作者机构：
[Wang, Xin-Wei; Jiang, Hai-Bo; Liu, Ling-Mei; Yong, Cheng-Wen] Ningbo Univ, Sch Marine Sci, Key Lab Marine Biotechnol Zhejiang Prov, Ningbo, Zhejiang, Peoples R China.;[Wang, Xin-Wei; Jiang, Hai-Bo; Yong, Cheng-Wen] Southern Marine Sci & Engn Guangdong Lab Zhuhai, Zhuhai, Guangdong, Peoples R China.;[Jiang, Hai-Bo; Liu, Ling-Mei; Deng, Bin] Cent China Normal Univ, Sch Life Sci, Wuhan, Hubei, Peoples R China.;[Jiang, Hai-Bo] Minist Nat Resources, Inst Oceanog 2, State Key Lab Satellite Ocean Environm Dynam, Hangzhou, Zhejiang, Peoples R China.
通讯机构：
[Xin-Wei Wang; Hai-Bo Jiang] K;Key Laboratory of Marine Biotechnology of Zhejiang Province, School of Marine Science, Ningbo University, Ningbo, Zhejiang, China<&wdkj&>Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, Guangdong, China<&wdkj&>Key Laboratory of Marine Biotechnology of Zhejiang Province, School of Marine Science, Ningbo University, Ningbo, Zhejiang, China<&wdkj&>Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, Guangdong, China<&wdkj&>School of Life Sciences, Central China Normal University, Wuhan, Hubei, China<&wdkj&>State Key Laboratory of Satellite Ocean Environment Dynamics, Second Institute of Oceanography, Ministry of Natural Resources, Hangzhou, Zhejiang, China
期刊：
Journal of Environmental Chemical Engineering,2023年11(3):109717 ISSN：2213-3437
通讯作者：
Liao, XM;Zhang, Lizhi;Sun, HW;Zhang, LZ
作者机构：
[Liao, Xiaomei; Liu, Qianhui; Chen, Yangyang; Mei, Ting; Wang, Shaohui] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.;[Zhang, Lizhi; Sun, Hongwei] Cent China Normal Univ, Inst Environm & Appl Chem, Coll Chem, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;[Zhang, Lizhi] Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, Shanghai 200240, Peoples R China.;[Liao, XM] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.;[Zhang, LZ; Sun, Hongwei] Cent China Normal Univ, Inst Environm & Appl Chem, Coll Chem, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Liao, XM ; Zhang, LZ; Sun, HW ; Zhang, LZ ] ;Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.;Cent China Normal Univ, Inst Environm & Appl Chem, Coll Chem, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, Shanghai 200240, Peoples R China.
关键词：
Sewage sludge;Ozonation;Zero-valent iron;Antibiotic resistance genes;Reactive oxygen species
摘要：
Wastewater treatment plants (WWTPs) are hotspots of antibiotic resistance genes (ARGs), and efficient technologies are needed to prevent the enrichment and spread of ARGs in municipal sludge. Herein, we demonstrated that oxalated zero-valent iron (OA-ZVIbm) catalyzed ozonation could effectively remove typical ARGs, tetG and sul1, from municipal sewage sludge, with the total abundance reduced by 3.02 and 2.00 log per gram sludge, respectively, surpassing the O-3 alone and O-3/ZVI(bm) counterparts. Meanwhile, the O-3/OA-ZVI(bm) treatment could simultaneously remove both intracellular and extracellular ARGs from the sludge, moreover, it also eliminated 1.83 log total Class 1 integron (total intI1), thus may suppress the horizontal gene transfer (HGT) potential of ARGs. The good performance of O-3/OA-ZVI(bm) was owing to the FeC2O4 center dot 2H(2)O shell of ZVI, which improved the accessibility of core iron species to catalyze the decomposition of O-3, producing more reactive oxygen species (ROSs) including center dot OH, center dot O-2(-), and O-1(2), for the removal of ARGs. This study provides a new method to control the dissemination of ARGs in sewage sludge.
通讯机构：
[Qiu, BS ] C;Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Hubei, Peoples R China.;Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Hubei, Peoples R China.
