天然产物吴茱萸碱一锅法合成的综合实验设计
作者：
吴彦东;佘能芳;周游;吴安心
期刊：
化学教育(中英文) ,2023年44(10):69-76 ISSN：1003-3807
作者机构：
[吴彦东; 佘能芳; 周游; 吴安心] 华中师范大学化学学院
关键词：
吴茱萸碱;一锅法合成;综合化学实验;反应机理
摘要：
结合天然产物全合成的理论知识，设计了从简单易得的底物出发实现吴茱萸碱一锅法合成的综合化学实验。实验过程包括背景文献调研与分析总结、吴茱萸碱一锅法合成、化合物波谱性质表征以及反应机理研究。该综合实验不仅可以培养学生的文献检索、合成操作以及谱图分析等方面的综合能力，而且可以提高学生对有机合成方法学及反应机理研究的理解，提升学生对科学研究逻辑的认知，为将来从事相关科研或实践工作打下基础。
语种：
中文
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师范院校有机化学教学融入课程思政的探索与实践
作者：
张栩晨;佘能芳;刘盛华;余广鳌;陈建;...
期刊：
化学教育(中英文) ,2022年43(10):90-99 ISSN：1003-3807
作者机构：
[张栩晨] 华中师范大学马克思主义学院;[陈建; 余广鳌; 原弘; 佘能芳; 彭浩; 刘盛华; 石德清] 华中师范大学化学学院
关键词：
课程思政;有机化学;探索与实践;师范院校
摘要：
通过有机化学的教学探索与实践,着力构建三维课程思政建设体系,让"课程思政"进课前、驻课中、留课后,挖掘有机化学思政元素、构建课程思政案例库,并在探索与实践中实施教学效果调查、跟踪学生发展、深化反思总结,努力发挥有机化学教学融入课程思政的积极成效,实现通过有机化学专业课程的教与学来达到育人目的,助力培养卓越未来教师.
语种：
中文
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BOPPPS教学模式的教学设计要素分析及案例设计
作者：
姚婉清;佘能芳
期刊：
化学教育(中英文) ,2022年43(18):51-57 ISSN：1003-3807
作者机构：
[姚婉清] 嘉应学院化学与环境学院;[佘能芳] 华中师范大学化学学院
关键词：
有机化学;教学设计;亲核取代
摘要：
BOPPPS教学模式与课堂的5W教学要素有紧密的联系,它强调以学生为中心,将课堂6个教学模块进行分解.研究探讨了 BOPPPS教学模式的教学设计要素涵义及应用策略,结合有机化学课程的双分子亲核取代机理教学设计及其教学效果,说明该模式的具体实施之策.
语种：
中文
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翻转课堂模式在有机化学实验教学中的探索与实践
作者：
佘能芳;曾春锋;张栩晨;曹云凤;张颖颖;...
期刊：
大学化学 ,2021年36(07):109-113 ISSN：1000-8438
作者机构：
华中师范大学化学学院,武汉430079;[张栩晨; 余广鳌; 曾春锋; 张颖颖; 原弘; 佘能芳; 曹云凤] 华中师范大学
关键词：
翻转课堂;有机化学实验;自主学习;课堂参与
摘要：
针对当前有机化学实验课程存在重讲授轻实验、重验证轻探究、重结果轻过程等弊端,学生积极性和主动性受抑制等问题,我们将翻转课堂模式应用于有机化学实验的教学中进行探索和实践。改变课前和课中学习方式,课前通过信息技术手段完成知识传授过程,课中师生研讨完成知识内化过程,将教学模式从"以教为主"转变为"以学为主",提高了学生的学习积极性、课堂参与度,培养了学生的自主学习、团队协作、表达交流等能力。我们发现翻转课堂模式下,学生在实验操作失败率、实验产物收率、实验报告质量、理论考试成绩等实验课程综合能力上获得提高,有机化学实验课程教学质量得到进一步提升。
语种：
中文
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新时代华中师范大学国家级一流化学专业建设的思考与实践
作者：
万坚;邓阳;原弘;佘能芳;龚静鸣;...
