Pillar[5]arene Promoted Selective Spreading of Chlormequat Droplets on a Hydrophobic Surface
作者：
Yu, Sheng;Gilbert, Nsengiyumva;Zhu, Fei;Dhinakaran, Manivannan Kalavathi;Liang, Feng* ;...
期刊：
LANGMUIR ,2020年36(8):1950-1955 ISSN：0743-7463
通讯作者：
Liang, Feng;Li, Haibing
作者机构：
[Liang, Feng; Yu, Sheng] Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, State Key Lab Refractories & Met, Coal Convers & New Carbon Mat Hubei Key Lab, Wuhan 430081, Hubei, Peoples R China.;[Gilbert, Nsengiyumva; Li, Haibing; Zhu, Fei; Dhinakaran, Manivannan Kalavathi] Cent China Normal Univ, Key Lab Pesticide & Chem Biol CCNU, Coll Chem,Chem Biol Canter,Minist Educ, Int Joint Res Ctr Intelligent Biosensor Technol &, Wuhan 430079, Peoples R China.
通讯机构：
[Liang, Feng] W;[Li, Haibing] C;Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, State Key Lab Refractories & Met, Coal Convers & New Carbon Mat Hubei Key Lab, Wuhan 430081, Hubei, Peoples R China.;Cent China Normal Univ, Key Lab Pesticide & Chem Biol CCNU, Coll Chem,Chem Biol Canter,Minist Educ, Int Joint Res Ctr Intelligent Biosensor Technol &, Wuhan 430079, Peoples R China.
摘要：
Promoting the spreading and deposition of agricultural sprays on the crop surface is of great significance for effective utilization of these chemicals. Selective host-guest interaction established between chlormequat and hydroxyl pillar[5]arene was well utilized in the present work for effective spreading of chlormequat droplets over the hydrophobic surface, which was silanized with triethoxy (octyl) silane and then assembled with hydroxybenzene pillar[5]arene molecules. Therefore, this surface was facile for the assembly of chlormequat in droplets and ultimately increased the selective adhesion of chlormequat through host-guest interactions. Moreover, the pillar[5]arene-fabricated surface shows considerable potential applications for rapid detection of chlormequat in environmental monitoring and also provides a novel approach for improving the chlormequat efficiency. Copyright © 2020 American Chemical Society.
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英文
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Molecularly imprinted polymers immobilized on graphene oxide film for monolithic fiber solid phase microextraction and ultrasensitive determination of triphenyl phosphate
作者：
Jian, Yajing;Chen, Linfeng;Cheng, Jing* ;Huang, Xiaolan;Yan, Ling;...
期刊：
Analytica Chimica Acta ,2020年1133:1-10 ISSN：0003-2670
通讯作者：
Cheng, Jing;Li, Haibing
作者机构：
[Huang, Xiaolan; Jian, Yajing; Yan, Ling; Li, Haibing; Cheng, Jing; Li, HB; Chen, Linfeng] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Inst Environm Chem,Coll Chem, Wuhan 430079, Peoples R China.
通讯机构：
[Cheng, J; Li, HB] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Inst Environm Chem,Coll Chem, Wuhan 430079, Peoples R China.
关键词：
Gas chromatography;Molecularly imprinted polymers immobilized on graphene oxide film;Monolithic fiber;Selective and ultrasensitive;Solid phase microextraction;Triphenyl phosphate
摘要：
Triphenyl phosphate (TPhP), a typical model of organophosphorus flame retardants (OPFRs), has been regarded as emerging environmental contaminants of health concern. In this study, TPhP molecularly imprinted polymers immobilized on graphene oxide (GO) film (TPhP-MIPs/GO) monolithic fiber for direct immersion solid phase microextraction (DI-SPME) was fabricated and evaluated. Compared with TPhP molecularly imprinted polymers (TPhP-MIPs) monolithic fiber, TPhP-MIPs/GO fiber had bigger extraction capacity, stronger hydrophilicity and faster mass transfer rate. Furthermore, TPhP-MIPs/GO fiber displayed excellent selectivity for TPhP among its structure analogues. It was thermally stable up to 320 degrees C so that it can withstand the high temperature of gas chromatography (GC) injection port for desorption and detection by flame photometric detector (FPD). Under optimal conditions, TPhP-MIPs/GO-SPME-GC/FPD method was developed by yielding satisfactory ultralow limit of quantification (0.4 ng L-1); linearity (>= 0.99), good intra- and inter-day precision for a single fiber and fiber-to-fiber reproducibility. The method was applied for the determination of TPhP in environmental water and the relative recoveries were found to be in the range from 70 to 110%. TPhP was detected in three out of four environmental water samples at concentration levels from 0.04 to 0.12 ng mL(-1), illustrating light pollution of TPhP in most environmental water. (C) 2020 Elsevier B.V. All rights reserved.
