期刊：
JOURNAL OF ORGANIC CHEMISTRY,2024年89(4):2505-2515 ISSN：0022-3263
通讯作者：
Wu, AX
作者机构：
[Wang, Can; Zhao, Peng] Taizhou Univ, Sch Pharmaceut Sci, Inst Adv Studies, Taizhou 318000, Zhejiang, Peoples R China.;[Wu, An-Xin; Zhou, You; Zhao, Peng] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
通讯机构：
[Wu, AX ] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
摘要：
A novel iodine-promoted difunctionalization of alpha-C sites in enaminones was demonstrated as a means of synthesizing a variety of fully substituted thiazoles by constructing C-C(CO), C-S, and C-N bonds. This transformation allows the realization of enaminones as unusual aryl C2 synthons and simultaneously allows the thioylation and dicarbonylation of alpha-C sites. A preliminary mechanistic study was performed and indicated that the cleavage of C=C bonds in enaminones involves a bicyclization/ring-opening and oxidative coupling sequence.
关键词：
Cancer biomarkers;Liquid biopsy;Microfluidics;Digital assay;Single molecule detection
摘要：
The current paradigm of cancer management relies on imaging modalities and tissue biopsy to characterize the tumor landscape and devise treatment. As a complementary approach to non-invasive cancer detection, liquid biopsy is gaining interest through the detection of biomarkers circulating in body fluids. However, the wider use of liquid biopsy in the clinical setting is often hindered by limited technologies that can reliably and sensitively detect trace biomarkers in bodily fluids. As one of the most promising emerging technologies, digital single-molecule platforms (DSMPs) offer unparalleled sensitivity using digital read-out that is poised to improve current cancer management. This review provides an overview of the recent development in DSMPs based on digital ELISA, digital flow cytometry, digital surface-enhanced Raman scattering, and other emerging DSMPs for circulating cancer biomarker detection, especially for those that were evaluated on clinical cancer cohorts. DSMPs are well-positioned to address the challenges of studying cancer heterogeneity and trace biomarker discovery with outcomes expected to deliver new tools for cancer screening, treatment monitoring, and tumor recurrence detection.
期刊：
JOURNAL OF NATURAL PRODUCTS,2024年87(1):141-151 ISSN：0163-3864
通讯作者：
Ruan, HL
作者机构：
[Ruan, Han-Li; Hu, Jia-Yun; Qin, Chun-Lun; Chang, Jin-Ling; Pei, Jiao; Ouyang, Qian-Xi; Ruan, HL; Zhou, Yin-Hui] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China.;[Meng, Xiang-Gao] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
通讯机构：
[Ruan, HL ] H;Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China.
摘要：
Twelve new austalide meroterpenoids (1-12) were isolated from the endophytic fungus Diaporthe sp. XC1211. Their structures were elucidated by extensive spectroscopic analysis. The absolute configurations of compounds 1, 3, 4, and 6 were established by single-crystal X-ray diffraction, whereas those for the others were established by experimental electronic circular dichroism (ECD) data analysis. Compounds 1-12 represent a rare class of austalides with a 24α-CH(3). Compounds 2 and 5 demonstrated potent proliferation inhibitory effects against LPS-induced B cells with IC(50) values of 6.7 (SI = 3.6) and 3.8 (SI > 13) μM, respectively. Compounds 2 and 5 decreased the secretion of IL-6 in LPS-induced B cells in a dose-dependent manner.
作者机构：
[Duan, Gui-Yun; Li, Hong-Shuang; Zhao, Jun; Tian, Kai-Qiang] Shandong First Med Univ & Shandong Acad Med Sci, Natl Key Lab Adv Drug Delivery & Release Syst, Sch Pharmaceut Sci, Jinan 250117, Peoples R China.;[Duan, Gui-Yun; Li, Hong-Shuang; Zhao, Jun; Tian, Kai-Qiang] Shandong First Med Univ & Shandong Acad Med Sci, Inst Mat Med, Jinan 250117, Peoples R China.;[Zhang, Shi-Jiao] Qingdao Univ, Pharm Intravenous Admixture Serv, Affiliated Taian City Cent Hosp, Tai An 271000, Peoples R China.;[Cui, Guo-Hao; Guo, R; Wang, Qiao-Ling; Guo, Rui] Cent China Normal Univ CCNU, Int Joint Res Ctr Intelligent Biosensing Technol &, CCNU uOttawa Joint Res Ctr, Key Lab Pesticides & Chem Biol,Minist Educ,Coll Ch, Wuhan 430079, Peoples R China.
