期刊：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2022年70(40):12746–12759 ISSN：0021-8561
通讯作者：
Jia Li<&wdkj&>Juan Zhou<&wdkj&>Jing Cheng<&wdkj&>Haibing Li
作者机构：
[Li, Wenjie; Xu, Weiwei; Li, Haibing; Cheng, Jing; Zhang, Siyun; Tian, Demei] Cent China Normal Univ CCNU, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Li, Jia; Zhou, Juan] South Cent Minzu Univ, Coll Resources & Environm Sci, Wuhan 430074, Peoples R China.;[Zhou, Juan] Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, State Key Lab Virol, Wuhan 430071, Peoples R China.
通讯机构：
[Jia Li] C;[Juan Zhou] S;[Jing Cheng; Haibing Li] K;Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University (CCNU), Wuhan, 430079, PR China<&wdkj&>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, PR China<&wdkj&>College of Resources and Environmental Science, South-Central Minzu University, Wuhan 430074, PR China
摘要：
Traditional drugs have the disadvantages of poor permeability and low solubility, which makes the utilization of pesticides lower and brings many side effects. With the continuous development of supramolecular chemistry in recent years, it has also played an irreplaceable role in the field of pharmaceutical science. Supramolecular macrocycles, such as crown ethers, cyclodextrins, calixarenes, pillararenes and cucurbiturils, are potentially good candidates for drug carriers due to their biocompatibility, hydrophobic cavity and ease of derivatization. The encapsulation of drugs based on host-guest interaction has the advantage of being adjustable and reversible as well as improving the low availability of drugs. Here, the recent advances in methods and strategies for drug encapsulation and release based on supramolecular macrocycles with host-guest interactions have been systematically summarized, laying a bright foundation for the development of novel nanopesticide preparations in the future and pointing out future directions of novel biopesticide research.
期刊：
Journal of Hazardous Materials,2022年435:128951 ISSN：0304-3894
通讯作者：
Hongwei Sun<&wdkj&>Xiaomei Liao
作者机构：
[Wang, Jian; Liu, Congcong; Liao, Xiaomei; Wang, Shaohui] Cent China Normal Univ, Sch Life Sci, Hubei Key Lab Genet Regulat & Integrat Biol, Wuhan 430079, Peoples R China.;[Zhang, Lizhi; Sun, Hongwei] Cent China Normal Univ, Inst Environm & Appl Chem, Coll Chem, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Hongwei Sun] K;[Xiaomei Liao] H;Hubei Key Lab of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, PR China<&wdkj&>Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Institute of Environmental & Applied Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, PR China
摘要：
The inactivation of microorganisms by nanoscale zero-valent iron (nZVI) was extensively reported, but what happens inside the cells is rarely explored. Herein, we revealed that nZVI caused the drastic increase of intracellular iron concentrations, which subsequently catalyzed the Haber-Weiss reaction to produce high levels of endogenous reactive oxygen species (ROSs) and inactivated E. coli cells by oxidative damage of DNA, evidenced by the significantly higher inactivation efficiencies of E. coli mutant strains deficient in iron uptake regulation and DNA repair than the parental strain. The intracellular iron levels, endogenous ROSs levels and the inactivation efficiencies of E. coli were positively correlated. The permeabilized cytomembrane due to the close contact between nZVI and E. coli was responsible for the iron overload. This work demonstrates experimentally for the first time that nZVI causes iron overload and endogenous oxidative stress to inactivate E. coli, thus deepening our knowledge of the nZVI antimicrobial mechanism.
期刊：
CHEMISTRY-AN ASIAN JOURNAL,2022年17(14):e202200455- ISSN：1861-4728
通讯作者：
Li, Haibing(lhbing@mail.ccnu.edu.cn)
作者机构：
[Chen, Chunxiu; Yang, Lei; Liu, Zhisheng; Li, Haibing; Liu, Lu] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.;[Zhang, Fan] Hubei Univ, Hubei Collaborat Innovat Ctr Adv Organ Chem Mat, Coll Chem & Chem Engn, Minist Educ,Key Lab Synth & Applicat Organ Funct, Wuhan 430062, Peoples R China.