语种：
英文
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Biomimetic nanochannels platform for detecting N-acetylglucosamine analogues
作者：
Sun, Yue;Cheng, Shi-Qi;Ma, Junkai;Zhu, Fei;Hong, Wei;...
期刊：
Sensors and Actuators B-Chemical ,2020年323:128705 ISSN：0925-4005
通讯作者：
Li, Haibing
作者机构：
[Cheng, Shi-Qi; Sun, Yue] South Cent Univ Nationalities, Coll Chem & Mat Sci, Hubei Key Lab Catalysis & Mat Sci, Wuhan 430074, Peoples R China.;[Li, Haibing; Hong, Wei; Zhu, Fei] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.;[Ma, Junkai] Hubei Univ Med, Sch Pharm, Dept Chem, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Peoples R China.
通讯机构：
[Li, Haibing] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.
关键词：
Pillararenes;Host-guest chemistry;Nanochannnels;Biomimetic
摘要：
N-acetylglucosamine analogues exist in nature as an important saccharide in human body and can regulate a variety of life activities captured through biological nanochannels. Herein we describe a biomimetic strategy via supramolecular host-guest chemistry for constructing artificial nanochannels to detect N-acetylglucosamine analogues. The functional nanochannels exhibited a high selectivity and good reversibility towards N-acetylglucosamine. Further studies indicate that the detecting behaviors was probably due to the multiple hydrogen bonding interactions and an appropriately fitting the functional and geometric requirements between the tryptophan-decorated pillararenes and N-acetylglucosamine, leading to the change of the surface charge and wettability within the nanochannels. These studies can give interesting insight for the research of biological processes caused by N-acetylglucosamine-sensitive ion channels, and also help to develop the platform for detecting N-acetylglucosamine in vitro.
语种：
英文
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Engineering a NO-Regulated Nanofluidic Sensor through the Cyclization Reaction Strategy
作者：
Han, Yunfeng;Sun, Zhongyue;Sun, Ziyan;Chen, Xiaoya;Zhang, Yongxue* ;...
期刊：
CHEMISTRY-A EUROPEAN JOURNAL ,2020年26(49):11099-11103 ISSN：0947-6539
通讯作者：
Zhang, Yongxue;Sun, Yao;Li, Haibing
作者机构：
[Han, Yunfeng; Zhang, Yongxue] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Nucl Med, Wuhan 430022, Peoples R China.;[Han, Yunfeng] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Nucl Med, Wuhan 430030, Peoples R China.;[Li, Haibing; Sun, Zhongyue; Chen, Xiaoya; Sun, Yao; Sun, Ziyan; Li, HB] Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Sun, Zhongyue] Hubei Univ Chinese Med, Sch Lab Med, Wuhan 430065, Peoples R China.;[Sun, Ziyan] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Radiol, Wuhan 430030, Peoples R China.
通讯机构：
[Zhang, Yongxue] H;[Sun, Y; Li, HB] C;Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Nucl Med, Wuhan 430022, Peoples R China.;Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
关键词：
cyclization reactions;ion rectification;nanochannel;nanosensors;nitic oxide
摘要：
Nitric oxide (NO) is known to be a secondary in vivo signaling agent, demonstrating various biological functions through regulating ion flux in channels. Considering the crucial role of NO in vivo, herein, a biomimetic NO-regulated nanofluidic sensor has been fabricated through a cyclization reaction strategy. This nanofluidic sensor exhibited a promising NO selectivity, sensitivity, and non-interference performance in complex matrices. Thus, such a NO-driven nanosensor will be meaningful for scientific researchers to grasp the in vivo functions of NO. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
语种：
英文
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Phenethylamine@Pillar[5]arene Biointerface for Highly Enantioselective Adsorption of Protein
作者：
Yan, Hewei;Ma, Junkai;Zhu, Fei;Quan, Jiaxin;Dhinakaran, Manivannan Kalavathi;...