期刊：
大学化学 ,2021年36(05):74-80 ISSN：1000-8438
作者机构：
彭浩徐晖王成刚华中师范大学化学学院化学国家级实验教学示范中心(华中师范大学);[邓阳; 万坚; 龚静鸣; 徐晖; 李武客; 原弘; 温丽丽; 李永健; 王成刚; 张文华; 郭能; 佘能芳; 彭浩] 华中师范大学
关键词：
高等师范院校;一流化学专业;专业建设
摘要：
面对新时代高等教育"双一流"建设的浪潮,高等师范院校化学专业必须有自己的特色作为。以华中师范大学化学专业（师范类）建设为例,从人才培养目标、培养方案和课程群的构建,课程的深度教学进化,教学管理新体系与新机制等三方面探讨了新时代国家级一流化学专业建设的相关问题、解决途径和实施方案与成效。
语种：
中文
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有机化学专业课中开展课程思政的探索与实践
作者：
佘能芳;张金兰;任瑞;蒋小妹;曾艳;...
期刊：
大学化学 ,2021年36(03):155-159 ISSN：1000-8438
作者机构：
华中师范大学化学学院,武汉430079;[刘盛华; 蒋小妹; 任瑞; 曾艳; 张金兰; 原弘; 佘能芳] 华中师范大学
关键词：
有机化学;课程思政;资源;挖掘;应用
摘要：
在有机化学专业课程中挖掘思政资源进行课程思政的探索与实践,进而达到传授专业知识并育人的目的。有机化学中的课程思政资源非常丰富,融入点也很多,作者概括为以下四个主要方面,并探索将其应用于有机化学专业教学中课程思政工作的途径:1)辩证唯物主义的呈现和深化;2)爱国情怀的激发和责任担当意识的培养;3)科学素养和创新意识的培养;4)科学发展与社会生活的结合和渗透。
语种：
中文
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Grignard Reagent Utilization Enables a Practical and Scalable Construction of 3-Substituted 5-Chloro-1,6-naphthyridin-4-one Derivatives
作者：
Wang, Ming-Shu;Gong, Yi;Yu, Zhi-Cheng;Tian, Yan-Guang;Zhuo, Lin-Sheng* ;...
期刊：
Molecules ,2020年25(23) ISSN：1420-3049
通讯作者：
Zhuo, Lin-Sheng;Huang, Wei;She, Neng-Fang
作者机构：
[Wang, Ming-Shu; Huang, Wei; Zhuo, Lin-Sheng; Gong, Yi; Yu, Zhi-Cheng; Zhuo, LS; Huang, W; She, Neng-Fang; Tian, Yan-Guang] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Zhuo, LS; Huang, W; She, NF] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
关键词：
6-naphthyridine;Grignard reagent;kinase inhibitor;antitumor drug candidate
摘要：
A robust, practical, and scalable approach for the construction of 3-substituted 5-chloro-1,6-naphthyridin-4-one derivatives 13 via the addition of Grignard reagents to 4-amino-2-chloronicotinonitrile (15) was developed. Starting with various Grignard reagents, a wide range of 3-substituted 5-chloro-1,6-naphthyridin-4-one derivatives 13 were conveniently synthesized in moderate-to-good yields through addition-acidolysis-cyclocondensation. In addition, the robustness and applicability of this synthetic route was proven on a 100 g scale, which would enable convenient sample preparation in the preclinical development of 1,6-naphthyridin-4-one-based MET-targeting antitumor drug candidates.
语种：
英文
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A 2, 7-naphthyridine-based fluorescent turn-on probe for detection of biothiols in vitro and in vivo
作者：
Sun, Qi;Ren, Rui;Wu, Pan-Pan;Zhuo, Lin-Sheng;Dong, Huan;...