通讯机构：
[Prof. Haibing Li] K;Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079 P. R. China
关键词：
BSA;host-guest.;light-responsive;pillararene;protein transport
作者机构：
[Gao, Ying; Ouyang, Qianxi; Duan, Fangfang; Chang, Jinling; Peng, Xiaogang; Gan, Yutian; Ruan, Hanli] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China.;[Meng, Xianggao] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
通讯机构：
[Hanli Ruan] S;School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People’s Republic of China
期刊：
International Journal of Biological Macromolecules,2022年208:720-730 ISSN：0141-8130
通讯作者：
Xili Liu
作者机构：
[Wang, Weizhen; Dai, Tan; Wang, Yuke; Shen, Jinghuan; Li, Tengjiao; Zhang, Can; Zhang, Borui; Liu, Xili] China Agr Univ, Coll Plant Protect, Beijing 100193, Peoples R China.;[Cai, Meng] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Liu, Xili] Northwest A&F Univ, Coll Plant Protect, State Key Lab Crop Stress Biol Arid Areas, Yangling 712100, Shaanxi, Peoples R China.
通讯机构：
[Xili Liu] C;College of Plant Protection, China Agricultural University, Beijing 100193, China<&wdkj&>State Key Laboratory of Crop Stress Biology for Arid Areas, College of Plant Protection, Northwest A&F University, Yangling 712100, China
摘要：
Phytophthora capsici is a destructive plant pathogen that infects a wide range of hosts worldwide. The P. capsici cell wall, rich in cellulose, is vital for hyphal growth and host interactions. However, the enzymes involved in its synthesis remain largely unelucidated. In the current study, we functionally characterized the cellulose synthase gene PcCesA1, which is highly conserved in Phytophthora. By using CRISPR/Cas9-mediated gene replacement and in situ complementation system, it was found PcCesA1 is essential for the mycelial growth, cystospore germination, and pathogenicity of P. capsici. The normal deposition of newly synthesized cell wall components and the polar growth point formation were disrupted in PcCesA1 knockout mutants, suggesting that PcCesA1 plays an important role in the polar growth of P. capsici. Compared with the wild-type strains, PcCesA1 knockout mutants displayed a thicker inner layer cell wall and were more sensitive to carboxylic acid amide fungicides (CAAs). The contents of the cell wall polysaccharides 1,4-Glc, 1,4,6-Glc, and 1,3,4-Glc were reduced in PcCesA1 knockout mutants, suggesting that PcCesA1 affected cellulose content and glycosidic linkage crosslinking in the cell wall. Our findings demonstrate that PcCesA1 is required for cell wall biogenesis. Therefore, PcCesA1 may be a potential target for Phytophthora disease control.
期刊：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2022年70(22):6644-6657 ISSN：0021-8561
通讯作者：
Ren-Yu Qu<&wdkj&>Hong-Yan Lin
作者机构：
[Yang, Guang-Fu; Yang, Wen-Chao; Wu, Wei; Qu, Ren-Yu; Yan, Yao-Chao; Chen, Qiong; Huang, Guang-Yi; Lin, Hong-Yan] Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, Wuhan 430079, Peoples R China.
通讯机构：
[Ren-Yu Qu; Hong-Yan Lin] K;Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
作者机构：
[Gao, Ying; Ouyang, Qianxi; Zhou, Jia; Gan, Yutian; Ruan, Hanli] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China.;[Meng, Xianggao] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.
