SWCNTs@GQDs composites as nanocarriers for enzyme-free dual-signal amplification electrochemical immunoassay of cancer biomarker
作者：
Luo, Yanan;Wang, Yuxin;Yan, Hongye;Wu, Yu;Zhu, Chengzhou* ;...
期刊：
Analytica Chimica Acta ,2018年1042:44-51 ISSN：0003-2670
通讯作者：
Zhu, Chengzhou
作者机构：
[Zhu, Chengzhou; Yan, Hongye; Wu, Yu; Du, Dan; Wang, Yuxin; Luo, Yanan] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.;[Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Zhu, Chengzhou] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
关键词：
Carcinoembryonic antigen;Electrochemical immunosensors;Graphene quantum dots;Peroxidase-like nanomaterials;Signal amplification
摘要：
Carcinoembryonic antigen (CEA) as a typical biomarker plays a remarkable role in various human physiological processes. A sensitive and rapid method should be developed to realize the precise diagnosis of cancer at its early stage. In this work, we successfully synthesized the peroxidase-like graphene quantum dots (GQDs) and utilized it to fabricate an enzyme-free electrochemical immunosensor towards CEA by forming a single-wall carbon nanotubes@GQDs (SWCNTs@GQDs) composite. In addition to the SWCNTs@GQDs, reduced graphene oxide-Au nanoparticles (rGO-Au NPs) with the huge specific surface area and excellent conductivity were employed to modify the electrodes, leading to a dual-signal amplification result. Both the electrochemical impedance spectroscopy and cyclic voltammetry measurements were performed to evaluate the interface properties of the layer-by-layer modified electrodes. The proposed electrochemical immunosensor displayed a good specificity and sensitivity towards the detection of CEA ranging from 50 pg mL(-1) to 650 pg mL(-1) with a low detection limit of 5.3 pg mL(-1). This simple and inexpensive immunosensor shows promising potential for the determination of other biomarkers in clinical translation. (C) 2018 Elsevier B.V. All rights reserved.
语种：
英文
展开
Porous Carbon-Hosted Atomically Dispersed Iron–Nitrogen Moiety as Enhanced Electrocatalysts for Oxygen Reduction Reaction in a Wide Range of pH
作者：
Fu, Shaofang;Zhu, Chengzhou* ;Su, Dong;Song, Junhua;Yao, Siyu;...
期刊：
Small ,2018年14(12):1703118- ISSN：1613-6810
通讯作者：
Zhu, Chengzhou;Lin, Yuehe
作者机构：
[Zhu, Chengzhou; Song, Junhua; Du, Dan; Fu, Shaofang; Lin, Yuehe; Feng, Shuo; Zhu, CZ; Lin, YH] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Zhu, Chengzhou; Du, Dan] Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Su, Dong] Brookhaven Natl Lab, Ctr Funct Nanomat, Upton, NY 11973 USA.;[Yao, Siyu] Brookhaven Natl Lab, Chem Dept, Upton, NY 11973 USA.;[Engelhard, Mark H.] Pacific Northwest Natl Lab, Environm Mol Sci Lab, Richland, WA 99354 USA.
通讯机构：
[Zhu, CZ; Lin, YH] W;[Zhu, Chengzhou] C;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
关键词：
Fe–N–C electrocatalysts;metal–organic frameworks;nonprecious metal nanocatalysts;oxygen reduction reaction;single-atom catalysts
摘要：
As one of the alternatives to replace precious metal catalysts, transition-metal–nitrogen–carbon (M–N–C) electrocatalysts have attracted great research interest due to their low cost and good catalytic activities. Despite nanostructured M–N–C catalysts can achieve good electrochemical performances, they are vulnerable to aggregation and insufficient catalytic sites upon continuous catalytic reaction. In this work, metal–organic frameworks derived porous single-atom electrocatalysts (SAEs) were successfully prepared by simple pyrolysis procedure without any further posttreatment. Combining the X-ray absorption near-edge spectroscopy and electrochemical measurements, the SAEs have been identified with superior oxygen reduction reaction (ORR) activity and stability compared with Pt/C catalysts in alkaline condition. More impressively, the SAEs also show excellent ORR electrocatalytic performance in both acid and neutral media. This study of nonprecious catalysts provides new insights on nanoengineering catalytically active sites and porous structures for nonprecious metal ORR catalysis in a wide range of pH. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
语种：
英文
展开
Ultrafine Pd ensembles anchored-Au2Cu aerogels boost ethanol electrooxidation
作者：
Shi, Qiurong;Zhu, Chengzhou* ;Tian, Mengkun;Su, Dong;Fu, Maosen;...
期刊：
Nano Energy ,2018年53:206-212 ISSN：2211-2855
通讯作者：
Lin, Yuehe;Zhu, Chengzhou
作者机构：
[Zhu, Chengzhou; Du, Dan; Lin, Yuehe; Feng, Shuo; Shi, Qiurong] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Zhu, Chengzhou; Du, Dan] Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.;[Tian, Mengkun] Univ Tennessee, Dept Chem & Biomol Engn, Knoxville, TN 37996 USA.;[Fu, Maosen; Su, Dong] Brookhaven Natl Lab, Ctr Funct Nanomat, Upton, NY 11973 USA.;[Engelhard, Mark H.] Pacific Northwest Natl Lab, Environm Mol Sci Lab, Richland, WA 99354 USA.
