Highly efficient ionic gating of solid-state nanosensors by the reversible interaction between pillar[6]arene-aunps and azobenzene
作者：
Zhang, Ruiping;Huang, Jinmei;Chen, Kai;Boussouar, Imene;Chen, Xiaoya;...
期刊：
Analytical Chemistry ,2021年93(6):3280-3286 ISSN：0003-2700
通讯作者：
Sun, Yao
作者机构：
[Zhang, Ruiping] Shanxi Med Univ, Affiliated Bethune Hosp, Taiyuan 030001, Peoples R China.;[Boussouar, Imene; Fan, Yifan; Huang, Jinmei; Li, Haibing; Sun, Yao] Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Huang, Jinmei; Chen, Kai] Nanjing Univ Informat Sci & Technol, Collaborat Innovat Ctr Atmospher Environm & Equip, Jiangsu Key Lab Atmospher Environm Monitoring & P, Nanjing 210044, Peoples R China.;[Chen, Xiaoya] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Liaoning, Peoples R China.;[Fan, Yifan] Guangdong Prov Key Lab Radioact & Rare Resource U, Shaoguan 512026, Peoples R China.
通讯机构：
[Sun, Yao] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
摘要：
By mimicking nature, various artificial nanofluidic platforms have been widely applied in a range of scientific fields. However, their low performance in terms of gating efficiency (<25) still hinders their practical applications. Herein, we present a highly efficient ionic gating nanosensor by fusing the merits of host-guest chemistry and Au nanoparticles (AuNPs). Based on this strategy, the pillar[6]arene (WP6)-functionalized AuNPs facilely regulated an azobenzene (AZO)-modified nanosensor with an excellent ion rectification ratio (∼22.2) and gating efficiency (∼89.5). More importantly, this gating nanosensor system also demonstrated promising stability and recyclability under conditions of alternative irradiation of visible and ultraviolet light. These excellent results would significantly help in expanding the utilization of artificial nanosensors for controllable drug delivery and biosensors. © 2021 The Authors.
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英文
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A Visible-Light-Regulated Chloride Transport Channel Inspired by Rhodopsin
作者：
Quan, Jiaxin;Zhu, Fei;Dhinakaran, Manivannan Kalavathi;Yang, Yingying;Johnson, Robert P.;...
期刊：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION ,2021年60(6):2892-2897 ISSN：1433-7851
通讯作者：
Li, Haibing
作者机构：
[Yang, Yingying; Li, Haibing; Zhu, Fei; Dhinakaran, Manivannan Kalavathi; Quan, Jiaxin] Cent China Normal Univ, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Coll Chem, Wuhan 430079, Peoples R China.;[Johnson, Robert P.] Univ Coll Dublin, Sch Chem, Dublin 4, Ireland.
通讯机构：
[Li, Haibing] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Coll Chem, Wuhan 430079, Peoples R China.
关键词：
Cl− selectivity;Cl− transport;host–guest systems;membrane channels;visible-light response
摘要：
Inspired by the light-regulating capabilities of naturally occurring rhodopsin, we have constructed a visible-light-regulated Cl−-transport membrane channel based on a supramolecular host–guest interaction. A natural retinal chromophore, capable of a visible-light response, is used as the guest and grafted into the artificial channel. Upon introduction of an ethyl-urea-derived pillar[6]arene (Urea-P6) host, threading or de-threading of the retinal and selective bonding of Cl− can be utilized to regulate ion transport. Based on the visible-light responsiveness of the host–guest interaction, Cl− transport can be regulated by visible light between ON and OFF states. Visible-light-regulated Cl− transport as a chemical model permits to understand comparable biological ion-selective transport behaviors. Furthermore, this result also supplies a smart visible-light-responsive Cl− transporter, which may have applications in natural photoelectric conversion and photo-controlled delivery systems. © 2020 Wiley-VCH GmbH
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英文
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Nanopore-Based Electrodes for Quinotrione Detection: Host-Guest-Induced Electrochemical Signal Switching
作者：
Zhang, Jin;Lucas, Rachel A.;Gu, Yulin;Yang, Yuxia;Sun, Kunpeng;...
期刊：
Analytical Chemistry ,2021年93(13):5430-5436 ISSN：0003-2700
通讯作者：
Sun, Kunpeng(sunkp@licp.cas.cn);Li, Haibing(lhbing@mail.ccnu.edu.cn)
作者机构：
[Sun, Kunpeng; Zhang, Jin] Chinese Acad Sci, Natl Engn Res Ctr Fine Petrochem Intermediates, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China.;[Zhang, Jin; Li, Haibing; Gu, Yulin; Yang, Yuxia] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.;[Lucas, Rachel A.] Univ Calif Irvine, Dept Phys & Astron, Irvine, CA 92697 USA.