通讯机构：
[Guo, R ] C;[Li, HS ] S;Shandong First Med Univ & Shandong Acad Med Sci, Natl Key Lab Adv Drug Delivery & Release Syst, Sch Pharmaceut Sci, Jinan 250117, Peoples R China.;Shandong First Med Univ & Shandong Acad Med Sci, Inst Mat Med, Jinan 250117, Peoples R China.;Cent China Normal Univ CCNU, Int Joint Res Ctr Intelligent Biosensing Technol &, CCNU uOttawa Joint Res Ctr, Key Lab Pesticides & Chem Biol,Minist Educ,Coll Ch, Wuhan 430079, Peoples R China.
摘要：
The regio- and diastereoselective alkene isomerization and hydrofunctionalization sequence enabled by transition-metal complexes allows rapid activation and assembly of the C-(sp(3))-H bond that is either adjacent or distal to the initial double bond, which has been a longstanding challenge in this field. Herein, we develop unusual rhodium-catalyzed isomerization of alkylidenecyclobutanes with subsequent hydroacylation reaction to provide multisubstituted cyclobutanes with continuous stereocenters. Note that this tandem process features a good regio- and diastereoselectivity profile. Isotopic labeling experiments support the "exo to endo" migration of the double bond to a coordinated cyclobutene that is responsible for the deuterium incorporation observed in the cyclobutane product.
摘要：
A mild strategy for the synthesis of boron‐handled pyrazoles through photocatalytic cascade radical cyclization of LBRs (Lewis base‐boryl radicals) with vinyldiazo reagents is described here. The reaction starts with the addition of LBRs at diazo site, followed by intramolecular radical cyclization to access a wide range of important boron‐handled pyrazoles in good to excellent yields. Control experiments, together with detailed mechanism studies well explain the observed reactivity. Abstract Vinyldiazo compounds are one of the most important synthons in the construction of a cyclic ring. Most photochemical transformations of vinyldiazo compounds are mainly focusing on utilization of their C═C bond site, while reactions taking place at terminal nitrogen atom are largely unexplored. Herein, a photocatalytic cascade radical cyclization of LBRs with vinyldiazo reagents through sequential B─N/C─N bond formation is described. The reaction starts with the addition of LBRs (Lewis base–boryl radicals) at diazo site, followed by intramolecular radical cyclization to access a wide range of important boron‐handled pyrazoles in good to excellent yields. Control experiments, together with detailed mechanism studies well explain the observed reactivity. Further studies demonstrate the utility of this approach for applications in pharmaceutical and agrochemical research.
摘要：
In the pursuit of advancing materials for methane storage, a critical consideration arises given the prominence of natural gas (NG) as a clean transportation fuel, which holds substantial potential for alleviating the strain on both energy resources and the environment in the forthcoming decade. In this context, a novel approach is undertaken, employing the rigid triptycene as a foundational building block. This strategy is coupled with the incorporation of dichloromethane and 1,3-dichloropropane, serving as rigid and flexible linkers, respectively. This combination not only enables cost-effective fabrication but also expedites the creation of two distinct triptycene-based hypercrosslinked polymers (HCPs), identified as PTN-70 and PTN-71. Surprisingly, despite PTN-71 manifesting an inferior Brunauer-Emmett-Teller (BET) surface area when compared to the rigidly linked PTN-70, it showcases remarkably enhanced methane adsorption capabilities, particularly under high-pressure conditions. At a temperature of 275 K and a pressure of 95 bars, PTN-71 demonstrates an impressive methane adsorption capacity of 329 cm(3) g(-1). This exceptional performance is attributed to the unique flexible network structure of PTN-71, which exhibits a pronounced swelling response when subjected to elevated pressure conditions, thus elucidating its superior methane adsorption characteristics. The development of these advanced materials not only signifies a significant stride in the realm of methane storage but also underscores the importance of tailoring the structural attributes of hypercrosslinked polymers for optimized gas adsorption performance.