通讯机构：
[Lin, Yuehe] W;[Zhu, Chengzhou] C;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.
关键词：
Electrocatalysis;Ethanol electrooxidation;Galvanic replacement reaction;Metal aerogels;Pd ensembles
摘要：
Modification of the noble metal-based aerogels from the atomic scale is rarely being investigated despite the rapid development of various metallic aerogels. Recent studies have verified that Pd ensembles are more effective than isolated Pd atoms toward electrooxidation of ethanol. However, the electrocatalytic efficiency is still insufficient. Here, for the first time, we successfully anchored Pd-ensembles on the surface of Au 2 Cu metallic hydrogels via kinetically controlled galvanic displacement reaction. The atomic configuration optimized Au 2 [email protected] metallic aerogels exhibited significantly enhanced mass activity ~ 11.6 times of commercial Pd and excellent stability with remained 90% of mass activity after 300 potential cycle test. The ligand effect and geometric effect generated by the finely tailored atomic configurations including Pd ensembles and core-shell structure are critical for enhancing electrocatalytic efficiencies. Thus, the Pd ensembles anchored-Au 2 Cu aerogels hold a great promise for being potentially applied in devices such as direct alcohol fuel cells, biosensors and electronics. © 2018
语种：
英文
展开
Fluorescent silicon nanoparticles-based ratiometric fluorescence immunoassay for sensitive detection of ethyl carbamate in red wine
作者：
Luo, Lin;Song, Yang;Zhu, Chengzhou;Fu, Shaofang;Shi, Qiurong;...
期刊：
Sensors and Actuators B-Chemical ,2018年255:2742-2749 ISSN：0925-4005
通讯作者：
Du, Dan;Xu, Zhen-Lin;Lin, Yuehe
作者机构：
[Sun, Yuan-Ming; Xu, Zhen-Lin; Luo, Lin] South China Agr Univ, Guangdong Prov Key Lab Food Qual & Safety, Guangzhou 510642, Guangdong, Peoples R China.;[Du, Dan] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.;[Zhu, Chengzhou; Du, D; Xu, Zhen-Lin; Lin, YH; Du, Dan; Song, Yang; Fu, Shaofang; Lin, Yuehe; Shi, Qiurong; Luo, Lin] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Jia, Baozhu] Guangdong Univ Educ, Coll Biol & Food Engn, Guangzhou 510303, Guangdong, Peoples R China.
通讯机构：
[Du, D; Xu, ZL; Lin, YH] W;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
关键词：
Ethyl carbamate;Immunoassay;Monoclonal antibody;Ratiometric fluorescence
摘要：
Herein, a ratiometric fluorescence (RF) enzyme-linked immunosorbent assay (RF-ELISA) for sensitive detection of ethyl carbamate (EC) was developed by introducing fluorescent silicon nanoparticles (Si NPs) into the chromogenic substrate system (o-phenylenediamine (OPD)/H<inf>2</inf>O<inf>2</inf>) of a conventional horseradish peroxidase (HRP)-based ELISA platform to assemble a RF-based signal output system. For this system, the fluorescence of Si NPs at 440 nm (I<inf>440</inf>) was acted as the reference signal which could be efficiently quenched by 2,3-diaminophenazine (DAP), the HRP-catalyzed oxidation product of OPD;Meanwhile, the fluorescence of DAP at 570 nm (I<inf>570</inf>) was served as response signal. Therefore, variation in the amount of HRP labeled secondary antibody bound on the microplate which is associated with antibody-antigen recognition events in conventional HRP-based ELISA could be transferred into a more sensitive RF signal (I<inf>570</inf>/I<inf>440</inf>). On the basis of monoclonal antibody (mAb) which could specifically recognize EC derivative, xanthyl ethyl carbamate (XEC), a Si NPs-based RF-ELISA for EC via a simple pre-analysis derivatization was developed. When detecting the EC content in red wine, this method exhibits a working range from 3.9 to 105.0 μg/L and a limit of detection (LOD) of 2.6 μg/L with excellent specificity, accuracy and reproducibility. The sensitivity is approximately 33-fold higher than that of traditional colorimetric ELISA. The proposed Si NPs-based RF-ELISA is not only highly suitable for screening EC in a large number of samples, but also provides a potential platform for high-throughput and sensitive determination of other analytes for food safety monitoring.<br/> ©2017 Elsevier B.V.
语种：
英文
展开
Core-shell PdPb@Pd aerogels with multiply-twinned intermetallic nanostructures: Facile synthesis with accelerated gelation kinetics and their enhanced electrocatalytic properties
作者：
Zhu, Chengzhou;Shi, Qiurong;Fu, Shaofang;Song, Junhua;Du, Dan;...