期刊：
CHEMISTRY-AN ASIAN JOURNAL ,2020年15(7):1025-1029 ISSN：1861-4728
通讯作者：
Li, Haibing
作者机构：
[Li, Haibing; Zhu, Fei; Dhinakaran, Manivannan Kalavathi; Quan, Jiaxin; Yan, Hewei] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China.;[Ma, Junkai] Hubei Univ Med, Sch Pharm, Dept Chem, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Hubei, Peoples R China.
通讯机构：
[Li, Haibing] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China.
关键词：
pillar[5]arene;chiral;biointerface;adsorption;proteins
摘要：
In the life system, the biointerface plays an important role in cell adsorption, platelet adsorption and activation. Therefore, the study of protein adsorption on the biointerface is of great significance for understanding life phenomena and treatment in vitro. In this paper, a chiral biointerface was constructed by the virtue of host-guest interaction between a water-soluble pillar[5]arene (WP5) and phenethylamine (PEA) over a gold surface for adsorption of lysozyme proteins. From the experimental results it was identified that the host-guest biointerface has a high adsorption capacity and strong chiral selectivity. Furthermotre, it was identified that the host-guest interaction plays the decisive role in the enhancement of chirality of the interface, which was much beneficial for increasing protein adsorption and amplifying the capacity of chiral discrimination. Therefore, this work provides a new idea for the construction of biointerface materials with high protein adsorption capacity and high chiral selectivity through supramolecular interaction, which will have potential applications in the fields of biosensors, biocatalysts, biomaterials. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
语种：
英文
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Glutathione modified Ag nanoparticles as efficient detector for pyrimethanil.
作者：
Zhang, Siyun;Hu, Ren;Li, Haibing*
期刊：
Nanotechnology ,2019年30(11):115502 ISSN：0957-4484
通讯作者：
Li, Haibing
作者机构：
[Li, Haibing; Hu, Ren; Zhang, Siyun] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Li, Haibing] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
关键词：
Ag nanoparticles;glutathione modification;pyrimethanil detection;pesticide
摘要：
This work reports on glutathione modified Ag nanoparticles (GSH-Ag NPs) as a chemosensor for detecting pyrimethanil in an aqueous medium. The GSH-Ag NPs were expediently obtained by reducing AgNO3 with NaBH4 and modified with glutathione based on the Ag-S bond. The rapid discrimination for pyrimethanil from other pesticides exhibited the high selectivity of GSH-Ag NPs, then the selectivity was proved by 1H NMR, FT-IR and computational simulation. Based on the good properties of localized surface plasmon resonance, the selective recognition was transformed to visible optical signal in colorimetric test. Additionally the quantitative detection was achieved with good sensitivity and could be applied to analyze practical samples. The experimental results have shown a good linear relationship with pyrimethanil concentration ranging from 10 μM to 1 mM and a low detection limit of 3.87 μM. © 2019 IOP Publishing Ltd.
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英文
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巯基-烯点击反应合成手性柱[6]芳烃及其对肾上腺素的手性识别性能研究
作者：
马俊凯;田德美;李海兵
作者机构：
[马俊凯; 田德美; 李海兵] 农药与化学生物学教育部重点实验室化学学院华中师范大学
会议名称：
全国第十八届大环化学暨第十届分子化学学术讨论会
会议时间：
20160825
会议地点：
长沙
会议论文集名称：
全国第十八届大环化学暨第十届分子化学学术讨论会 论文集
关键词：
柱[6]芳烃;巯基-烯反应;肾上腺素;手性识别
摘要：
<正>儿茶酚胺类药物,如多巴胺、L-多巴、肾上腺素及去甲基肾上腺素等是一类主要的神经递质,在中枢神经系统中具有多种重要功能。R-构型的肾上腺素是其左旋体,其生理活性比其对映体高12倍。其在细胞膜表面的手性选择性作用是如何实现的?本文通过巯基-烯点击反应合成了N-乙酰-D/L-半胱氨酸修饰的手性柱[6]芳烃,并修饰到纳米硅表面,实现了对肾上
语种：
中文
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A highly selective and recyclable NO-responsive nanochannel based on a spiroring opening−closing reaction strategy
作者：
Sun, Yao;Chen, Sen;Chen, Xiaoya;Xu, Yuling;Zhang, Siyun;...
