作者机构：
[Li, Guang; Xu, Weiwei; Hameed, Muhammad Salman; Yang, Qinglin; Li, Haibing; Qu, Haonan] Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Quan, Jiaxin; Quan, JX] Hanjiang Normal Univ, Dept Chem Biol & Environm Engn, Shiyan 442000, Peoples R China.;[Zhang, J; Zhang, Jin] Yunnan Normal Univ, Coll Chem & Chem Engn, Kunming 650092, Peoples R China.;[Sun, Zhongyue] Hubei Univ Chinese Med, Sch Lab Med, Wuhan 430065, Peoples R China.
通讯机构：
[Quan, JX ; Sun, ZY ] H;[Li, HB ] C;[Zhang, J ] Y;Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;Hanjiang Normal Univ, Dept Chem Biol & Environm Engn, Shiyan 442000, Peoples R China.
关键词：
arginine;biomimetic;mimic Cyt C transport;nanochannel;pH
摘要：
Proteins are vital components in cells, biological tissues, and organs, playing a pivotal role in growth and developmental processes in living organisms. Cytochrome C (Cyt C) is a class of heme proteins found in almost all life and is involved in cellular energy metabolic processes such as respiration, mainly as electron carriers or terminal reductases. It binds cardiolipin in the inner mitochondrial membrane, leading to apoptosis. It is a challenge to design a simple and effective artificial system to mimic the complex Cyt C biological transport process. In this paper, an asymmetric biomimetic pH-driven protein gate is described by introducing arginine (Arg) at one end of an hourglass-shaped nanochannel. The nanochannel shows a sensitive protonation-driven protein gate that can be "off" at pH = 7 and "on" at pH = 2. Further studies show that differences in the binding of Arg and Cyt C at different levels of protonation lead to different switching behaviors within the nanochannels, which in turn lead to different surface charges within the nanochannels. It can be used for detecting Cyt C and as an excellent and robust gate for developing integrated circuits and nanoelectronic logic devices.
期刊：
CHEMISTRY-A EUROPEAN JOURNAL,2024年30(18):e202303742 ISSN：0947-6539
通讯作者：
Li, HB
作者机构：
[Chen, Chunxiu; Li, Guang; Xu, Weiwei; Cai, Meng; Li, Haibing; Ma, Cuiguang; Li, HB; Zhang, Haifan; Noruzi, Ehsan Bahojb; Qu, Haonan] Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Li, Haibing; Li, HB] Guangxi Univ, State Key Lab Featured MetaMat & Life Cycle Safety, Nanning 530004, Peoples R China.;[Wang, Miao] Xiamen Univ, Coll Mat, Xiamen 361005, Peoples R China.;[Hou, Xu] Xiamen Univ, Coll Chem & Chem Engn, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China.
通讯机构：
[Li, HB ] C;Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;Guangxi Univ, State Key Lab Featured MetaMat & Life Cycle Safety, Nanning 530004, Peoples R China.
