A dopamine-induced Au hydrogel nanozyme for enhanced biomimetic catalysis
作者：
Jiao, Lei;Xu, Weiqing;Yan, Hongye;Wu, Yu;Gu, Wenling;...
期刊：
Chemical Communications ,2019年55(66):9865-9868 ISSN：1359-7345
通讯作者：
Zhu, Chengzhou
作者机构：
[Xu, Weiqing; Zhu, Chengzhou; Yan, Hongye; Wu, Yu; Jiao, Lei; Gu, Wenling] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China.;[Li, He] Chengdu Univ Informat Technol, Coll Optoelect Technol, Chengdu 610225, Sichuan, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Zhu, Chengzhou] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China.
摘要：
Au hydrogel with a well-defined nanowire network was rationally designed through one-step dopamine-induced self-assembly. Due to the porous nanostructure along with the polydopamine induced accumulation and interfacial electron transfer effects, the resulting Au hydrogel nanozyme exhibits enhanced glucose oxidase-like activity and peroxidase-like activity, with a biomimetic cascade catalysis.
语种：
英文
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A review of optical probes based on nanomaterials for the detection of hydrogen sulfide in biosystems
作者：
Luo, Yanan;Zhu, Chengzhou* ;Du, Dan;Lin, Yuehe*
期刊：
Analytica Chimica Acta ,2019年1061:1-12 ISSN：0003-2670
通讯作者：
Zhu, Chengzhou;Lin, Yuehe
作者机构：
[Zhu, Chengzhou; Luo, Yanan] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Zhu, Chengzhou] C;[Lin, Yuehe] W;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China.;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
关键词：
Biosystems;Hydrogen sulfide;Nanomaterials;Optical probes;Sensors
摘要：
It has become increasingly crucial to implement the precise determination of hydrogen sulfide (H 2 S) in biosystems since the abnormal level of H 2 S may induce various diseases. However, due to the high volatility and fast catabolism of H 2 S, traditional H 2 S detection methods are confronted with great challenges. Fortunately, the development of optical nanotechnology sheds new light on the real-time and sensitive detection of intracellular or subcellular H 2 S. Nanomaterials emerged as potential candidates for the optical detection of biomolecule analytes due to their excellent properties, such as easy preparation and modification, tunable optical characteristics and high photostability. Recently, many probes based on nanomaterials, ranging from inorganic nanostructures to organic polymers, have been demonstrated to exhibit high sensitive and selective detection toward H 2 S both in vitro and in vivo. Different from the previous review articles, we mainly summarize the advancements of optical probes, including fluorescence and non-fluorescence probes, for endogenous H 2 S detection based on nanomaterials in recent five years. © 2019 Elsevier B.V.
语种：
英文
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Oxidase-Like Fe-N-C Single-Atom Nanozymes for the Detection of Acetylcholinesterase Activity
作者：
Wu, Yu;Jiao, Lei;Luo, Xin;Xu, Weiqing;Wei, Xiaoqian;...
期刊：
Small ,2019年15(43):ARTN 1903108 ISSN：1613-6810
通讯作者：
Zhu, Chengzhou
作者机构：
[Wu, Yu; Jiao, Lei; Luo, Xin; Xu, Weiqing; Wei, Xiaoqian; Wang, Hengjia; Yan, Hongye; Gu, Wenling; Zhu, Chengzhou] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticides & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China;[Xu, Bo Z.] Univ Calif Berkeley, Dept Mat Sci & Engn, Berkeley, CA 94720 USA;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA
通讯机构：
[Zhu, Chengzhou] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticides & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China.
关键词：
acetylcholinesterase;biosensors;nanozymes;organophosphorus compounds;single-atom catalysts
摘要：
Single-atom catalysts (SACs) have attracted extensive attention in the catalysis field because of their remarkable catalytic activity, gratifying stability, excellent selectivity, and 100% atom utilization. With atomically dispersed metal active sites, Fe-N-C SACs can mimic oxidase by activating O-2 into reactive oxygen species, O-2(-)center dot radicals. Taking advantages of this property, single-atom nanozymes (SAzymes) can become a great impetus to develop novel biosensors. Herein, the performance of Fe-N-C SACs as oxidase-like nanozymes is explored. Besides, the Fe-N-C SAzymes are applied in biosensor areas to evaluate the activity of acetylcholinesterase based on the inhibition toward nanozyme activity by thiols. Moreover, this SAzymes-based biosensor is further used for monitoring the amounts of organophosphorus compounds.
语种：
英文
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Polydopamine-Capped Bimetallic AuPt Hydrogels Enable Robust Biosensor for Organophosphorus Pesticide Detection
作者：
Wu, Yu;Jiao, Lei;Xu, Weiqing;Gu, Wenling;Zhu, Chengzhou* ;...