期刊：
Journal of Materials Chemistry A ,2018年6(17):7517-7521 ISSN：2050-7488
通讯作者：
Lin, Yuehe;Su, Dong
作者机构：
[Zhu, Chengzhou; Song, Junhua; Du, Dan; Fu, Shaofang; Lin, Yuehe; Shi, Qiurong] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Zhu, Chengzhou; Du, Dan] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Su, Dong] Brookhaven Natl Lab, Ctr Funct Nanomat, Upton, NY 11973 USA.;[Engelhard, Mark H.] Pacific Northwest Natl Lab, Environm Mol Sci Lab, Richland, WA 99354 USA.
通讯机构：
[Lin, Yuehe] W;[Su, Dong] B;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Brookhaven Natl Lab, Ctr Funct Nanomat, Upton, NY 11973 USA.
摘要：
Delicately engineering well-defined noble metal aerogels with favorable structural and compositional features is of vital importance for wide applications. Here, we reported a one-pot and facile method for synthesizing core-shell [email protected] hydrogels/aerogels with multiply-twinned grains and an ordered intermetallic phase using sodium hypophosphite as a multifunctional reducing agent. Due to the accelerated gelation kinetics induced by increased reaction temperature and the specific function of sodium hypophosphite, the formation of hydrogels can be completed within 4 h. Owing to their unique porous structure and favorable geometric and electronic effects, the optimized [email protected] aerogels exhibit enhanced electrochemical performance towards ethylene glycol oxidation with a mass activity of 5.8 times higher than Pd black. © 2018 The Royal Society of Chemistry.
语种：
英文
展开
Ultrathin dendritic IrTe nanotubes for an efficient oxygen evolution reaction in a wide pH range
作者：
Shi, Qiurong;Zhu, Chengzhou* ;Du, Dan* ;Wang, Jin;Xia, Haibing;...
期刊：
Journal of Materials Chemistry A ,2018年6(19):8855-8859 ISSN：2050-7488
通讯作者：
Zhu, Chengzhou;Du, Dan;Lin, Yuehe
作者机构：
[Zhu, Chengzhou; Du, Dan; Zhu, CZ; Du, D; Lin, YH; Lin, Yuehe; Feng, Shuo; Shi, Qiurong] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Zhu, Chengzhou; Du, Dan; Zhu, CZ; Du, D] Cent China Normal Univ, Coll Chem, Minist Educ PR China, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Wang, Jin; Xia, Haibing] Shandong Univ, Inst Crystal Mat, Jinan 250100, Shandong, Peoples R China.;[Engelhard, Mark H.] Pacific Northwest Natl Lab, Environm Mol Sci Lab, Richland, WA 99352 USA.
通讯机构：
[Zhu, CZ; Du, D; Lin, YH] W;[Zhu, CZ; Du, D] C;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Cent China Normal Univ, Coll Chem, Minist Educ PR China, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
摘要：
The shape control of Ir-based nanostructured materials, which are considered as the state-of-the-art anode electrocatalyst candidates toward the oxygen evolution reaction (OER), has been rarely reported. Here, we reported an efficient synthesis of ultrathin dendritic IrTe nanotubes (NTs) via a galvanic replacement reaction using Te nanowires as the template at 190 °C for 1 h. The as-obtained IrTe NTs exhibited improved electrocatalytic activity and stability toward the OER with a much smaller overpotential of 290 mV and Tafel slope of 60.3 mV dec-1 to attain a current density of 10 mA cm-2 in acidic medium, compared with commercial IrO2 nanoparticles. Moreover, IrTe NTs also demonstrated enhanced electrocatalytic performances in neutral and alkaline media. The outstanding electrochemical properties of IrTe NTs in a wide pH range hold great promise in energy storage and conversion devices. © 2018 The Royal Society of Chemistry.
语种：
英文
展开
Mesoporous carbon nanospheres with ZnO nanolids for multimodal therapy of lung cancer
作者：
Cai, Xiaoli;Yan, Hongye;Luo, Yanan;Song, Yang;Zhao, Yuting;...
期刊：
ACS Applied Bio Materials ,2018年1(4):1165-1173 ISSN：2576-6422
通讯作者：
Du, Dan(dan.du@mail.ccnu.edu.cn)
作者机构：
[Cai, Xiaoli; Yan, Hongye; Luo, Yanan; Du, Dan] Key Laboratory of Pesticide and Chemical Biology, College of Chemistry, Central China Normal University, Wuhan;430079, China;[Song, Yang; Zhao, Yuting; Li, He; Lin, Yuehe] School of Mechanical and Materials Engineering, Washington State University, PO Box 642920, Pullman;WA;99164, United States
通讯机构：
[Dan Du] K;[Yuehe Lin] S;Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, People’s Republic of China<&wdkj&>School of Mechanical and Materials Engineering, Washington State University, PO Box 642920, Pullman, Washington 99164, United States<&wdkj&>School of Mechanical and Materials Engineering, Washington State University, PO Box 642920, Pullman, Washington 99164, United States
关键词：
Chemo-/photothermal therapy;Hyaluronic acid;Mesoporous carbon nanospheres;PH-responsive;ZnO quantum dots
摘要：
To improve therapeutic efficacy, we designed novel poly(ethylene glycol) (PEG)-modified oxidized mesoporous carbon nanospheres (OMCNPs) that were loaded with the therapeutic drug doxorubicin (DOX) and targeted with ligand hyaluronic acid (HA) to kill lung cancer cells. ZnO quantum dots (ZnO QDs) were introduced not only to cap OMCNP-based carriers but also to chelate with DOX, which exhibited a high drug-loading capacity. Upon cellular uptake, the pH-sensitive ZnO lids dissolved to Zn2+ in tumor cells, resulting in dissociation of the Zn2+-DOX complex and controlled release of DOX. Moreover, the novel OMCNPbased system could generate hyperthermia and facilitate the release of loaded DOX with near-infrared (NIR) irradiation. The combined chemo-/photothermal-targeted therapy exhibited significant advantages superior to single chemotherapy or photothermal therapy. This technology provided an excellent lung cancer cell-targeted drug delivery system, integrating chemotherapy with photothermal therapy. This chemo-/photothermal therapy effectively improved the therapeutic efficacy with lower adverse effects to normal tissues. © 2018 American Chemical Society.