通讯机构：
[Kunpeng Sun] N;[Haibing Li] K;National Engineering Research Center for Fine Petrochemical Intermediates, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou730000, P. R. China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
摘要：
Nanopore-based detection techniques, with a wide range of transport properties, exhibit impressive selectivity and sensitivity for analytes. To expand the application of nanoporous sensors, real-time and fast detection of targets, all within a portable device, is highly desired for nanopore-based sensors. In addition, to improve the accuracy of the output signal, more appropriate readout methods also need to be explored. In this manuscript, we describe a nanopore-based electrode, regarded as NAC-P6-PC@AuE, prepared by coupling a pillararene-based nanoporous membrane with an electrochemical impedance measurement method. The fabricated device is demonstrated by exposing pillararene-based receptors to trace amounts of pesticide molecules. NAC-P6-PC@AuE devices exhibit distinguished selectivity to quinotrione, as well as the ability to quantify quinotrione with a limit of quantitation (LOQ) of 10 nM. The mechanism that allows sensing was verified using finite-element simulations and may be explained as host-guest-induced surface charge shielding, which influences the electrochemical response of probe molecules. The applications of this nanopore-based electrode may be extended toward other target molecules by decorating the nanopore surfaces with specifically chosen receptors. ©
语种：
英文
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Temperature-Dependent Tunneling in Furan Oligomer Single-Molecule Junctions
作者：
Li, Haipeng B.;Xi, Yan-Feng;Hong, Ze-Wen;Yu, Jingxian;Li, Xiao-Xia;...
期刊：
ACS SENSORS ,2021年6(2):565-572 ISSN：2379-3694
通讯作者：
Jin, S.;Hihath, J.;Zhou, X.-S.
作者机构：
[Xi, Yan-Feng; Jin, Shan; Li, Xiao-Xia; Liu, Wen-Xia; Li, Haipeng B.] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Hihath, Joshua; Domulevicz, Lucas; Li, Haipeng B.] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA.;[Zhou, Xiao-Shun; Hong, Ze-Wen] Zhejiang Normal Univ, Inst Phys Chem, Zhejiang Key Lab React Chem Solid Surfaces, Jinhua 321004, Zhejiang, Peoples R China.;[Yu, Jingxian] Univ Adelaide, ARC Ctr Excellence Nanoscale BioPhoton CNBP, Inst Photon & Adv Sensing, Dept Chem, Adelaide, SA 5005, Australia.
通讯机构：
[Shan Jin] K;[Xiao-Shun Zhou] Z;[Joshua Hihath] D;Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China<&wdkj&>Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, Institute of Physical Chemistry, Zhejiang Normal University, Jinhua, Zhejiang 321004, China<&wdkj&>Department of Electrical and Computer Engineering, University of California Davis, Davis, California 95616, United States
关键词：
molecular electronics;charge transport;thermally assisted tunneling;furan-based molecular wire;single-molecular conductance;single-molecule break junction
摘要：
Two commonly observed charge transport mechanisms in single-molecule junctions are coherent tunneling and incoherent hopping. It has been generally believed that tunneling processes yield temperature-independent conductance behavior and hopping processes exhibit increasing conductance with increasing temperature. However, it has recently been proposed that tunneling can also yield temperature-dependent transport due to the thermal broadening of the Fermi energy of the contacts. In this work, we examine a series of rigid, planar furan oligomers that are free from a rotational internal degree of freedom to examine the temperature dependence of tunneling transport directly over a wide temperature range (78-300 K). Our results demonstrate conductance transition from a temperature-independent regime to a temperature-dependent regime. By examining various hopping and tunneling models and the correlation between the temperature dependence of conductance and molecular orbital energy offset from the Fermi level, we conclude thermally assisted tunneling is the dominant cause for the onset of temperature-dependent conductance in these systems. © 2021 American Chemical Society.
语种：
英文
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Pillar[5]arene-functionalized nanochannel platform for detecting chiral drugs
作者：
Yu, Sheng;Wang, Yaqi;Chatterjee, Sobhan;Liang, Feng* ;Zhu, Fei;...
