A cascade coupling strategy for one-pot total synthesis of β-carboline and isoquinoline-containing natural products and derivatives
作者:
Zhu, Yan-Ping;Liu, Mei-Cai;Cai, Qun;Jia, Feng-Cheng;Wu, An-Xin
* ( 吴安心 )
期刊:
CHEMISTRY-A EUROPEAN JOURNAL ,2013年19(31):10132-10137 ISSN:0947-6539
作者机构:
[Wu, An-Xin; Jia, Feng-Cheng; Cai, Qun; Liu, Mei-Cai; Zhu, Yan-Ping] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan, Peoples R China.
通讯机构:
[Wu, An-Xin] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan, Peoples R China.
关键词:
carboline;cascade reactions;C? H coupling;isoquinoline;natural products
摘要:
Multi-birds with one stone: A cascade coupling strategy was developed for the synthesis of β-carbolines. The method can direct the synthesis of β-carboline and isoquinoline-containing natural products with high yields. Moreover, this protocol can also be further applied towards the total synthesis of natural products fascaplysin and papaverin (see scheme). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
语种:
英文
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Selective synthesis of six-membered and five-membered spiro compounds by controlling the molar ratio of ternary gallium/ indium/copper (Ga/In/Cu) catalysts
作者:
Pang, Tao;Sun, Yu;Xue, Wei-Jian;Zhu, Yan-Ping;Yu, Guang-Ao* ;...
期刊:
ADVANCED SYNTHESIS & CATALYSIS ,2013年355(11-12):2208-2216 ISSN:1615-4150
通讯作者:
Yu, Guang-Ao
作者机构:
[Wu, An-Xin; Sun, Yu; Xue, Wei-Jian; Pang, Tao; Yu, Guang-Ao; Zhu, Yan-Ping] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Yu, Guang-Ao] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构:
[Yu, Guang-Ao] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
关键词:
chemoselectivity;Diels-Alder reaction;heterogeneous catalysis;reaction mechanisms;spiro compounds
摘要:
Selective syntheses of six-membered and five-membered spiro-naphthalenones from the same starting substrates by controlling the molar ratio of ternary gallium/indium/copper (Ga/In/Cu) catalysts have been demonstrated. The method may have potential applications in natural product synthesis. © 2013 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim.
语种:
英文
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A benzimidazole-based ratiometric fluorescent sensor for Cr3+ and Fe3+ in aqueous solution
作者:
Meng Wang;Jungang Wang;Weijian Xue;Anxin Wu
( 吴安心 )
期刊:
Dyes and Pigments ,2013年97(3):475-480 ISSN:0143-7208
通讯作者:
Wu, Anxin
作者机构:
[Anxin Wu; Weijian Xue; Meng Wang; Jungang Wang] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Anxin Wu] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构:
[Wu, Anxin] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
关键词:
Aqueous solution;Benzimidazole;Cr3+;Fe 3+;Fluorescent sensor;Ratiometric
摘要:
A novel ratiometric fluorescent sensor bearing two benzimidazole groups has been synthesized. The sensor showed a ratiometric fluorescence response with an enhancement of the ratios of emission intensities at 443 and 378 nm from 0.17 to 3.21 for Cr3+. The ratios of emission intensities at 443 and 380 nm were enhanced from 0.40 to 2.09 for Fe3+. Fe3+ revealed significant adsorption in the UV-vis region, which can be used to discriminate Cr3+ and Fe3+. Detection limits of the method for Cr 3+ and Fe3+ were 25 μM and 2 μM, respectively. In addition, the sensor showed good selectivity to Cr3+ and Fe 3+ over other metal ions. © 2013 Elsevier Ltd. All rights reserved.
语种:
英文
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Synthesis of functionalized 2-aryl-4-(indol-3-yl)-4H-chromenes via iodine-catalyzed domino Michael addition-intramolecular cyclization reaction
作者:
Yin, Guodong* ;Fan, Ling;Ren, Tianbing;Zheng, Chunyang;Tao, Qing;...