期刊：
Small ,2019年15(17):e1900632 ISSN：1613-6810
通讯作者：
Zhu, Chengzhou
作者机构：
[Xu, Weiqing; Zhu, Chengzhou; Wu, Yu; Jiao, Lei; Gu, Wenling] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Zhu, Chengzhou] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
关键词：
biosensors;electrocatalysis;enzyme immobilization;noble metal hydrogels;organophosphorus pesticides detection
摘要：
Noble metal hydrogels/aerogels with macroscopic nanoassemblies characterized by ultralow density, profuse continuous porosity, and extremely large surface area have gained abundant interest due to not only their tunable physicochemical properties, but also promising applications in catalysis and sensing. Coupling the increased reaction temperature with dopamine-induced effect, herein, a one-step synthetic approach with accelerated gelation kinetics is reported for the synthesis of polydopamine-capped bimetallic AuPt hydrogels. 3D porous nanowire networks with surface functionalization of polydopamine make them a promising biocompatible microenvironment for immobilizing acetylcholinesterase (AChE) and constructing enzyme-based biosensors for sensitive detection of organophosphorus compounds. Taking advantage of their favorable structure and composition, the optimized product exhibits superior electrochemical activity toward thiocholine produced by AChE-catalyzed hydrolysis of acetylthiocholine. Based on the inhibition of organophosphorus pesticide on the enzymatic activity of AChE, the inhibition mode for the detection of paraoxon-ethyl is established, displaying linear regions over the range of 0.5–1000 ng L −1 with a low detection limit of 0.185 ng L −1 . © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
语种：
英文
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Robust noble metal-based electrocatalysts for oxygen evolution reaction
作者：
Shi, Qiurong;Zhu, Chengzhou* ;Du, Dan;Lin, Yuehe*
期刊：
CHEMICAL SOCIETY REVIEWS ,2019年48(12):3181-3192 ISSN：0306-0012
通讯作者：
Lin, Yuehe;Zhu, Chengzhou
作者机构：
[Du, Dan; Lin, Yuehe; Shi, Qiurong] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Zhu, Chengzhou] Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Lin, Yuehe] W;[Zhu, Chengzhou] C;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.
摘要：
The oxygen evolution reaction (OER) is a kinetically sluggish anodic reaction and requires a large overpotential to deliver appreciable current. Despite the fact that non-precious metal-based alkaline water electrocatalysts are receiving increased attention, noble metal-based electrocatalysts (NMEs) applied in proton exchange membrane water electrolyzers still have advantageous features of larger current and power densities with lower stack cost. Engineering NMEs for OER catalysis with high efficiency, durability and utilization rate is of vital importance in promoting the development of cost-effective renewable energy production and conversion devices. In this tutorial review, we covered the recent progress in the composition and structure optimization of NMEs for OER including Ir- and Ru-based oxides and alloys, and noble-metals beyond Ir and Ru with a variety of morphologies. To shed light on the fundamental science and mechanisms behind composition/structure-performance relationships and activity-stability relationships, integrated experimental and theoretical studies were pursued for illuminating the metal-support interaction, size effect, heteroatom doping effect, phase transformation, degradation processes and single-atom catalysis. Finally, the challenges and outlook are provided for guiding the rational engineering of OER electrocatalysts for applications in renewable energy-related devices. © 2019 The Royal Society of Chemistry.
语种：
英文
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Ternary PtRuCu aerogels for enhanced methanol electrooxidation
作者：
Wang, Hengjia;Wu, Yu;Luo, Xin;Jiao, Lei;Wei, Xiaoqian;...
期刊：
Nanoscale ,2019年11(22):10575-10580 ISSN：2040-3364
通讯作者：
Gu, Wenling;Zhu, Chengzhou
作者机构：
[Zhu, Chengzhou; Gu, Wenling; Zhu, CZ; Wu, Yu; Wei, Xiaoqian; Jiao, Lei; Luo, Xin; Wang, Hengjia] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Coll Chem, Wuhan 430079, Hubei, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Gu, WL; Zhu, CZ] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Coll Chem, Wuhan 430079, Hubei, Peoples R China.
摘要：
Ternary PtRuCu aerogels are facilely synthesized by one-step in situ reduction. The formation of ternary PtRuCu aerogels can be completed within 2 hours owing to the accelerated gelation kinetics. Because of the unique porous architectures and synergistic effect, the optimized Pt4Ru1Cu5 aerogels exhibited good electrochemical performance for methanol oxidation reaction.
语种：
英文
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Metal-organic frameworks-based catalysts for electrochemical oxygen evolution
作者：
Shi, Qiurong;Fu, Shaofang;Zhu, Chengzhou* ;Song, Junhua;Du, Dan;...