通讯机构：
[Hanli Ruan] S;School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Wuhan 430030, People’s Republic of China
作者：
Lu, Hai-Hua;Gan, Kang-Ji;Ni, Fu-Qiang;Zhang, Zhihan;Zhu, Yao
期刊：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2022年144(41):18778-18783 ISSN：0002-7863
通讯作者：
Hai-Hua Lu
作者机构：
[Ni, Fu-Qiang; Lu, Hai-Hua; Zhu, Yao; Gan, Kang-Ji] Westlake Univ, Sch Sci, Dept Chem, Key Lab Precise Synth Funct Mol Zhejiang Prov, Hangzhou 310030, Peoples R China.;[Ni, Fu-Qiang; Lu, Hai-Hua; Zhu, Yao; Gan, Kang-Ji] Westlake Univ, Res Ctr Ind Future, Hangzhou 310030, Peoples R China.;[Ni, Fu-Qiang; Lu, Hai-Hua; Zhu, Yao; Gan, Kang-Ji] Westlake Inst Adv Study, Inst Nat Sci, Hangzhou, Peoples R China.;[Gan, Kang-Ji] Zhejiang Univ, Dept Chem, Hangzhou 310058, Peoples R China.;[Zhang, Zhihan] Cent China Normal Univ, Coll Chem, CCNU uOttawa Joint Res Ctr, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Hai-Hua Lu] K;Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, Department of Chemistry, School of Science and Research Center for Industries of the Future, Westlake University, 600 Dunyu Road, Hangzhou 310030, China<&wdkj&>Institute of Natural Sciences, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou 310024, China
摘要：
We achieved a concise total synthesis of salimabromide by using a novel intramolecular radical cyclization to simultaneously construct the unique benzo-fused [4.3.1] carbon skeleton and the vicinal quaternary stereocenters. Other notable transformations include a tandem Michael/Mukaiyama aldol reaction to introduce most of the molecule's structural elements, along with hidden information for late-stage transformations, an intriguing tandem oxidative cyclization of a diene to form the bridged butyrolactone and enone moieties spontaneously, and a highly enantioselective hydrogenation of a cycloheptenone derivative (97% ee) that paved the way for the asymmetric synthesis of salimabromide.
作者机构：
[Wang, Jian; Yang, Guang-Fu; Zhang, Ru-Yan; Feng, Ran-Ran; Wen, Yu; He, Chen-Bin; Yin, Xu-Guang; Guo, Jun; Zhou, Shi-Hao] Cent China Normal Univ, Coll Chem,Hubei Int Sci & Technol Cooperat Base Pe, Int Joint Res Ctr Intelligent Biosensing Technol &, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Guang-Fu Yang; Jun Guo] K;Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, College of Chemistry, Central China Normal University, Wuhan 430079, China
关键词：
TLR7 agonist;adjuvant-protein conjugate;recombinant protein vaccine;COVID-19;SARS-CoV-2
作者机构：
[Zhao, Zeping; Zhu, Jiajun; Tan, Lei; Zhou, Ting; Han, Yuling; Lacko, Lauretta A.; Tan, Christina; tenOever, Benjamin R.; Yang, Liuliu; Evans, Todd; Chen, Shuibing; Giani, Alice Maria; Cahir, Clare; Dong, Xue; Danziger, Ron; Feng, Lingling; Koo, Soyeon; Ba, Qian] Weill Cornell Med Coll, Dept Surg, 1300 York Ave, New York, NY 10065 USA.;[Tan, Lei] Chinese Acad Sci, Inst Biomed & Biotechnol, Shenzhen Inst Adv Technol, Ctr Energy Metab & Reprod, Shenzhen, Peoples R China.;[Zhou, Ting; Zhong, Aaron] Mem Sloan Kettering Canc Ctr, Stem Cell Res Facil, 1275 York Ave, New York, NY 10065 USA.;[Nilsson-Payant, Benjamin E.; Carrau, Lucia] NYU, Dept Microbiol, 430 29th St, New York, NY 10016 USA.;[Rice, Charles M.; Saeed, Mohsan] Rockefeller Univ, Lab Virol & Infect Dis, New York, NY 10065 USA.
