作者机构：
[Zhang, Jing; Liu, Sheng Hua; Wang, Xiao-Yan; Yin, Jun] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Zhang, Jing; Tang, Ben Zhong] Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Dept Chem & Biol Engn, Inst Adv Study,Dept Chem,Kowloon, Clear Water Bay, Hong Kong, Peoples R China.;[Zhang, Jing; Tang, Ben Zhong] Hong Kong Univ Sci & Technol, Inst Mol Funct Mat, Kowloon, Clear Water Bay, Hong Kong, Peoples R China.
通讯机构：
[Liu, Sheng Hua] C;[Tang, Ben Zhong] H;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Dept Chem & Biol Engn, Inst Adv Study,Dept Chem,Kowloon, Clear Water Bay, Hong Kong, Peoples R China.;Hong Kong Univ Sci & Technol, Inst Mol Funct Mat, Kowloon, Clear Water Bay, Hong Kong, Peoples R China.
作者机构：
[Liu, Sheng Hua; Yin, Jun; He, Yongxin] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ,Hubei I, Wuhan 430079, Peoples R China.;[Yoon, Juyoung] Ewha Womans Univ, Dept Chem & Nanosci, Seoul 120750, South Korea.
通讯机构：
[Yin, Jun] C;[Yoon, Juyoung] E;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ,Hubei I, Wuhan 430079, Peoples R China.;Ewha Womans Univ, Dept Chem & Nanosci, Seoul 120750, South Korea.
摘要：
Reactive oxygen species (ROS) are a type of active species in body, and can participate in the process of tumor development under the condition of oxidative stress, which can lead to the apoptosis of cancer cells through a variety of different mechanisms. Photodynamic therapy (PDT) is a novel method of treating tumor with photosensitive drugs and laser activation. However, PDT suffers from the poor penetrating depth of tissue of excitation light. By comparison, sonodynamic therapy (SDT) adopts high-penetrating sound waves to trigger the ultrasound-responsive materials called sonosensitizers for the treatment of cancer by different mechanisms such as ROS, ultrasound response cavitation, and thermal effects. The efficiency of SDT is bound up with molecular structures and performances of sonosensitizers, which has promoted the design of sonosensitive agents and their development in various biological fields. In clinical treatment, regulating the tumor microenvironment offers a door and new ideas for effective tumor treatment. For tumor microenvironment (TME) involving pH values, excessive production of hydrogen peroxide, scientists have designed and synthesized many nanomaterials to produce hydroxyl radicals (center dot OH) for tumor chemodynamic therapy (CDT) through Fenton and Fenton-like reactions. Many studies have indicated that its therapeutic efficiency is associated with the increase of center dot OH production in situ of the tumor. Many approaches based on Fenton reaction have been used to improve the production of center dot OH, including the choice of nanomaterials and the adjustment of the microenvironment. In view of the above two new treatment methods, this article summarizes, discusses and enlightens the SDT-related sonosensitizers and CDT-related nanomaterials in recent years, and discusses their applications and potential challenges. (C) 2020 Elsevier B.V. All rights reserved.
作者机构：
[Yin, Jun] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensing Technol, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
通讯机构：
[Yin, Jun] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
关键词：
Alkali metal ions;Bioimaging application;Fluorescent dyes;Fluorescent probes;pH
摘要：
The homeostasis of acid/base and alkali metal played critical roles in life process. To get insight into their functional mechanism, a large amount of detectors, especially based on organic fluorescent probes have been largely developed and used to monitor the dynamic changes of pH and alkali metal ions. Importantly, fluorescent probes provide a portable means to carry out a real-time determination and even a clinical diagnosis for abnormal pathological states. Over the past decades, numerous fluorescent probes for the pH and alkali metals analytes have been extensively developed and applied in living systems. In this review, we outlined the recent advances on fluorescent probes for pH and alkali metal ions containing their sensing mechanism, binding modes and application. (C) 2020 Elsevier B.V. All rights reserved.