期刊：
Materials Horizons ,2019年6(4):684-702 ISSN：2051-6347
通讯作者：
Lin, Yuehe;Zhu, Chengzhou
作者机构：
[Song, Junhua; Du, Dan; Fu, Shaofang; Lin, Yuehe; Shi, Qiurong] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Zhu, Chengzhou] Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Lin, Yuehe] W;[Zhu, Chengzhou] C;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
摘要：
Engineering highly efficient and cost-effective catalysts for the electrochemical oxygen evolution reaction (OER) is crucial for accelerating the development of renewable energy techniques due to the pivotal role of OER in rechargeable metal-Air batteries and water electrolyzers. Recently, porous nonprecious metal catalysts (PNMCs) have received tremendous interest for application in the OER. Metal-organic frameworks (MOFs) built from metal ions and organic linkers have been demonstrated to be promising precursors for preparing PNMCs for the OER owing to their tunable structures/compositions, high surface area and large pore volume. Benefitting from the versatility of compositional/structural modification, MOFs and MOFs-derived PNMCs are robust in generating various high density active sites, which greatly contribute to their electrochemical OER performances. In this review, we first summarize the composition engineering of pristine MOFs and their derivatives, such as heteroatom-doped carbon, metal oxides/phosphides/sulfides/selenides and their hybrids, followed by structural/morphology engineering, including nano-coating and nano-perforating, and the configuration of high-dimensional architecture and single atom sites. Simultaneously, insights toward an in-depth understanding of the actual active sites and the intrinsic mechanism for OER enhancement are highlighted combined with experimental and theoretical studies. Finally, the challenges and perspectives for engineering MOF-based electrocatalysts are addressed. © The Royal Society of Chemistry 2019.
语种：
英文
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Self-assembly of all-inclusive allochroic nanoparticles for the improved ELISA
作者：
Jiao, Lei;Yan, Hongye;Xu, Weiqing;Wu, Yu;Gu, Wenling;...
期刊：
Analytical Chemistry ,2019年91(13):8461-8465 ISSN：0003-2700
通讯作者：
Zhu, Chengzhou;Li, He;Lin, Yuehe
作者机构：
[Xu, Weiqing; Zhu, Chengzhou; Yan, Hongye; Wu, Yu; Jiao, Lei; Gu, Wenling] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Wuhan 430079, Hubei, Peoples R China.;[Li, He] Chengdu Univ Informat Technol, Coll Optoelect Technol, Chengdu 610225, Sichuan, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Zhu, Chengzhou; Li, He] C;[Lin, Yuehe] W;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Wuhan 430079, Hubei, Peoples R China.;Chengdu Univ Informat Technol, Coll Optoelect Technol, Chengdu 610225, Sichuan, Peoples R China.;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
摘要：
Improvement in the sensitivity and portability of enzyme-linked immunosorbent assay (ELISA) still faced huge challenges recently. Inspired by the nanoprecipitation process for the carrier-free nanodrug in drug delivery systems, we developed an self-assembly strategy to prepare a kind of all-inclusive allochroic 3,3′,5,5′-tetramethylbenzidine (TMB) nanoparticles for developing improved ELISA (named TLISA). During the self-assembly of TMB molecules, the antibody as signal recognition units and bovine serum albumin as the stabilizing agents could be accommodated simultaneously through hydrogen-bonding and van der Waals interactions to form all-inclusive signal tags, which can avoid the complex cross-linking procedures. Due to the ultrahigh loading capacity (817 mg/g) of TMB molecules, the sensitivity of TLISA toward inflammatory biomarkers interleukin-6 was 11.82 times higher than that of conventional ELISA, which paves an avenue to develop an ultrasensitive colorimetric immunoassay. © 2019 American Chemical Society.
语种：
英文
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Tuning polyelectrolyte-graphene interaction for enhanced electrochemical nonenzymatic hydrogen peroxide sensing.
作者：
Yan, Hongye;Wu, Yu;Luo, Xin;Jiao, Lei;Zhu, Chengzhou* ;...
期刊：
Analytica Chimica Acta ,2019年1049:98-104 ISSN：0003-2670
通讯作者：
Zhu, Chengzhou;Du, Dan
作者机构：
[Zhu, Chengzhou; Yan, Hongye; Wu, Yu; Jiao, Lei; Luo, Xin] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Du, Dan] Washington State Univ, Sch Mech & Mat Engn, POB 642920, Pullman, WA 99164 USA.
通讯机构：
[Zhu, Chengzhou] C;[Du, Dan] W;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;Washington State Univ, Sch Mech & Mat Engn, POB 642920, Pullman, WA 99164 USA.