期刊:
Organic & Biomolecular Chemistry ,2012年10(44):8877-8883 ISSN:1477-0520
作者机构:
[Yin, Guodong; Ren, Tianbing; Zheng, Chunyang; Fan, Ling; Tao, Qing] Hubei Normal Univ, Coll Chem & Environm Engn, Hubei Key Lab Pollutant Anal & Reuse Technol, Huangshi 435002, Peoples R China.;[She, Nengfang; Wu, Anxin] Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticides & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构:
[Yin, Guodong] H;Hubei Normal Univ, Coll Chem & Environm Engn, Hubei Key Lab Pollutant Anal & Reuse Technol, Huangshi 435002, Peoples R China.
摘要:
An efficient synthesis of novel functionalized 2-aryl-4-(indol-3-yl)-4H-chromenes has been developed, in the presence of a catalytic amount of iodine, from easily available starting materials, 2-hydroxychalcone derivatives. Indole, substituted indoles and 7-azaindole are suitable for this transformation. The possible domino Michael addition-intramolecular cyclization reaction mechanism is proposed.
语种:
英文
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A Multipathway Coupled Domino Strategy: Metal-free Oxidative Cyclization for One-Pot Synthesis of 2-Acylbenzothiazoles from Multiform Substrates
作者:
Yan-ping Zhu;Feng-cheng Jia;Mei-cai Liu;An-xin Wu
( 吴安心 )
期刊:
Organic Letters ,2012年14(17):4414-4417 ISSN:1523-7060
通讯作者:
Wu, An-xin
作者机构:
[An-xin Wu; Yan-ping Zhu; Feng-cheng Jia; Mei-cai Liu] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[Wu, An-xin] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
摘要:
A multipathway coupled domino strategy has been developed for the efficient synthesis of 2-acylbenzothiazoles from multiform substrates arylethenes, arylacetylenes, 2-hydroxy-aromatic ketones, and carbinols via four distinct pathways. Through a logical coupled oxidation/heterocyclization domino process, a variety of 2-acylbenzothiazoles were synthesized free of metal in one pot.
语种:
英文
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I2/CuO-catalyzed tandem cyclization strategy for one-pot synthesis of substituted 2-aminothiozole from easily available aromatic ketones/α,β-unsaturated ketones and thiourea
作者:
Zhu, Yan-Ping;Yuan, Jing-Jing;Zhao, Qin;Lian, Mi;Gao, Qing-He;...
期刊:
Tetrahedron ,2012年68(1):173-178 ISSN:0040-4020
作者机构:
[Wu, An-Xin; Gao, Qing-He; Yang, Yan; Liu, Mei-Cai; Lian, Mi; Zhu, Yan-Ping; Yuan, Jing-Jing; Zhao, Qin] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构:
[Wu, An-Xin] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
关键词:
2-Aminothiazole;One-pot reaction;Tandem cyclization;alpha-Halogenation ketones;I-2/CuO
摘要:
A concise and efficient one-pot process from easily available methyl ketones/unsaturated methyl ketones and thiourea was developed for the synthesis of 2-aminothiazoles under the media of I-2/CuO. The method can highly stereoselectivity obtain the E-isomers of 4-ethenyl-2-aminothiazoles (5a-f). All these target molecules were characterized by NMR, HRMS and IR spectra. Furthermore, the target compounds 3c and 5b were further determined by X-ray crystallographic analysis. (C) 2011 Elsevier Ltd. All rights reserved.
语种:
英文
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Synthesis of trisubstituted isoxazoles via in situ trapping strategy from α-nitro carbonyl compounds and methyl ketones or terminal aryl alkenes
作者:
Yang, Yan;Gao, Meng;Deng, Cong;Zhang, Dong-Xue;Wu, Liu-Ming;...