期刊：
Dyes and Pigments ,2020年182:108702 ISSN：0143-7208
通讯作者：
She, Neng-Fang
作者机构：
[Ren, Rui; Peng, Hong-Tao; Wu, Pan-Pan; Sun, Qi; Zhuo, Lin-Sheng; Dong, Huan; Cao, Yun-Feng; She, Neng-Fang] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Sun, Qi; Luo, Xiao-Gang] Wuhan Inst Technol, Key Lab Green Chem Proc, Minist Educ, Wuhan 430205, Peoples R China.;[Sun, Qi; Luo, Xiao-Gang] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430205, Peoples R China.;[Luo, Xiao-Gang] Zhengzhou Univ, Sch Mat Sci & Engn, 100 Sci Ave, Zhengzhou 450001, Henan, Peoples R China.
通讯机构：
[She, Neng-Fang] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
关键词：
2,7-Naphthyridine;Bioimaging;Fluorescent probe;GSH;Zebrafish
摘要：
A 2,7-naphthyridine derivative (AND-OH) was used as a fluorophore in the development of a novel fluorescent turn-on probe (AND-DNBS) by introducing a 2,4-dinitrobenzenesulfonate functionality. This fluorescent probe was successfully used for sensing glutathione (GSH) in aqueous media and showed favorable properties such as a rapid response time (45 s) and a significant Stokes shift (227 nm). The characteristics of the developed probe are better than those of another probe, namely ND-DNBS, which was also synthesized by our group and most other previously reported fluorescent probes for GSH. The AND-DNBS probe was able to detect GSH via a red emission in living A549 cells and zebrafishes. These results show that AND-DNBS has potential applications as an excellent probe for detecting GSH in various environments. © 2020 Elsevier Ltd
语种：
英文
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Discovery of N-substituted-3-phenyl-1,6-naphthyridinone derivatives bearing quinoline moiety as selective type II c-Met kinase inhibitors against VEGFR-2
作者：
Xu, Hongchuang;Wang, Minshu;Wu, Fengxu;Zhuo, Linsheng* ;Huang, Wei* ;...
期刊：
Bioorganic & Medicinal Chemistry ,2020年28(12):115555 ISSN：0968-0896
通讯作者：
Zhuo, Linsheng;Huang, Wei;She, Nengfang
作者机构：
[Huang, Wei; She, Nengfang; Zhuo, Linsheng; Wu, Fengxu; Wang, Minshu; Zhuo, LS; Huang, W; She, NF; Xu, Hongchuang] Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, Wuhan 430079, Peoples R China.
通讯机构：
[Zhuo, LS; Huang, W; She, NF] C;Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, Wuhan 430079, Peoples R China.
关键词：
1,6-Naphthyridone;Antitumor efficacy;VEGFR-2 selectivity;c-Met kinase inhibitor
摘要：
New N-substituted-3-phenyl-1,6-naphthyridinone derivatives are designed and synthesized, based on structural modification of our previously reported compound 3. Extensive enzyme-based SAR studies and PK evaluation led to the discovery of compound 4r, with comparable c-Met potency to that of Cabozantinib and high VEGFR-2 selectivity, while Cabozantinib displayed no VEGFR-2 selectivity. More importantly, at oral doses of 45 mg/kg (Q.D.), compound 4r exhibits significant tumor growth inhibition (93%) in a U-87MG human gliobastoma xenograft model. The promising selectivity against VEGFR-2 and excellent tumor growth inhibition of compound 4r suggest that it could be used as a new lead molecule for further discovery of selective type II c-Met inhibitors.
语种：
英文
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Ultrafast 2,7-Naphthyridine-Based fluorescent probe for detection of thiophenol with a remarkable Stokes shift and its application In vitro and in vivo
作者：
Ren, Rui;Xu, Hong-Chuang;Dong, Huan;Peng, Hong-Tao;Wu, Pan-Pan;...