摘要：
Excess fluoride ions in groundwater accumulate through the roots of crops, affecting photosynthesis and inhibiting their growth. Long-term bioaccumulation also threatens human health because it is poorly degradable and toxic. Currently, one of the biggest challenges is developing a unique material that can efficiently remove fluoride ions from the environment. The excellent properties of functionalized pillar[5]arene polymer-filled nanochannel membranes were explored to address this challenge. Constructing a multistage porous nanochannel membrane, consisting of microscale etched nanochannels and nanoscale pillar[5]arene cross-linked polymer voids. A fluoride removal rate of 0.0088 mmol & sdot; L-1 & sdot; min-1 was achieved. Notably, this rate surpassed the rates observed with other control ions by a factor of 6 to 8.8. Our research provides a new direction for developing water fluoride ion removal materials. Fluoride contamination of groundwater has become one of the most serious problems in the world. Currently, excessive absorption of fluoride can be toxic to humans and crops. To address the challenge, we explored the excellent properties of functionalized pillar[5]arene polymer framework. By constructing a multistage porous nanochannel membrane, the pillar[5]arene polymer-filled nanochannel membrane achieves a fluoride removal. image
期刊：
CHEMISTRY OF MATERIALS,2024年36(4):1975-1981 ISSN：0897-4756
通讯作者：
Cheng, Jing;Li, HB
作者机构：
[Cheng, Jing; Li, Guang; Xu, Weiwei; Li, Haibing; Ma, Cuiguang; Li, HB; He, Qiang; Zhang, Haifan; Qu, Haonan] Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
通讯机构：
[Cheng, J; Li, HB ] C;Cent China Normal Univ, Coll Chem, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
摘要：
Chiral fungicides have been widely used for disease control in agricultural cultivation due to their advantages of high efficiency, low toxicity, high selectivity, and low residue. However, the enantiomers of chiral fungicides in the chiral environment often exhibit different physiological and biochemical properties and sometimes even diametrically opposite effects. This work modified the chiral alanine-functionalized pillar[5]arene within PET nanochannels. The binary hybridized nanochannel exhibits high selectivity for the chiral fungicide Propranolol, with a selectivity coefficient of 7.36, which is seven times higher than that of the LAP[5] nanochannel membrane. The mechanism of chiral selectivity was explored by COMSOL finite element simulation, which proves the high selectivity of the binary hybrid nanochannel originated from the high surface charge density of the nanochannel. This study provides a novel and effective method for the selective enrichment and release of chiral pesticides in green agriculture.
摘要：
In an effort to make pesticide use safer, more efficient, and sustainable, micro-/nanocarriers are increasingly being utilized in agriculture to deliver pesticide-active agents, thereby reducing quantities and improving effectiveness. In the use of nanopesticides, the choice to further design and prepare pesticide stimulus-responsive nanocarriers based on changes in the plant growth environment (light, temperature, pH, enzymes, etc.) has received more and more attention from researchers. Based on this, this paper examines recent advancements in nanomaterials for the design of stimulus-responsive micro-/nanocarriers. It delves into the intricacies of preparation methods, material enhancements, in vivo/ex vivo controlled release, and application techniques for controlled release formulations. The aim is to provide a crucial reference for harnessing nanotechnology to pursue reduced pesticide use and increased efficiency.
摘要：
Achieving fast transmembrane transmission of molecules in organisms is a challenging problem. Inspired by the transport of Dopmine (DA) in organisms, the DA transporter (DAT) binds to DA in a way that has a ring recognition (the recognition group is the tryptophan group). Herein, D-Tryptophan-pillar[5]arene (D-Trp-P5) functionalized conical nanochannel is constructed to achieve fast transmission of DA. The D-Trp-P5 functionalized nanochannel enables specific wettability recognition of DA molecules and has great cycle stability. With the controlling of voltage to wettability, the transport flux of DA is up to 499.73 nmol cm(-2) h(-1) at -6 V, 16.88 times higher than that under positive voltages. In response to these results, a high-throughput DA transport device based on controlled electricity-wettability is provided.
摘要：
In living organisms, chiral molecules have specific chiral conformations that produce different physiological effects. Ribose is one of the components of RNA, which mainly plays a role in regulating biological activity. Inspired by the biological recognition of sugars, functional chiral surfaces for recognizing L-ribose through non-covalent interactions were constructed. In the strategy of this study, a functional chiral gold surface based on host-guest interactions was constructed through the assembly of the host molecule single-function alynyl pillar[5]arene(SAP5) and the guest molecule (S) -mandelate-violet (SMV). The association constant of SMV and SAP5 was calculated to be 2.95×10(4)M(-1), with a binding ratio of 1:1. By impedance and contact angle detection, the constructed functional interface has good detection effect on L-ribose in the range of 1×10(-7)M to1×10(-2)M. In addition, CV was disassembled from the aromatic cavity of pillar[5]arene after adding zinc powder and it can repeat five times with good recyclability, thus achieving the organic combination of interface recognition and intelligence.