摘要：
Designing safer chemicals is an integral part of green chemistry that supports good health and well-being. The teaching of molecule design through relevant courses has important implications for the education of sustainable chemists. In these courses, training in toxicology and hazard assessment is essential for students to study benign chemical design that promotes social and environmental justices. However, toxicology training has been rarely included in the course of molecular design, and education of green molecular design at the postgraduate level has been less involved. In this study, we developed an online classroom for toxicology training as a new component of our chemical molecular design course. This class was designed to provide students with a toxicity perspective for viewing chemicals by integrating our three web-based tools. The average score of students' attitude evaluation toward the web-based class was 4.0/5.0, indicating that the toxicology class achieved the expected effects and provided a good experience for students to learn about designing safer chemicals. This work may facilitate the education of green molecular design and inspire students to seriously consider chemically toxic side effects.
作者机构：
[Shu, C; Xuan, Chenglong; Shu, Chao; Liu, Meng; Ouyang, Xinke] Cent China Normal Univ CNNU, Coll Chem,Engn Res Ctr Photoenergy Utilizat Pollut, CCNU UOttawa Joint Res Ctr,Natl Key Lab Green Pest, Key Lab Pesticide & Chem Biol,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;[Shu, C; Shu, Chao] Wuhan Inst Photochem & Technol, 7 North Bingang Rd, Wuhan 430083, Hubei, Peoples R China.
通讯机构：
[Shu, C ] C;Cent China Normal Univ CNNU, Coll Chem,Engn Res Ctr Photoenergy Utilizat Pollut, CCNU UOttawa Joint Res Ctr,Natl Key Lab Green Pest, Key Lab Pesticide & Chem Biol,Minist Educ, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;Wuhan Inst Photochem & Technol, 7 North Bingang Rd, Wuhan 430083, Hubei, Peoples R China.
摘要：
Cyclic architectures refer to a class of molecules that are highly valuable and play significant roles in various well-known organic compounds. These compounds have great industrial and pharmacological importance, particularly in areas such as optics, electronics, and material sciences. Cyclic architectures also exhibit potential as anticancer, antifungal, and antibacterial agents. Due to their wide range of applications, there is a growing interest in researching the development of efficient and straightforward methods for constructing these complex structures. Photoinduced radical-polar crossover cyclization (RPCC) of bifunctional alkenes represents a class of reactions that are of great synthetic utility, because they show high chemoselectivity, broad functional group tolerance and proceed under mild conditions to produce high-value cyclic products with precise alkene design. This mini review summarizes the recent representative advances in the development of RPCC over the past two decades, through different synthetic strategies in the reactions, highlighting their product diversity, selectivity and applicability, and the mechanistic rationale where possible. The intention is to provide readers with a comprehensive understanding of the current state-of-play in this field and contribute to future research efforts
摘要：
Trichloroethylene (TCE) with trace concentrations is often detected in soils and groundwater, posing potential damages to public health. The elimination of TCE can be achieved through reductive dechlorination using zero-valent iron (ZVI). However, ZVI usually suffers from the presence of passive iron (hydro)oxides layer and low electron transfer rate, thus leading to the unsatisfactory reactivity. Herein, we fabricated oxalated ZVI (Ox-ZVI(bm)) by mechanical ball-milling of micro-scale ZVI and H2C2O4 center dot 2H(2)O to modify the ZVI surface composition. To be specific, the modification of the iron oxide shell by oxalic acid facilitated the generation of unsaturated coordination Fe(II), enhancing TCE adsorption. Furthermore, the formed FeC2O4 on the iron oxide shell improved electron transfer efficiency, contributing to the enhanced TCE reductive dechlorination. Impressively, the rate of TCE degradation by Ox-ZVI(bm) was 10-fold higher than that of ZVI(bm) without oxalate modification. Moreover, Ox-ZVI(bm) samples were filled in a laboratory Permeable Reactive Barriers (PRB) column to treat actual underground wastewater containing TCE pollutants. The effluent concentration of TCE maintained steadily below 0.21 mg/L for over 10 days, complying with the National Groundwater Class IV standard (GBT 14848-2017). This marks a significant step toward practical groundwater treatment.