期刊：
中国化学快报：英文版 ,2021年32(1):179-183 ISSN：1001-8417
通讯作者：
Liang, Feng;Li, Haibing
作者机构：
[Chatterjee, Sobhan; Liang, Feng; Yu, Sheng; Wang, Yaqi] Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, State Key Lab Refractories & Met, Wuhan 430081, Peoples R China.;[Li, Haibing; Zhu, Fei] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Liang, Feng] W;[Li, Haibing] C;Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, State Key Lab Refractories & Met, Wuhan 430081, Peoples R China.;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.
关键词：
Chiral recognition;Pillar[5]arene;Bionic nanochannel;Electrochemical sensor;Chiral drugs
摘要：
Chirality is a fascinating and essential feature of life and highly associated with many significant pharmaceutical, chemical, and biological processes. The construction of chiral recognition platform is a hot research topic and challenging assignment. Herein, we report an electrochemical method by differential pulse voltammetry (DPV) for the enantioselective recognition of chiral drug propranolol (R/S-PPL) through a nanochannel platform based on the N-acetyl-L-cysteine functionalized pillar[5]arenes derivative NALC-P5 and the porous polycarbonate membrane. The chiral discrimination depends on the difference in the supramolecular host-guest interaction between the chiral NALC-P5 and the R/S-PPL. The transmission rate of the R/S-PPL can be regulated in the nanochannel and we can achieve the selective transport of the chiral drugs. This simple electrochemical technique has potential applications as a general platform for the recognition of chiral molecules.
语种：
英文
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Selective transmembrane transport of A beta protein regulated by tryptophan enantiomers
作者：
Zhu, Fei;Wang, Wenqian;Zhang, Fan;Dhinakaran, Manivannan Kalavathi;Wang, Yingqian;...
期刊：
Chemical Communications ,2021年57(2):215-218 ISSN：1359-7345
通讯作者：
Cheng, Jing;Li, Haibing
作者机构：
[Wang, Yingqian; Wang, Wenqian; Li, Haibing; Cheng, Jing; Li, HB; Zhu, Fei; Dhinakaran, Manivannan Kalavathi; Zhang, Fan; Wang, Rui] Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China.;[Trautmann, Christina; Toimil-Molares, Maria Eugenia] GSI Helmholtzzentrum Schwerionenforsch, D-64291 Darmstadt, Germany.;[Trautmann, Christina] Tech Univ Darmstadt, D-64287 Darmstadt, Germany.
通讯机构：
[Cheng, J; Li, HB] C;Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China.
摘要：
Tryptophan enantiomers (d/l-Trp) were introduced into artificial nanochannels to regulate the chiral selective transport of Aβ proteins. The l-Trp channel performs effectively selectivity for the transport of Aβ protein, which would provide a new perspective for the pathological studies of Alzheimer's disease. This journal is © The Royal Society of Chemistry.
语种：
英文
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Glutathione transmembrane transmission gated by light-switches
作者：
Wang, Yingqian;Gu, Yulin;Yang, Yuxia;Sun, Kunpeng* ;Li, Haibing*
期刊：
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY ,2021年405:112954 ISSN：1010-6030
通讯作者：
Sun, Kunpeng;Li, Haibing
作者机构：
[Sun, Kunpeng; Wang, Yingqian; Gu, Yulin; Yang, Yuxia] Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou, Peoples R China.;[Wang, Yingqian; Li, Haibing] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China.
通讯机构：
[Sun, Kunpeng; Li, Haibing] C;Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou, Peoples R China.;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China.
关键词：
Light-responsive;Nanochannel;Glutathione transport;beta-cyclodextrin;Switches;Light-controlled
摘要：
Photoresponsive azobenzene-cyclodextrin light-switches fabricated artificial film which can be used to regulate the transmission of glutathione (GSH) across the membrane will gain much significance due to the important role of GSH in various biological process. In this work, we used azobenzene-cyclodextrin complex as switchable unit to manipulate gating transport. Under the control of ultraviolet (UV 365 nm) and visible (Vis 430 nm) light, two states of "ON" and "OFF" transport of GSH can be realized by the switches. This study achieved controlled molecule transport through channels by taking GSH as the research object, providing a new theoretical model for biological research and hold promise for future applications such as light-controlled drug transmission.
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英文
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The light-driven macroscopic directional motion of a water droplet on an azobenzene-calix[4]arene modified surface
作者：
Zhu, Fei;Tan, Shiliang;Dhinakaran, Manivannan Kalavathi;Cheng, Jing* ;Li, Haibing*
期刊：
Chemical Communications ,2020年56(74):10922-10925 ISSN：1359-7345
通讯作者：
Cheng, Jing;Li, Haibing
作者机构：
[Li, Haibing; Tan, Shiliang; Cheng, Jing; Li, HB; Zhu, Fei; Dhinakaran, Manivannan Kalavathi] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Cheng, J; Li, HB] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.