摘要：
Inspired by ion pair cotransport channels in biological systems, a bionic nanochannel modified with lithium ion pair receptors is constructed for selective transport and enrichment of lithium ions (Li(+)). NH(2)-pillar[5]arene (NP5) is chosen as ion pair receptors, and the theoretical simulation and NMR titration experiments illustrate that NP5 has good affinity for the ion pair of LiCl through a strong host-guest interaction at the molecular level. Due to the confinement effect and ion pair cooperation recognition, an NP5-based receptor was introduced into an artificial PET nanochannel. An I-V test indicated that the NP5 channel realized the highly selective recognition for Li(+). Meanwhile, transmembrane transport and COMSOL simulation experiments proved that the NP5 channel achieved the transport and enrichment of Li(+) through the cooperative interaction between NP5 and LiCl. Moreover, the receptor solution of transmembrane transport LiCl in the NP5 channel was used to cultivate wheat seedlings, which obviously promoted their growth. This nanochannel based on the ion pair recognition will be much useful for practical applications like metal ion extraction, enrichment, and recycle.
期刊：
ACS Agricultural Science and Technology,2023年3(2):158-164 ISSN：2692-1952
通讯作者：
Haibing Li
作者机构：
[Huijuan Zhang; Siyun Zhang; Guang Li; Haonan Qu; Weiwei Xu; Qianqian Song; Haibing Li] Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan430079, P. R. China
通讯机构：
[Haibing Li] K;Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan430079, P. R. China
期刊：
ACS Agricultural Science and Technology,2023年3(11):1025–1033 ISSN：2692-1952
通讯作者：
Junkai Ma<&wdkj&>Jing Cheng<&wdkj&>Haibing Li
作者机构：
[Dalia A. Barakat] Department of Economic Entomology and Pesticides Faculty of Agriculture, Cairo University, Giza 12411, Egypt;[Seid Mahdi Jafari] Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Science and Natural Resources, Gorgan 49165, Iran;[Junkai Ma] Hubei Key Laboratory of Wudang Local Chinese Medicine Research (Hubei University of Medicine), Department of Chemistry, School of Pharmacy Hubei University of Medicine, Shiyan 442000, Hubei Province, China;[Elena G. Kovaleva] Department of Technology for Organic Synthesis, Ural Federal University, Mira Street, 28, 620002 Yekaterinburg, Russia;[Siwan Wu; Guang Li; Haonan Qu; Weiwei Xu; Yuan Xu; Jing Cheng; Haibing Li] National Key Laboratory of Green Pesticide (CCNU), College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
通讯机构：
[Junkai Ma] H;[Jing Cheng; Haibing Li] N;Hubei Key Laboratory of Wudang Local Chinese Medicine Research (Hubei University of Medicine), Department of Chemistry, School of Pharmacy Hubei University of Medicine, Shiyan 442000, Hubei Province, China<&wdkj&>National Key Laboratory of Green Pesticide (CCNU), College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
关键词：
nanoemulsion;anise oil;wetting and spreading;antifungal
摘要：
As an alternative to synthetic pesticides, essential oils can be used to treat various diseases that affect food safety, such as soybean sheath blight, which poses fewer health and environmental risks. However, conventional formulations, such as emulsions, often bounce, drift, and splash, which results in low pesticide utilization. The splashing phenomenon is especially serious on the hydrophobic soybean leaf surface, leading to the ineffective utilization of pesticide formulations. To this end, our goal is to develop a formulation with exceptional wetting and spreading properties on hydrophobic soybean leaf surfaces by using nanotechnology. We have successfully constructed anise oil nanoemulsions (AO NEs) as an alternative to conventional emulsion formulations. Anise oil microemulsion and anise oil submicroemulsion were selected as control groups to study the spreading performance of emulsions with different sizes. With smaller particle sizes, AO NE exhibited significantly improved wetting and spreading characteristics on the hydrophobic surface of soybean leaves. It also demonstrated excellent inhibition against the pathogen Rhizoctonia solani. AO NE effectively addresses the rebound and spatter problems of traditional emulsions without the addition of extra additives. The agricultural applications of nanoemulsions for delivering essential oils have great potential to increase pesticide utilization.
