摘要：
Alcoholic liver disease (ALD) has attracted widespread attention because of the ever-increasing alcohol consumption and high morbidity. However, there is still no effective detection method to prevent the deterioration of the disease. Cholesterol, as the main component of the cell membrane (CM), often transported to lipid droplets (LDs) for storage in hepatocytes. Meanwhile, abnormal changes of cholesterol could cause liver diseases, such as Tangier disease. Based on cholesterol could serve as a hub that affects the cell membrane fluidity (CMF) and the number of LDs, we planned to study the microscopic changes of CMF and LDs in ALD. As viscous media could limit the intramolecular motion of fluorescent probes, aggregation induced emission luminogens (AIEgens), which typically have rotators and vibrators in their structures and emit strongly in the aggregate state, may be promising candidates for CMF and LD study. So two AIE probes (TPCN and NDPB) were designed and synthesized based on the typical AIE skeleton, tetraphenylethylene (TPE), which could selectively target CMs and LDs, respectively. These probes exhibited high chemical stability, controllable emission, and excellent subcellular specificity. They successfully sensed the correlated changes of CMs and LDs in ALD model, which would contribute to understanding the microscopic process of ALD pathogenesis and further development of ALD therapeutic drugs.
作者机构：
Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China;Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China;School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore, Singapore;[Tierui Zhang; Tierui Zhang Tierui Zhang Tierui Zhang] Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China;[Jinyu Yan; Yuan Li; Shuxin Ouyang; Jinyu Yan Jinyu Yan Jinyu Yan; Yuan Li Yuan Li Yuan Li; Shuxin Ouyang Shuxin Ouyang Shuxin Ouyang] Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China
通讯机构：
[Shuxin Ouyang; Shuxin Ouyang Shuxin Ouyang Shuxin Ouyang] E;[Tierui Zhang; Tierui Zhang Tierui Zhang Tierui Zhang] K;Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China<&wdkj&>Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China
摘要：
We classify the representative photocatalytic materials for photosynthesis of hydrogen peroxide (H2O2) in recent years and discuss the related modification methods in detail, providing inspiration and insights for the future design of photocatalysts for H2O2 production. Abstract Hydrogen peroxide (H2O2), an environmental‐friendly oxidant and renewable liquid fuel, has received wide attention in various research and industrial fields. Current industrial production of H2O2 relies on the anthraquinone method, which is hardly viewed as a sustainable and green process. Photocatalysis, harnessing solar energy as the driving force for redox reactions, provides a green and promising approach for H2O2 production. However, due to the poor ability of light absorption, fast recombination of carriers, and poor intrinsic activity of active sites of pristine photocatalysts, photocatalytic H2O2 production cannot provide great yield. Thus, great efforts have been dedicated to design efficient photocatalysts for photosynthesis of H2O2 in the past decades. In this review, we summarize significant progress in the development of advanced photocatalytic materials for light‐driven H2O2 production. Starting with a brief introduction on basic principles and advantages of photosynthesis of H2O2, the representative materials are classified and discussed in detail; finally, a brief outlook on addressing future challenges and opportunities of photocatalytic H2O2 production is proposed. This review aims to confirm current challenges and research developments in the photosynthesis of H2O2 and provide inspiration for the development of high‐efficiency photocatalysts for photocatalytic H2O2 production in the future.
通讯机构：
[Cuiju Zhu; Mingqiang Qiu] A;Authors to whom correspondence should be addressed.<&wdkj&>Key Laboratory of Pesticides & Chemical Biology Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, China
摘要：
Organic electrochemistry has attracted tremendous interest within the novel sustainable methodologies that have not only reduced the undesired byproducts, but also utilized cleaner and renewable energy sources. Particularly, oxidative electrochemistry has gained major attention. On the contrary, reductive electrolysis remains an underexplored research direction. In this context, we discuss advances in transition-metal-free cathodically generated radicals for selective organic transformations since 2016. We highlight the electroreductive reaction of alkyl radicals, aryl radicals, acyl radicals, silyl radicals, fluorosulfonyl radicals and trifluoromethoxyl radicals.