摘要：
A novel photo-responsive surface was constructedviamodifying azobenzene-calix[4]arene (ABC4) on a microstructured silicon surface. Asymmetric UV light irradiation could drive the macroscopic directional motion of a water droplet on this photo-responsive surface. © The Royal Society of Chemistry 2020.
语种：
英文
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Chiral Selective Adhesion of Protein Droplets on Calix[4]arene-Enantiomer-Modified Surfaces
作者：
Mei, Yuxiao;Quan, Jiaxin;Gu, Yulin;Yang, Yuxia;Huang, Jinmei;...
期刊：
ACS Applied Bio Materials ,2020年3(2):1226-1232 ISSN：2576-6422
通讯作者：
Sun, Kunpeng(sunkp@licp.cas.cn)
作者机构：
[Mei, Yuxiao; Quan, Jiaxin; Gu, Yulin; Yang, Yuxia; Sun, Kunpeng] National Engineering Research Center for Fine Petrochemical Intermediates, Lanzhou Institute of Chemical Physics, Chinese Academic Sciences, Lanzhou;730000, China;[Huang, Jinmei; Li, Haibing] Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan;430079, China;[Mei, Yuxiao; Quan, Jiaxin] 730000, China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan
通讯机构：
[Kunpeng Sun] N;[Haibing Li] K;Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China<&wdkj&>National Engineering Research Center for Fine Petrochemical Intermediates, Lanzhou Institute of Chemical Physics, Chinese Academic Sciences, Lanzhou, 730000, P. R. China
关键词：
BSA-adhesion;calix[4]arene;chiral surface;enantio-selectivity;signal transduction
摘要：
Chiral-specific assembly is involved in many biochemical processes, such as DNA hybridization, protein adhesion, and sugar recognition. However, the signals of chiral interaction are usually very weak, and it is difficult to investigate the enantioselective behaviors. Therefore, it is necessary to construct the functional materials to regulate the selective behaviors of protein droplets via weak chiral interaction, which is also significant for the biological process of protein adhesive behaviors and proteinic drug delivery. Here, S- and R-amino alcohol derivative of calix[4]arene enantiomers (R/S-AC4) were synthesized and modified onto Au-surfaces to fabricate the enantiomer's materials and investigate the chiral selective adhesion of protein droplets. Through the experiment of fluorescence titration and molecular docking simulation, bovine serum albumin (BSA) showed the stronger interaction with R-amino alcohol-calix[4]arene than S-amino alcohol-calix[4]arene on the molecular level. Notably, the sliding angle showed that the droplet of BSA selectively adhered to the R-amino alcohol-calix[4]arene-modified surface, while it released rapidly from S-amino alcohol-calix[4]arene-modified surface by virtue of chiral selectivity. This result not only provides an easy and convenient model to regulate the selective adhesion and release of protein from chemical view, but also realizes the signal transduction through the weak chiral interaction. © 2020 American Chemical Society.
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英文
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β-Cyclodextrin-Self-Assembled Nanochannel Membrane for the Separation of Chiral Drugs
作者：
Zhang, Siyun;Chen, Xue;Sun, Lingda;Li, Haibing*
期刊：
ACS Applied Nano Materials ,2020年3(5):4351-4356 ISSN：2574-0970
通讯作者：
Li, Haibing
作者机构：
[Li, Haibing; Sun, Lingda; Zhang, Siyun; Chen, Xue] Cent China Normal Univ CCNU, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ MOE, Wuhan 430079, Peoples R China.
通讯机构：
[Li, Haibing] C;Cent China Normal Univ CCNU, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ MOE, Wuhan 430079, Peoples R China.
关键词：
chiral drugs;host-guest chemistry;nanochannel membrane;separation;β-cyclodextrin
摘要：
The fabrication of a membrane with the capability of chiral selective transport is a big challenge in the membrane separation of chiral drugs. To solve the problem of chiral selectivity in membrane separation, drug/metabolite transport (DMT) in the cell membrane inspires a bionic strategy based on the nanochannel membrane. Herein, the DMT-inspired nanochannel membrane is fabricated by the self-assembly of cyclodextrin (CD) in nanochannels and used for the chiral transport and separation of model chiral drugs such as naproxen (NAP). As a result, the β-CD-self-assembled nanochannel membrane shows chiral transport of (S)-naproxen (S-NAP) and achieves the chiral separation of racemic drugs. Moreover, a mechanism of chiral separation is proposed that the chiral selective interaction increases the surface charge density, causing chiral enrichment and transport. Given these promising results, the study of the β-CD-self-assembled nanochannel membrane suggests a bionic strategy for the separation of chiral drugs. © 2020 American Chemical Society.