期刊：
Talanta ,2019年205:120067 ISSN：0039-9140
通讯作者：
She, Neng-Fang;Sun, Qi
作者机构：
[Ren, Rui; Peng, Hong-Tao; Wu, Pan-Pan; Dong, Huan; Xu, Hong-Chuang; She, Neng-Fang] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Sun, Qi; Qiu, Yuan] Wuhan Inst Technol, Minist Educ, Key Lab Green Chem Proc, Wuhan 430205, Hubei, Peoples R China.;[Sun, Qi; Qiu, Yuan] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430205, Hubei, Peoples R China.;[Yan, Sheng-Gang] Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang 550025, Guizhou, Peoples R China.
通讯机构：
[She, Neng-Fang] C;[Sun, Qi] W;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;Wuhan Inst Technol, Minist Educ, Key Lab Green Chem Proc, Wuhan 430205, Hubei, Peoples R China.;Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430205, Hubei, Peoples R China.
关键词：
2,7-Naphthyridine;Bioimaging;Fluorescent probe;Theoretical calculation;Zebrafish
摘要：
2,7-Naphthyridine derivatives were developed as fluorophores for the first time to design two fluorescence probes, AND-DNP and ND-DNP, which can be applied for detecting thiophenol in aqueous media. Comparing with ND-DNP, AND-DNP showed more favorable properties such as lower background, larger Stokes shift, and higher fluorescence quantum yield for detecting thiophenol. Moreover, the experimental results were verified by theoretical calculations. Hence, AND-DNP was selected as the superior fluorescence probe to detect thiophenol because of its high sensitivity and selectivity. Based on the experimental results, AND-DNP showed a remarkably larger Stokes shift (225nm), faster response speed (30s) and higher fluorescence enhancement (240-fold) than most other fluorescent probes for thiophenol reported in the literature. For an extended application, AND-DNP was applied to detect thiophenol quantitatively in real water samples. Meanwhile, AND-DNP also detected thiophenol via red emission in living A549cells and zebrafish. All these results proved AND-DNP's potential value as an accurate probe for imaging thiophenol in different environments.
语种：
英文
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Discovery of 8-Amino-Substituted 2-Phenyl-2,7-Naphthyridinone Derivatives as New c-Kit/VEGFR-2 Kinase Inhibitors
作者：
Sun, Haiyan* ;Zhuo, Linsheng;Dong, Huan;Huang, Wei* ;She, Nengfang*
期刊：
Molecules ,2019年24(24) ISSN：1420-3049
通讯作者：
Sun, Haiyan;Huang, Wei;She, Nengfang
作者机构：
[Sun, Haiyan] Nanjing Polytech Inst, Nanjing 210048, Peoples R China.;[Huang, Wei; She, NF; She, Nengfang; Zhuo, Linsheng; Dong, Huan] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Sun, Haiyan] N;[Huang, W; She, NF] C;Nanjing Polytech Inst, Nanjing 210048, Peoples R China.;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
关键词：
2,7-naphthyridone;C-Kit;Kinase inhibitor;VEGFR-2
摘要：
The 2,7-naphthyridone scaffold has been proposed as a novel lead structure ofMETinhibitors by our group. To broaden the application of this new scaffold, a series of 8-amino-substituted 2-phenyl-2,7-naphthyridin-1(2H)-one derivatives were designed and synthesized. Preliminary biological screening resulted in the discovery of a new lead of c-Kit and VEGFR-2 kinase inhibitors. Compound 9k exhibited excellent c-Kit inhibitory activity, with an IC50 value of 8.5 nM, i.e., it is 38.8-fold more potent than compound 3 (IC50 of 329.6 nM). Moreover, the compounds 10l and 10r exhibited good VEGFR-2 inhibitory activity, with IC50 values of 56.5 and 31.7 nM, respectively, i.e., they are 5.0-8.8-fold more potent than compound 3 (IC50 of 279.9 nM). Molecular docking experiments provided further insight into the binding interactions of the new lead compounds with c-Kit and VEGFR-2 kinase. In this study, an 8-amino-substituted 2-phenyl-2,7-naphthyridin-1(2H)-one scaffold was identified as the new lead structure of c-Kit and VEGFR-2 kinase inhibitors. © 2019 by the authors.