摘要：
Copper, an essential micronutrient, controls multiple fundamental processes throughout all forms of life, such as respiration, cell proliferation and neurotransmitter biosynthesis. High redox activity makes copper a double-edged sword for cell survival, and abnormal copper metabolism is commonly associated with cancer and other diseases. Recently, advances in copper biology have forged new links between researchers from different disciplines to dissect the use of copper targets in cancer treatment. Copper is crucial for maintaining the rapid growth and proliferation of cancer cells, a process known as ‘cuproplasia’. However, excess mitochondrial copper accumulation also triggers ‘cuproptosis’, a new form of programmed cell death, involving the destabilization of Fe-S cluster proteins and the aggregation of DLAT. Accordingly, both activating cuproptosis by copper ionophores and suppressing cuproplasia through copper depletion are noteworthy anticancer options, but this field currently lacks systematic reviews from both biological and chemical perspectives. This review provides a comprehensive overview of the leading known copper biology and copper-targeted cancer therapy, focusing on copper homeostasis, signal transduction, and copper overload/depletion, which should be beneficial for the development of the next-generation of inorganic anticancer drugs. We expect that our review will provide a balanced perspective to the development and comprehension of copper-based cancer therapy.
通讯作者：
Prof. Jong Seung Kim<&wdkj&>Prof. Yao Sun<&wdkj&>Prof. Jong Seung Kim Prof. Jong Seung Kim Prof. Jong Seung Kim<&wdkj&>Prof. Yao Sun Prof. Yao Sun Prof. Yao Sun
作者机构：
[Le Tu; Chonglu Li; Longcan Mei; Prof. Junrong Li; Prof. Yao Sun; Le Tu Le Tu Le Tu; Chonglu Li Chonglu Li Chonglu Li; Longcan Mei Longcan Mei Longcan Mei; Prof. Junrong Li Prof. Junrong Li Prof. Junrong Li; Prof. Yao Sun Prof. Yao Sun Prof. Yao Sun] National Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan, 430079 China;[Prof. Xiaoxing Xiong; Prof. Xiaoxing Xiong Prof. Xiaoxing Xiong Prof. Xiaoxing Xiong] Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, 430060 China;[Ji Hyeon Kim; Prof. Jong Seung Kim; Ji Hyeon Kim Ji Hyeon Kim Ji Hyeon Kim; Prof. Jong Seung Kim Prof. Jong Seung Kim Prof. Jong Seung Kim] Department of Chemistry, Korea University, Seoul, 02841 Korea;[Qian Li; Qian Li Qian Li Qian Li] Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, Qingdao University of Science & Technology, Qingdao, 266100 China;[Prof. Shuang Liu; Prof. Shuang Liu Prof. Shuang Liu Prof. Shuang Liu] School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, 430070 China
通讯机构：
[Prof. Jong Seung Kim; Prof. Jong Seung Kim Prof. Jong Seung Kim Prof. Jong Seung Kim] D;[Prof. Yao Sun; Prof. Yao Sun Prof. Yao Sun Prof. Yao Sun] N;National Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan, 430079 China<&wdkj&>Department of Chemistry, Korea University, Seoul, 02841 Korea
摘要：
Although metallacycle-based supramolecular photosensitizers (PSs) have attracted increasing attention in biomedicine, their clinical translation is still hindered by their inherent dark toxicity. Herein, we report what to our knowledge is the first example of a molecular engineering approach to building blocks of metallacycles for constructing a series of supramolecular PSs (RuA–RuD), with the aim of simultaneously reducing dark toxicity and enhancing phototoxicity, and consequently obtaining high phototoxicity indexes (PI). Detailed in vitro investigations demonstrate that RuA–RuD display high cancer cellular uptake and remarkable antitumor activity even under hypoxic conditions. Notably, RuD exhibited no dark toxicity and displayed the highest PI value (≈406). Theoretical calculations verified that RuD has the largest steric hindrance and the lowest singlet-triplet energy gap (ΔEST, 0.61 eV). Further in vivo studies confirmed that RuD allows safe and effective phototherapy against A549 tumors.
摘要：
A sensitive extraction and instrumental method was established to detect topramezone and its metabolite (M670H05) in maize and animal-origin foods. Two years of field experiments were carried out to study the dissipation dynamics of topramezone in maize straw, and their residue levels of actual samples collected from the supermarket were determined. They were extracted using liquid-liquid extraction (LLE), and ultra-high-performance liquid chromatography-tandem mass spectrometry was used for detection. The limit of quantification was 0.005 mg kg(-1). Recoveries ranged between 73.8% and 109.9% at 3 spiking levels with intraday relative standard deviation (RSD) <= 17.7% and the inter-day <= 18.1%, which meets the requirements of SANTE/12682/2019. Dissipation dynamics experiment showed that, the deposition of topramezone in maize straw in Jilin were <0.005-0.62 mg kg(-1)with 28 days after application. And the residue level of market samples were all less than 0.005 mg kg(-1), much lower than the MRLs (range from 0.01 to 0.8 mg kg(-1)) set by European Union, United States Food and Drug Administration, China, and Canada. This method was effective to analyse the residues of topramezone and M670H05.