期刊:
Tetrahedron ,2012年68(31):6257-6262 ISSN:0040-4020
作者机构:
[Wu, An-Xin; Wu, Liu-Ming; Gao, Meng; Yang, Yan; Zhang, Dong-Xue; Deng, Cong; Shu, Wen-Ming] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Wu, An-Xin] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构:
[Wu, An-Xin] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
关键词:
Isoxazoles;Domino reaction;alpha-Nitro carbonyl compounds;Methyl ketones;Terminal aryl alkenes
摘要:
A highly efficient domino method for the synthesis of trisubstituted isoxazoles has been established from alpha-nitro carbonyl compounds and methyl ketones or terminal aryl alkenes. Simple and readily available starting materials, mild reaction conditions and very simple operation are significant advantages of the reaction. (C) 2012 Elsevier Ltd. All rights reserved.
语种:
英文
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Substrate-controlled and highly stereoselective synthesis of 2-aminobut-2-ene-1, 4-diones
作者:
Deng, Cong;Yang, Yan;Gao, Meng;Zhu, Yan-Ping;Wu, An-Xin
* ( 吴安心 ) ;...
期刊:
Tetrahedron ,2012年68(20):3828-3834 ISSN:0040-4020
作者机构:
[Wu, An-Xin; Gao, Meng; Yang, Yan; Zhu, Yan-Ping; Deng, Cong] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Ma, Jun-Rui; Yin, Guo-Dong] Hubei Normal Univ, Hubei Key Lab Pollutant Anal & Reuse Technol, Huangshi 435002, Peoples R China.
通讯机构:
[Wu, An-Xin] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
关键词:
2-Aminobut-2-ene-1,4-diones;Amines;Aryl methyl ketones;Substrate- controlled;Z/E-Stereoselectivity
摘要:
2-Methylthio-substituted 1,4-enediones, obtained from readily available aryl methyl ketones, were reacted with primary or secondary amines to afford the desired 1,4-diaryl-2-aminobut-2-ene-1,4-diones in excellent yields with high Z/E-stereoselectivity. (C) 2012 Elsevier Ltd. All rights reserved.
语种:
英文
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Diversity-oriented synthesis of chromenes via metal-free domino reactions from ketones and phenols
作者:
Xue, Wei-Jian;Li, Qi;Gao, Fang-fang;Zhu, Yan-ping;Wang, Jun-gang;...
期刊:
ACS Combinatorial Science ,2012年14(8):478-483 ISSN:2156-8952
作者机构:
[Wu, An-Xin; Xue, Wei-Jian; Zhu, Yan-ping; Li, Qi; Zhang, Wei; Gao, Fang-fang; Wang, Jun-gang] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[Wu, An-Xin] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
关键词:
diversity-oriented synthesis;metal-free;domino reaction
摘要:
Functionalized chromenes have been synthesized via highly selective metal-free domino reactions from ketones and phenols. 2H-Chromenes, 4H-chromenes, spiran and benzocyclopentane can be respectively prepared starting from the corresponding cyclic ketones, aryl methyl ketones, acetone, and 3-pentanone.
语种:
英文
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Convergent domino synthesis of 1,2,3-triaroylindolizines from methyl ketones and pyridines via self-division of labor strategy
作者:
Yang, Yan;Gao, Meng;Zhang, Dong-Xue;Wu, Liu-Ming;Shu, Wen-Ming;...
期刊:
Tetrahedron ,2012年68(36):7338-7344 ISSN:0040-4020
作者机构:
[Wu, An-Xin; Wu, Liu-Ming; Gao, Meng; Yang, Yan; Zhang, Dong-Xue; Shu, Wen-Ming] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Coll Chem, Wuhan 430079, Peoples R China.;[Wu, An-Xin] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Coll Chem, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构:
[Wu, An-Xin] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Coll Chem, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
关键词:
Convergent domino;Indolizine;Methyl ketone;Pyridine;Self-division of labor
摘要:
A highly efficient method for the synthesis of 1,2,3-triaroylindolizines has been established from readily available methyl ketones and pyridines in the presence of iodine. This reaction also examplified the self-division of labor strategy in convergent domino synthesis.