语种：
英文
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Frontispiece: Glycoluril‐Derived Molecular Clips are Potent and Selective Receptors for Cationic Dyes in Water
作者：
Nengfang She;Damien Moncelet;Laura Gilberg;Xiaoyong Lu;Vladimir Sindelar;...
期刊：
Chemistry – A European Journal ,2016年22(43):- ISSN：1521-3765
作者机构：
Key Laboratory of Pesticide and Chemical Biology Ministry of Education College of Chemistry Central China Normal University Wuhan 430079 P. R. China<&wdkj&>Department of Chemistry and Biochemistry University of Maryland College Park MD 20742 USA<&wdkj&>Department of Cell Biology and Molecular Genetics University of Maryland College Park MD 20742 USA<&wdkj&>Department of Chemistry and RECETOX Masaryk University, Kamenice 5 625 00 Brno Czech Republic
关键词：
cation–π interactions;dyes;glycoluril;hydrophobic effects;molecular clip
语种：
中文
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Phenyl substituted indenylphosphine ruthenium complexes as catalysts for dehydrogenation of alcohols
作者：
Yuan, Jia;Sun, Yue;Yu, Guang-Ao* ;Zhao, Cui;She, Neng-Fang;...
期刊：
DALTON TRANSACTIONS ,2012年41(34):10309-10316 ISSN：1477-9226
通讯作者：
Yu, Guang-Ao
作者机构：
[Sun, Yue; Han, Zhi-Jun; Yuan, Jia; Yin, Jun; Yu, Guang-Ao; Zhao, Cui; Liu, Sheng-Hua; Huang, Peng-Shou] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[She, Neng-Fang] Nankai Univ, State Key Lab Elementoorgan Chem, Dept Chem, Tianjin 300071, Peoples R China.;[Mao, Shu-Lan] Hubei Univ, Minist Educ, Key Lab Green Preparat & Applicat Funct Mat, Wuhan 430062, Peoples R China.
通讯机构：
[Yu, Guang-Ao] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
Thermal treatment of (1H-inden-3-yl)dicyclohexylphosphinium tetrafluoroborate (1) and (3-mesityl-1H-inden-3-yl)dicyclohexylphosphinium tetrafluoroborate (3) with tBuONa followed by [(η 6-cymene) RuCl 2)] 2 in methanol gave the adduct {(η 6- cymene)RuCl 2[(1H-inden-3-yl)PCy 2]} (6) and {(η 6-cymene)RuCl 2[(3-mesityl-1H-inden-3-yl)PCy 2]} (7), respectively. Thermal treatment of (2-phenyl-1H-inden-3-yl) dicyclohexylphosphinium tetrafluoroborate (4) with tBuONa followed by [(η 6-cymene)RuCl 2)] 2 or RuCl 3·3H 2O in methanol gave {Ru[κ(P): (η 6-2-phenyl-1H-inden-3-yl)PCy 2]Cl 2} (8). Whereas (2-mesityl-1H-inden-3-yl)dicyclohexylphosphine (5) reacted with [(η 6-cymene)RuCl 2)] 2 (in toluene) or RuCl 3·3H 2O (in ethanol) to afford {Ru[κ(P):(η 6-2-mesityl-1H-inden-3-yl)PCy 2]Cl 2} (9). The molecular structures of complexes 6, 8 and 9 have been determined by single-crystal X-ray diffraction analysis. In addition, complexes 8 and 9 have been found to catalyze the acceptorless dehydrogenation of alcohols in toluene. 9 displayed high activity and different substrates, including cyclic and linear alcohols, were efficiently oxidized to ketones by using 2.0 mol% of catalyst. © 2012 The Royal Society of Chemistry.