通讯作者：
Prof. Chengzhou Zhu<&wdkj&>Prof. Chengzhou Zhu Prof. Chengzhou Zhu Prof. Chengzhou Zhu
作者机构：
[Dr. Xiaoli Cai; Dr. Xiaoli Cai Dr. Xiaoli Cai Dr. Xiaoli Cai] Department of Nutrition, Hygiene and Toxicology, School of Public Health, Medical College, Wuhan University of Science and Technology, 430065 Wuhan, P. R. China;[Weiqing Xu; Yu Wu; Yuling Xu; Prof. Wenling Gu; Prof. Chengzhou Zhu; Weiqing Xu Weiqing Xu Weiqing Xu; Yu Wu Yu Wu Yu Wu; Yuling Xu Yuling Xu Yuling Xu; Prof. Wenling Gu Prof. Wenling Gu Prof. Wenling Gu; Prof. Chengzhou Zhu Prof. Chengzhou Zhu Prof. Chengzhou Zhu] National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, 430079 Wuhan, P. R. China
通讯机构：
[Prof. Chengzhou Zhu; Prof. Chengzhou Zhu Prof. Chengzhou Zhu Prof. Chengzhou Zhu] N;National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, 430079 Wuhan, P. R. China
摘要：
Enzymatic catalysis with high efficiency allows them a great prospect in metabolite monitoring in living cells. However, complex tumor microenvironments, such as acidity, H2O2, and hypoxia, are bound to disturb catalytic reactions for misleading results. Here, we report a spatially compartmentalized artificial organelle to correct intratumoral glucose analysis, where the zeolitic imidazolate framework-8 immobilized glucose oxidase-horseradish peroxidase cascade core and catalase-directed shell act as signal transduction and guarding rooms respectively. The acid-digested core and stable shell provide appropriate spaces to boost biocatalytic efficiency with good tolerability. Notably, the endogenous H2O2 is in situ decomposed to O2 by catalase, which not only overcomes the interference in signal output but also alleviates the hypoxic states to maximize glucose oxidation. The marked protective effect and biocompatibility render artificial organelles to correct the signal transduction for dynamic monitoring glucose in vitro and in vivo, achieving our goal of accurate intratumoral metabolite analysis.
作者机构：
[Fu, Lijie; Liu, Fanglei; Zhao, Jiayi; Yang, Guohai; Qu, Lulu; Gu, Yingqiu] Jiangsu Normal Univ, Sch Chem & Mat Sci, Xuzhou 221116, Peoples R China.;[Zhu, Chengzhou] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Zhu, Jun-Jie] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210093, Peoples R China.;[Lin, Yuehe] Washington State Univ, Sch Mech & Mat Engn, Pullman, WA 99164 USA.
通讯机构：
[Lulu Qu] S;[Chengzhou Zhu] N;School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou 221116, PR China<&wdkj&>National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, P.R. China
摘要：
As recently developed two-dimensional (2D) materials, MXenes have attracted great attention in the fields of sensing, catalysis, energy, and electromagnetism due to their good electrical, mechanical, and optical properties and their biocompatibility. Their rich elemental composition, diverse surface functional groups and flexible bandgaps enable them to exhibit ideal physicochemical properties that are superior to those of traditional 2D materials. Therefore, MXenes not only serve as ideal biosensing materials but also show great potential in biomedical-related applications. In this review, we summarize the latest research on MXenes in the fields of biosensing and biomedicine. First, we introduce the different synthe-sis strategies and unique properties of MXenes. Then, according to the sensing mechanism, we divide the biosensing applications of MXenes into three subcategories: electrochemical, photochemical, and opto-electrochemical biosensors. Moreover, we systematically evaluate the biomedical applications of MXenes from four aspects: antibacterial activity, bioimaging, therapeutics and theranostics. How the specific chemical and physical properties of MXenes that can influence the efficiency of biosensing and biomedicine are highlighted, as well as the structure-performance relationships determining detection sensitivity and the toxicity of materials. Finally, we discuss the recent challenges and future prospects and opportunities for MXenes. It is expected that the review could promote the development of related fields.(c) 2022 Elsevier B.V. All rights reserved.