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英文
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Pillar[5]arene Promoted Selective Spreading of Chlormequat Droplets on a Hydrophobic Surface
作者：
Yu, Sheng;Gilbert, Nsengiyumva;Zhu, Fei;Dhinakaran, Manivannan Kalavathi;Liang, Feng* ;...
期刊：
LANGMUIR ,2020年36(8):1950-1955 ISSN：0743-7463
通讯作者：
Liang, Feng;Li, Haibing
作者机构：
[Liang, Feng; Yu, Sheng] Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, State Key Lab Refractories & Met, Coal Convers & New Carbon Mat Hubei Key Lab, Wuhan 430081, Hubei, Peoples R China.;[Gilbert, Nsengiyumva; Li, Haibing; Zhu, Fei; Dhinakaran, Manivannan Kalavathi] Cent China Normal Univ, Key Lab Pesticide & Chem Biol CCNU, Coll Chem,Chem Biol Canter,Minist Educ, Int Joint Res Ctr Intelligent Biosensor Technol &, Wuhan 430079, Peoples R China.
通讯机构：
[Liang, Feng] W;[Li, Haibing] C;Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, State Key Lab Refractories & Met, Coal Convers & New Carbon Mat Hubei Key Lab, Wuhan 430081, Hubei, Peoples R China.;Cent China Normal Univ, Key Lab Pesticide & Chem Biol CCNU, Coll Chem,Chem Biol Canter,Minist Educ, Int Joint Res Ctr Intelligent Biosensor Technol &, Wuhan 430079, Peoples R China.
摘要：
Promoting the spreading and deposition of agricultural sprays on the crop surface is of great significance for effective utilization of these chemicals. Selective host-guest interaction established between chlormequat and hydroxyl pillar[5]arene was well utilized in the present work for effective spreading of chlormequat droplets over the hydrophobic surface, which was silanized with triethoxy (octyl) silane and then assembled with hydroxybenzene pillar[5]arene molecules. Therefore, this surface was facile for the assembly of chlormequat in droplets and ultimately increased the selective adhesion of chlormequat through host-guest interactions. Moreover, the pillar[5]arene-fabricated surface shows considerable potential applications for rapid detection of chlormequat in environmental monitoring and also provides a novel approach for improving the chlormequat efficiency. Copyright © 2020 American Chemical Society.
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英文
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Spreading of benquitrione droplets on superhydrophobic leaves through pillar[5]arene-based host-guest chemistry
作者：
Song, Qianqian;Mei, Longcan;Zhang, Xujie;Xu, Pingping;Dhinakaran, Manivannan Kalavathi;...
期刊：
Chemical Communications ,2020年56(55):7593-7596 ISSN：1359-7345
通讯作者：
Li, Haibing;Yang, Guangfu
作者机构：
[Xu, Pingping; Li, HB; Yang, GF; Zhang, Xujie; Yang, Guangfu; Song, Qianqian; Li, Haibing; Dhinakaran, Manivannan Kalavathi; Mei, Longcan] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China.
通讯机构：
[Li, HB; Yang, GF] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China.
摘要：
Spreading of agricultural sprays on plant surfaces is a significant task as it helps decrease pesticide usage and thereby reduces the risk of environmental pollution. Here, we report a method of increasing the spreading of herbicide benquitrione droplets on superhydrophobic surfaces through its selective dynamic self-assembly with amino pillar[5]arenes. Supramolecular interaction such as host-guest interaction was utilized for the complete diffusion of benquitrione over the hydrophobic plant surface. Furthermore, molecular dynamics simulations were used to verify that AP5A improved the spreading of benquitrione droplets on superhydrophobic interfaces. Moreover, complexation of benquitrione did not affect its biological activity. The present work provides a new method for improving the utilization rate of pesticides and reducing pesticide use. © The Royal Society of Chemistry.
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英文
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Tailoring two-dimensional surfaces with pillararenes based host-guest chemistry
作者：
Li, Run-Hao;Ma, Junkai;Sun, Yue* ;Li, Haibing*
期刊：
中国化学快报：英文版 ,2020年31(12):3095-3101 ISSN：1001-8417
通讯作者：
Sun, Yue;Li, Haibing
作者机构：
[Sun, Yue; Li, Run-Hao] South Cent Univ Nationalities, Coll Chem & Mat Sci, Hubei Key Lab Catalysis & Mat Sci, Wuhan 430074, Peoples R China.;[Ma, Junkai] Hubei Univ Med, Sch Pharm, Dept Chem, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Peoples R China.;[Li, Haibing] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Sun, Yue] S;[Li, Haibing] C;South Cent Univ Nationalities, Coll Chem & Mat Sci, Hubei Key Lab Catalysis & Mat Sci, Wuhan 430074, Peoples R China.;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.
