通讯机构：
[Ernest Koranteng] L;Laboratory of Sustainable Polymers and Synthesis, Department of Chemistry Education, University of Education, Winneba, Ghana
摘要：
Abstract Developing green composites has received intense attention among the scientific community because of their ability to help alleviate the global environmental pollution challenges. This current work focused on preparing a bio‐based composite material with desirable performance using renewable materials like diatomaceous earth, and polylactic acid (PLA) with poly(butanediol adipate ester) prepolymer (PBAPU) as a compatibilizer. The composites were prepared by reactive mixing using an intensive mixer. Subsequently, the effects of the PBAPU content on the structure and properties of the composites were studied. From the test results, it was revealed that increasing the PBAPU content resulted in an increasing trend in the properties of the composites. For instance, the thermal stability of the composites was improved as the PBAPU content was increased, and the best thermal stability was obtained when 20 wt% PBAPU was added. In addition, the mechanical properties test results showed that the elongation at break and impact strength of the composites increased with increasing PBAPU content. On the contrary, the tensile strength of the composites decreased with increasing PBAPU content. The scanning electron microscope images showed that the compatibility between the PLA matrix and PBAPU in the composites was improved significantly. Based on the analysis of the test results for the material's structure, morphology, thermal stability, fluidity, and other properties, it can be concluded that a bio‐based composite material with desirable performance was successfully prepared.
通讯机构：
[Wu, DY ] X;Xiamen Univ, State Key Lab Phys Chem Solid Surface, Collaborat Innovat Ctr Chem Energy Mat, Xiamen 361005, Peoples R China.;Xiamen Univ, Coll Chem & Chem Engn, Dept Chem, Xiamen 361005, Peoples R China.
摘要：
Stereoelectronic effects in single-molecule junctions have been widely utilized to achieve a molecular switch, but high-efficiency and reproducible switching remain challenging. Here, we demonstrate that there are three stable intramolecular conformations in the 9,10-diphenyl-9,10-methanoanthracen-11-one (DPMAO) systems due to steric effect. Interestingly, different electronic coupling approaches including weak coupling (through-space), decoupling, and strong coupling (through-bond) between two terminal benzene rings are accomplished in the three stable conformations, respectively. Theoretical calculations show that the molecular conductance of three stable conformations differs by more than 1 order of magnitude. Furthermore, the populations of the three stable conformations are highly dependent on the solvent effect and the external electric field. Therefore, an excellent molecular switch can be achieved using the DPMAO molecule junctions and external stimuli. Our findings reveal that modulating intramolecular electronic coupling approaches may be a useful manner to enable molecular switches with high switching ratios. This opens up a new route for building high-efficiency molecular switches in single-molecular junctions.
摘要：
Removing microcystins (MCs) safely and effectively has become an urgent global problem because of their extremely hazardous to the environment and public health. Microcystinases derived from indigenous microorganisms have received widespread attention due to their specific MC biodegradation function. However, linearized MCs are also very toxic and need to be removed from the water environment. How MlrC binds to linearized MCs and how it catalyzes the degradation process based on the actual three-dimensional structure have not been determined. In this study, the binding mode of MlrC with linearized MCs was explored using a combination of molecular docking and site-directed mutagenesis methods. A series of key substrate binding residues, including E70, W59, F67, F96, S392 and so on, were identified. Sodium dodecane sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) was used to analyze samples of these variants. The activity of MlrC variants were measured using high performance liquid chromatography (HPLC). We used fluorescence spectroscopy experiments to research the relationship between MlrC enzyme (E), zinc ion (M), and substrate (S). The results showed that MlrC enzyme, zinc ion and substrate formed E-M-S intermediates during the catalytic process. The substrate-binding cavity was made up of N and C-terminal domains and the substrate-binding site mainly included N41, E70, D341, S392, Q468, S485, R492, W59, F67, and F96. The E70 residue involved in both substrate catalysis and substrate binding. In conclusion, a possible catalytic mechanism of the MlrC enzyme was further proposed based on the experimental results and a literature survey. These findings provided new insights into the molecular mechanisms of the MlrC enzyme to degrade linearized MCs, and laid a theoretical foundation for further biodegradation studies of MCs.