摘要：
Hypothetical chloroplast open reading frames (ycfs) are putative genes in the plastid genomes of photosynthetic eukaryotes. Many ycfs are also conserved in the genomes of cyanobacteria, the presumptive ancestors of present-day chloroplasts. The functions of many ycfs are still unknown. Here, we generated knock-out mutants for ycf51 (sll1702) in the cyanobacterium Synechocystis sp. PCC 6803. The mutants showed reduced photoautotrophic growth due to impaired electron transport between photosystem II (PSII) and PSI. This phenotype results from greatly reduced PSI content in the ycf51 mutant. The ycf51 disruption had little effect on the transcription of genes encoding photosynthetic complex components and the stabilization of the PSI complex. In vitro and in vivo analyses demonstrated that Ycf51 cooperates with PSI assembly factor Ycf3 to mediate PSI assembly. Furthermore, Ycf51 interacts with the PSI subunit PsaC. Together with its specific localization in the thylakoid membrane and the stromal exposure of its hydrophilic region, our data suggest that Ycf51 is involved in PSI complex assembly. Ycf51 is conserved in all sequenced cyanobacteria, including the earliest branching cyanobacteria of the Gloeobacter genus, and is also present in the plastid genomes of glaucophytes. However, Ycf51 has been lost from other photosynthetic eukaryotic lineages. Thus, Ycf51 is a PSI assembly factor that has been functionally replaced during the evolution of oxygenic photosynthetic eukaryotes. Chloroplast reading frame Ycf51 is a photosystem I assembly factor conserved in all sequenced cyanobacteria and glaucophyte plastids but lost from other photosynthetic eukaryotic lineages.
作者机构：
[Luo, Jingwen; Li, Mengyun; Chen, Feng; Xu, Wenliang; Gao, Yanan; Guo, Yanjun; Qiao, Mengfei; Xu, WL] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan, Peoples R China.;[Guo, Yanjun] Xinjiang Normal Univ, Coll Life Sci, Urumqi, Peoples R China.;[Persson, Staffan] Univ Copenhagen, Copenhagen Plant Sci Ctr, Frederiksberg, Denmark.;[Persson, Staffan] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Joint Int Res Lab Metab & Dev Sci, Shanghai, Peoples R China.;[Zeng, Wei; Zeng, W] Taizhou Univ, Sch Life Sci, Taizhou, Peoples R China.
通讯机构：
[Zeng, W ] T;[Xu, WL ] C;Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan, Peoples R China.;Taizhou Univ, Sch Life Sci, Taizhou, Peoples R China.
摘要：
This toxicology study was conducted to assess the impact of formaldehyde, a common air pollutant found in Chinese gymnasiums, on the brain function of athletes. In this research, a total of 24 Balb/c male mice of SPF-grade were divided into four groups, each consisting of six mice. The mice were exposed to formaldehyde at different concentrations, including 0 mg/m(3), 0.5mg/m(3), 3.0mg/m(3), and 3.0mg/m(3) in combination with an injection of L-NMMA (N(G)-monomethyl-L-arginine), which is a nitric oxide synthase antagonist. Following a one-week test period (8h per day, over 7days), measurements of biomarkers related to the nitric oxide (NO)/cGMP-cAMP signaling pathway were carried out on the experimental animals post-treatment. The study found that: (1) Exposure to formaldehyde can lead to brain cell apoptosis and neurotoxicity; (2) Additionally, formaldehyde exposure was found to alter the biomarkers of the NO/cGMP-cAMP signaling pathway, with some changes being statistically significant (p < 0.05 or p < 0.01); (3) The use of L-NMMA, an antagonist of the NO/cGMP-cAMP signaling pathway, was found to prevent these biomarker changes and had a protective effect on brain cells. The study suggests that the negative impact of formaldehyde on the brain function of mice is linked to the regulation of the NO/cGMP-cAMP signaling pathway.
作者：
Gomes, Marcelo Pedrosa;Pereira, Eduardo Gusmão;Qiu, Bao-Sheng;Juneau, Philippe
期刊：
FRONTIERS IN PLANT SCIENCE,2023年14:1131656 ISSN：1664-462X
通讯作者：
Gomes, M.P.