关键词：
Pillararenes;Host-guest chemistry;Two-dimensional surfaces
摘要：
The two-dimensional surfaces have been fueled by the infinite possibility they offered for basic research, and for novel technologies in nanoelectronics. To realize many of these promises, the effective strategies were to design and control their surface chemistry, which plays a vital role in determining the chemical and physical properties. Macrocyclic host–guest chemistry with the reversible noncovalent interactions between macrocyclic hosts and suitable guests can be readily used for constructing multifunctional surfaces. Macrocyclic pillararenes, possessed the unique structure, have attracted the attentions of researchers in recent years. This feature article covers the recent development of pillararene-based two-dimensional interfaces, including the fabrication and function of the hybrid composite. The combination of pillararenes and materials platform exhibited the novel property because of the characteristic of cavity of macrocyclic host and confined spaces of surfaces. We anticipate that this review will be helpful to the researchers working in the fields of supramolecular chemistry and materials science. © 2020
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英文
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Engineering a NO-Regulated Nanofluidic Sensor through the Cyclization Reaction Strategy
作者：
Han, Yunfeng;Sun, Zhongyue;Sun, Ziyan;Chen, Xiaoya;Zhang, Yongxue* ;...
期刊：
CHEMISTRY-A EUROPEAN JOURNAL ,2020年26(49):11099-11103 ISSN：0947-6539
通讯作者：
Zhang, Yongxue;Sun, Yao;Li, Haibing
作者机构：
[Han, Yunfeng; Zhang, Yongxue] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Nucl Med, Wuhan 430022, Peoples R China.;[Han, Yunfeng] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Nucl Med, Wuhan 430030, Peoples R China.;[Li, Haibing; Sun, Zhongyue; Chen, Xiaoya; Sun, Yao; Sun, Ziyan; Li, HB] Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Sun, Zhongyue] Hubei Univ Chinese Med, Sch Lab Med, Wuhan 430065, Peoples R China.;[Sun, Ziyan] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Radiol, Wuhan 430030, Peoples R China.
通讯机构：
[Zhang, Yongxue] H;[Sun, Y; Li, HB] C;Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Nucl Med, Wuhan 430022, Peoples R China.;Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
关键词：
cyclization reactions;ion rectification;nanochannel;nanosensors;nitic oxide
摘要：
Nitric oxide (NO) is known to be a secondary in vivo signaling agent, demonstrating various biological functions through regulating ion flux in channels. Considering the crucial role of NO in vivo, herein, a biomimetic NO-regulated nanofluidic sensor has been fabricated through a cyclization reaction strategy. This nanofluidic sensor exhibited a promising NO selectivity, sensitivity, and non-interference performance in complex matrices. Thus, such a NO-driven nanosensor will be meaningful for scientific researchers to grasp the in vivo functions of NO. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
语种：
英文
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Biomimetic nanochannels platform for detecting N-acetylglucosamine analogues
作者：
Sun, Yue;Cheng, Shi-Qi;Ma, Junkai;Zhu, Fei;Hong, Wei;...
期刊：
Sensors and Actuators B-Chemical ,2020年323:128705 ISSN：0925-4005
通讯作者：
Li, Haibing
作者机构：
[Cheng, Shi-Qi; Sun, Yue] South Cent Univ Nationalities, Coll Chem & Mat Sci, Hubei Key Lab Catalysis & Mat Sci, Wuhan 430074, Peoples R China.;[Li, Haibing; Hong, Wei; Zhu, Fei] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.;[Ma, Junkai] Hubei Univ Med, Sch Pharm, Dept Chem, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Peoples R China.
通讯机构：
[Li, Haibing] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.