摘要：
The different oxidation states of sulphur atom play a significant role on functional materials. In this work, a aryl-thioether and its sulphone substituted benzo[c][1,2,5]oxadiazole dyes were synthesized and utilized to determine thiol-containing amino acids. The result of selectivity experiments showed they detected the cysteine and homocysteine under physiological condition with negligible interference from other amino acids. In comparison to the thioether dye, the sulphone-based dye exhibited much faster response time for Cys and Hcy. However, the sulphone restricted its thiol-reactivity and bioimaging performance in living cells. By reducing the oxidation state of sulphur atom, we amazedly found that the sulfoxide-based dye still maintained high selectivity ultrafast response time for Cys/Hcy under physiological condition. It was worth mentioning that it also had high reactivity and good bioimaging performance that sulfone compounds did not have.
期刊：
Journal of Inorganic and Organometallic Polymers and Materials,2020年30(5):1490-1496 ISSN：1574-1443
通讯作者：
Lam, Jacky W. Y.;Tang, Ben Zhong;Liu, Sheng Hua
作者机构：
[Zhang, Jing; Zou, Hang; He, Benzhao; Lam, Jacky W. Y.; Tang, Ben Zhong] Hong Kong Univ Sci & Technol, Inst Adv Study, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Dept Chem,Hong Kong Branch,Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China.;[Zhang, Jing; Zou, Hang; He, Benzhao; Lam, Jacky W. Y.; Tang, Ben Zhong] Hong Kong Univ Sci & Technol, Dept Chem & Biol Engn, Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China.;[Liu, Sheng Hua; Wang, Xiaoyan] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Lam, JWY; Tang, BZ] H;[Liu, Sheng Hua] C;Hong Kong Univ Sci & Technol, Inst Adv Study, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Dept Chem,Hong Kong Branch,Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China.;Hong Kong Univ Sci & Technol, Dept Chem & Biol Engn, Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China.;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
Novel classes of contorted hexabenzocoronenes (c-HBCs) which exhibit a doubly concave configuration were synthesized by using hexabenzocoronene as bridge ligand and diphenylamine/triphenylamine as the redox-active termini. Although the analysis of the crystal structures of tri-di(4-methoxyphenyl) amino-substituted HBC (1), trimethoxy-substituted HBC (3) and tri(triphenylamine)-substituted HBC (4) show that the peripheral modified arylamine groups have a certain influence on the interaction force between molecules, the results of UV-vis absorption and fluorescence emission spectra indicate that these arylamine-modified hexabenzocoronenes have similar photophysical properties, which are primarily regulated by the c-HBC center. Subsequent electrochemical tests found that these compounds have multi-step redox process, and there is a certain degree of overlap between the arylamine and arylamine or between the arylamine and the bridge (c-HBC) during the oxidation process. Combining the UV-vis-NIR spectroelectrochemistry with the density functional theory (DFT) calculations, we further explored the electronic characters of the neutral and one-electron oxidation states of tri-di(4-methoxyphenyl)amino-substituted HBC (1), trimethoxy-substituted HBC (3) and tri(triphenylamine)substituted HBC (4). (C) 2020 Elsevier Ltd. All rights reserved.
作者机构：
[Peng, Junhui; Zou, Hang; Lam, Jacky W. Y.; Zhang, Jing; Zhang, Haoke; Wu, Wenjie; Zhang, Jun; Tang, Ben Zhong] HKUST, Dept Chem,Inst Mol Funct Mat,Div Life Sci,Kowloon, Hong Kong Branch,Inst Adv Study,Dept Chem & Biol, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Clear Water Bay, Hong Kong, Peoples R China.;[Peng, Junhui; Zou, Hang; Lam, Jacky W. Y.; Zhang, Jing; Zhang, Haoke; Wu, Wenjie; Zhang, Jun; Tang, Ben Zhong] HKUST, State Key Lab Mol Neurosci, Kowloon, Clear Water Bay, Hong Kong, Peoples R China.;[Xu, Weiqing; Xu, Shuping; Li, Aisen] Jilin Univ, Coll Chem, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China.;[Qin, Anjun; Guo, Jiali; Tang, Ben Zhong] South China Univ Technol, Ctr Aggregat Induced Emiss, SCUT HKUST Joint Res Ins, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Peoples R China.;[Gu, Xinggui] Beijing Univ Chem Technol, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, Beijing 100029, Peoples R China.