关键词：
Charge transfer;Electrocatalysis;Graphene;Hydrogen peroxide detection;Polyelectrolytes
摘要：
Herein, tuning polyelectrolyte-graphene interaction was demonstrated to enhance electrocatalytic activity for non-enzymatic hydrogen peroxide detection. The introduction of positively charged poly(diallyldimethylammonium chloride) (PDDA) onto graphene surface not only prevent the aggregation of graphene sheets through electrostatic repulsion but also create net positive charge on adjacent carbon atoms in the graphene due to the occurrence of the intermolecular charge transfer by virtue of the robust electron-withdrawing ability of PDDA. Notably, we revealed the influence of the adsorbed polyelectrolytes on the redox of H 2 O 2 and the related mechanism was discussed in detail. In a word, the catalytic activities of the graphene could be effectively tuned via the induction of the polyelectrolytes with different attributes. It was expected that this finding could be favorable for the tuning graphene electronic structure and further developing the novel graphene-based electrochemical sensing platforms. © 2018 Elsevier B.V.
语种：
英文
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A “sense-and-treat” ELISA using zeolitic imidazolate framework-8 as carriers for dual-modal detection of carcinoembryonic antigen
作者：
Yan, Hongye;Jiao, Lei;Wang, Hengjia;Xu, Weiqing;Wu, Yu;...
期刊：
Sensors and Actuators B-Chemical ,2019年297:126760 ISSN：0925-4005
通讯作者：
Zhu, Chengzhou
作者机构：
[Xu, Weiqing; Zhu, Chengzhou; Yan, Hongye; Wu, Yu; Jiao, Lei; Gu, Wenling; Wang, Hengjia] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Du, Dan; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Zhu, Chengzhou] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
关键词：
Carcinoembryonic antigen;Dual-modal detection;ELISA;Metal-organic frameworks;Sense-and-treat
摘要：
Enzyme-linked immunosorbent assay (ELISA) has been widely used in the area of biological analysis, while there are still some challenges getting in the way to ensure both excellent sensitivity and reliable accuracy. To overcome these obstacles, we simulated the “smart” sense-and-treat carriers in a drug delivery system to fabricate an improved ELISA, employing zeolitic imidazolate framework-8 (ZIF-8) as the carrier to deliver the tracer agent carbon dots (CDs) and the “drug” thymolphthalein (TP), which was referred to as a “sense-and-treat” ELISA. In the “sense” part, the strong fluorescence intensity of CDs could be observed directly to achieve the sensitive detection of the target. In the “treat” part, after stimulation of alkaline solution, TP was released from ZIF-8 carriers and generated a color change with an obvious absorption, which was beneficial for increasing the sensitivity of this ELISA due to the high loading of the TP. Finally, we took carcinoembryonic antigen (CEA) as a model and performed dual-modal detection using this improved “sense-and-treat” ELISA to accomplish quantitative determinations sensitively and accurately. In addition, the results indicated by the two parts kept good concordance, which could demonstrate the reliable accuracy of this ELISA. © 2019 Elsevier B.V.
语种：
英文
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基于磁纳米和铁蛋白类酶性质的免疫传感器在p53蛋白检测中的应用
作者：
葛晓晓;刘碧荣;张爱东;杜丹
作者机构：
华中师范大学化学学院,湖北省武汉市洪山区珞瑜路152号,430079
会议名称：
中国化学会第29届学术年会
会议时间：
20140804
会议地点：
北京
会议论文集名称：
中国化学会第29届学术年会摘要集-第04分会:纳米生物传感新方法
关键词：
免疫传感器;磁纳米;铁蛋白;类酶性质
摘要：
p53蛋白是机体细胞内一种重要的抗癌蛋白,在细胞增殖,DNA修复等过程中有着极为重要的作用。当受到外界环境刺激时,该蛋白的一些氨基酸位点会发生异常的磷酸化,从而引起细胞癌变。[1]因此对磷化蛋白p53快速、灵敏、有效的检测对癌症早期诊断及治疗有着重要的意义。免疫传感器灵敏度高、选择性好、线性范围宽,是一种高效、快速的定量检测手段。[2]本文以p53蛋白丝氨酸15号位点的磷酸化蛋白(p53S15)做为待测物,Fe3O4作为纳米载体,Ferritin作为信号标记物,构建了一个新颖的免疫传感器,利用磁纳米颗粒和Ferritin的类酶性质,催化H2O2和TMB显色,放大了检测信号,从而实现对Phospho-p53S15高灵敏的定量检测。
语种：
中文
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Nanovoid Incorporated IrxCu Metallic Aerogels for Oxygen Evolution Reaction Catalysis
作者：
Shi, Qiurong;Zhu, Chengzhou* ;Zhong, Hong;Su, Dong;Li, Na;...