语种：
英文
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Novel Fluorescent Molecular Sensor For Fe3+
作者：
李琳;费转;蔡群;佘能芳;吴安心
作者机构：
[李琳; 费转; 蔡群; 佘能芳; 吴安心] Key Laboratory of Pesticide & Chemical Biology,Ministry of Education,Central China Normal University
会议名称：
大环化学和超分子化学的新发展——当前学科交叉的一个重要桥梁——中国化学会全国第十五届大环化学暨第七届超分子化学学术讨论会
会议时间：
2010-10-15
会议地点：
中国重庆
摘要：
<正>Iron is an important element for human life.Abnormal level of iron could be related to some serious diseases.Because of iron’s essential yet toxic nature,it is necessary to develop accurate and rap
语种：
英文
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Two-dimensional hydrogen-bonded networks in two novel glycoluril derivatives
作者：
Cao, Li-Ping* ;Meng, Xiang-Gao;Gao, Meng;She, Neng-Fang;Wu, An-Xin
期刊：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY ,2008年64(2):o69-o72 ISSN：2053-2296
通讯作者：
Cao, Li-Ping
作者机构：
[Cao, Li-Ping; Gao, Meng; Wu, An-Xin; Meng, Xiang-Gao; She, Neng-Fang] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Cao, Li-Ping] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
Two new glycoluril derivatives, namely diethyl 6-ethyl-1,4-dioxo-1,2,2a,3, 4,6,7,7b-octa-hydro-5H-2,3,4a,6,7a-penta-aza-cyclo-penta-[cd]indene-2a, 7b-dicarboxyl-ate, C<inf>14</inf>H<inf>21</inf>N<inf>5</inf>O<inf>6</inf>, (I), and 6-ethyl-2a,7b-diphenyl-1,2,2a,3,4,6,7,7b-octa-hydro-5H-2,3,4a,6,7a-penta- azacyclo-penta-[cd]indene-1,4-dione, C<inf>20</inf>H<inf>21</inf>N <inf>5</inf>O<inf>2</inf>, (II), both bearing two free syn-urea NH groups and two ureidyl C=O groups, assemble the same one-dimensional chains in the solid state running parallel to the [010] direction via N - H&mellip;O hydrogen bonds. Furthermore, the chains of (I) are linked together into two-dimensional networks via C - H&mellip;O hydrogen bonds. ©2008 International Union of Crystallography.
语种：
英文
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Diethyl cis-4,8-dioxo-3,4,7,8-tetra-hydro-1H,5H-2,6-dioxa-3a,4a,7a,8a- tetra-azacyclo-penta-[def]fluorene-8b,8c-dicarboxyl-ate
作者：
She, Neng-Fang* ;Xi, Hai-Ling
期刊：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY ,2007年63(8):O3495-U3360 ISSN：2053-2296
通讯作者：
She, Neng-Fang
作者机构：
[She, Neng-Fang] Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol Minist Educ, Wuhan 430079, Peoples R China.;Res Inst Chem Def, Beijing 102205, Peoples R China.
通讯机构：
[She, Neng-Fang] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol Minist Educ, Wuhan 430079, Peoples R China.
摘要：
The title compound, C14H18N4O8, is a glycoluril derivative, composed of two five-membered rings in envelope conformations and two six-membered rings in chair conformations. In the crystal structure, inter-molecular C - H⋯O hydrogen bonds link the mol-ecules into a three-dimensional network. One methyl group and the H atoms on the adjacent C atom are disordered over two positions; the site-occupancy factors are ca 0.62 and 0.38. © International Union of Crystallography 2007.