期刊：
Nature Communications ,2019年10(1):1323 ISSN：2041-1723
通讯作者：
Yang, Guangfu;Li, Haibing
作者机构：
[Xu, Yuling; Chen, Sen; Ouyang, Qingying; Yang, Guangfu; Li, Haibing; Sun, Yao; Zhang, Siyun; Yang, GF; Li, HB] Cent China Normal Univ, Key Lab Pesticide & Chem Biol CCNU, Minist Educ,Chem Biol Ctr,Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Wuhan 430079, Hubei, Peoples R China.;[Chen, Xiaoya] Hunan Univ, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.
通讯机构：
[Yang, GF; Li, HB] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol CCNU, Minist Educ,Chem Biol Ctr,Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Wuhan 430079, Hubei, Peoples R China.
摘要：
Endogenous nitric oxide (NO) is an important messenger molecule, which can directly activate K + transmission and cause relaxation of vascular smooth muscle. Here, inspired by the K + channel of smooth muscle cells, we report, a novel NO-regulated artificial nanochannel based on a spiro ring opening−closing reaction strategy. This nanofluidic diode system shows an outstanding NO selective response owing to the specific reaction between o-phenylenediamine (OPD) and NO on the channel surface with high ion rectification ratio (~6.7) and ion gating ratio (~4). Moreover, this NO gating system exhibits excellent reversibility and stability as well as high selectivity response. This system not only helps us understand the process of NO directly regulating biological ion channels, but also has potential application value in the field of biosensors. © 2019, The Author(s).
语种：
英文
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Chiral galactose responsive S-phenethylamine calix [4] arene-based sensing surface
作者：
Zhang, Xujie;Yang, Yuxia;Gu, Yulin;Zhang, Jin;Cheng, Jian;...
期刊：
Sensors and Actuators B-Chemical ,2019年297:126662 ISSN：0925-4005
通讯作者：
Sun, Kunpeng;Li, Haibing
作者机构：
[Sun, Kunpeng; Zhang, Xujie; Gu, Yulin; Yang, Yuxia] Chinese Acad Sci, Natl Engn Res Ctr Fine Petrochem Intermediates, Lanzhou Inst Chem Phys, Lanzhou 730000, Gansu, Peoples R China.;[Zhang, Jin; Zhang, Xujie; Cheng, Jian; Li, Haibing; Wang, Junhua] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Sun, Kunpeng; Li, Haibing] C;Chinese Acad Sci, Natl Engn Res Ctr Fine Petrochem Intermediates, Lanzhou Inst Chem Phys, Lanzhou 730000, Gansu, Peoples R China.;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
关键词：
Calix[4]arene;Chiral selective;Galactose enantiomer;Self-assembly;Sensing surface
摘要：
Herein, we reported a novel surface based chemosensor, a highly chiral responsive surface recognized galactose enantiomer based on the self-assembly system, which exhibits highly efficient chiral selective for D-galactose via contact angle measurements (CA). We primarily studied the interaction between S-phenethylamine-calix[4]arene (S-DPC4A) and L/D-galactose through the characterization of 1H NMR spectroscopic and UV spectroscopic, then a functional S-DPC4A-based sensing surface were constructed by click reaction and characterized by the analysis of contact angle and X-ray photoelectron spectroscopy (XPS). Interestingly, the S-DPC4A-based sensing surface exhibited highly dynamic responsive for the D-galactose on the tilted interface, realized the weak chiral-interaction signals to convert into the macroscopic properties of materials and reached visual distinction accompanying the changes of surface wettability. © 2019
语种：
英文