期刊：
ACS Energy Letters ,2018年3(9):2038-2044 ISSN：2380-8195
通讯作者：
Zhu, Chengzhou;Lin, Yuehe
作者机构：
[Zhu, Chengzhou; Peng, Shuo; Du, Dan; Zhong, Hong; Lin, Yuehe; Shi, Qiurong; Beckman, Scott P.; Zhu, CZ; Lin, YH] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Zhu, Chengzhou; Du, Dan] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ PR China, Wuhan 430079, Hubei, Peoples R China.;[Zhu, Chengzhou; Du, Dan] Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.;[Li, Na; Su, Dong] Brookhaven Natl Lab, Ctr Funct Nanomat, Upton, NY 11973 USA.;[Engelhard, Mark H.] Pacific Northwest Natl Lab, Environm Mol Sci Lab, Richland, WA 99352 USA.
通讯机构：
[Zhu, CZ; Lin, YH] W;[Zhu, Chengzhou] C;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ PR China, Wuhan 430079, Hubei, Peoples R China.;Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.
摘要：
Ir-based nanomaterials are regarded as state-of-the-art cathode electrocatalysts in proton exchange membrane water electrolyzers (PEMWEs). Engineering the morphology of Ir-based three-dimensional architectures as electrocatalysts toward oxygen evolution reaction (OER) has been rarely studied. Here, we report the gelation of IrxCu metallic hydrogels self-assembled with ultrafine and nanovoid incorporated building blocks for enhancing the electrocatalytic performance toward OER. The composition-optimized Ir3Cu metallic aerogels exhibited improved catalytic activity and durability toward OER. The mesosized voids generated through the in situ galvanic replacement reaction and the macrosized porous systems make a great contribution to the increased number of active sites. First-principle calculations revealed the intrinsic optimized binding energy of Ir by alloying with Cu. The best catalytic performance necessities a balance of the adsorption and desorption energy. The well-defined morphology and enhanced OER electrochemical performances of nanovoid incorporated IrxCu metallic aerogels hold great promise in further applications in PEMWEs. © 2018 American Chemical Society.
语种：
英文
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Highly photoluminescent carbon dots derived from linseed and their applications in cellular imaging and sensing
作者：
Song, Yang;Yan, Xu;Li, Zhaohui;Qu, Lingbo;Zhu, Chengzhou;...
期刊：
JOURNAL OF MATERIALS CHEMISTRY B ,2018年6(19):3181-3187 ISSN：2050-750X
通讯作者：
Du, Dan;Lin, Yuehe
作者机构：
[Zhu, Chengzhou; Du, Dan; Song, Yang] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Ye, Ranfeng; Zhu, Chengzhou; Li, Suiqiong; Yan, Xu; Du, Dan; Song, Yang; Lin, Yuehe; Du, D; Lin, YH] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Yan, Xu] Jilin Univ, State Key Lab Integrated Optoelect, Coll Electron Sci & Engn, 2699 Qianjin St, Changchun 130012, Jilin, Peoples R China.;[Qu, Lingbo; Li, Zhaohui] Zhengzhou Univ, Henan Joint Int Res Lab Green Construct Funct Mol, Zhengzhou 450001, Henan, Peoples R China.;[Li, Suiqiong] Soochow Univ, Sch Elect & Informat Engn, Suzhou 215006, Peoples R China.
通讯机构：
[Du, Dan] C;[Du, D; Lin, YH] W;Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
摘要：
Carbon dots (CDs) synthesized from natural organic precursors, such as glucose, citric acid, glycerol, and chitosan, have attracted great interest since natural organic precursors provide abundant carbon sources, a variety of heteroatoms for doping (such as N, S, and P) and good biocompatibility. However, previous approaches utilized organic solvents during synthesis procedures, which limited their widespread development in biomedical applications. Herein, the facile synthesis of a new type of bright CDs through an eco-friendly method that employs linseed as a natural precursor has been reported. The as-obtained CDs possessed high quantum yield of 14.2%, excellent solubility and photostability as well as excitation-dependent photoluminescence (PL). In addition, the as-prepared CDs exhibited great potential in cell imaging owing to negligible cytotoxicity as well as excellent biocompatibility and great resistance to photobleaching. Subsequently, the as-prepared CDs were also applied in the fabrication of a biosensor for sensitive detection of butyrylcholinesterase (BChE) based on the fluorescence quenching mechanism, which could be used as an indicator for detecting pesticides and nerve gases. By monitoring the change in the fluorescence intensity of the CDs, the activity of BChE was sensitively analyzed. The limit of detection (LOD) of BChE was 0.035 mU mL<sup>-1</sup>. The as-prepared CDs have potential applications in both biosensors and bio-imaging.<br/> ©2018 The Royal Society of Chemistry.