语种:
英文
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Novel furo[2,3-d] pyrimidine derivative as fluorescent chemosensor for HSO4-
作者:
Xue, Weijian;Li, Lin;Li, Qi;Wu, Anxin
* ( 吴安心 )
期刊:
Talanta ,2012年88:734-738 ISSN:0039-9140
作者机构:
[Wu, Anxin; Xue, Weijian; Li, Lin; Li, Qi] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Wu, Anxin] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构:
[Wu, Anxin] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
关键词:
Fluorescent chemosensor;HSO4- ion;Selectivity;Sonogashira reaction
摘要:
A class of novel heterocyclic compounds 1a-1c has been designed and synthesized. And our initial discovery is that these compounds can effectively recognize HSO<inf>4</inf><sup>-</sup>. With the addition of HSO<inf>4</inf> <sup>-</sup>, a new energy band appears at 360-390 nm in the absorption spectra. The emission spectrum (λ<inf>ex</inf> = 328 nm) undergoes an important change in its fluorescent effect in the presence of HSO<inf>4</inf><sup>-</sup>. All available data (absorption and emission) strongly support the formation of hydrogen-bonded complexes between 1a and 1c and HSO<inf>4</inf><sup>-</sup>. ©2011 Elsevier B.V. All rights reserved.
语种:
英文
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An unprecedented triple helix based on the tetrameric assembly of a macrocycle driven by weak C-H⋯π and C-H⋯O interactions
作者:
Pang, Tao;Shang, Jie;Yang, Qin-Wan;Sun, Yu;Wu, An-Xin
* ( 吴安心 ) ;...
期刊:
CrystEngComm ,2012年14(16):5170-5173 ISSN:1466-8033
作者机构:
[Wu, An-Xin; Sun, Yu; Pang, Tao; Yang, Qin-Wan] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Shang, Jie; Jiang, Hua] Chinese Acad Sci, Beijing Natl Lab Mol Sci CAS, Key Lab Photochem, Inst Chem, Beijing 100190, Peoples R China.;[Wu, An-Xin] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构:
[Wu, An-Xin] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
摘要:
The formation of an unprecedented metal-free triple helix is driven by weak C-H⋯π and C-H⋯O interactions based on a unique supramolecular synthon macrocycle. © 2012 The Royal Society of Chemistry.
语种:
英文
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I-2 promoted domino oxidative cyclization for one-pot synthesis of 2-acylbenzothiazoles via metal-free sp(3) C-H functionalization
作者:
Zhu, Yan-Ping;Lian, Mi;Jia, Feng-Cheng;Liu, Mei-Cai;Yuan, Jing-Jing;...
期刊:
Chemical Communications ,2012年48(72):9086-9088 ISSN:1359-7345
作者机构:
[Wu, An-Xin; Gao, Qing-He; Jia, Feng-Cheng; Liu, Mei-Cai; Lian, Mi; Zhu, Yan-Ping; Yuan, Jing-Jing] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Coll Chem, Wuhan 430079, Peoples R China.;[Wu, An-Xin] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Coll Chem, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构:
[Wu, An-Xin] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Coll Chem, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
摘要:
An I 2 promoted domino protocol was developed to construct 2-acylbenzothiazoles from simple and readily available aromatic ketones/unsaturated methyl ketones and o-aminobenzenethiols. The reaction proceeded smoothly under metal-free and peroxide-free conditions. © 2012 The Royal Society of Chemistry.
语种:
英文
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Logic design and synthesis of quinoxalines via the integration of iodination/oxidation/cyclization sequences from ketones and 1,2-diamines
作者:
Lian, Mi;Li, Qi;Zhu, Yanping;Yin, Guodong
* ;Wu, Anxin
( 吴安心 )
期刊:
Tetrahedron ,2012年68(47):9598-9605 ISSN:0040-4020
通讯作者:
Yin, Guodong
作者机构:
[Wu, Anxin; Zhu, Yanping; Li, Qi; Lian, Mi] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Yin, Guodong; Zhu, Yanping] Hubei Normal Univ, Hubei Key Lab Pollutant Anal & Reuse Technol, Huangshi 435002, Peoples R China.
通讯机构:
[Yin, Guodong] H;Hubei Normal Univ, Hubei Key Lab Pollutant Anal & Reuse Technol, Huangshi 435002, Peoples R China.