语种：
英文
展开
Catalytic Activity of Co-X (X = S, P, O) and Its Dependency on Nanostructure/Chemical Composition in Lithium-Sulfur Batteries
作者：
Feng, Shuo;Zhong, Hong;Song, Junhua;Zhu, Chengzhou* ;Dong, Panpan;...
期刊：
ACS Applied Energy Materials ,2018年1(12):7014-7021 ISSN：2574-0962
通讯作者：
Zhu, Chengzhou;Lin, Yuehe
作者机构：
[Zhu, Chengzhou; Dong, Panpan; Song, Junhua; Shi, Qurong; Du, Dan; Zhong, Hong; Lin, Yuehe; Feng, Shuo; Liu, Dong; Li, Jincheng; Song, Min-kyu; Chang, Yu-Chung; Beckman, Scott P.; Zhu, CZ; Lin, YH] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Zhu, Chengzhou] Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Zhu, CZ; Lin, YH] W;[Zhu, Chengzhou] C;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.
关键词：
catalytic effects;chemical interactions;cobalt sulfide nanosheets;lithium-sulfur batteries;ZIF-67
摘要：
Recently, cobalt-based polar materials with an unique catalytic behavior have been discovered and have shown promising electrochemical performance in lithium-sulfur (Li-S) batteries. However, there is lack of consensus on the relationship between catalytic activity and composition of different polar materials. Inconsistencies in morphologies, chemical compositions, and testing conditions lead to disparate results from laboratory to laboratory. To this end, we use zeolitic imidazolate frameworks (ZIF-67) nanosheets derived CoS2, CoP, and Co3O4 with nearly identical morphology and nanostructure to study the compositional effects on their catalytic activities and chemical absorption abilities. Combining with density functional theory calculations and electrochemical screening, we are able to confirm that CoS2 has the highest adsorption energy with polysulfides as well as the strongest catalytic activity toward polysulfides. We believe this work can inspire a more rational way to design efficient catalysts for Li-S batteries. © 2018 American Chemical Society.
语种：
英文
展开
A Nanozyme- and Ambient Light-Based Smartphone Platform for Simultaneous Detection of Dual Biomarkers from Exposure to Organophosphorus Pesticides
作者：
Zhao, Yuting;Yang, Mingming;Fu, Qiangqiang;Ouyang, Hui;Wen, Wei;...
期刊：
Analytical Chemistry ,2018年90(12):7391-7398 ISSN：0003-2700
通讯作者：
Lin, Yuehe;Du, Dan
作者机构：
[Zhu, Chengzhou; Fu, Qiangqiang; Zhao, Yuting; Du, Dan; Lin, YH; Du, D; Ouyang, Hui; Wen, Wei; Song, Yang; Lin, Yuehe; Yang, Mingming] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Zhao, Yuting] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Lin, YH; Du, D] W;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
摘要：
A transparent, lateral-flow test strip coupled with a smartphone-based ambient light sensor was first proposed for detecting enzymatic inhibition and phosphorylation. The principle of the platform is based on the simultaneous measurement of the total amount of the enzyme and enzyme activity to biomonitor exposure to organophosphorus (OP) pesticides. In this study, butyrylcholinesterase (BChE) was adopted as the model enzyme and ethyl paraoxon was chosen as an analyte representing OP pesticides. The total amount of BChE was quantified by a sensitive colorimetric signal originating from a sandwich immunochromatographic assay utilizing PtPd nanoparticles as a colorimetric probe, which exhibited excellent catalytic activity for phenols. In the sandwich immunoassay, only one antibody against BChE was simultaneously utilized as the recognition antibody and the labeling antibody due to the tetrameric structure of native BChE. The BChE activity was estimated by another colorimetric signal using the Ellman assay. Both colorimetric signals on two separated test strips were detected by the smartphone-based ambient light sensor. The proposed sensor operated with an LED in a 3D-printed substrate, which emitted excitation light and transmitted it through a transparent, lateral-flow test strip. With the increase in the colorimetric signal in the test line of the test strip, the intensity of the transmitted light decreased. The smartphone-based sensor showed excellent linear responses for assaying the total amount of BChE and active BChE ranging from 0.05 to 6.4 nM and from 0.1 to 6.4 nM, respectively. A high portability and low detection limit were simultaneously realized in the common smartphone-based device. This low-cost, portable, easy-operation, and sensitive immunoassay strategy shows great potential for online detection of OP exposure and monitoring other disease biomarkers. © 2018 American Chemical Society.