作者机构：
[Gomes, Marcelo Pedrosa] Laboratório de Fisiologia de Plantas sob Estresse, Departamento de Botânica, Setor de Ciências Biológicas, Universidade Federal do Paraná, Paraná, Curitiba, Brazil;[Pereira, Eduardo Gusmão] Laboratório de Fisiologia do Estresse Abiótico, Instituto de Ciências Biológicas, Universidade Federal de Viçosa, Minas Gerais, Florestal, Brazil;[Qiu, Bao-Sheng] School of Life Sciences, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Central China Normal University, Hubei, Wuhan, China;[Juneau, Philippe] Ecotoxicology of Aquatic Microorganisms Laboratory, EcotoQ, GRIL, TOXEN, Department of Biological Sciences, Université du Québec à Montréal, Montréal, Montréal, QC, Canada
通讯机构：
[Gomes, M.P.] L;Laboratório de Fisiologia de Plantas sob Estresse, Paraná, Brazil
通讯作者：
Cuihong Wan<&wdkj&>Cuihong Wan Cuihong Wan Cuihong Wan
作者机构：
[Wan, Cuihong; Huwanixi, Aishuake; Peng, Zhao] Cent China Normal Univ, Sch Life Sci, Wuhan, Hubei, Peoples R China.;[Wan, Cuihong; Huwanixi, Aishuake; Peng, Zhao] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan, Hubei, Peoples R China.;[Wan, Cuihong] Cent China Normal Univ, Sch Life Sci, 152 Luoyu Rd, Wuhan 430079, Peoples R China.;[Wan, Cuihong] Cent China Normal Univ, Hubei Key Lab Genet Regulat & Integrat Biol, 152 Luoyu Rd, Wuhan 430079, Peoples R China.
通讯机构：
[Cuihong Wan; Cuihong Wan Cuihong Wan Cuihong Wan] S;School of Life Sciences and Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan, Hubei, PR China
摘要：
Nostoc flagelliforme, a terrestrial cyanobacterium spread throughout arid and semi-arid areas, has been long known for its outstanding adaptability to extremely dry conditions. This microorganism is able to recover biological activities within hours after months of anhydrobiosis state, attracting investigation through proteomic analysis. Except for canonical proteome, microproteins encoded by small ORFs (smORFs) have recently been regarded as indispensable participants in metabolic processes. However, the involvement of smORFs in N. flagelliforme remains unknown. Here we first constructed a smORF database in N. flagelliforme using bioinformatic prediction, resulting in 6072 novel smORFs. Then LS-MS/MS analysis was applied to identify expression patterns of microproteins and seek smORFs and their encoded microprotein playing a role during rehydration. In total, 18 novel microproteins were mined based on a smORF searching strategy combined with three proteomic assays, of which five were annotated as ribosomal proteins, one as RNA polymerase subunit, and one as acetohydroxy acid isomeroreductase. We also suggested the possible functions of smORFs according to their expression pattern and discovered two neighboring and homologous smORFs. All these results will expand our knowledge of smORFs-encoded microproteins and their relation to the stress response of extremophilic microorganisms.
作者机构：
[Li, Yiming; Niu, Meiling; Yang, Jiaxue; Zhang, Jinyu; Li, Yuanyi; Li, YM; Du, Jiacong; Zhang, Jun] Hebei Univ, Inst Life Sci & Green Dev, Sch Life Sci, Baoding 071002, Peoples R China.;[Li, Yiming; Song, Tianjian; Wang, Siqi; Luo, Zexu; Li, Wenhao; Li, YM; Deng, Teng] Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, 1 Beichen West Rd, Beijing 100101, Peoples R China.;[Li, Yiming; Song, Tianjian; Wang, Siqi; Luo, Zexu; Li, Wenhao; Li, YM; Deng, Teng] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.;[Blackburn, Tim M.] UCL, Ctr Biodivers & Environm Res, Gower St, London WC1E 6BT, England.;[Blackburn, Tim M.] Zool Soc London, Inst Zool, Regents Pk, London NW1 4RY, England.