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英文
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Synthesis, structural characterization, and fluorescent chemosensory properties of novel molecular clips based on diethoxycarbonyl glycoluril
作者：
Hu, Sheng-Li;She, Neng-Fang;Yin, Guo-Dong;Guo, Hui-Zhen;Wu, An-Xin;...
期刊：
Tetrahedron Letters ,2007年48(9):1591-1594 ISSN：0040-4039
通讯作者：
Yang, Chu-Luo
作者机构：
[Yang, Chu-Luo] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China.;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Yang, Chu-Luo] W;Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China.
关键词：
Diethoxycarbonyl glycoluril;Molecular clip;Fe(III);Fluorescent chemosensor
摘要：
A pair of novel fluorescent molecular clips was synthesized from diethoxycarbonal glycoluril cyclic ether and 1,2-dihydroindazol-3-one. Their structures and conformations were confirmed by single crystal X-ray diffraction and chemosensory properties were studied by fluorescent spectroscope. Both of them exhibited selective recognition toward Fe3+ over other metal ions examined in DMF/CH3OH (50:1, v/v). (c) 2007 Elsevier Ltd. All rights reserved.
语种：
英文
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(13bR, 13cS)-rel-11b, 11c-Diphenyl-6, 11-dihydro-1H,3H,4H,13H-2-oxa-3a,4a, 5a,11a,12a,13a-hexaazabenz[f]indeno[2,1,8-ija]naphth[2,3-f]azulene-4,6,11, 13-tetrone chloroform solvate
作者：
Hu, Sheng-li* ;Guo, Hui-Zhen;She, Neng-Fang
期刊：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY ,2006年62(7):o2945-o2946 ISSN：2053-2296
通讯作者：
Hu, Sheng-li
作者机构：
[Hu, Sheng-li] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Peoples R China.;Hubei Normal Univ, Dept Environm Chem & Engn, Huangshi 435002, Peoples R China.
通讯机构：
[Hu, Sheng-li] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
The crystal structure of the title compound, C28H 22N6O5·-CHCl3, an important intermediate for molecular tweezers, shows intermolecular hydrogen bonding. © 2006 International Union of Crystallography. All rights reserved.
语种：
英文
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1,2,4,5-Tetrakis(bromomethyl)benzene
作者：
Wang, Zhi-Guo* ;Wang, Yu-Zhou;She, Neng-Fang;Gao, Meng
期刊：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY ,2006年62(11):o5106-o5107 ISSN：2053-2296
通讯作者：
Wang, Zhi-Guo
作者机构：
[Wang, Zhi-Guo; Gao, Meng; She, Neng-Fang; Wang, Yu-Zhou] Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticides & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Wang, Zhi-Guo] C;Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticides & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
The title molecule, C10H10Br4, lies on a crystallographic inversion center which is located at the center of the benzene ring. The crystal structure is stabilized by intermolecular Br⋯Br and C—H⋯Br interactions.
语种：
英文
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拥有多π功能团的新型分子夹受体
作者：
佘能芳;郭慧珍;李义涛;吴安心
作者机构：
[佘能芳; 郭慧珍; 李义涛; 吴安心] 华中师范大学化学学院农药与化学生物学教育部重点实验室
会议名称：
中国化学会第四届有机化学学术会议
会议时间：
2005-08
会议地点：
中国云南昆明
摘要：
<正>在超分子化学研究中,设计并合成一些能键合中性客体分子的主体分子一直是人们关注的热点．Nolte等小组自1987年来报道了一系列衍生于甘脲的夹状主体分子,它们可以通过氢键,π-π堆积等弱相互作用键合一些芳香客体,这些分子夹受体多数都是通过甘脲衍生物与边墙分子反应得到．这里,我们报道了一种新型的分子夹受体3,直接利用酯基甘脲与边墙分子1一步合成得到分子夹2,分子夹2再与苯炔通过Sonogashi
语种：
中文
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