语种：
英文
展开
Mitochondrial-targeted multifunctional mesoporous Au@Pt nanoparticles for dual-mode photodynamic and photothermal therapy of cancers
作者：
Song, Yang;Shi, Qiurong;Zhu, Chengzhou;Luo, Yanan;Lu, Qian;...
期刊：
Nanoscale ,2017年9(41):15813-15824 ISSN：2040-3364
通讯作者：
Du, Dan;Lin, Yuehe
作者机构：
[Ye, Ranfeng; Zhu, Chengzhou; Lu, Qian; Li, He; Du, Dan; Song, Yang; Lin, Yuehe; Shi, Qiurong; Luo, Yanan; Du, D; Lin, YH] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99161 USA.;[Du, Dan; Luo, Yanan] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Du, D; Lin, YH] W;[Du, Dan] C;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99161 USA.;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
摘要：
In the conventional non-invasive cancer treatments, such as photodynamic therapy (PDT) and photothermal therapy (PTT), light irradiation is precisely focused on tumors to induce apoptosis via the generation of reactive oxygen species (ROS) or localized heating. However, overconsumption of oxygen and restricted diffusion distance of ROS limit the therapeutic effects on hypoxic tumors. Herein, we developed a platform for the rapid uptake of multifunctionalized Au@Pt nanoparticles (NPs) by mitochondria in cancer cells. The mesoporous Au@Pt nanoparticles were labeled with a cell-targeting ligand (folic acid), a mitochondria-targeting group (triphenylphosphine (TPP)), and a photosensitizer (Ce6). This led to significant improvement of the PDT efficacy due to an enhanced cellular uptake, an effective mitochondrial ROS burst, and a rapid intelligent release of oxygen. Moreover, Au@Pt NPs can convert laser radiation into heat, resulting in thermally induced cell damage. This nanosystem could be used as a dual-mode phototherapeutic agent for enhanced cancer therapy and molecular targets associated with disease progression. We achieved a mitochondria-targeted multifunctional therapy strategy (a combination of PDT and PTT) to substantially improve the therapeutic efficiency.
语种：
英文
展开
Intermetallic Pd3Pb nanowire networks boost ethanol oxidation and oxygen reduction reactions with significantly improved methanol tolerance
作者：
Shi, Qiurong;Zhu, Chengzhou* ;Bi, Cuixia;Xia, Haibing;Engelhard, Mark H.;...
期刊：
Journal of Materials Chemistry A ,2017年5(45):23952-23959 ISSN：2050-7488
通讯作者：
Zhu, Chengzhou;Du, Dan;Lin, Yuehe
作者机构：
[Zhu, Chengzhou; Du, Dan; Zhu, CZ; Du, D; Lin, YH; Lin, Yuehe; Shi, Qiurong] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Zhu, Chengzhou; Du, Dan; Zhu, CZ; Du, D] Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Bi, Cuixia; Xia, Haibing] Shandong Univ, Inst Crystal Mat, Jinan 250100, Shandong, Peoples R China.;[Engelhard, Mark H.] Pacific Northwest Natl LAb, Environm Mol Sci Lab, Richland, WA 99352 USA.
通讯机构：
[Zhu, CZ; Du, D; Lin, YH] W;[Zhu, CZ; Du, D] C;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
摘要：
Intermetallic nanocrystals are currently receiving extensive attention due to their well-defined crystal structures, highly ordered atomic distribution and superior structural stability that endow them with optimized catalytic activities, stabilities and high selectivity for use as electrocatalysts for fuel cells. Here, for the first time, we reported the facile synthesis of intermetallic Pd3Pb nanowire networks (IM-Pd3Pb NNs) with a one-step wet-chemical strategy at a relatively low temperature (i.e. 170 °C) in 1 h. The as-prepared IM-Pd3Pb NNs exhibited superior bifunctional catalytic performances toward the oxygen reduction reaction (ORR) and the ethanol oxidation reaction (EtOR) compared to commercial Pt/C and Pd black, respectively. Significantly, IM-Pd3Pb NNs also showed excellent methanol- and CO-tolerant ability as ORR cathode and EtOR anode electrocatalysts, respectively. The electrochemically active surface area and mass activity of IM-Pd3Pb NNs are about 3.4 times and 2 times higher than those of Pd black toward the EtOR, respectively. As the Pt-free bifunctional electrocatalysts, 3D IM-Pd3Pb architectures with exceptional catalytic performances hold great promise in various applications such as energy conversion and storage devices, sensors, electronics, optics and so on. © 2017 The Royal Society of Chemistry.
语种：
英文
展开
One-step synthesis of carbon nanosheet-decorated carbon nanofibers as a 3D interconnected porous carbon scaffold for lithium-sulfur batteries
作者：
Feng, Shuo;Song, Junhua;Fu, Shaofang;Zhu, Chengzhou;Shi, Qiurong;...