通讯机构：
[Li, YM ] H;Hebei Univ, Inst Life Sci & Green Dev, Sch Life Sci, Baoding 071002, Peoples R China.;Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, 1 Beichen West Rd, Beijing 100101, Peoples R China.;Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
摘要：
The global trade in live wildlife elevates the risk of biological invasions by increasing colonization pressure (the number of alien species introduced to an area). Yet, our understanding of species traded as aliens remains limited. We created a comprehensive global database on live terrestrial vertebrate trade and use it to investigate the number of traded alien species, and correlates of establishment richness for aliens. We identify 7,780 species involved in this trade globally. Approximately 85.7% of these species are traded as aliens, and 12.2% of aliens establish populations. Countries with greater trading power, higher incomes, and larger human populations import more alien species. These countries, along with island nations, emerge as hotspots for establishment richness of aliens. Colonization pressure and insularity consistently promote establishment richness across countries, while socio-economic factors impact specific taxa. Governments must prioritize policies to mitigate the release or escape of traded animals and protect global biosecurity. This study compiled a comprehensive global database on live terrestrial vertebrate trade and used it to investigate traded alien species. The authors identify 7,780 species involved in trade globally and show that countries with greater trading power, higher incomes and larger human populations import more alien species, which emerge as hotspots for establishment richness of aliens.
期刊：
Cell Communication and Signaling,2023年21(1):1-7 ISSN：1478-811X
通讯作者：
Ting Zhao
作者机构：
[Jin, Jian] Anhui Normal Univ, Sch Educ Sci, Wuhu 241000, Peoples R China.;[Zhao, Ting] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Zhao, Ting] S;School of Life Science, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan, 430079, People's Republic of China.
关键词：
Niche;Drosophila;Hippo;Insulin;Ovary
摘要：
Adult stem cells have a unique ability to self-renew and to generate differentiated daughter cells that are required in the body tissues. The identity of adult stem cells is maintained by extrinsic signals from other cell types, known as niche cells. Thus, the niche is required for appropriate tissue homeostasis. Niche is formed and recruits stem cells during tissue development; therefore, it is essential to establish niche cells and stem cells in proper numbers during development. A small niche may recruit too few stem cells and cause tissue degeneration, while a large niche may maintain too many stem cells and lead to tumorigenesis. Given that vertebrate tissues are not suitable for large-scale forward genetics studies, the Drosophila ovary stands out as an excellent model for studying how multiple niche cell types and germ cells (GCs) are coordinately regulated in vivo. Recent studies are beginning to reveal how various signaling molecules regulate niche formation and how niche cells non-autonomously influence GC number. In this review, we summarize the ovarian niche structure, the key signaling pathways for niche formation, and how niche cells generate extrinsic factors to control GC proliferation during ovarian development.
期刊：
Annals of Botany,2023年132(6):viii-x ISSN：0305-7364
通讯作者：
Huang, SQ
作者机构：
[Huang, Shuang-Quan; Huang, SQ] Cent China Normal Univ, Sch Life Sci, Inst Evolut & Ecol, Wuhan 430079, Peoples R China.
通讯机构：
[Huang, SQ ] C;Cent China Normal Univ, Sch Life Sci, Inst Evolut & Ecol, Wuhan 430079, Peoples R China.
关键词：
Enantiostyly;floral sexual polymorphism;geitonogamous self-pollination;tracing pollen movement
摘要：
This article comments on:Steven D. Johnson, Jeremy J. Midgley and Nicola Illing. The enantiostylous floral polymorphism of Barberetta aurea (Haemodoraceae) faci
作者：
Cao, Ya Ya;Chen, Yuan Yuan;Wang, Ming Shu;Tong, Jing Jing;Xu, Meng;...
期刊：
Redox Biology,2023年63:102751 ISSN：2213-2317
通讯作者：
Zhang, Dan;Yang, GF
作者机构：
[Chen, Yuan Yuan; Zhang, Wen Lin; Yang, Guang Fu; Lin, Hong Yan; Mei, Long Can; Wang, Ming Shu; Dong, Jin; Zhang, Dan; Zhang, D; Cao, Ya Ya; Huang, Wei; Qin, Yu Xuan; Zhao, Chi] Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Tong, Jing Jing; Xu, Meng] Cent China Normal Univ, Sch Life Sci, Wuhan 430079, Peoples R China.;[Chen, Yuan Yuan] Hunan Univ, Inst Chem Biol & Nanomed, Coll Chem & Chem Engn, Changsha 410082, Peoples R China.