关键词:
Quinoxaline;I-2/CuO;One-pot reaction;1,2-Diamines;Logic design
摘要:
A novel protocol for the synthesis of quinoxalines has been developed from simple ketones and 1,2-diamines. This process underwent a logic approach to bis-substituted quinoxalines via a consecutive iodination/Kornblum oxidation/cyclization in the presence of I-2/CuO/DMSO and to mono-substituted quinoxalines via an iodination/cyclization/aromatization in the presence of I-2/CuO/K3PO4 center dot 3H(2)O. (c) 2012 Elsevier Ltd. All rights reserved.
语种:
英文
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Metal-Free sp(3) C-H Bond Dual-(Het)arylation: I-2-Promoted Domino Process to Construct 2,2-Bisindolyl-1-arylethanones
作者:
Yan-ping Zhu;Mei-cai Liu;Feng-cheng Jia;Jing-jing Yuan;Qing-he Gao;...
期刊:
Organic Letters ,2012年14(13):3392-3395 ISSN:1523-7060
通讯作者:
Wu, An-xin
作者机构:
[An-xin Wu; Qing-he Gao; Yan-ping Zhu; Feng-cheng Jia; Mei-cai Liu; Mi Lian; Jing-jing Yuan] Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[Wu, An-xin] C;Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
摘要:
A molecular I 2-promoted sp 3 C-H bond dual-(het)arylation protocol was developed for the synthesis of 2,2-bisindolyl-1-arylethanones. Through a logical design, three mechanism-different reactions (iodination, Kornblum oxidation, and Friedel-Crafts reaction) were assembled in a single reactor. A variety of 2,2-bisindolyl-1-aryl ethanones were synthesized from simple and readily available aryl methyl ketones and indoles. In the reaction, metal, base, and ligand were all avoidable. © 2012 American Chemical Society.
语种:
英文
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Unsymmetrical N and/or O-bridged calixarene derivatives: synthesis, structure and encapsulation of solvent molecules in the solid state
作者:
Yuan, Jingjing;Zhu, Yanping;Lian, Mi;Gao, Qinghe;Liu, Meicai;...
期刊:
Tetrahedron Letters ,2012年53(10):1222-1226 ISSN:0040-4039
作者机构:
[Wu, Anxin; Jia, Fengcheng; Zhu, Yanping; Lian, Mi; Yuan, Jingjing; Gao, Qinghe; Liu, Meicai] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构:
[Wu, Anxin] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
关键词:
Fragment coupling strategy;Unsymmetrical;Heterocalixaromatics
摘要:
Eight unsymmetrical N and/or O-bridged calixarene derivatives were obtained by 1 (naphthalene-2,7-diol), 2 (bis(4-hydroxyphenyl)methanone), 3 (4,4′-methylenedianiline), 4 (3,3′-methylenedianiline), 5 (4,4′-oxydianiline) and 6 (4,4′-(perfluoropropane-2,2-diyl)dianiline) reacting with fragment a (4,4′-bis(dichloro-s-triazinyloxy)propane-2,2-diyldibenzene) and b (N,N′-bis(dichloro-s-triazinyl)-4,4′-methylenedianiline) under very mild reaction conditions via efficient fragment coupling strategy. We also obtained the crystal structure of 1a (tetraoxocalix[2](propane-2,2-diyldibenzene,naphthalene)[2]triazine) which can form a molecular capsule by two dimers with C–H⋯N and C–H⋯O quadruple hydrogen bonds, and it has the encapsulation ability toward solvent molecules.
语种:
英文
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Convergent integration of two self-labor domino sequences: a novel method for the synthesis of oxazole derivatives from methyl ketones and benzoins
作者:
Xue, Wei-Jian;Li, Qi;Zhu, Yan-Ping;Wang, Jun-Gang;Wu, An-Xin
* ( 吴安心 )
期刊:
Chemical Communications ,2012年48(29):3485-3487 ISSN:1359-7345
作者机构:
[Wu, An-Xin; Xue, Wei-Jian; Li, Qi; Wang, Jun-Gang; Zhu, Yan-Ping] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Wu, An-Xin] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构:
[Wu, An-Xin] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
摘要:
A highly efficient method for the synthesis of oxazole derivatives from methyl ketones, benzoins and ammonium acetate has been established via a novel strategy - convergent integration of two self-labor domino sequences. Owing to the simple and readily available starting materials, mild reaction conditions, facile operation, and the high bioactivity of oxazole derivatives, this reaction promises diverse applications in medical chemistry. Additionally, this reaction could provide an efficient example for self-labor synthesis strategy of organic compounds. © 2012 The Royal Society of Chemistry.