期刊：
Journal of Thermoplastic Composite Materials,2023年36(11):4349 - 4364 ISSN：0892-7057
通讯作者：
Qiangxian Wu
作者机构：
[Wu, Qiangxian; Zhang, Peirui; Jian, Kui] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan, Peoples R China.;[Weng, Fangqing] Hubei Univ Educ, Coll Chem & Life Sci, Wuhan, Peoples R China.;[Zhuang, Kejia; Hong, Liu; Gao, Shanjun; Zhao, Weiwei] Wuhan Univ Technol, Sch Mat Sci & Engn, Wuhan, Peoples R China.;[Wu, Qiangxian] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Luoyu Rd 152, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Qiangxian Wu] K;Key Laboratory of Pesticide and Chemical Biology of the Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China
关键词：
shell;polycaprolactone;composite;CaCO3
摘要：
Agricultural waste shells are another source of calcium carbonate (CaCO3). Waste shells contain natural polymers such as polysaccharides and protein which can react with active groups in a polymer by melt mixing to form a compatible layer in a composite material. The formation of a compatible layer helps to improve the compatibility and material toughness of a composite. At the same time, the presence of CaCO3 in waste shells can also help to improve the hardness of a material. Therefore, this work mainly focused on the preparation of composite materials using different kinds of shell powder, and also studied the effects of the interface structure between shell powder and polycaprolactone (PCL) and properties of the composite materials. In particular, this work, studied the effects of the crystal forms of various shell powder as well as the content of polysaccharide and protein on the tensile performance and thermal properties of composite materials. The results implied that the tensile performance of the composites prepared from different kinds of shell powder were slightly different. The composite prepared from shell powder containing aragonite-structured CaCO3 had a better elastic modulus than the composite prepared from shell powder containing calcite-structured CaCO3. Likewise, the composite material prepared from scallop shell powder had the best toughness and thermal properties. This work has laid a foundation for exploring the effects of all sorts of shell powder on the structure and properties of composite material.
摘要：
Catalytic oxidation technology is currently considered as a feasible approach to degrade and mineralize volatile organic compounds (VOCs). However, it is still challenging to realize efficient removal of VOCs through catalytic oxidation at room temperature. In our study, a novel flow-through electrocatalytic reactor was designed, composed of porous solid-electrolyte, gas-permeable titanium sub-oxides/titanium-foam (TiSO/Ti-foam) as anode and platinum coated titanium foam (Pt/Ti-foam) as cathode. This device could oxidize nearly 100% of benzene (10 ppm) to carbon dioxide at a current density of 1.2 mA/cm2 under room temperature. More importantly, the device maintained excellent stability over 1000 h. Mechanism of benzene mineralization was discussed. Hydroxyl radicals generated on the TiSO/Ti-foam anode played a crucial role in the oxidation of benzene. This study provides a promising prototype of the electrochemical air purifier, and may find its application in domestic and industrial air pollution control.
摘要：
The comprehensive understanding of contaminant interfacial behavior strongly depends on the in situ characterization technique, which is still a great challenge. In this study, we constructed a device integrated with open-circuit potentialand attenuated total reflectance Fourier transform infrared (OCP-ATR-FTIR) spectroscopy to simultaneously monitor the electrochemical and infrared spectral information on the interfacial reaction for the process analysis, taking the competitive adsorption of hexavalent chromium (Cr(VI)) and oxalate on hematite nanocubes (HNC) as an example. The synchronous OCP and infrared results revealed that Cr(VI) interacted with HNC via bidentate binuclear inner-sphere coordination, accompanied by electron transfer from HNC to Cr(VI), while oxalate was adsorbed on HNC through bidentate mononuclear side-on inner-sphere coordination with electron transfer from HNC to oxalate, and also outer-sphere coordination with negative charge accumulation. When oxalate was added to HNC with preadsorbed Cr(VI), oxalate would occupy the inner-sphere adsorption sites and thus cause the detaching of preadsorbed Cr(VI) from HNC. This study provides a promising in situ characterization technique for real-time interfacial reaction monitoring and also sheds light on the competitive adsorption mechanism of oxalate and Cr(VI) on the mineral surface.
摘要：
Alcoholic liver disease (ALD) has attracted widespread attention because of the ever-increasing alcohol consumption and high morbidity. However, there is still no effective detection method to prevent the deterioration of the disease. Cholesterol, as the main component of the cell membrane (CM), often transported to lipid droplets (LDs) for storage in hepatocytes. Meanwhile, abnormal changes of cholesterol could cause liver diseases, such as Tangier disease. Based on cholesterol could serve as a hub that affects the cell membrane fluidity (CMF) and the number of LDs, we planned to study the microscopic changes of CMF and LDs in ALD. As viscous media could limit the intramolecular motion of fluorescent probes, aggregation induced emission luminogens (AIEgens), which typically have rotators and vibrators in their structures and emit strongly in the aggregate state, may be promising candidates for CMF and LD study. So two AIE probes (TPCN and NDPB) were designed and synthesized based on the typical AIE skeleton, tetraphenylethylene (TPE), which could selectively target CMs and LDs, respectively. These probes exhibited high chemical stability, controllable emission, and excellent subcellular specificity. They successfully sensed the correlated changes of CMs and LDs in ALD model, which would contribute to understanding the microscopic process of ALD pathogenesis and further development of ALD therapeutic drugs.