摘要：
The immune checkpoint blockade (ICB) antibody immunotherapy has demonstrated clinical benefits for multiple cancers. However, the efficacy of immunotherapy in tumors is suppressed by deficient tumor immunogenicity and immunosuppressive tumor microenvironments. Pyroptosis, a form of programmed cell death, can release tumor antigens, activate effective tumor immunogenicity, and improve the efficiency of ICB, but efficient pyroptosis for tumor treatment is currently limited. Herein, we show a mild hyperthermia-enhanced pyroptosis-mediated immunotherapy based on hollow carbon nanozyme, which can specifically amplify oxidative stress-triggered pyroptosis and synchronously magnify pyroptosis-mediated anticancer responses in the tumor microenvironment. The hollow carbon sphere modified with iron and copper atoms (HCS-FeCu) with multiple enzyme-mimicking activities has been engineered to induce cell pyroptosis via the radical oxygen species (ROS)-Tom20-Bax-Caspase 3-gasdermin E (GSDME) signaling pathway under light activation. Both in vitro and in vivo antineoplastic results confirm the superiority of HCS-FeCu nanozyme-induced pyroptosis. Moreover, the mild photothermal-activated pyroptosis combining anti-PD-1 can enhance antitumor immunotherapy. Theoretical calculations further indicate that the mild photothermal stimulation generates high-energy electrons and enhances the interaction between the HCS-FeCu surface and adsorbed oxygen, facilitating molecular oxygen activation, which improves the ROS production efficiency. This work presents an approach that effectively transforms immunologically "cold" tumors into "hot" ones, with significant implications for clinical immunotherapy.
通讯机构：
[Zhang, AD ] C;Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
We report herein a dynamic facet-selective capping (dFSC) strategy for α-calcium sulfate hemihydrate crystal growth from dihydrate gypsum in the presence of a catechol-derived PEI capping agent (DPA-PEI) with inspiration by the biomineralization process of mussel. The crystal shape is controllable and varies from long and pyramid-tipped prisms to thin hexagonal plate. The highly uniform truncated crystals have extremely high compression and bending strengths after hydration molding.
期刊：
Chemical Papers,2023年77(11):6763-6771 ISSN：2585-7290
通讯作者：
Sun, Y;Zhang, AD
作者机构：
[Zhou, Ya-Qing; Sun, Yong; Wang, Ji-Li; Sun, Y; Wu, Wen-Hai] Hanjiang Normal Univ, Coll Chem & Environm Engn, Shiyan 442000, Peoples R China.;[Zhang, Aidong; Duan, Jiang] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
通讯机构：
[Zhang, AD ] C;[Sun, Y ] H;Hanjiang Normal Univ, Coll Chem & Environm Engn, Shiyan 442000, Peoples R China.;Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
关键词：
Aqueous film-forming foam;Formulation;Short-chain perfluorinated surfactant;Extinguishing time;Burnback time
摘要：
As the essential component(s), long-chain perfluorinated or short-chain perfluorinated ionic surfactants are required for effective aqueous film-forming foam (AFFF); nevertheless, the associated qualities of persistent pollution and toxicity have raised significant concerns. It has become critical to develop alternatives to the present fluorine component for AFFF to offset the negative effects. In this study, a short-chain perfluorinated nitrogen-heterocyclic nonionic amine oxide surfactant was combined with hydrocarbon surfactants and additives to prepare an AFFF concentrate. A laboratory technique was developed to evaluate the influence of ingredients on the performance of a 6% AFFF diluent, resulting in an improved AFFF formulation. The performance parameters for pool fire extinguishment and fire resistance of the AFFF formulation were encouraging, including a spreading coefficient of 5.4, foam expansion of 8.11, 25% drainage time of 4.6 min, extinguishing times for forceful application of 58 s, and fire burnback time of 18.6 min. In addition, the AFFF concentrate showed significant freezing resistance when stored at - 20 & DEG;C for an extended period of time. The formulation outperformed the technical standard criteria and has the potential to be used as a novel AFFF agent. [GRAPHICS]
摘要：
A compact 4-port coplanar waveguide (CPW) fed ultra-wideband (UWB) multiple-input-multiple-output (MIMO) antenna with enhanced isolation is proposed to operate from 3.66 GHz to 16.61 GHz with 127.78% impedance bandwidth. The proposed antenna system consists of 4 orthogonal arrays of monopole antennas improved by four iterations. The UWB characteristic of the antenna is obtained from an improved monopole antenna fed by CPW. The final MIMO antenna is machined on a Rogers 4003C substrate with dimensions of 60 x 60 x 0.3 mm(3). The orthogonal arrangement of antennas brings about the polarization diversity and certain isolation of MIMO antennas. Four rows of orthogonal metasurface elements with via holes and the ring of the backplane further improve the isolation between antenna elements in the MIMO system. The MIMO antenna has an impedance bandwidth of 12.95 GHz with S-11 < -10 dB and good isolation (S-21 =S-41 < -30 dB and S-31 < -20 dB). In particular, S31 is always less than -25 dB at frequencies greater than 6 GHz. The measured results of MIMO antenna agree with the simulated results. The optimized MIMO antenna has excellent performance in many aspects, such as UWB, compact size, omnidirectional radiation, enhanced isolation and high efficiency, which means that it has application potential in UWB wireless communication systems.