关键词：
Pillararenes;Host-guest chemistry;Nanochannnels;Biomimetic
摘要：
N-acetylglucosamine analogues exist in nature as an important saccharide in human body and can regulate a variety of life activities captured through biological nanochannels. Herein we describe a biomimetic strategy via supramolecular host-guest chemistry for constructing artificial nanochannels to detect N-acetylglucosamine analogues. The functional nanochannels exhibited a high selectivity and good reversibility towards N-acetylglucosamine. Further studies indicate that the detecting behaviors was probably due to the multiple hydrogen bonding interactions and an appropriately fitting the functional and geometric requirements between the tryptophan-decorated pillararenes and N-acetylglucosamine, leading to the change of the surface charge and wettability within the nanochannels. These studies can give interesting insight for the research of biological processes caused by N-acetylglucosamine-sensitive ion channels, and also help to develop the platform for detecting N-acetylglucosamine in vitro.
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英文
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Molecularly imprinted polymers immobilized on graphene oxide film for monolithic fiber solid phase microextraction and ultrasensitive determination of triphenyl phosphate
作者：
Jian, Yajing;Chen, Linfeng;Cheng, Jing* ;Huang, Xiaolan;Yan, Ling;...
期刊：
Analytica Chimica Acta ,2020年1133:1-10 ISSN：0003-2670
通讯作者：
Cheng, Jing;Li, Haibing
作者机构：
[Huang, Xiaolan; Jian, Yajing; Yan, Ling; Li, Haibing; Cheng, Jing; Li, HB; Chen, Linfeng] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Inst Environm Chem,Coll Chem, Wuhan 430079, Peoples R China.
通讯机构：
[Cheng, J; Li, HB] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Inst Environm Chem,Coll Chem, Wuhan 430079, Peoples R China.
关键词：
Gas chromatography;Molecularly imprinted polymers immobilized on graphene oxide film;Monolithic fiber;Selective and ultrasensitive;Solid phase microextraction;Triphenyl phosphate
摘要：
Triphenyl phosphate (TPhP), a typical model of organophosphorus flame retardants (OPFRs), has been regarded as emerging environmental contaminants of health concern. In this study, TPhP molecularly imprinted polymers immobilized on graphene oxide (GO) film (TPhP-MIPs/GO) monolithic fiber for direct immersion solid phase microextraction (DI-SPME) was fabricated and evaluated. Compared with TPhP molecularly imprinted polymers (TPhP-MIPs) monolithic fiber, TPhP-MIPs/GO fiber had bigger extraction capacity, stronger hydrophilicity and faster mass transfer rate. Furthermore, TPhP-MIPs/GO fiber displayed excellent selectivity for TPhP among its structure analogues. It was thermally stable up to 320 degrees C so that it can withstand the high temperature of gas chromatography (GC) injection port for desorption and detection by flame photometric detector (FPD). Under optimal conditions, TPhP-MIPs/GO-SPME-GC/FPD method was developed by yielding satisfactory ultralow limit of quantification (0.4 ng L-1); linearity (>= 0.99), good intra- and inter-day precision for a single fiber and fiber-to-fiber reproducibility. The method was applied for the determination of TPhP in environmental water and the relative recoveries were found to be in the range from 70 to 110%. TPhP was detected in three out of four environmental water samples at concentration levels from 0.04 to 0.12 ng mL(-1), illustrating light pollution of TPhP in most environmental water. (C) 2020 Elsevier B.V. All rights reserved.
语种：
英文
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Phenethylamine@Pillar[5]arene Biointerface for Highly Enantioselective Adsorption of Protein
作者：
Yan, Hewei;Ma, Junkai;Zhu, Fei;Quan, Jiaxin;Dhinakaran, Manivannan Kalavathi;...
期刊：
CHEMISTRY-AN ASIAN JOURNAL ,2020年15(7):1025-1029 ISSN：1861-4728
通讯作者：
Li, Haibing
作者机构：
[Li, Haibing; Zhu, Fei; Dhinakaran, Manivannan Kalavathi; Quan, Jiaxin; Yan, Hewei] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China.;[Ma, Junkai] Hubei Univ Med, Sch Pharm, Dept Chem, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Hubei, Peoples R China.
通讯机构：
[Li, Haibing] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China.
关键词：
pillar[5]arene;chiral;biointerface;adsorption;proteins
摘要：
In the life system, the biointerface plays an important role in cell adsorption, platelet adsorption and activation. Therefore, the study of protein adsorption on the biointerface is of great significance for understanding life phenomena and treatment in vitro. In this paper, a chiral biointerface was constructed by the virtue of host-guest interaction between a water-soluble pillar[5]arene (WP5) and phenethylamine (PEA) over a gold surface for adsorption of lysozyme proteins. From the experimental results it was identified that the host-guest biointerface has a high adsorption capacity and strong chiral selectivity. Furthermotre, it was identified that the host-guest interaction plays the decisive role in the enhancement of chirality of the interface, which was much beneficial for increasing protein adsorption and amplifying the capacity of chiral discrimination. Therefore, this work provides a new idea for the construction of biointerface materials with high protein adsorption capacity and high chiral selectivity through supramolecular interaction, which will have potential applications in the fields of biosensors, biocatalysts, biomaterials. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
语种：
英文
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Glutathione modified Ag nanoparticles as efficient detector for pyrimethanil.