摘要：
As a hotspot issue of global concern, the abuse of environmental and biological related molecules, including antibiotics, small organic molecules and inorganic anions poses a severe threat to the biological health and ecological environment. Accurate and effective monitoring of these species is of great significance. In this study, one novel nickel(II)-based coordination polymer [Ni(H(2)edda)(2)(Hbmoe)(2)] (Ni-CP) has been successfully designed and synthesized by using the mixed ligands 5,5 '-(ethane-1,2-diylbis(oxy)) diisophthalic acid (H(4)edda) and 1,1 '-bis(1H-benzimidazolyl) oxydiethane (bmoe). Significantly, this framework reveals great thermal and chemical stability and can retain its structural integrity when immersed in water or even in a certain acid/base aqueous solution (pH = 2-13) for a period of time. As expected, this material also exhibits strong fluorescence. Further investigations indicate that as-synthesized Ni-CP can be served as a multi-responsive sensing platform for the highly selective and sensitive detection of nitrofurazone (NFZ), acetylacetone (ACAC), MnO4- and Cr(VI) in aqueous media. The mechanisms for fluorescence quenching have been disclosed through thorough experimental and computational investigations.
作者机构：
[Zhou, Yan; Zhu, Chengzhou; Li, Jingshuai; Xi, Mengzhen; Gu, Wenling] National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China;[Hu, Liuyong] Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, Hubei Engineering Technology Research Center of Optoelectronic and New Energy Materials, Wuhan Institute of Technology, Wuhan 430205, P. R. China;[Lu, Bingzhang] School of Chemical Engineering and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P. R. China;[Zhu, Chengzhou] College of Material Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Hangzhou Normal University, Hangzhou 311121, P. R. China
摘要：
For conventional potential-resolved ratiometric electrochemiluminescence (ECL) systems, the introduction of multiplex coreactants is imperative. However, the undesirable interactions between different coreactants inevitably affect analytical accuracy and sensitivity. Herein, through the coordination of aggregation-induced emission ligands with gadolinium cations, the self-luminescent metal-organic framework (Gd-MOF) is prepared and serves as a novel coreactant-free anodic ECL emitter. By the intercalation of [Ru(bpy)(2)dppz](2+) with light switch effect into DNA duplex, one high-efficiency cathodic ECL probe is obtained using K(2)S(2)O(8) as a coreactant. In the presence of acetamiprid, the strong affinity between the target and its aptamer induces the release of [Ru(bpy)(2)dppz](2+), resulting in a decreasing cathode signal and an increasing anode signal owing to the ECL resonance energy transfer from Gd-MOF to [Ru(bpy)(2)dppz](2+). In this way, an efficient dual-signal ECL aptasensor is constructed for the ratiometric analysis of acetamiprid, exhibiting a remarkably low detection limit of 0.033 pM. Strikingly, by using only one exogenous coreactant, the cross interference from multiple coreactants can be eliminated, thus improving the detection accuracy. The developed high-performance ECL sensing platform is successfully applied to monitor the residual level of acetamiprid in real samples, demonstrating its potential application in the field of food security.
作者机构：
[Wang, SW; Wang, Shaowei; Liu, Shuang] Chinese Acad Sci, Shanghai Inst Tech Phys, State Key Lab Infrared Phys, 420 Zhongshan Rd, Shanghai 200434, Peoples R China.;[Zhang, Qiuxin] Brandeis Univ, Dept Chem, 415 South St, Waltham, MA 02454 USA.;[Peng, Xingrao; Sun, Yao] Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Hu, Cong] Guilin Univ Elect Technol, Guangxi Key Lab Automat Detecting Technol & Instru, Guilin 541004, Peoples R China.
通讯机构：
[Wang, SW ; Sun, Y ; Liu, S] C;Chinese Acad Sci, Shanghai Inst Tech Phys, State Key Lab Infrared Phys, 420 Zhongshan Rd, Shanghai 200434, Peoples R China.;Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
摘要：
Herein, we show a pair of leucine-rich l- and d-phosphopeptides which self-assemble into twisting nanofibers, whose secondary structures contain a strong beta-sheet component after being dephosphorylated by alkaline phosphatase (ALP). While being incubated with ALP overexpressing osteosarcoma cells, both of the peptides self-assemble in the nuclei and induce cell death. The cell death involves multiple cell death modalities and occurs along with the disruption of cell membranes. Enzyme-instructed self-assembly (EISA) inhibits osteosarcoma cells and shows no side effect to other cells. In addition, the cancer cells hardly gain drug resistance after repeated treatment. This work reports a pair of EISA-based nanofibers to target cell nuclei, and also provides a novel chemotherapeutic agent to inhibit osteosarcoma cells without side effects and drug resistance. Dephosphorylated by the highly expressed alkaline phosphatase, phosphopeptides self-assemble into twisted nanofibers in nuclei to selectively induce the death of osteosarcoma cells.