期刊：
Journal of Thermoplastic Composite Materials,2023年36(11):4349 - 4364 ISSN：0892-7057
通讯作者：
Qiangxian Wu
作者机构：
[Wu, Qiangxian; Zhang, Peirui; Jian, Kui] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan, Peoples R China.;[Weng, Fangqing] Hubei Univ Educ, Coll Chem & Life Sci, Wuhan, Peoples R China.;[Zhuang, Kejia; Hong, Liu; Gao, Shanjun; Zhao, Weiwei] Wuhan Univ Technol, Sch Mat Sci & Engn, Wuhan, Peoples R China.;[Wu, Qiangxian] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Luoyu Rd 152, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Qiangxian Wu] K;Key Laboratory of Pesticide and Chemical Biology of the Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China
关键词：
shell;polycaprolactone;composite;CaCO3
摘要：
Agricultural waste shells are another source of calcium carbonate (CaCO3). Waste shells contain natural polymers such as polysaccharides and protein which can react with active groups in a polymer by melt mixing to form a compatible layer in a composite material. The formation of a compatible layer helps to improve the compatibility and material toughness of a composite. At the same time, the presence of CaCO3 in waste shells can also help to improve the hardness of a material. Therefore, this work mainly focused on the preparation of composite materials using different kinds of shell powder, and also studied the effects of the interface structure between shell powder and polycaprolactone (PCL) and properties of the composite materials. In particular, this work, studied the effects of the crystal forms of various shell powder as well as the content of polysaccharide and protein on the tensile performance and thermal properties of composite materials. The results implied that the tensile performance of the composites prepared from different kinds of shell powder were slightly different. The composite prepared from shell powder containing aragonite-structured CaCO3 had a better elastic modulus than the composite prepared from shell powder containing calcite-structured CaCO3. Likewise, the composite material prepared from scallop shell powder had the best toughness and thermal properties. This work has laid a foundation for exploring the effects of all sorts of shell powder on the structure and properties of composite material.
通讯机构：
[Ernest Koranteng] L;Laboratory of Sustainable Polymers and Synthesis, Department of Chemistry Education, University of Education, Winneba, Ghana
摘要：
Abstract Developing green composites has received intense attention among the scientific community because of their ability to help alleviate the global environmental pollution challenges. This current work focused on preparing a bio‐based composite material with desirable performance using renewable materials like diatomaceous earth, and polylactic acid (PLA) with poly(butanediol adipate ester) prepolymer (PBAPU) as a compatibilizer. The composites were prepared by reactive mixing using an intensive mixer. Subsequently, the effects of the PBAPU content on the structure and properties of the composites were studied. From the test results, it was revealed that increasing the PBAPU content resulted in an increasing trend in the properties of the composites. For instance, the thermal stability of the composites was improved as the PBAPU content was increased, and the best thermal stability was obtained when 20 wt% PBAPU was added. In addition, the mechanical properties test results showed that the elongation at break and impact strength of the composites increased with increasing PBAPU content. On the contrary, the tensile strength of the composites decreased with increasing PBAPU content. The scanning electron microscope images showed that the compatibility between the PLA matrix and PBAPU in the composites was improved significantly. Based on the analysis of the test results for the material's structure, morphology, thermal stability, fluidity, and other properties, it can be concluded that a bio‐based composite material with desirable performance was successfully prepared.