摘要：
The conspicuous surface activity and exceptional chemical stability of perfluorooctanoic acid, commonly referred to as PFOA, have led to its extensive utilization across a broad spectrum of industrial and commercial products. Nonetheless, significant concerns have arisen regarding the environmental presence of PFOAs, driven by their recognized persistence, bioaccumulative nature, and potential human health risks. In the realm of sustainable agriculture, a pivotal challenge revolves around the development of specialized materials capable of effectively and selectively eliminating PFOA from the environment. This study proposes harnessing the exceptional properties of a pillar[5]arene polymer to construct a nanochannel membrane filled with tryptophan-alanine dipeptide pillar[5]arene polymer. Through the functionalization of these nanochannel membranes, we achieved a PFOA removal rate of 0.01 mmol L-1 min(-1), surpassing the rates observed with other control chemicals by a factor of 4.5-15. The research on PFOA removal materials has been boosted because of the creation of this highly selective PFOA removal membrane.
通讯作者：
Siyun Zhang<&wdkj&>Yue Sun<&wdkj&>Haibing Li<&wdkj&>Siyun Zhang Siyun Zhang Siyun Zhang<&wdkj&>Yue Sun Yue Sun Yue Sun<&wdkj&>Haibing Li Haibing Li Haibing Li
作者机构：
[Yang, Lei; Li, Haibing] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.;[Sun, Zhongyue] Hubei Univ Chinese Med, Sch Lab Med, Wuhan 430065, Peoples R China.;[Zhang, Siyun] North China Univ Sci & Technol, Coll Chem Engn, Tangshan 063210, Peoples R China.;[Sun, Yue] Tiangong Univ, Sch Chem, State Key Lab Separat Membrane & Membrane Proc, Tianjin 300387, Peoples R China.
通讯机构：
[Siyun Zhang; Yue Sun; Siyun Zhang Siyun Zhang Siyun Zhang; Yue Sun Yue Sun Yue Sun] S;[Haibing Li; Haibing Li Haibing Li Haibing Li] K;School of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, 430065 P. R. China<&wdkj&>State Key Laboratory of Separation Membrane and Membrane Process, School of Chemistry, Tiangong University, Tianjin, 300387 P. R. China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079 P. R. China<&wdkj&>State Key Laboratory of Separation Membrane and Membrane Process, School of Chemistry, Tiangong University, Tianjin, 300387 P. R. China
摘要：
The precise regulation of chiral drug transmembrane transport can be achieved through drug transporters in living organisms. However, implementing this process in vitro is still a formidable challenge due to the complexity of the biological systems that control drug enantiomeric transport. Herein, a facile and feasible strategy is employed to construct chiral L-tyrosine-modified nanochannels (L-Tyr nanochannels) based on polyethylene terephthalate film, which could enhance the chiral recognition of propranolol isomers (R-/S-PPL) for transmembrane transport. Moreover, conventional fluorescence spectroscopy, patch-clamp technology, laser scanning confocal microscopy, and picoammeter technology are employed to evaluate the performance of nanochannels. The results show that the L-Tyr nanochannel have better chiral selectivity for R-/S-PPL compared with the L-tryptophan (L-Trp) channel, and the chiral selectivity coefficient is improved by about 4.21-fold. Finally, a detailed theoretical analysis of the chirality selectivity mechanism is carried out. The findings would not only enrich the basic theory research related to chiral drug transmembrane transport, but also provide a new idea for constructing artificial channels to separate chiral drugs.