语种：
英文
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Integrating in situ formation of nanozymes with three-dimensional dendritic mesoporous silica nanospheres for hypoxia-overcoming photodynamic therapy
作者：
Cai, Xiaoli;Luo, Yanan;Song, Yang;Liu, Dong;Yan, Hongye;...
期刊：
Nanoscale ,2018年10(48):22937-22945 ISSN：2040-3364
通讯作者：
Zhu, Chengzhou;Lin, Yuehe
作者机构：
[Cai, Xiaoli; Zhu, Chengzhou; Yan, Hongye] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.;[Cai, Xiaoli; Li, He; Du, Dan; Song, Yang; Lin, Yuehe; Luo, Yanan; Liu, Dong] Washington State Univ, Sch Mech & Mat Engn, POB 642920, Pullman, WA 99164 USA.
通讯机构：
[Zhu, Chengzhou] C;[Lin, Yuehe] W;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.;Washington State Univ, Sch Mech & Mat Engn, POB 642920, Pullman, WA 99164 USA.
摘要：
Despite great progress in photodynamic therapy (PDT), the therapeutic effect is still limited by some points, such as tumor hypoxia, the short lifetime and the limited action region of 1O2. Herein, a special kind of three-dimensional dendritic mesoporous silica nanosphere (3D-dendritic MSN) was synthesized and used as a robust nanocarrier to deliver abundant hydrophobic photosensitizer chlorin e6 (Ce6) to the A549 lung cancer cells. To address the tumor hypoxia issue, the nanozyme Pt nanoparticles (Pt NPs) were immobilized onto the channels of 3D-dendritic MSNs to catalyze the conversion of intracellular H2O2 to oxygen. Moreover, due to the in situ reduction process, the uniform Pt NPs distributed well on the surface of 3D-dendritic MSNs with high homogeneous dispersity. Additionally, a mitochondria-targeting ligand, triphenylphosphine (TPP), was conjugated to the Pt-decorated 3D-dendritic MSN composites to form a mitochondria targeted system for the PDT. In a combination of the peroxidase-like Pt NPs with mitochondria-targeting ability of TPP, a reactive oxygen species (ROS) burst in the mitochondria was achieved and resulted in the cell apoptosis. This well-designed system shows an enhanced PDT effect of killing A549 cells, and promotes a new H2O2-activatable strategy to overcome hypoxia for tumor PDT. © 2018 The Royal Society of Chemistry.
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英文
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A portable smart-phone device for rapid and sensitive detection of E. coli O157:H7 in Yoghurt and Egg
作者：
Zeinhom, Mohamed Maarouf Ali* ;Wang, Yijia;Song, Yang;Zhu, Mei-Jun;Lin, Yuehe;...
期刊：
Biosensors and Bioelectronics ,2018年99:479-485 ISSN：0956-5663
通讯作者：
Zeinhom, Mohamed Maarouf Ali;Du, Dan
作者机构：
[Zeinhom, MMA; Du, D; Zeinhom, Mohamed Maarouf Ali; Du, Dan; Wang, Yijia; Song, Yang; Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Zeinhom, Mohamed Maarouf Ali] Beni Suef Univ, Fac Vet Med, Food Hyg Dept, Bani Suwayf 62512, Egypt.;[Wang, Yijia] Hubei Univ, Coll Chem & Chem Engn, Wuhan 430062, Hubei, Peoples R China.;[Zhu, Mei-Jun] Washington State Univ, Sch Food Sci, Pullman, WA 99164 USA.;[Du, Dan] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Zeinhom, MMA; Du, D] W;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
关键词：
E. coli O157:H7;Egg;FITC;Magnetic beads;Smartphone;Yogurt
摘要：
The detection of E. coli O157:H7 in foods has held the attention of many researchers because of the seriousness attributed to this pathogen. In this study, we present a simple, sensitive, rapid and portable smartphone based fluorescence device for E. coli O157:H7 detection. This field-portable fluorescent imager on the smartphone involves a compact laser-diode-based photosource, a long-pass (LP) thin-film interference filter and a high-quality insert lenses. The design of the device provided a low noise to background imaging system. Based on a sandwich ELISA and the specific recognition of antibody to E. coli O157:H7, the sensitive detection of E. coli O157:H7 were realized both in standard samples and real matrix in yoghurt and egg on our device. The detection limit are 1 CFU/mL and 10 CFU/mL correspondingly. Recovery percentages of spiked yogurt and egg samples with 103, 104 and 105 CFU/mL E. coli O157:H7 were 106.98, 96.52 and 102.65 (in yogurt) and 107.37, 105.64 and 93.84 (in egg) samples using our device, respectively. Most importantly, the entire process could be quickly completed within two hours. This smartphone based device provides a simple, rapid, sensitive detection platform for fluorescent imaging which applied in pathogen detection for food safety monitoring. © 2017 Elsevier B.V.