期刊：
Drug Discovery Today,2023年:103546 ISSN：1359-6446
通讯作者：
Li, Qing X;Yang, Guang-Fu
作者机构：
[Yang, Jing-Fang; Yang, Guang-Fu; Wang, Meng-Yao; Wang, Di; Wang, Fan; Hao, Ge-Fei] Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, PR China;[Yang, Jing-Fang; Yang, Guang-Fu; Wang, Meng-Yao; Wang, Di; Wang, Fan; Hao, Ge-Fei] International Joint Research Center for Intelligent Biosensor Technology and Health, Central China Normal University, Wuhan, 430079, PR China;[Yang, Jing-Fang] State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China;[Zhou, Zhong-Shi] State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China;[Hao, Ge-Fei] State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Research and Development Center for Fine Chemicals, Guizhou University, Guiyang 550025, PR China
通讯机构：
[Li, Qing X] D;[Yang, Guang-Fu] C;Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, HI 96822, USA. Electronic address:;Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, PR China. Electronic address:
摘要：
As major forces for modulating protein folding and molecular recognition, cation-π interactions are extensively identified in protein structures. They are even more competitive than hydrogen bonds in molecular recognition and, thus, are vital in numerous biological processes. In this review, we introduce the methods for the identification and quantification of cation-π interactions, provide insights into the characteristics of cation-π interactions in the natural state, and reveal their biological function together with our developed database (Cation-π Interaction in Protein Data Bank; CIPDB; http://chemyang.ccnu.edu.cn/ccb/database/CIPDB). This review lays the foundation for the in-depth study of cation-π interactions and will guide the use of molecular design for drug discovery. Teaser: We provide an overview of the cation-π interaction from its emergence to measurement and collection, along with a data set developed by us, which guides further research in biology and drug design.
摘要：
An amphiphilic AIE photosensitizer has been successfully developed, which allows for easily inserting into the bacterial membranes. Binding experiments with phospholipid preliminary demonstrates its membrane specificity. As expected, it is proved to possess a broad-spectrum bacterial staining performance and photodynamic antibacterial activity toward S. aureus and E. coli.
作者机构：
[Qin, Ying; Zhu, Chengzhou; Liu, Mingwang; Li, Jinli; Tan, Rong; Gu, Wenling; Wang, Hengjia] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;[Hu, Liuyong] Wuhan Inst Technol, Hubei Engn Technol Res Ctr Optoelect & New Energy, Hubei Key Lab Plasma Chem & Adv Mat, Wuhan 430205, Peoples R China.;[Li, Jinli] Jingchu Univ Technol, Sch Elect & Informat Engn, Jingmen 448000, Peoples R China.
通讯机构：
[Liuyong Hu] H;[Wenling Gu; Chengzhou Zhu] K;Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, Hubei Engineering Technology Research Center of Optoelectronic and New Energy Materials, Wuhan Institute of Technology, Wuhan 430205, PR China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, PR China
作者机构：
Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China;Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China;School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore;[Tierui Zhang; Tierui Zhang Tierui Zhang Tierui Zhang] Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China;[Jinyu Yan; Yuan Li; Shuxin Ouyang; Jinyu Yan Jinyu Yan Jinyu Yan; Yuan Li Yuan Li Yuan Li; Shuxin Ouyang Shuxin Ouyang Shuxin Ouyang] Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China
通讯机构：
[Shuxin Ouyang; Shuxin Ouyang Shuxin Ouyang Shuxin Ouyang] E;[Tierui Zhang; Tierui Zhang Tierui Zhang Tierui Zhang] K;Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China<&wdkj&>Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China
摘要：
We classify the representative photocatalytic materials for photosynthesis of hydrogen peroxide (H2O2) in recent years and discuss the related modification methods in detail, providing inspiration and insights for the future design of photocatalysts for H2O2 production. Abstract Hydrogen peroxide (H2O2), an environmental‐friendly oxidant and renewable liquid fuel, has received wide attention in various research and industrial fields. Current industrial production of H2O2 relies on the anthraquinone method, which is hardly viewed as a sustainable and green process. Photocatalysis, harnessing solar energy as the driving force for redox reactions, provides a green and promising approach for H2O2 production. However, due to the poor ability of light absorption, fast recombination of carriers, and poor intrinsic activity of active sites of pristine photocatalysts, photocatalytic H2O2 production cannot provide great yield. Thus, great efforts have been dedicated to design efficient photocatalysts for photosynthesis of H2O2 in the past decades. In this review, we summarize significant progress in the development of advanced photocatalytic materials for light‐driven H2O2 production. Starting with a brief introduction on basic principles and advantages of photosynthesis of H2O2, the representative materials are classified and discussed in detail; finally, a brief outlook on addressing future challenges and opportunities of photocatalytic H2O2 production is proposed. This review aims to confirm current challenges and research developments in the photosynthesis of H2O2 and provide inspiration for the development of high‐efficiency photocatalysts for photocatalytic H2O2 production in the future.
