作者机构：
[Wang, Yingqian; Li, Haibing; Qu, Haonan; Zhu, Fei; Dhinakaran, Manivannan Kalavathi; Quan, Jiaxin; Yan, Hewei] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.;[Han, Ting; Yan, Hewei] Shenzhen Univ, Coll Mat Sci & Engn, Ctr AIE Res, Guangdong Res Ctr Interfacial Engn Funct Mat, Shenzhen 518060, Peoples R China.;[Quan, Jiaxin] Hanjiang Normal Univ, Dept Chem & Environm Engn, Shiyan 442000, Peoples R China.
通讯机构：
[Haibing Li] K;Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan430079, China
摘要：
Redox regulation is an inherent feature of nature and plays a crucial role in the transport of ions/small molecules. However, whether redox status affects the biomolecule transport remains largely unknown. To explore the effects of redox status on biomolecule transport, herein, we constructed a glutathione/glutathione disulfide (GSH/GSSG)-driven and pillar[5]arene (P5)-modified artificial nanochannel for protein transport. The results indicate that hemoglobin (Hb) protein is selectively and effectively transported across the GSH-driven P5-modified nanochannel, which suggests that the redox status of the nanochannel could affect the process of protein transport. Therefore, this redox-driven nanochannel could provide a potential application for biomolecule detection and redox-controllable biomolecular drug release.
期刊：
ACS Agricultural Science and Technology,2022年2(5):1063–1070 ISSN：2692-1952
通讯作者：
Li, J.;Li, H.;Zhang, X.
作者机构：
[Xiaobing Zhang] Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, and Aptamer Engineering Center, Hunan University, Changsha 410082, P. R. China;[Jia Li] College of Resources and Environmental Science, South-Central Minzu University, Wuhan 430074, P. R. China;[Guang Li; Siyun Zhang; Lei Yang; Weiwei Xu; Haonan Qu; Demei Tian; Haibing Li] Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
通讯机构：
[Jia Li] C;[Haibing Li] K;College of Resources and Environmental Science, South-Central Minzu University, Wuhan 430074, P. R. China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
作者机构：
[Cheng, Ming; Li, Haibing] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Hubei, Peoples R China.;[Ma, Junkai] Hubei Univ Med, Dept Chem, Hubei Key Lab Wudang Local Chinese Med Res, Sch Pharm, Shiyan 442000, Hubei, Peoples R China.;[Lu, Mingxiang; Lu, Zhiyan] Wuhan Univ, Dept Forens Med, Zhongnan Hosp, 169 East Lake Rd, Wuhan 430071, Hubei, Peoples R China.;[Gong, Wen] Hubei Prov Hosp Hubei Prov, Peoples Hosp 3, Dept Cardiol, Wuhan 430030, Hubei, Peoples R China.
通讯机构：
[Li, Haibing] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Hubei, Peoples R China.
关键词：
R-Adrenaline;Pillar[6]arene;Chiral surface;Molecular recognition;Host-guest systems
摘要：
Chiral properties of biological surface is of importance as they dominate interactions with biomolecules (such as proteins, nucleic acids, hormones) in a living system. Inspired by this phenomenon, we designed and constructed a L-/D-N-acetyl-cysteine-pillar[6]arene functionalized Si surface (L-/D-NACP surface) for studying the influence of superficial chirality on selective adsorption of R-adrenaline. The fabricated chiral L-/D-NACP surface with consistency in hydrophilia and elementary composition exhibited a strong mirror-symmetric circular dichroism signal. In the adsorption study, the contact-angle of R-adrenaline droplet on D-NACP surface was more hydrophilic from macroscopical view, and the size and quantity of R-adrenaline aggregation on D-NACP surface was larger than L-NACP surface, implying selective adsorption of R-adrenaline appeared on the D-NACP surface. The possible mechanism was due to the stronger host-guest interaction between D-NACP and R-adrenaline, which facilitated the selective adsorption. Besides, the D-NACP surface with good selectivity can be used for chiral separation of racemic adrenaline. The results enhance the understanding of hormones adsorption affected by surface chirality, and may provide some helpful inspiration for practical application of chiral surface.
通讯机构：
[Junrong Li; Yao Sun] K;[Xiaoxing Xiong] D;Department of Neurosurgery, The Affiliated Huzhou Hospital, Zhejiang University School of Medicine (Huzhou Central Hospital), Huzhou 313099, P.R. China<&wdkj&>Department of Neurosurgery, Remin Hospital of Wuhan University, Wuhan 430079, P. R. China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
关键词：
bioinspired nanochannel;protein transport;redox driven;pillar[5]arene;gating ratio
作者机构：
[Li, Yu; Xu, Chuanlai; Li, Haibing; Cheng, Jing] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi, Jiangsu, Peoples R China.;[Li, Yu; Li, Wenjie; Huang, Jinmei; Li, Haibing; Xu, Weiwei; Cheng, Jing] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.;[Sun, Zhongyue] Hubei Univ Chinese Med, Sch Lab Med, Wuhan 430065, Peoples R China.;[Liao, Tangbin] Hubei Univ Chinese Med, Sch Pharm, Wuhan 430065, Peoples R China.;[Kovaleva, Elena G.] Ural Fed Univ, Dept Technol Organ Synth, Mira St 28, Ekaterinburg 620002, Russia.