期刊：
Journal of Materials Chemistry A ,2017年5(45):23737-23743 ISSN：2050-7488
通讯作者：
Du, Dan;Lin, Yuehe
作者机构：
[Zhu, Chengzhou; Song, Junhua; Du, Dan; Fu, Shaofang; Lin, Yuehe; Feng, Shuo; Shi, Qiurong; Song, Min-Kyu; Du, D; Lin, YH] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Du, Dan] Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Du, D; Lin, YH] W;[Du, Dan] C;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
摘要：
Among the emerging energy storage methods, lithium-sulfur (LIS) batteries have drawn plenty of attention due to their high theoretical energy density, low cost and environmental benignity. Nevertheless, the insulating nature of sulfur and notorious polysulfide shuttling result in low sulfur utilization and short cycling life. In recent years, various carbon structures have been reported as effective sulfur hosts to tolerate volume expansion, prevent polysulfide dissolution and enhance electrical conductivity. It is hard for carbon materials, however, to satisfy all these aspects with a simple structural design. Thus, developing hierarchical carbon structures that serve as a multi-functional host is necessary for high-performance LIS batteries. Herein, we reported a facile method to prepare a three-dimensional carbon nanofiber (3DCNF) through a hydrothermal reaction. With the structural advantages, the 3DCNF and sulfur composite delivered a capacity as high as 1266 and 977 mA h g-1 at 0.1 and 0.5 C, respectively. After 500 cycles at 0.5 C, it still retains a capacity of 607 mA h g-1 (0.07% capacity fading per cycle), exhibiting excellent cycling capability. © 2017 The Royal Society of Chemistry.
语种：
英文
展开
Metal-Organic Framework-Derived Non-Precious Metal Nanocatalysts for Oxygen Reduction Reaction
作者：
Fu, Shaofang;Zhu, Chengzhou* ;Song, Junhua;Du, Dan;Lin, Yuehe*
期刊：
Advanced Energy Materials ,2017年7(19):1700363- ISSN：1614-6832
通讯作者：
Zhu, Chengzhou;Lin, Yuehe
作者机构：
[Zhu, Chengzhou; Song, Junhua; Du, Dan; Fu, Shaofang; Lin, Yuehe; Zhu, CZ; Lin, YH] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Du, Dan] Cent China Normal Univ, Minist Educ PR China, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Du, Dan] Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Zhu, CZ; Lin, YH] W;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
关键词：
electrocatalysis;metal-organic frameworks;non-precious metal catalysts;oxygen reduction reactions;porous nanostructures
摘要：
By virtue of diverse structures and tunable properties, metal-organic frameworks (MOFs) have presented extensive applications including gas capture, energy storage, and catalysis. Recently, synthesis of MOFs and their derived nanomaterials provide an opportunity to obtain competent oxygen reduction reaction (ORR) electrocatalysts due to their large surface area, controllable composition and pore structure. This review starts with the introduction of MOFs and current challenges of ORR, followed by the discussion of MOF-based non-precious metal nanocatalysts (metal-free and metal/metal oxide-based carbonaceous materials) and their application in ORR electrocatalysis. Current issues in MOF-derived ORR catalysts and some corresponding strategies in terms of composition and morphology to enhance their electrocatalytic performance are highlighted. In the last section, a perspective for future development of MOFs and their derivatives as catalysts for ORR is discussed. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
语种：
英文
展开
Recent Advances in Electrochemical Immunosensors
作者：
Wen, Wei;Yan, Xu;Zhu, Chengzhou;Du, Dan* ;Lin, Yuehe*
期刊：
Analytical Chemistry ,2017年89(1):138-156 ISSN：0003-2700
通讯作者：
Du, Dan;Lin, Yuehe
作者机构：
[Zhu, Chengzhou; Yan, Xu; Du, Dan; Wen, Wei; Lin, Yuehe; Du, D; Lin, YH] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Du, Dan] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Du, D; Lin, YH] W;[Du, Dan] C;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
语种：
英文
展开
Single-Atom Electrocatalysts
作者：
Zhu, Chengzhou;Fu, Shaofang;Shi, Qiurong;Du, Dan;Lin, Yuehe*
期刊：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION ,2017年56(45):13944-13960 ISSN：1433-7851
通讯作者：
Lin, Yuehe
作者机构：
[Zhu, Chengzhou; Du, Dan; Fu, Shaofang; Lin, Yuehe; Shi, Qiurong] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Du, Dan] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Lin, Yuehe] W;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
关键词：
electrocatalysis;electrochemistry;energy generation;single-atom catalysts;supported catalysts
摘要：
Recent years have witnessed a dramatic increase in the production of sustainable and renewable energy. However, the electrochemical performances of the various systems are limited, and there is an intensive search for highly efficient electrocatalysts by more rational control over the size, shape, composition, and structure. Of particular interest are the studies on single-atom catalysts (SACs), which have sparked new interests in electrocatalysis because of their high catalytic activity, stability, selectivity, and 100 % atom utilization. In this Review, we introduce innovative syntheses and characterization techniques for SACs, with a focus on their electrochemical applications in the oxygen reduction/evolution reaction, hydrogen evolution reaction, and hydrocarbon conversion reactions for fuel cells (electrooxidation of methanol, ethanol, and formic acid). The electrocatalytic performance is further considered at an atomic level and the underlying mechanisms are discussed. The ultimate goal is the tailoring of single atoms for electrochemical applications. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
语种：
英文
展开
Drug-Derived Bright and Color-Tunable N-Doped Carbon Dots for Cell Imaging and Sensitive Detection of Fe3+ in Living Cells
作者：
Song, Yang;Zhu, Chengzhou;Song, Junhua;Li, He;Du, Dan* ;...