作者机构：
[Bao, Guang-Ming; Wang, Yongze; Luo, Xin; Li, Shentian] Hubei Univ Technol, Hubei Prov Cooperat Innovat Ctr Ind Fermentat, Natl Ctr Cellular Regulat & Mol 111, Hubei Res Ctr Food Fermentat Engn,Key Lab Fermenta, Wuhan 430068, Hubei, Peoples R China.;[Xu, Weiqing; Luo, Zhen; Fang, Qie; Zhu, Chengzhou; Gu, Wenling; Wang, Hengjia] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Zhu, CZ] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
通讯机构：
[Zhu, CZ ] ;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
作者：
Li Li;Xiaoxie Ma;Yusong Peng;Jun Yin;Nida El Islem Guissi;...
期刊：
ACS Applied Bio Materials,2023年6(4):1639-1649 ISSN：2576-6422
通讯作者：
Jun Yin<&wdkj&>Nida El Islem Guissi<&wdkj&>Yiqing Wang
作者机构：
[Li Li; Yusong Peng; Nida El Islem Guissi; Yiqing Wang] Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210023, People’s Republic of China;[Xiaoxie Ma; Jun Yin] Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, People’s Republic of China
通讯机构：
[Jun Yin] K;[Nida El Islem Guissi; Yiqing Wang] D;Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210023, People’s Republic of China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, People’s Republic of China
摘要：
Fluorescent probes with fluorescence emission in the NIR-II window have been widely studied due to increased imaging depth. However, the currently reported NIR-II fluorescent probes present some disadvantages, such as complicated synthesis routes and low fluorescence quantum yields (QYs). The shielding strategy has been used in the development of NIR-II probes to improve their QYs. So far, this strategy has only been used for the symmetric NIR-II probes, especially those based on the benzo[1,2-c:4,5-c']bis([1,2,5]thiadiazole) (BBTD) skeleton. This work reports the synthesis of a series of asymmetric NIR-II probes based on shielding strategies accompanied by simple synthetic routes, high synthetic yields (above 90%), high QYs, and large Stoke shifts. Furthermore, the use of d-α-tocopheryl polyethylene glycol succinate (TPGS) as a surfactant for an NIR-II fluorescence probe (NT-4) improved its water solubility. In vivo studies showed that TPGS-NT-4 NPs with a high QY (3.46%) achieve high-resolution angiography and efficient local photothermal therapy, while displaying good biocompatibility. Hence, we combined angiography and local photothermal therapy to improve the tumor uptake of nanophotothermal agents while reducing their damage to normal tissues.
摘要：
Circularly polarized luminescence (CPL) materials have attracted considerable attention for their promising applications in encryption, chiral sensing, and three-dimensional (3D) displays. However, the preparation of high-efficiency, pure blue CPL materials remains challenging. In this study, we reported an enantiomeric pair of triangle copper(I) clusters (R/S-Cu(3)) rigidified by employing chiral N-heterocyclic carbene (NHC) ligands with two pyridine-functionalized wingtips. These chiral clusters emitted pure blue phosphorescence that overlapped with that of the commercial blue phosphor having Commission Internationale de l'Eclairage (CIE) chromaticity coordinates of (0.14, 0.10), and the films exhibited an unprecedented photoluminescence quantum yield (PLQY) of ∼70.0%. Additionally, the solutions showed very bright circularly polarized phosphorescence (CPP) with a dissymmetry factor of ±2.1 × 10(-3). The excellent solubility and photostability endowed these pure-blue-emitting chiral clusters with promising applications as pure blue CPP inks for 3D printing white objects, such as precise-atomic-enlarged models of metal clusters and a lovely white stereoscopic "rabbit". The intricate mechanism underlying blue phosphorescence in this small cluster and across various states is elucidated through a comprehensive approach that integrates thorough analysis of luminescence properties, controlled experiments, and theoretical calculations. For the first time, we propose that the dominant high-energy emission center is constituted by delocalized hybrid orbitals over multiple atomic centers, encompassing both the metal and the coordinated atoms. This challenges stereotypical assumptions that the cluster center solely supports low-energy emissions. This work expands the currently limited range of CPP functional materials and provides a new direction for CPP applications involving NHC-stabilized metal clusters.