通讯机构：
[Tang, Ben Zhong] H;[Xu, Weiqing] J;[Tang, Ben Zhong] S;HKUST, Dept Chem,Inst Mol Funct Mat,Div Life Sci,Kowloon, Hong Kong Branch,Inst Adv Study,Dept Chem & Biol, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Clear Water Bay, Hong Kong, Peoples R China.;HKUST, State Key Lab Mol Neurosci, Kowloon, Clear Water Bay, Hong Kong, Peoples R China.
摘要：
There is still an urgent demand for novel smart materials that can achieve a diverse range of practical applications in the synthetic material area. Herein, we developed a simple but versatile aggregation-induced emission luminogen (AIEgen, 1). Compound 1 was sensitive to an electric stimulus and displayed reversibly three-color switched electrochromism and on-to-off electroluminochromism. Such properties allowed the fabrication of high-performance non-doped OLEDs with a high external quantum efficiency of 5.22%. Due to its AIE property and remarkable sensitive color change in response to polarity change, it can serve as a unique imaging probe for detecting environmental polarity in cells and selective visualization of lipid droplets in live tissues. More impressively, compound 1 exhibited a wide range of thermoresponsive behaviors with a ratiometric luminescence change and noticeable fluorescence color switching. As another remarkable feature, it can respond to anisotropic shearing force and isotropic hydrostatic pressure with prominent and contrasting luminescence conversion due to the distinct disturbance of the weak intermolecular interactions and charge transfer process. The present results may offer an important guideline for multifunctional molecular design and provide an important step forward to expand the real-life applications of smart materials.
摘要：
IR780 as a commercially available dye with near-infrared emission has been extensively applied in fluorescent probes and bioimaging. In this work, to further intensify the optical behavior, a tetrahydropyridine ring was used to replace the cyclohexene ring at the center of IR780, forming a cyanine dye Cy-NH with near-infrared emission. Photophysical properties demonstrated that Cy-NH exhibits good optical performance. In particular, Cy-NH contains two functional reaction sites (e.g. Cl and NH sites on the tetrahydropyridine ring) and can be used to construct functional cyanine dyes. Investigation on imaging showed that these cyanines can be used as near-infrared fluorescent imaging agents in living cells and in vivo.
摘要：
We present herein the synthesis, structure, redox and electronic absorption studies of a series of cyclometalated iridium-triarylamine complexes 1 -7. For complexes 1-4 where the amine nitrogen is in the meta position to the Ir-C-C<^>N bond, the electronic nature of the triarylamine units is varied by using different substituents (H, Me, OMe and Cl). In order to study the relationship between the connection mode and the intramolecular electron coupling properties, the amine nitrogen is placed in the para position with respect to the Ir-C-C<^>N bond in complexes 5 and 6 . And it should be noted that all of these complexes exhibit two well-defined redox processes (N/N center dot+ and Ir-III/IV) within the available potential window at appreciably low potentials. The neutral, one-electron-oxidized states of complexes 3 and 6 were investigated by cyclic voltammetry (CV) and square-wave voltammetry (SWV), UV-vis-NIR spectroelectrochemistry and theoretical calculations. Experimental results show that the above mentioned four different substituents does not have a significant effect on the potential splitting AE between the two anodic redox waves of complexes 1-4 . But, the AE of complex 6 is larger than that of complex 3 , indicating that the electron coupling of arylamine and iridium units in the para position (6) is stronger than that in the meta position (3), which is also verified by in-situ absorption spectroelectrochemistry. It is worth noting that the directions of intramolecular charge-transfer in complexes 1 and 5 is reversed due to the different arylamine groups attachment sites (either meta or para to the Ir-C-C<^>N bond). (c) 2020 Elsevier B.V. All rights reserved.