期刊：
ACS Applied Materials & Interfaces ,2017年9(8):7399-7405 ISSN：1944-8244
通讯作者：
Du, Dan;Lin, Yuehe
作者机构：
[Zhu, Chengzhou; Li, He; Song, Junhua; Du, Dan; Song, Yang; Lin, Yuehe; Du, D; Lin, YH] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Du, Dan] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Du, D; Lin, YH] W;[Du, Dan] C;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Peoples R China.
关键词：
carbon nanodots;nitrogen doping;color tuning;cell imaging;Fe3+ detection
摘要：
Inspired by the diverse drug compounds with various heteroatoms (such as N, S, and P) in the drug library, facile synthesis of a new kind of bright and color-tunable N-doped carbon dots (NCDs) has been reported by using a popular antibiotic - aminosalicylic acid - as precursor. The N doping of CDs not only enable great improvement of photoluminescence (PL) efficiency and tunability of PL emission, but also enrich surface functional groups to broaden its application. The as-prepared NCDs possess tunable PL and show a quantum yield of 16.4%, which is the result of PL improvement effect of introduced nitrogen atoms among CDs. The cellular toxicity on H1299 cancer cells indicates that the NCDs have negligible cytotoxicity, excellent biocompatibility, and great resistance to photobleaching. Moreover, the drug-derived NCDs showed excellent sensitivity in detection of Fe3+ in living cells, which indicates the potential application in diagnosis and related biological study. © 2017 American Chemical Society.
语种：
英文
展开
Two-Dimensional N,S-Codoped Carbon/Co9S8 Catalysts Derived from Co(OH)(2) Nanosheets for Oxygen Reduction Reaction
作者：
Fu, Shaofang;Zhu, Chengzhou;Song, Junhua;Feng, Shuo;Du, Dan* ;...
期刊：
ACS Applied Materials & Interfaces ,2017年9(42):36755-36761 ISSN：1944-8244
通讯作者：
Du, Dan;Lin, Yuehe
作者机构：
[Zhu, Chengzhou; Song, Junhua; Du, Dan; Fu, Shaofang; Lin, Yuehe; Feng, Shuo; Du, D; Lin, YH] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Du, Dan] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ PR China, Wuhan 430079, Hubei, Peoples R China.;[Du, Dan] Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.;[Li, Dongsheng; Engelhard, Mark H.; Xiao, Dongdong] Pacific Northwest Natl Lab, Environm Mol Sci Lab, Richland, WA 99354 USA.
通讯机构：
[Du, D; Lin, YH] W;[Du, Dan] C;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ PR China, Wuhan 430079, Hubei, Peoples R China.;Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.
关键词：
nonprecious metal catalysts;two-dimensional composites;nitrogen/sulfur-codoped carbon;Co9S8;oxygen reduction reaction
摘要：
The development of highly active and cost-efficient electrocatalysts for the oxygen reduction reaction (ORR) is of great importance in a wide range of clean energy devices, including fuel cells and metal-air batteries. Herein, the simultaneous formation of Co9S8 and N,S-codoped carbon with high ORR catalytic activity was achieved in an efficient strategy with a dual templates system. First, Co(OH)2 nanosheets and tetraethyl orthosilicate were utilized to direct the formation of two-dimensional carbon precursors, which were then dispersed into thiourea solution. After subsequent pyrolysis and template removal, N,S-codoped porous carbon-sheet-confined Co9S8 catalysts (Co9S8/NSC) were obtained. Owing to the morphological and compositional advantages as well as the synergistic effects, the resultant Co9S8/NSC catalysts with a modified doping level and pyrolysis degree exhibit superior ORR catalytic activity and long-term stability compared with the state-of-the-art Pt/C catalysts in alkaline media. Remarkably, the as-prepared carbon composites also reveal exceptional tolerance of methanol, indicating their potential applications in fuel cells. © 2017 American Chemical Society.