作者机构：
[Fu, Lijie; Liu, Fanglei; Zhao, Jiayi; Yang, Guohai; Qu, Lulu; Gu, Yingqiu] Jiangsu Normal Univ, Sch Chem & Mat Sci, Xuzhou 221116, Peoples R China.;[Zhu, Chengzhou] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Zhu, Jun-Jie] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210093, Peoples R China.;[Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Lulu Qu] S;[Chengzhou Zhu] N;School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China<&wdkj&>National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, P.R. China
摘要：
As recently developed two-dimensional (2D) materials, MXenes have attracted great attention in the fields of sensing, catalysis, energy, and electromagnetism due to their good electrical, mechanical, and optical properties and their biocompatibility. Their rich elemental composition, diverse surface functional groups and flexible bandgaps enable them to exhibit ideal physicochemical properties that are superior to those of traditional 2D materials. Therefore, MXenes not only serve as ideal biosensing materials but also show great potential in biomedical-related applications. In this review, we summarize the latest research on MXenes in the fields of biosensing and biomedicine. First, we introduce the different synthe-sis strategies and unique properties of MXenes. Then, according to the sensing mechanism, we divide the biosensing applications of MXenes into three subcategories: electrochemical, photochemical, and opto-electrochemical biosensors. Moreover, we systematically evaluate the biomedical applications of MXenes from four aspects: antibacterial activity, bioimaging, therapeutics and theranostics. How the specific chemical and physical properties of MXenes that can influence the efficiency of biosensing and biomedicine are highlighted, as well as the structure-performance relationships determining detection sensitivity and the toxicity of materials. Finally, we discuss the recent challenges and future prospects and opportunities for MXenes. It is expected that the review could promote the development of related fields.(c) 2022 Elsevier B.V. All rights reserved.
摘要：
Enrichment of OVs on oxide semiconductors is an effective strategy to promote their photocatalytic performances but limited by the maximum concentration allowed by lattice thermodynamics. Herein, we report that an In(I) doping strategy, realized by an UV light-induced reduction of a sluggish In(III) precursor, can promote OVs-laden BiOCl by up to 6.5 times for the visible-light sodium pentachlorophenate (PCPNa) degradation. The photocatalysis mechanism study highlighted the In(I) site as an electron transfer site could reduce PCPNa directly, related to the In(I) induced more negative conduction band and faster transfer of electron. Moreover, several monocyclic aromatic organic compounds (AOC) exhibited degradation selectivity over In(I) doped OVs-laden BiOCl (BOVs-In) by an electron reduction path, PCPNa with the lowest negative charge density on the benzene ring has been degraded fastest. Differently, the doped In(I) in BOVs-In mainly triggered the multiring Rhodamine B degradation by promoting the O-center dot(2)- generation not the directly electron reduction path. The electron transfer ability, band structure, and the free energy of O-2 activation over BOVs-In were confirmed by TPV spectra, EPR spectra and DFT calculation. This study illustrates an In(I) doping strategy to couple with OVs engineering for champion photoactivity of BiOCl for AOC degradation under visible light irradiation.
作者：
Gao, Yang-Yang;Yang, Wei-Cheng;Ashby Jr, Charles R.;Hao, Ge-Fei
期刊：
Drug Resistance Updates,2023年67:100934 ISSN：1368-7646
通讯作者：
Charles R. Ashby
作者机构：
[Yang, Wei-Cheng; Gao, Yang-Yang; Hao, Ge-Fei] Guizhou Univ, Ctr Res & Dev Fine Chem, Natl Key Lab Green Pesticide, Key Lab Green Pesticide & Agr Bioengn,Minist Educ, Guiyang 550025, Peoples R China.;[Hao, Ge-Fei] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Ashby Jr, Charles R.] St Johns Univ, Dept Pharmaceut Sci, New York, NY 10003 USA.
通讯机构：
[Charles R. Ashby] D;Department of Pharmaceutical Sciences, St. John’s University, New York, NY, USA
关键词：
Drug resistance;Cryptic binding sites;Resistance management
摘要：
The emergence of drug resistance is a primary obstacle for successful chemotherapy. Drugs that target cryptic binding sites (CBSs) represent a novel strategy for overcoming drug resistance. In this short communication, we explain and discuss how the discovery of CBSs and their inhibitors can overcome drug resistance.