关键词：
Dengue Virus;NDUFA4;SARS-CoV-2;genome-wide association study;iPSC array;isogenic hiPSC lines;mtDNA;risk allele;single-nucleotide polymorphism;type I interferon
摘要：
Population-based studies to identify disease-associated risk alleles typically require samples from a large number of individuals. Here, we report a human-induced pluripotent stem cell (hiPSC)-based screening strategy to link human genetics with viral infectivity. A genome-wide association study (GWAS) identified a cluster of single-nucleotide polymorphisms (SNPs) in a cis-regulatory region of the NDUFA4 gene, which was associated with susceptibility to Zika virus (ZIKV) infection. Loss of NDUFA4 led to decreased sensitivity to ZIKV, dengue virus, and SARS-CoV-2 infection. Isogenic hiPSC lines carrying non-risk alleles of SNPs or deletion of the cis-regulatory region lower sensitivity to viral infection. Mechanistic studies indicated that loss/reduction of NDUFA4 causes mitochondrial stress, which leads to the leakage of mtDNA and thereby upregulation of type I interferon signaling. This study provides proof-of-principle for the application of iPSC arrays in GWAS and identifies NDUFA4 as a previously unknown susceptibility locus for viral infection.
通讯机构：
[Prof. Jing Wang] S;State Key Laboratory of Natural and Biomimetic Drugs and Department of Chemical Biology, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Peking University, Beijing, 100191 China
通讯机构：
[Tingjuan Gao; Zachary J. Smith] K;Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, Anhui 230027, China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China
摘要：
Small-molecule Raman probes for cellular imaging have attracted great attention owing to their sharp peaks that are sensitive to environmental changes. The small cross section of molecular Raman scattering limits dynamic cellular Raman imaging to expensive and complex coherent approaches that acquire single-channel images and lose hyperspectral Raman information. We introduce a new method, dynamic azo-enhanced Raman imaging (DAERI), to couple the new class of azo-enhanced Raman probes with a high-speed line-scan Raman imaging system. DAERI achieved high-resolution low-power imaging of fast cellular dynamics resolved at ∼270 nm along the confocal direction, 75 μW/μm(2) and 3.5 s/frame. Based on the azo-enhanced Raman probes with characteristic signals 10(2)-10(4) stronger than classic Raman labels, DAERI was not restricted to the cellular Raman-silent region as in prior work and enabled multiplex visualization of organelle motions and interactions. We anticipate DAERI to be a powerful tool for future studies in biophysics and cell biology.
作者机构：
[Gu, Wenling; Wang, Xiaosi; Xi, Mengzhen; Wei, Xiaoqian; Jiao, Lei; Qin, Ying; Huang, Jiajia; Zhu, Chengzhou] Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan;430079, China;[Hu, Liuyong] Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan;430205, China;[Cui, Xiaowen; Zheng, Lirong] Institute of High Energy Physics, Chinese Academy of Sciences, Beijing
通讯机构：
[Liuyong Hu] H;[Chengzhou Zhu] K;Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China<&wdkj&>Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, China
作者机构：
[Luo, Zhen; Qin, Ying; Zhu, Chengzhou; Wang, Xiaosi; Gu, Wenling; Wu, Zhichao] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticides & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;[Wang, Canglong] Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China.;[Wang, Canglong] Adv Energy Sci & Technol Guangdong Lab, Huizhou 516000, Peoples R China.;[Wen, Jing; Hu, Liuyong] Wuhan Inst Technol, Hubei Engn Technol Res Ctr Optoelect & New Energy, Hubei Key Lab Plasma Chem & Adv Mat, Wuhan 430205, Peoples R China.
通讯机构：
[Liuyong Hu] H;[Wenling Gu; Chengzhou Zhu] K;Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, Hubei Engineering Technology Research Center of Optoelectronic and New Energy Materials, Wuhan Institute of Technology, Wuhan 430205, P. R. China<&wdkj&>Key Laboratory of Pesticides and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
摘要：
Tris(bipyridine) ruthenium(II)-based luminophores have been well developed in the area of electrochemiluminescence, while their applications in chemiluminescence (CL) are rarely studied due to the poor luminous efficiency and complicated CL reaction. Herein, a novel tris(bipyridine) ruthenium(II)-based ternary CL system is proposed by introducing cobalt single atoms integrated with graphene-encapsulated cobalt nanoparticles (Co SAs/Co@C) and peroxymonosulfate (PMS) as advanced coreaction accelerator and promising coreactant, respectively. On the basis of the experimental results and density functional theory calculations, it is concluded that Co@C can synergistically modulate the adsorption behavior of PMS on Co SAs and then efficiently activate PMS to produce massive singlet oxygen for remarkable CL emission. Under the optimum conditions, the as-prepared CL biosensor exhibits a good linear range, excellent sensitivity, and selectivity, holding great potential for the practical detection of prostate-specific antigen in human serum.