作者：
Zhang, Siyun;Hu, Ren;Li, Haibing*
期刊：
Nanotechnology ,2019年30(11):115502 ISSN：0957-4484
通讯作者：
Li, Haibing
作者机构：
[Li, Haibing; Hu, Ren; Zhang, Siyun] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Li, Haibing] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
关键词：
Ag nanoparticles;glutathione modification;pyrimethanil detection;pesticide
摘要：
This work reports on glutathione modified Ag nanoparticles (GSH-Ag NPs) as a chemosensor for detecting pyrimethanil in an aqueous medium. The GSH-Ag NPs were expediently obtained by reducing AgNO3 with NaBH4 and modified with glutathione based on the Ag-S bond. The rapid discrimination for pyrimethanil from other pesticides exhibited the high selectivity of GSH-Ag NPs, then the selectivity was proved by 1H NMR, FT-IR and computational simulation. Based on the good properties of localized surface plasmon resonance, the selective recognition was transformed to visible optical signal in colorimetric test. Additionally the quantitative detection was achieved with good sensitivity and could be applied to analyze practical samples. The experimental results have shown a good linear relationship with pyrimethanil concentration ranging from 10 μM to 1 mM and a low detection limit of 3.87 μM. © 2019 IOP Publishing Ltd.
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英文
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巯基-烯点击反应合成手性柱[6]芳烃及其对肾上腺素的手性识别性能研究
作者：
马俊凯;田德美;李海兵
作者机构：
[马俊凯; 田德美; 李海兵] 农药与化学生物学教育部重点实验室化学学院华中师范大学
会议名称：
全国第十八届大环化学暨第十届分子化学学术讨论会
会议时间：
20160825
会议地点：
长沙
会议论文集名称：
全国第十八届大环化学暨第十届分子化学学术讨论会 论文集
关键词：
柱[6]芳烃;巯基-烯反应;肾上腺素;手性识别
摘要：
<正>儿茶酚胺类药物,如多巴胺、L-多巴、肾上腺素及去甲基肾上腺素等是一类主要的神经递质,在中枢神经系统中具有多种重要功能。R-构型的肾上腺素是其左旋体,其生理活性比其对映体高12倍。其在细胞膜表面的手性选择性作用是如何实现的?本文通过巯基-烯点击反应合成了N-乙酰-D/L-半胱氨酸修饰的手性柱[6]芳烃,并修饰到纳米硅表面,实现了对肾上
语种：
中文
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A highly selective and recyclable NO-responsive nanochannel based on a spiroring opening−closing reaction strategy
作者：
Sun, Yao;Chen, Sen;Chen, Xiaoya;Xu, Yuling;Zhang, Siyun;...
期刊：
Nature Communications ,2019年10(1):1323 ISSN：2041-1723
通讯作者：
Yang, Guangfu;Li, Haibing
作者机构：
[Xu, Yuling; Chen, Sen; Ouyang, Qingying; Yang, Guangfu; Li, Haibing; Sun, Yao; Zhang, Siyun; Yang, GF; Li, HB] Cent China Normal Univ, Key Lab Pesticide & Chem Biol CCNU, Minist Educ,Chem Biol Ctr,Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Wuhan 430079, Hubei, Peoples R China.;[Chen, Xiaoya] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.
通讯机构：
[Yang, GF; Li, HB] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol CCNU, Minist Educ,Chem Biol Ctr,Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Wuhan 430079, Hubei, Peoples R China.
摘要：
Endogenous nitric oxide (NO) is an important messenger molecule, which can directly activate K + transmission and cause relaxation of vascular smooth muscle. Here, inspired by the K + channel of smooth muscle cells, we report, a novel NO-regulated artificial nanochannel based on a spiro ring opening−closing reaction strategy. This nanofluidic diode system shows an outstanding NO selective response owing to the specific reaction between o-phenylenediamine (OPD) and NO on the channel surface with high ion rectification ratio (~6.7) and ion gating ratio (~4). Moreover, this NO gating system exhibits excellent reversibility and stability as well as high selectivity response. This system not only helps us understand the process of NO directly regulating biological ion channels, but also has potential application value in the field of biosensors. © 2019, The Author(s).
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英文
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