语种：
英文
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Graphene-like Metal-Free 2D Nanosheets for Cancer Imaging and Theranostics
作者：
Luo, Yanan;Li, Zhaohui;Zhu, Chengzhou;Cai, Xiaoli;Qu, Lingbo;...
期刊：
Trends in Biotechnology ,2018年36(11):1145-1156 ISSN：0167-7799
通讯作者：
Du, Dan;Lin, Yuehe
作者机构：
[Cai, Xiaoli; Zhu, Chengzhou; Du, Dan; Luo, Yanan] Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.;[Cai, Xiaoli; Zhu, Chengzhou; Du, Dan; Lin, Yuehe; Luo, Yanan; Du, D; Lin, YH] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Qu, Lingbo; Li, Zhaohui] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China.
通讯机构：
[Du, Dan] C;[Du, D; Lin, YH] W;Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
关键词：
*2D nanosheets;*black phosphorous;*imaging;*metal free;*theranostics
摘要：
The great success of graphene has driven the discovery and development of new 2D nanomaterials with different optical, electrical, and thermal properties. Compared with other graphene-like 2D nanomaterials, metal-free 2D nanomaterials hold great potential in biomedical applications since they exhibit much better biocompatibility and biosafety. We give an overview of some rapidly emerging graphene-like metal-free 2D nanomaterials including black phosphorus, hexagonal boron nitride, and graphitic carbon nitride, as well as 2D organic polymer-based nanomaterials, and highlight their impressive advances for bioimaging and cancer theranostics in recent years. The challenges and some thoughts on future perspectives in this field are also addressed.
语种：
英文
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Single-Atom Catalysts for Electrochemical Water Splitting
作者：
Zhu, Chengzhou* ;Shi, Qiurong;Feng, Shuo;Du, Dan;Lin, Yuehe*
期刊：
ACS Energy Letters ,2018年3(7):1713-1721 ISSN：2380-8195
通讯作者：
Zhu, Chengzhou;Lin, Yuehe
作者机构：
[Zhu, Chengzhou; Du, Dan; Lin, Yuehe; Feng, Shuo; Shi, Qiurong; Zhu, CZ; Lin, YH] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Zhu, Chengzhou; Du, Dan] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Zhu, CZ; Lin, YH] W;[Zhu, Chengzhou] C;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
摘要：
High-efficiency electrocatalysts with superior activity and stability are crucial to practical applications in water splitting, including the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER). Downsizing the conventional nanoparticle catalyst to single atoms and constructing single-atom catalysts (SACs) is a rapidly emerging research focus. Because of the involvement of unique single-atom active moieties and the strong metal-support interactions arising from interfacial bonding, SACs as promising alternatives to noble metal-based nanoparticle catalysts exhibit profound power in the HER and OER. Here, we present a perspective on the exciting advances of SACs for HER and OER applications, with an emphasis on innovative synthetic strategies and an in-depth understanding of the structure-activity relationship through a combination of systematic characterization and theoretical studies. Finally, the challenges and some of the critical issues in this field are addressed. © Copyright 2018 American Chemical Society.
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英文
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Hierarchically Porous M–N–C (M = Co and Fe) Single-Atom Electrocatalysts with Robust MNx Active Moieties Enable Enhanced ORR Performance
作者：
Zhu, Chengzhou* ;Shi, Qiurong;Xu, Bo Z.;Fu, Shaofang;Wan, Gang;...
期刊：
Advanced Energy Materials ,2018年8(29):1801956- ISSN：1614-6832
通讯作者：
Zhu, Chengzhou;Lin, Yuehe;Su, Dong
作者机构：
[Zhu, Chengzhou; Song, Junhua; Du, Dan; Lin, Yuehe; Fu, Shaofang; Shi, Qiurong; Beckman, Scott P.; Zhu, CZ; Lin, YH] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Zhu, Chengzhou; Du, Dan] Cent China Normal Univ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.;[Xu, Bo Z.] Univ Calif Berkeley, Dept Mat Sci & Engn, Berkeley, CA 94720 USA.;[Wan, Gang] Argonne Natl Lab, Div Mat Sci, Argonne, IL 60439 USA.;[Yang, Ce] Argonne Natl Lab, Chem Sci & Engn, Argonne, IL 60439 USA.
通讯机构：
[Zhu, CZ; Lin, YH] W;[Su, Dong] B;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;Brookhaven Natl Lab, Ctr Funct Nanomat, Upton, NY 11973 USA.