作者机构：
[Cheng, Ying; Xiao, Wen-Jing; Chen, Jia-Rong; Shi, De-Qing; Li, Tian-Tian; Chen, JR] Cent China Normal Univ, Coll Chem, Engn Res Ctr Photoenergy Utilizat Pollut Control &, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.;[Xiao, Wen-Jing] Shanghai Inst Organ Chem, State Key Lab Organometall Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China.
通讯机构：
[Shi, DQ; Chen, JR ] C;Cent China Normal Univ, Coll Chem, Engn Res Ctr Photoenergy Utilizat Pollut Control &, 152 Luoyu Rd, Wuhan 430079, Hubei, Peoples R China.
摘要：
Radical Cross‐CouplingA copper‐catalyzed enantioselective three‐component radical relay 1,2‐alkylesterification of 1,3‐dienes using cycloalkyl hydroperoxides and carboxylic acids was reported. This protocol features broad substrate scope and good functional group tolerance with respect to each component, providing practical access to a variety of distally keto‐functionalized chiral allylic esters with high enantioselectivity under mild and redox‐neutral conditions. Abstract Transition‐metal‐catalyzed radical relay cross‐coupling reactions of 1,3‐dienes have recently emerged as one of the most powerful methods for construction of structurally diverse allylic compound in a single chemical step. However, there still has been limited success in expanding substrate scope of radical precursors and coupling partners, as well as exploring catalytic asymmetric variants. Herein, we report a copper‐catalyzed enantioselective three‐component 1,2‐alkylesterification of 1,3‐dienes using cycloalkyl hydroperoxides as the carbonyl‐containing alkyl radical sources and carboxylic acids as O‐nucleophiles under mild and redox‐neutral conditions. This protocol features broad substrate scope and good functional group tolerance with respect to each component, providing practical access to a variety of distally keto‐functionalized allylic esters with high enantioselectivity. Mechanistic studies suggest the involvement of a sequential radical relay and C−O cross‐coupling in this three‐component radical reaction.
作者机构：
[Xu, Yuling; Sun, Yao; Li, Chonglu; Yang, Jingfang] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticides & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;[An, Jusung; Kim, Jong Seung] Korea Univ, Dept Chem, Seoul 02841, South Korea.;[Ma, Xin] Hubei Univ, Key Lab Synth & Applicat Organ Funct Mol, Minist Educ, Wuhan 430062, Peoples R China.;[Luo, Lishi] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China.;[Deng, Yun] Jianghan Univ, Key Lab Optoelect Chem Mat & Devices, Minist Educ, Wuhan 430056, Peoples R China.
通讯机构：
[Jong Seung Kim] D;[Yao Sun] K;Department of Chemistry, Korea University, Seoul, Republic of Korea<&wdkj&>Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, China
摘要：
Although metal-based chemical agents have demonstrated promising bacteriostatic effects in phototherapy, their short excitation/emission wavelengths and inadequate phototherapy efficiencies make their application in vivo difficult. We therefore synthesized a novel Pt(II) metallacycle (Pt1110) that can be activated with a 980 nm laser for photodiagnosis/treatment in deep tissue. We found that Pt1110 significantly improved photothermal conversion (95% improvement) and O-1(2) generation (phi(& UDelta;) 75% increase) compared to the ligand itself 1 and was well capable of light-induced sterilization under safe laser irradiation (0.72 W/cm(2)). In addition, Pt1110 has little to no toxicity to cells. After incorporated into liposome, Pt1110 NPs was effective in wound healing in infection and keratitis models upon laser irradiation, which was accurately observed by NIR-II fluorescence imaging. This novel metal-coordinated supramolecular material has a potential to become a universal platform for phototherapy in deep tissue.
摘要：
A new fluorescent imaging probe indocyanine green-VC (ICG-VC) in the second near-infrared window (NIR-II) was fabricated based on the urokinase-type plasminogen activator receptor (uPAR) targeted polypeptide VC (VSNKYFSNIHWGC). The relative quantum yield (phi(F))was 0.34 %. The tail of its fluorescence emission wavelength exceeded 1000 nm with excellent photostability. In vitro cell analysis, MTT results indicated the high biocompatibility of ICG-VC with U87MG cells. ICG-VC showed good photothermal conversion behavior and photothermal stability.In vivo NIR-II fluorescence imaging, ICG-VC exhibited high spatiotemporal resolution in the lymphatic vessels with a high resolution of 717 mu m and signal-to-noise ratio of 4.36, and displayed an excellent U87MG tumor uptake within 4 h, which reached the maximum at 8 h with a signal-to-noise ratio of 5.32.