通讯机构：
[Zhongyue Sun; Tangbin Liao; Chuanlai Xu; Jing Cheng; Haibing Li] S;School of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan 430065, P. R. China<&wdkj&>State Key Laboratory of Food Science and Technology, Jiangnan University, China<&wdkj&>School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, P. R. China<&wdkj&>State Key Laboratory of Food Science and Technology, Jiangnan University, China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
作者机构：
[Zhang, Siyun; Li, Haibing] Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan;430079, China;College of Chemical Engineering, North China University of Science and Technology, Tangshan;063210, China;[Zhou, Juan] State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan
通讯机构：
[Prof. Juan Zhou] S;[Prof. Haibing Li] K;Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079 P. R. China<&wdkj&>State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071 P. R. China
作者机构：
[Qu, Yanjuan; Hu, Hao] Wuhan Univ, Zhongnan Hosp, Dept Radiol, 169 East Lake Rd, Wuhan 430071, Hubei, Peoples R China.;[Hu, Heng] Huazhong Univ Sci & Technol, Tongji Med Coll, Liyuan Hosp, Dept Resp & Crit Care Med, East Lake Rd, Wuhan 430071, Hubei, Peoples R China.;[Lu, Zhiyan; Liu, Zhuo; Lu, Minxiang] Wuhan Univ, Zhongnan Hosp, Dept Forens Med, 169 East Lake Rd, Wuhan 430071, Hubei, Peoples R China.;[Liang, Feng] Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan 430065, Hubei, Peoples R China.;[Li, Guang; Li, Haibing] Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Yanjuan Qu; Minxiang Lu] D;[Feng Liang] S;[Haibing Li] K;Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China<&wdkj&>Department of Forensic Medicine, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China<&wdkj&>School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, People’s Republic of China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, People’s Republic of China
作者机构：
[Wang, Li; Li, Guang; Yang, Lei; Li, Haibing; Cheng, Jing; Qu, Haonan] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.;[Barakat, Dalia A.; Abdallah, Mohammed] Cairo Univ, Fac Agr, Dept Econ Entomol & Pesticides, Giza 12411, Egypt.
通讯机构：
[Jing Cheng; Haibing Li] K;Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R China
期刊：
ACS Agricultural Science and Technology,2022年2(6):1230–1238 ISSN：2692-1952
通讯作者：
Cai, M.;Lu, Z.;Li, H.
作者机构：
[Yue Wang; Zhiyan Lu] Department of Forensic Medicine, Zhongnan Hospital of Wuhan University, No. 169 East Lake Road, Wuchang District, Wuhan430071, P. R. China;[Ruying Zhong] Department of Cardiology, Wuhan Asia Heart Hospital, Wuhan435000, Hubei, P. R. China;[Xiao-Bing Zhang] Molecular Science and Biomedicine Laboratory, State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, and Aptamer Engineering Center, Hunan University, Changsha410082, P. R. China;[Bizhu Lv; Guang Li; Siyun Zhang; Lei Yang; Meng Cai; Jin Zhang; Haibing Li] Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan430079, P. R. China
通讯机构：
[Meng Cai; Haibing Li] K;[Zhiyan Lu] D;Department of Forensic Medicine, Zhongnan Hospital of Wuhan University, No. 169 East Lake Road, Wuchang District, Wuhan430071, P. R. China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan430079, P. R. China
通讯机构：
[Haibing Li] K;Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
通讯机构：
[Haibing Li] K;Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
通讯机构：
[Xiaowei Mao] H;[Haibing Li] K;Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, Institute of Environment and Health, Jianghan University, Wuhan, 430056, PR China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China
摘要：
Phoxim, is a common pollutant present in the environment and food chains, which exhibits irreversible neurotoxicity and poses a grave threat to food security. Herein, a novel 8-hydroxyquinoline-pillar[5]arene was synthesized and applied in a fluorometric chemosensor to detect phoxim. The fluorometric chemosensor shows great selectivity/sensitivity to phoxim, which is due to the formation of inclusion complex between 8-hydroxyquinoline-pillar[5]arene host and phoxim guest. Besides, the presence of other common pesticides did not disturb the responsivity of this chemosensor. This work provided a reliable and rapid method for detecting the pesticide residue.
期刊：
Chemical Communications,2021年57(46):5706-5709 ISSN：1359-7345
通讯作者：
Lu, Zhiyan(luzhiyan@znhospital.cn)
作者机构：
[Li, Xiong] Wuhan Univ, Zhongnan Hosp, Dept Ultrasound, Wuhan 430071, Peoples R China.;[Yang, Yingying; Zhang, Jin; Cheng, Ming; Yang, Lei; Li, Haibing; Quan, Jiaxin; Zhang, Siyun; Yan, Hewei] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China.;[Lu, Zhiyan] Wuhan Univ, Zhongnan Hosp, Dept Forens Med, 169 East Lake Rd, Wuhan 430071, Hubei, Peoples R China.
通讯机构：
[Yang, Yingying] K;[Li, Xiong; Lu, Zhiyan] D;Department of ultrasound, Zhongnan Hospital, Wuhan University, Wuhan 430071, China.;Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China.;Department of Forensic Medicine, Zhongnan Hospital of Wuhan University, No. 169 East Lake Road, Wuchang District, Wuhan 430071, Hubei, China.
摘要：
Chiral arginine was introduced by layer-by-layer assembly onto a calix[4]arene-diacid modified silica surface to control the adsorption of different kinds of ibuprofen droplets. The droplet of (S)-ibuprofen slid off rapidly, whereas the droplet of (R)-ibuprofen absorbed on the modified surface.