语种:
英文
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A Novel and Highly Regioselective Route to Construct Methylthio-Substituted Pyridazines from Aryl Methyl Ketones at Room Temperature
作者:
Wu, Luming;Yang, Yan;Gao, Meng;Zhang, Dongxue;Shu, Wenming;...
期刊:
SYNLETT ,2012年23(14):2137-2141 ISSN:0936-5214
作者机构:
[Wu, Anxin; Shu, Wenming; Zhu, Yanping; Gao, Meng; Yang, Yan; Zhang, Dongxue; Wu, Luming] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构:
[Wu, Anxin] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
关键词:
regioselectivity;homocoupling/cyclization;aryl methyl ketones;hydrazine hydrate;methylthio-substituted pyridazine
摘要:
A novel and highly regioselective two-step homocoupling/cyclization procedure from easily available aryl methyl ketones and hydrazine hydrate was developed for the synthesis of methylthio-substituted pyridazines at room temperature. The method has remarkable advantages owing to the simple substrates, mild reaction conditions, ease of manipulation, good yields and high regioselectivity. © Georg Thieme Verlag Stuttgart New York.
语种:
英文
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Direct Synthesis of Substituted Naphthalenes from 1,3-Dicarbonyl Compounds and 1,2-Bis(halomethyl)benzenes Including a Novel Rearrangement Aromatization of Benzo[c]oxepine
作者:
Wang, Jun-gang;Wang, Meng;Xiang, Jia-chen;Zhu, Yan-ping;Xue, Wei-jian;...
期刊:
Organic Letters ,2012年14(23):6060-6063 ISSN:1523-7060
作者机构:
[Wu, An-xin; Xiang, Jia-chen; Zhu, Yan-ping; Wang, Meng; Xue, Wei-jian; Wang, Jun-gang] Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构:
[Wu, An-xin] C;Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
摘要:
An unexpected rearrangement aromatization of benzo[c]oxepine has been revealed to synthesize substituted naphthalenes. This observation was further exploited to develop an efficient approach for the construction of naphthalenes from simple and commercially available 1,3-dicarbonyl compounds and 1,2-bis(halomethyl)benzene compounds via a new domino reaction sequence.
语种:
英文
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Unexpected C-C bond cleavage: A route to 3,6-diarylpyridazines and 6-arylpyridazin-3-ones from 1,3-dicarbonyl compounds and methyl ketones
作者:
Gao, Qinghe;Zhu, Yanping;Lian, Mi;Liu, Meicai;Yuan, Jingjing;...
期刊:
JOURNAL OF ORGANIC CHEMISTRY ,2012年77(21):9865-9870 ISSN:0022-3263
通讯作者:
Yin, Guodong
作者机构:
[Wu, Anxin; Zhu, Yanping; Lian, Mi; Gao, Qinghe; Yuan, Jingjing; Liu, Meicai] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Yin, Guodong] Hubei Normal Univ, Coll Chem & Environm Engn, Hubei Key Lab Pollutant Anal & Reuse Technol, Huangshi 435002, Peoples R China.
通讯机构:
[Yin, Guodong] H;Hubei Normal Univ, Coll Chem & Environm Engn, Hubei Key Lab Pollutant Anal & Reuse Technol, Huangshi 435002, Peoples R China.
摘要:
An unexpected C-C bond cleavage has been revealed in the absence of metal. This observation has been exploited to develop an efficient approach toward 3,6-diarylpyridazines and 6-arylpyridazin-3-ones from simple and commercially available 1,3-dicarbonyl compounds and methyl ketones. ©2012 American Chemical Society.
语种:
英文
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