关键词：
M–N–C catalysts;nonprecious metal catalysts;oxygen reduction reaction;porous nanostructures;single-atom catalysts
摘要：
The great interest in fuel cells inspires a substantial amount of research on nonprecious metal catalysts as alternatives to Pt-based oxygen reduction reaction (ORR) electrocatalysts. In this work, bimodal template-based synthesis strategies are proposed for the scalable preparation of hierarchically porous M–N–C (M = Fe or Co) single-atom electrocatalysts featured with active and robust MN2 active moieties. Multiscale tuning of M–N–C catalysts regarding increasing the number of active sites and boosting the intrinsic activity of each active site is realized simultaneously at a single-atom scale. In addition to the antipoisoning power and high affinity for O2, the optimized Fe–N–C catalysts with FeN2 active site presents a superior electrocatalytic activity for ORR with a half-wave potential of 0.927 V (vs reversible hydrogen electrode (RHE)) in an alkaline medium, which is 49 and 55 mV higher than those of the Co–N–C counterpart and commercial Pt/C, respectively. Density functional theory calculations reveal that the FeN2 site is more active than the CoN2 site for ORR due to the lower energy barriers of the intermediates and products involved. The present work may help rational design of more robust ORR electrocatalysts at the atomic level, realizing the significant advances in electrochemical conversion and storage devices. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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英文
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pH-sensitive ZnO quantum dots-doxorubicin nanoparticles for lung cancer targeted drug delivery
作者：
蔡小丽;杜丹;林跃河
期刊：
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE ,2018年14(5):1761-1762 ISSN：1549-9634
通讯作者：
Dan Du<&wdkj&>Yuehe Lin
作者机构：
[Xiaoli Cai] Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China;School of Mechanical and Materials Engineering, Washington State University, PO Box 642920, Pullman, Washington 99164, United States;[Dan Du; Yuehe Lin] Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China<&wdkj&>School of Mechanical and Materials Engineering, Washington State University, PO Box 642920, Pullman, Washington 99164, United States
通讯机构：
[Dan Du; Yuehe Lin] K;Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China<&wdkj&>School of Mechanical and Materials Engineering, Washington State University, PO Box 642920, Pullman, Washington 99164, United States
会议名称：
中国化学会第30届学术年会
会议时间：
20160701
会议地点：
大连
会议论文集名称：
中国化学会第30届学术年会论文集
关键词：
载药体系;肺癌;量子点
摘要：
肺癌是我国目前死亡率第一的恶性肿瘤。近年来，随着空气污染越来越严重，肺癌死亡率不断增加[1]。但是，传统的抗癌药物无法选择性的杀死癌细胞，药效低，水溶性等，则急需开发功能化纳米载体，将药物选择性运送到治疗部位，提高治疗效率。量子点具有优异的性质，它被广泛应用于体内和体外荧光成像中。
语种：
中文
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Recent advances in emerging 2D nanomaterials for biosensing and bioimaging applications
作者：
Wen, Wei;Song, Yang;Yan, Xu;Zhu, Chengzhou;Du, Dan* ;...
期刊：
Materials Today ,2018年21(2):164-177 ISSN：1369-7021
通讯作者：
Du, Dan;Lin, Yuehe
作者机构：
[Wang, Shengfu; Wen, Wei] Hubei Univ, Key Lab Synth & Applicat Organ Funct Mol, Hubei Collaborat Innovat Ctr Adv Organ Chem Mat, Minist Educ, Wuhan 430062, Hubei, Peoples R China.;[Du, Dan] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Wang, Shengfu; Wen, Wei] Hubei Univ, Coll Chem & Chem Engn, Wuhan 430062, Hubei, Peoples R China.;[Zhu, Chengzhou; Yan, Xu; Du, Dan; Wen, Wei; Song, Yang; Lin, Yuehe; Du, D; Lin, YH] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.;[Yan, Xu] Jilin Univ, Coll Chem, State Key Lab Supramol Struct & Mat, Changchun 130012, Jilin, Peoples R China.
通讯机构：
[Du, D; Lin, YH] W;Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
摘要：
The great success of graphene throws new light on discovering more two-dimensional (2D) layered nanomaterials that stem from atomically thin 2D sheets. Compared with a single element of graphene, emerging graphene-like 2D materials composed of multiple elements that possess more versatility, greater flexibility and better functionality with a wide range of potential applications. In this review, we provide insights into the rapidly emerging 2D materials and their biosensing and bioimaging applications in recent three years, including 2D transition metal nanomaterials, graphitic nitride materials, black phosphorus, and emerging 2D organic polymers. We first briefly highlight their unique 2D morphology and physicochemical properties and then focus on their recent applications in electrochemical biosensing, optical biosensing and bioimaging. The challenges and some thoughts on future perspectives in this field are also addressed. © 2017 Elsevier Ltd
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英文
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