作者机构：
[Zhisheng Liu; Weiwei Xu; Jing Cheng; Haibing Li] Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University(CCNU), Wuhan, 430079, PR China;[Elena G. Kovaleva] Department of Technology for Organic Synthesis, Institute of Chemical Engineering, Ural Federal University(UrFU), Yekaterinburg, 620002, Russia
摘要：
In the context of the continuous increase in global grain production, accompanied by a large amount of investment in various pesticides, herbicides, fungicides, and other chemical pesticides. It has caused inevitable environmental problems and food safety problems. Current research suggests that the use of cyclodextrins and their derivatives to protect pesticides can significantly reduce the number of agrochemicals that pollute the environment. Using the cavity properties of cyclodextrins, we can refer to the similar way in which drug molecules make cyclodextrins and cyclodextrin polymers to form inclusion compounds. Overall, β-cyclodextrin and its derivatives are used as a new pesticide excipient to improve the stability of pesticides, prevent their oxidation and decomposition, improve the solubility and bioavailability of pesticides, reduce the toxic side effects of drugs, and mask the odour of drugs. In this review, we focus on summarising the recent research progress of β-cyclodextrins and their derivatives in pesticides and other fields, and provide a systematic classification of β-cyclodextrin polymers, as well as new synthesis methods and techniques in various applications. Finally, the future development of cyclodextrin-like polymers is foreseen, and issues arising from the research are discussed and addressed in depth.
作者机构：
[Yang, Lei; Li, Haibing] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China.;[Zhang, Fan] Hubei Univ, Hubei Collaborat Innovat Ctr Adv Organ Chem Mat, Minist Educ, Key Lab Synth & Applicat Organ Funct Mol,Coll Che, Wuhan 430062, Peoples R China.;[Quan, Jiaxin] Hanjiang Normal Univ, Coll Chem & Environm Engn, Shi Yan 432200, Peoples R China.;[Li, Jia] South Cent Minzu Univ, Coll Resources & Environm Sci, Wuhan 430074, Peoples R China.
通讯机构：
[Prof. Jia Li; Prof. Jia Li Prof. Jia Li Prof. Jia Li] C;[Prof. Dr. Haibing Li; Prof. Dr. Haibing Li Prof. Dr. Haibing Li Prof. Dr. Haibing Li] K;Key Laboratory of Pesticide and Chemical Biology (CCNU) Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079 P. R. China<&wdkj&>College of Resources and Environmental Science, South-Central Minzu University, Wuhan, 430074 P. R. China
作者机构：
[Li, Haibing; Qu, Haonan; Zhang, Siyun] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.;[Qu, Yanquan; Lu, Mingxiang] Tradit Chinese Med Hosp Wuxue, Dept Radiol, Huanggang 438200, Hubei, Peoples R China.;[Qu, Yanquan; Lu, Zhiyan] Wuhan Univ, Zhongnan Hosp, Dept Radiol, Wuhan 430071, Hubei, Peoples R China.;[Zhou, Juan; Li, Haibing] Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, State Key Lab Virol, Wuhan 430071, Peoples R China.;[Li, Haibing; Lu, Mingxiang] Wuhan Univ, Zhongnan Hosp, Dept Forens Med, Wuhan 430071, Peoples R China.
通讯机构：
[Zhiyan Lu] D;[Juan Zhou] S;[Haibing Li] K;State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, P. R. China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China<&wdkj&>Department of Forensic Medicine, Zhongnan Hospital of Wuhan University, No.169 East Lake Road, Wuchang District, Wuhan 430071, P. R. China<&wdkj&>Department of Forensic Medicine, Zhongnan Hospital of Wuhan University, No.169 East Lake Road, Wuchang District, Wuhan 430071, P. R. China
关键词：
pillar[5]arenes;sub-nanoporous;proton;selective;unidirectional transport
作者机构：
[Wang, Li; Li, Haibing; Feng, Fudan; Cheng, Jing; Zhu, Fei] Cent China Normal Univ CCNU, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Zhou, Juan] Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, State Key Lab Virol, R China, Wuhan 430071, Peoples R China.;[Zhu, Fei] Hubei Univ Med, Sch Basic Med Sci, Dept Pharmacol, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Hubei, Peoples R China.;[Trautmann, Christina; Toimil-Molares, Maria Eugenia] GSI Helmholtzzentrum Schwerionenforsch, D-64291 Darmstadt, Germany.;[Trautmann, Christina] Tech Univ Darmstadt, D-64287 Darmstadt, Germany.