通讯机构：
[Xiang, Jia-Chen] S;[Ma, Jin-Tian] K;School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China<&wdkj&>Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
摘要：
We herein report an efficient synthesis of 2-aroyl-3-arylquinolines from phenylalanines and anilines. The mechanism involves I(2)-mediated Strecker degradation enabled catabolism and reconstruction of amino acids and a cascade aniline-assisted annulation. Both DMSO and water act as oxygen sources in this convenient protocol.
作者机构：
[Xu, Weiqing; Luo, Zhen; Fang, Qie; Zhu, Chengzhou; Xiao, Runshi; Xi, Mengzhen; Gu, Wenling; Wang, Hengjia; Wu, Zhichao; Ling, Ling] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Xiao, Runshi; Hu, Liuyong] Wuhan Inst Technol, Hubei Engn Technol Res Ctr Optoelect & New Energy, Hubei Key Lab Plasma Chem & Adv Mat, Wuhan 430205, Peoples R China.
通讯机构：
[Prof. Liuyong Hu] H;[Prof. Wenling Gu; Prof. Chengzhou Zhu] N;National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079 P. R. China<&wdkj&>Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, Hubei Engineering Technology Research Center of Optoelectronic and New Energy Materials, Wuhan Institute of Technology, Wuhan, 430205 P. R. China
摘要：
In conventional luminol electrochemiluminescence (ECL) systems, hydrogen peroxide and dissolved oxygen are employed as typical co-reactants to produce reactive oxygen species (ROS) for efficient ECL emission. However, the self-decomposition of hydrogen peroxide and limited solubility of oxygen in water inevitably restrict the detection accuracy and luminous efficiency of luminol ECL system. Inspired by ROS-mediated ECL mechanism, for the first time, we used cobalt-iron layered double hydroxide as co-reaction accelerator to efficiently activate water to generate ROS for enhancing luminol emission. Experimental investigations verify the formation of hydroxyl and superoxide radicals in the process of electrochemical water oxidation, which subsequently react with luminol anion radicals to trigger strong ECL signals. Finally, the detection of alkaline phosphatase has been successfully achieved with impressive sensitivity and reproducibility for practical sample analysis.
期刊：
Chemical Papers,2023年77(11):6763-6771 ISSN：2585-7290
通讯作者：
Sun, Y;Zhang, AD
作者机构：
[Zhou, Ya-Qing; Sun, Yong; Wang, Ji-Li; Sun, Y; Wu, Wen-Hai] Hanjiang Normal Univ, Coll Chem & Environm Engn, Shiyan 442000, Peoples R China.;[Zhang, Aidong; Duan, Jiang] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
通讯机构：
[Zhang, AD ] C;[Sun, Y ] H;Hanjiang Normal Univ, Coll Chem & Environm Engn, Shiyan 442000, Peoples R China.;Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
关键词：
Aqueous film-forming foam;Formulation;Short-chain perfluorinated surfactant;Extinguishing time;Burnback time
摘要：
As the essential component(s), long-chain perfluorinated or short-chain perfluorinated ionic surfactants are required for effective aqueous film-forming foam (AFFF); nevertheless, the associated qualities of persistent pollution and toxicity have raised significant concerns. It has become critical to develop alternatives to the present fluorine component for AFFF to offset the negative effects. In this study, a short-chain perfluorinated nitrogen-heterocyclic nonionic amine oxide surfactant was combined with hydrocarbon surfactants and additives to prepare an AFFF concentrate. A laboratory technique was developed to evaluate the influence of ingredients on the performance of a 6% AFFF diluent, resulting in an improved AFFF formulation. The performance parameters for pool fire extinguishment and fire resistance of the AFFF formulation were encouraging, including a spreading coefficient of 5.4, foam expansion of 8.11, 25% drainage time of 4.6 min, extinguishing times for forceful application of 58 s, and fire burnback time of 18.6 min. In addition, the AFFF concentrate showed significant freezing resistance when stored at - 20 & DEG;C for an extended period of time. The formulation outperformed the technical standard criteria and has the potential to be used as a novel AFFF agent. [GRAPHICS]