作者机构：
[Yin, Jun] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensing Technol, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
通讯机构：
[Yin, Jun] C;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
Heptamethine cyanine dyes (Cy7) have attracted much attention in the field of biological application due to their unique structure and attractive near infrared (NIR) photophysical properties. In this review, the influences of different modification sites on the absorption characteristics, photostability, Stokes shift, fluorescence characteristics, water solubility, and singlet oxygen generation efficiency of this class of dyes are summarized, and the application development of the corresponding dyes in the field of biological application is introduced, which will provide a reference for the optimization and improvement of heptamethine cyanine dyes in the future.
期刊：
CHEMISTRY-AN ASIAN JOURNAL,2020年15(20):3338-3349 ISSN：1861-4728
通讯作者：
Ou, Ya-Ping;Liu, Sheng Hua
作者机构：
[Ou, Ya-Ping; Wang, Aihui; Yin, Chuang; Yuan, Ande] Hengyang Normal Univ, Coll Chem & Mat Sci, Key Lab Funct Met Organ Cpds Hunan Prov, Key Lab Funct Organometall Mat Hunan Prov, Hengyang 421008, Hunan, Peoples R China.;[Zhang, Jing; Liu, Sheng Hua] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Ou, Ya-Ping] H;[Liu, Sheng Hua] C;Hengyang Normal Univ, Coll Chem & Mat Sci, Key Lab Funct Met Organ Cpds Hunan Prov, Key Lab Funct Organometall Mat Hunan Prov, Hengyang 421008, Hunan, Peoples R China.;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
关键词：
ruthenium complexes;triarylamine;electronic coupling;mixed-valence;spin density distribution
摘要：
<jats:title>Abstract</jats:title><jats:p>Four rutheniumethynyl‐triarylamine complexes <jats:bold>1</jats:bold>–<jats:bold>4</jats:bold> with different aryl bridge cores were prepared. The solid structures of complexes <jats:bold>2</jats:bold>–<jats:bold>4</jats:bold> were fully confirmed by X‐ray single‐crystal diffraction analysis. Two consecutive one‐electron oxidation processes of complexes <jats:bold>1</jats:bold>–<jats:bold>4</jats:bold> were attributed to the ruthenium and nitrogen centers, as revealed by cyclic voltammetry and square‐wave voltammogram. Results also showed decreasing potential difference Δ<jats:italic>E</jats:italic> of complexes <jats:bold>1</jats:bold>, <jats:bold>3</jats:bold>, and <jats:bold>4</jats:bold>, with the largest value for <jats:bold>2</jats:bold>. Upon chemical oxidation of complexes <jats:bold>1</jats:bold>–<jats:bold>4</jats:bold> by 1.0 eq oxidation reagents FcPF<jats:sub>6</jats:sub> or AgSbF<jats:sub>6</jats:sub>, the mixed‐valence complexes, except for <jats:bold>2</jats:bold><jats:sup>+</jats:sup>, show characteristic broad NIR absorptions in the UV‐vis‐NIR spectroscopic experiments. NIR multiple absorptions were assigned to NAr<jats:sub>2</jats:sub>→RuCp*(dppe) intervalence charge transfer (IVCT) and metal‐to‐ligand charge transfer transitions by TDDFT calculations. Coupling parameter (<jats:italic>H</jats:italic><jats:sub>ab</jats:sub>) from Hush theory revealed that increasing electronic communication in <jats:bold>1</jats:bold><jats:sup>+</jats:sup>, <jats:bold>3</jats:bold><jats:sup>+</jats:sup>, and <jats:bold>4</jats:bold><jats:sup>+</jats:sup>. Electron density distribution of the HOMO for neutral molecules (<jats:bold>1</jats:bold>, <jats:bold>3</jats:bold>, and <jats:bold>4</jats:bold>) and spin density distribution of the corresponding single‐oxidized states (<jats:bold>1</jats:bold><jats:sup>+</jats:sup>, <jats:bold>3</jats:bold><jats:sup>+</jats:sup>, and <jats:bold>4</jats:bold><jats:sup>+</jats:sup>) increases progressively on the bridge as the size of the aromatic system increases, proving incremental contributions from bridge cores during oxidation.</jats:p>