通讯作者：
Sheng Hua Liu<&wdkj&>Jing Zhang<&wdkj&>Sheng Hua Liu Sheng Hua Liu Sheng Hua Liu<&wdkj&>Jing Zhang Jing Zhang Jing Zhang
作者机构：
[Hang Zou; Jing Zhang; Hang Zou Hang Zou Hang Zou; Jing Zhang Jing Zhang Jing Zhang] Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China;[Junyi Gong; Junyi Gong Junyi Gong Junyi Gong] School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen, Guangdong, China;[Sheng Hua Liu; Sheng Hua Liu Sheng Hua Liu Sheng Hua Liu] Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, Hubei, China;College of Chemical Engineering, Shijiazhuang University, Shijiazhuang, P. R. China;[Xiao-Yan Wang; Xiao-Yan Wang Xiao-Yan Wang Xiao-Yan Wang] Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, Hubei, China<&wdkj&>Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China<&wdkj&>College of Chemical Engineering, Shijiazhuang University, Shijiazhuang, P. R. China
通讯机构：
[Sheng Hua Liu; Sheng Hua Liu Sheng Hua Liu Sheng Hua Liu] K;[Jing Zhang; Jing Zhang Jing Zhang Jing Zhang] D;Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, Hubei, China
摘要：
Long‐lived luminescent materials have attracted considerable attention from researchers. However, how to build long‐lived materials in solution still remains a challenge. In this work, a new class of gold(I) complexes have been designed and showed unprecedented aggregation‐induced conversion from TADF to phosphorescence. Their long millisecond lifetime in aggregate also made them excellent candidates in cell imaging. Abstract Long‐lived luminescent materials possess wide application prospects in various areas, but their constructions still face a huge challenge, especially the achievement in solution. Manipulating aggregate is an effective method to attain intriguing luminescence, thus it is expected to build long‐lived materials in solution. In this work, a series of new gold(I) complexes were developed by employing unique carbazole and phosphine as the ligands, and these resulting systems exhibited rare long lifetimes of milliseconds in the aggregate state. It was well unveiled that these complexes emitted blue thermally activated delayed fluorescence (TADF) with the lifetimes of several microseconds in dilute solution; while orange‐red phosphorescence with much longer lifetimes of several milliseconds were achieved in the aggregate state. To our knowledge, this is the first implementation of aggregation‐induced conversion from TADF to phosphorescence. Based on their excellent luminescent properties, we successfully applied these complexes in cell imaging and inhibition of cancer cells.
摘要：
A new fluorescent imaging probe indocyanine green-VC (ICG-VC) in the second near-infrared window (NIR-II) was fabricated based on the urokinase-type plasminogen activator receptor (uPAR) targeted polypeptide VC (VSNKYFSNIHWGC). The relative quantum yield (phi(F))was 0.34 %. The tail of its fluorescence emission wavelength exceeded 1000 nm with excellent photostability. In vitro cell analysis, MTT results indicated the high biocompatibility of ICG-VC with U87MG cells. ICG-VC showed good photothermal conversion behavior and photothermal stability.In vivo NIR-II fluorescence imaging, ICG-VC exhibited high spatiotemporal resolution in the lymphatic vessels with a high resolution of 717 mu m and signal-to-noise ratio of 4.36, and displayed an excellent U87MG tumor uptake within 4 h, which reached the maximum at 8 h with a signal-to-noise ratio of 5.32.
作者机构：
[Bao, Guang-Ming; Wang, Yongze; Luo, Xin; Li, Shentian] Hubei Univ Technol, Hubei Prov Cooperat Innovat Ctr Ind Fermentat, Natl Ctr Cellular Regulat & Mol 111, Hubei Res Ctr Food Fermentat Engn,Key Lab Fermenta, Wuhan 430068, Hubei, Peoples R China.;[Xu, Weiqing; Luo, Zhen; Fang, Qie; Zhu, Chengzhou; Gu, Wenling; Wang, Hengjia] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.;[Zhu, CZ] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
通讯机构：
[Zhu, CZ ] ;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Natl Key Lab Green Pesticide, Wuhan 430079, Peoples R China.