通讯机构：
[Juan Zhou] S;[Jing Cheng] K;State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, P. R. China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (CCNU), Wuhan 430079, P. R. China
通讯机构：
[Jing Cheng; Haibing Li] S;State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
通讯机构：
[Cheng, J; Li, HB ] C;[Liang, F ] W;Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, State Key Lab Refractories & Met, Wuhan 430081, Peoples R China.;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticide & Chem Biol CCNU,Minist Educ,Ch, Wuhan 430079, Peoples R China.
摘要：
Chirality is an important property, especially for chiral drug enantiomers with huge differences in pharmacology and toxicity. Chiral recognition of drug enantiomers is the first step to understanding the physiological phenomenon and ensuring medical safety. To efficiently identify and isolate these chiral drugs, we prepared a nanochannel. Here, a chiral sensor was fabricated by introducing the host-guest system of pillar[5]arene (WAP5) and phenethylamine into solid-state nanochannels. The chiral guest R-phenethylamine (R-PEA) induced the chirality of the host-guest system and amplified the chiral selectivity for ibuprofen enantiomers in the host-guest-based nanochannels, which was significantly greater than that in the aqueous phase or the R-PEA modified nanochannels. This study provides a strategy to fabricate highly enantioselective nanosensors for chiral drugs.
期刊：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2022年70(40):12746–12759 ISSN：0021-8561
通讯作者：
Jia Li<&wdkj&>Juan Zhou<&wdkj&>Jing Cheng<&wdkj&>Haibing Li
作者机构：
[Li, Wenjie; Xu, Weiwei; Li, Haibing; Cheng, Jing; Zhang, Siyun; Tian, Demei] Cent China Normal Univ CCNU, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Li, Jia; Zhou, Juan] South Cent Minzu Univ, Coll Resources & Environm Sci, Wuhan 430074, Peoples R China.;[Zhou, Juan] Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, State Key Lab Virol, Wuhan 430071, Peoples R China.
通讯机构：
[Jia Li] C;[Juan Zhou] S;[Jing Cheng; Haibing Li] K;Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (CCNU), Wuhan, 430079, PR China<&wdkj&>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, PR China<&wdkj&>College of Resources and Environmental Science, South-Central Minzu University, Wuhan 430074, PR China
摘要：
Traditional drugs have the disadvantages of poor permeability and low solubility, which makes the utilization of pesticides lower and brings many side effects. With the continuous development of supramolecular chemistry in recent years, it has also played an irreplaceable role in the field of pharmaceutical science. Supramolecular macrocycles, such as crown ethers, cyclodextrins, calixarenes, pillararenes and cucurbiturils, are potentially good candidates for drug carriers due to their biocompatibility, hydrophobic cavity and ease of derivatization. The encapsulation of drugs based on host-guest interaction has the advantage of being adjustable and reversible as well as improving the low availability of drugs. Here, the recent advances in methods and strategies for drug encapsulation and release based on supramolecular macrocycles with host-guest interactions have been systematically summarized, laying a bright foundation for the development of novel nanopesticide preparations in the future and pointing out future directions of novel biopesticide research.
期刊：
CHEMISTRY-AN ASIAN JOURNAL,2022年17(14):e202200455- ISSN：1861-4728
通讯作者：
Li, Haibing(lhbing@mail.ccnu.edu.cn)
作者机构：
[Chen, Chunxiu; Yang, Lei; Liu, Zhisheng; Li, Haibing; Liu, Lu] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.;[Zhang, Fan] Hubei Univ, Hubei Collaborat Innovat Ctr Adv Organ Chem Mat, Coll Chem & Chem Engn, Minist Educ,Key Lab Synth & Applicat Organ Funct, Wuhan 430062, Peoples R China.
通讯机构：
[Prof. Haibing Li] K;Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079 P. R. China
关键词：
BSA;host-guest.;light-responsive;pillararene;protein transport