通讯机构：
[Hongwei Sun] K;Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Institute of Environmental & Applied Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, People’s Republic of China
摘要：
Safe treatment of antibiotics requires efficient removal of both antibiotics and their degraded intermediates. In this study, we demonstrate that FeC(2)O(4)•2H(2)O enables the more sustainable conversion of H(2)O(2) to (•)OH than commonly used FeSO(4)•7H(2)O, promoting the detoxification of a typical antibiotic sulfadimidine. It was found that the FeC(2)O(4)/H(2)O(2) system could completely degrade 250mgL(-1) of sulfadimidine within 40min at pH 3.0, along with decreasing the contents of chemical oxygen demand and total organic carbon by 295.0 and 33.5mgL(-1), respectively, more efficient than those in a classical Fenton system (FeSO(4)/H(2)O(2)). Analysis of sulfadimidine degraded intermediates and toxicity evaluation suggested that the FeC(2)O(4)/H(2)O(2) treatment could more effectively decrease the overall toxicity of the sulfadimidine solution than the FeSO(4)/H(2)O(2) counterpart. The sustainability of FeC(2)O(4)•2H(2)O in H(2)O(2) conversion to (•)OH was attributed to its controlled release of Fe(2+) into the solution to prevent the quenching of (•)OH by excessive Fe(2+), as well as the simultaneous release of C(2)O(4)(2-) to complex with Fe(2+) and Fe(3+), which could inhibit iron sludge formation and accelerate Fe(3+)/Fe(2+) redox cycle. This study provides a promising Fenton system for the safe treatment of antibiotics and sheds light on the potential of FeC(2)O(4)•2H(2)O in environmental remediation.
作者机构：
[Qin, Ying; Zhu, Chengzhou; Wu, Yu; Zhang, Yu; Wei, Xiaoqian; Wu, Nannan; Jiao, Lei; Gu, Wenling; Wang, Hengjia; Wu, Zhichao] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;[Hu, Liuyong] Wuhan Inst Technol, Hubei Engn Technol Res Ctr Optoelect & New Energy, Hubei Key Lab Plasma Chem & Adv Mat, Wuhan 430205, Peoples R China.;[Zhong, Hong] Chongqing Univ, Coll Mat Sci & Engn, Chongqing 400030, Peoples R China.
通讯机构：
[Wenling Gu; Chengzhou Zhu] K;Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China
关键词：
Atomic scale materials;Electrocatalysis;Electrochemical sensors;Heavy metal ions;Metallene
通讯机构：
[Yongmin Ma] I;[An-Xin Wu] K;Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China<&wdkj&>Institute of Advanced Studies and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, Taizhou 318000 Zhejiang, China
摘要：
An efficient I2-promoted one-pot one-step three-component reaction for the synthesis of sulfhydryl indolizines from methyl ketones, 2-pyridylacetate derivatives, and sulfonyl hydrazides via an in situ cyclization–rethiolation strategy has been developed. This protocol shows excellent substrate compatibility, including for chain and cyclic aliphatic methyl ketones, natural product pregnenolone acetate, and phosphorus-containing methyl ketones, affording a series of valuable aliphatic-substituted indolizines in good yields.
通讯机构：
[Wei Huang; Ge-Fei Hao] K;Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079, China
关键词：
Cancer treatment;Drug modification;Drug resistance;Multiple resistance mutations;TRK inhibitor
作者机构：
[Hu, Kai; Yang, Guang-Fu; Zhang, Hu; Qu, Ren-Yu; Zhou, Shao-Meng; Yan, Yao-Chao; Chen, Qiong] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Ren-Yu Qu; Guang-Fu Yang] K;Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, PR China