通讯机构：
[Zhang, D; Yang, GF ] C;Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
关键词：
Catalase inhibitors;NADPH-Binding site;Ferroptosis;Castration-resistant prostate cancer
摘要：
Catalase (CAT) is an important antioxidant enzyme that breaks down H(2)O(2) into water and oxygen. Inhibitor-modulating CAT activity in cancer cells is emerging as a potential anticancer strategy. However, the discovery of CAT inhibitors towards the heme active center located at the bottom of long and narrow channel has made little progress. Therefore, targeting new binding site is of great importance for the development of efficient CAT inhibitors. Here, the first NADPH-binding site inhibitor of CAT, BT-Br, was designed and synthesized successfully. The cocrystal structure of BT-Br-bound CAT complex was determined with a resolution of 2.2Å (PDB ID:8HID), which showed clearly that BT-Br bound at the NADPH-binding site. Furthermore, BT-Br was demonstrated to induce ferroptosis in castration-resistant prostate cancer (CRPC) DU145cells and eventually reduce CRPC tumors in vivo effectively. The work indicates that CAT has potential as a novel target for CRPC therapy based on ferroptosis inducing.
摘要：
Engleromyces goetzei Henn (EgH) is a natural fungus that has been used as a traditional edible and medicine for long time in Southwest China. Our study found EgH aqueous extract (EgH‐AE) has very strong activities on antioxidant and anti‐inflammation. At the same time, we also found EgH‐AE has good biocompatibility and cell protective function, so it is biosafe, EgH‐AE may have the prospect of developing into functional beverage. Abstract High body mass index (high BMI, obesity) is a serious public health problem, and “obesity‐induced oxidative stress, inflammation, and cancer” have become modern epidemic diseases. We carried out this study to explore a functional beverage that may protect against obesity‐induced diseases. The Engleromyces goetzei Henn herbal tea is such a candidate. For this study, we carried out LC–MS analysis of E. goetzei Henn aqueous extract (EgH‐AE); then used the Caco‐2 cell line for the model cells and treated the cells with t‐BHP to form an oxidative stress system. An MTT assay was used for testing the biocompatibility and cytoprotective effects; reactive oxygen species and malondialdehyde determination was used for evaluating the antioxidative stress effect; TNF‐α and IL‐1β were used for observing the anti‐inflammatory effect, and 8‐OHdG for monitoring anticancer activity. The results of this study demonstrate that the EgH‐AE has very good biocompatibility with the Caco‐2 cell line and has good cytoprotective, antioxidant, anti‐inflammatory, and anticancer properties. It is clear that EgH‐AE, a kind of ancient herbal tea, may be used to develop a functional beverage that can be given to people with a high BMI to protect against obesity‐induced diseases.
作者：
Luo, Jinhong*;Lu, Manman;Luo, Jie;Moss, Cynthia F.
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY,2023年209(1):203-214 ISSN：0340-7594
通讯作者：
Luo, Jinhong;Moss, Cynthia F
作者机构：
[Lu, Manman; Luo, Jie; Luo, Jinhong] Cent China Normal Univ, Sch Life Sci, Inst Evolut & Ecol, Wuhan 430079, Peoples R China.;[Moss, Cynthia F.] Johns Hopkins Univ, Dept Psychol & Brain Sci, Baltimore, MD 21218 USA.
通讯机构：
[Luo, Jinhong] I;[Moss, Cynthia F] D;Institute of Evolution and Ecology, School of Life Sciences, Central China Normal University, Wuhan, 430079, China.;Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD, 21218, USA. cynthia.
摘要：
Diverse animal taxa are capable of rapidly modifying vocalizations to mitigate interference from environmental noise. Echolocating bats, for example, must frequently perform sonar tasks in the presence of interfering sounds. Numerous studies have documented sound production flexibility in echolocating bats; however, it remains unknown whether noise-induced vocal modifications (NIVMs) mitigate interference effects on echoes or calls. In this study, we leverage echo level compensation behavior of echolocating bats to answer this question. Using a microphone array, we recorded echolocation calls of Hipposideros pratti trained to approach and land on a perch in the laboratory under quiet and noise conditions. We found that H. pratti exhibited echo level compensation behavior during approaching flights, which depended critically on distance to the landing perch. Broadcast noise delayed and affected the rate of echo level compensation in H. pratti. Moreover, H. pratti increased vocalization amplitude, i.e., exhibited the Lombard effect, while also adjusting call duration and bandwidth with increasing noise levels. Quantitative analyses of the data show that H. pratti relies on echo feedback, not vocal feedback, to adjust signals in the presence of noise. These findings provide compelling evidence that NIVMs in echolocating animals and non-echolocating animals operate through different mechanisms.
