks. DNA-protein crosslinks in exposed and nonexposed students were 25.72±6.48％ and 22.88±5.34％ (p＜0.05), respectively. Air formaldehyde caused a significant increase in DNA-protein crosslinks of the females in two groups (27.72±5.76％ and 22.29±4.20％,p＜0.01). However, there was no difference in males (24.02±6.72 and 23.48±6.33, p＞0.05). Conclusions: The results suggest that exposure to formaldehyde in medical students increase the frequency of DNA-protein crosslinks in buccal cells. Our results also indicate that females may be more sensitive to formaldehyde exposure.