语种：
英文
展开
Integrated immunochromatographic strip with glucometer readout for rapid quantification of phosphorylated proteins
作者：
Zhao, Yuting;Chen, Xiao;Lin, Sophie;Du, Dan* ;Lin, Yuehe*
期刊：
Analytica Chimica Acta ,2017年964:1-6 ISSN：0003-2670
通讯作者：
Du, Dan;Lin, Yuehe
作者机构：
[Zhao, Yuting; Du, Dan; Chen, Xiao] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Zhao, Yuting; Du, Dan; Lin, Yuehe; Lin, Sophie] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Du, Dan] C;[Lin, Yuehe] W;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
关键词：
*Glucometer;*Immunochromatographic test strip;*Liposome;*Phospho-p53(15)
摘要：
A new technology to quantify phospho-p5315 by converting its content to the amount of glucose which is detectable by a glucometer was developed. An immunochromatographic test strip (ITS) was used as a disposable platform, where primary antibody (Ab1)-modified Fe3O4 magnetic nanoparticles (Fe3O4-Ab1) were settled on the test zone to capture both the target phospho-p5315 and the detection antibody (Ab2)-glucose encapsulating liposome (GEL) conjugate. The measurement was based on the release and subsequent detection of glucose from Ab2-GEL using a glucose meter (GM). The amount of glucose is proportional to the phospho-p5315 concentration from 0.1 to 50ngmL−1, the limit of detection is 50pgmL−1 (3S/N). The high sensitivity was a result of the huge number of glucose encapsulated in the liposome. Taking the advantage of low cost, widespread availability and portability of the test trip, together with the personal GM, the presented approach can be easily used to detect other disease biomarkers in medical diagnostics and environmental monitoring. © 2017 Elsevier B.V.
语种：
英文
展开
PH-Responsive ZnO Nanocluster for Lung Cancer Chemotherapy
作者：
Cai, Xiaoli;Luo, Yanan;Yan, Hongye;Du, Dan* ;Lin, Yuehe*
期刊：
ACS Applied Materials & Interfaces ,2017年9(7):5739-5747 ISSN：1944-8244
通讯作者：
Du, Dan;Lin, Yuehe
作者机构：
[Cai, Xiaoli; Yan, Hongye; Du, Dan; Luo, Yanan] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Du, Dan; Lin, Yuehe; Luo, Yanan; Du, D; Lin, YH] Washington State Univ, Sch Mech & Mat Engn, POB 642920, Pullman, WA 99164 USA.;[Du, Dan; Lin, Yuehe; Du, D; Lin, YH] Washington State Univ, Paul G Allen Sch Global Anim Hlth, POB 647090, Pullman, WA 99164 USA.
通讯机构：
[Du, Dan] C;[Du, D; Lin, YH] W;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;Washington State Univ, Sch Mech & Mat Engn, POB 642920, Pullman, WA 99164 USA.;Washington State Univ, Paul G Allen Sch Global Anim Hlth, POB 647090, Pullman, WA 99164 USA.
关键词：
ZnO cluster;pH-responsive;doxorubicin;tumor homing;EPR effect
摘要：
Here, we demonstrated a pH-responsive nanocluster based on ZnO quantum dots (QDs) and investigated its potential in drug delivery with tumor-specific accumulation. The nanoclusters were composed of small single ZnO QDs by cross-linking dicarboxyl-terminated poly(ethylene glycol) (PEG), showing high stability and biocompatibility in physiological fluids. The clustered ZnO QDs were capable of loading a large quantity of doxorubicin (DOX) via complexation and covalent interactions. After cellular uptake, the drug was efficiently released because the carrier was completely dissolved; the metal-drug complex was disassembled in response to decreasing pH in the endosomes within tumor cells. Moreover, the viability of cancer cells was significantly decreased because the ZnO QDs exhibited cytotoxicity postdissolution and preferentially killed cancerous cells compared to normal cells. Furthermore, this pH-responsive PEG-cZnO QDs cluster system may be capable of tumor homing while circulating in the blood via the enhanced permeability and retention (EPR) effect. © 2017 American Chemical Society.
语种：
英文
展开
Kinetically controlled synthesis of AuPt bi-metallic aerogels and their enhanced electrocatalytic performances
作者：
Shi, Qiurong;Zhu, Chengzhou* ;Du, Dan* ;Bi, Cuixia;Xia, Haibing;...
期刊：
Journal of Materials Chemistry A ,2017年5(37):19626-19631 ISSN：2050-7488
通讯作者：
Zhu, Chengzhou;Du, Dan;Lin, Yuehe
作者机构：
[Zhu, Chengzhou; Du, Dan; Zhu, CZ; Du, D; Lin, YH; Lin, Yuehe; Feng, Shuo; Shi, Qiurong] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Du, Dan] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Bi, Cuixia; Xia, Haibing] Shandong Univ, Inst Crystal Mat, Jinan 250100, Shandong, Peoples R China.;[Engelhard, Mark H.] Pacific NW Natl Lab, Environm Mol Sci Lab, Richland, WA 99352 USA.
通讯机构：
[Zhu, CZ; Du, D; Lin, YH] W;[Du, Dan] C;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
摘要：
Recently, metallic hydrogels/aerogels have received tremendous attention due to their unique physical and chemical properties. For the first time, we reported the successful synthesis of AuPtx metallic hydrogels at 60 °C in 2-4 h. Surfactant-free AuPt5 metallic hydrogels displayed enhanced electrocatalytic activities and stabilities toward methanol oxidation. © 2017 The Royal Society of Chemistry.
语种：
英文
展开