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巯基-烯点击反应合成手性柱芳烃及其识别性能研究
作者：
马俊凯;张凡;李海兵
作者机构：
湖北医药学院药学院 十堰 442000;湖北大学化学化工学院 武汉 430062;华中师范大学化学学院 武汉 430079
会议名称：
中国化学会第十六届全国有机合成化学学术研讨会
会议时间：
2019-08-08
会议地点：
河南开封
会议论文集名称：
中国化学会第十六届全国有机合成化学学术研讨会论文集
关键词：
点击反应;柱芳烃;纳米孔道;超分子化学
摘要：
光引发的巯基与烯(炔)点击反应是一类新型的点击反应,它以光引发产生自由基作为催化介质,反应体系简单、后处理方便、产率高[1,2]。将成为高分子科学和有机合成化学的一个新的研究方向。通过“光引发”点击反应设计合成了羧基、氨基修饰的水溶性柱[5,6]芳烃；N-乙酰半胱氨酸修饰的手性柱[5,6]芳烃(图1)。基于上述合成的功能化分子,设计构建了半胱氨酸对映体修饰的手性纳米通道,探究了手性纳米孔对蛋白质传输的影响。通过原位荧光检测和脉冲电流测试手段,考察了手性通道调控蛋白质传输的过程。并且通过计算机分子模拟及AFM的对比实验对其分子相互机理进行探究。结果 表明,L-Cys柱芳烃修饰的纳米通道与BSA有更强的相互作用,会促进BSA优先富集进入L-通道。此外,通过电场调控的对比实验进一步说明了分子运动的驱动力,说明了手性选择性促进蛋白进入限域空间后需要电场的驱动促进分子迁移。该研究为我们进一步研究复杂体系中分子动力学过程提供了一个新的理论基础。为生物科学研究提供了一个新的理论模型,同时有助于我们进一步认识手性在生理和病理行为的作用。
语种：
中文
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Rhomboidal Pt(II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy
作者：
Sun, Yue;Ding, Feng;Zhou, Zhixuan;Li, Chonglu;Pu, Maoping;...
期刊：
Proceedings of the National Academy of Sciences of the United States of America ,2019年116(6):1968-1973 ISSN：0027-8424
通讯作者：
Li, Haibing;Yang, Guangfu;Sun, Yao;Stang, Peter J.
作者机构：
[Xu, Yuling; Sun, Yue; Yang, Guangfu; Li, Haibing; Yang, GF; Sun, Y; Sun, Yao; Li, Chonglu; Ding, Feng] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Xu, Yuling; Sun, Yue; Yang, Guangfu; Li, Haibing; Yang, GF; Sun, Y; Sun, Yao; Li, Chonglu; Ding, Feng] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Chem Biol Ctr, Wuhan 430079, Hubei, Peoples R China.;[Sun, Yue; Stang, Peter J.; Zhou, Zhixuan] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA.;[Pu, Maoping] Rheinisch Westfalische Tech Hsch Aachen Univ, Inst Organ Chem, D-52074 Aachen, Germany.;[Lu, Xiaoju; Zhan, Yibei] Hubei Polytech Univ, Sch Chem & Chem Engn, Huangshi 435003, Peoples R China.
通讯机构：
[Li, HB; Yang, GF; Sun, Y] C;[Stang, Peter J.] U;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticides & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Chem Biol Ctr, Wuhan 430079, Hubei, Peoples R China.;Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA.
关键词：
*image-guided therapy;*metallacycle;*second near-infrared region;*supramolecular coordination complexes;*theranostic
摘要：
Fluorescent theranostics probes at the second near-IR region (NIR-II; 1.0-1.7 μm) are in high demand for precise theranostics that minimize autofluorescence, reduce photon scattering, and improve the penetration depth. Herein, we designed and synthesized an NIR-II theranostic nanoprobe 1 that incorporates a Pt(II) metallacycle 2 and an organic molecular dye 3 into DSPE-mPEG5000 (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000]). This design endows 1 with good photostability and passive targeting ability. Our studies show that 1 accurately diagnoses cancer with high resolution and selectively delivers the Pt(II) metallacycle to tumor regions via an enhanced permeability and retention effect. In vivo studies reveal that 1 efficiently inhibits the growth of tumor with minimal side effects. At the same time, improved fluorescent imaging quality and signal-to-noise ratios are shown due to the long emission wavelengths. These studies demonstrate that 1 is a potential theranostic platform for tumor diagnosis and treatment in the NIR-II region. © 2019 National Academy of Sciences. All Rights Reserved.
语种：
英文
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Switchable Nanochannel Biosensor for H 2 S Detection Based on an Azide Reduction Reaction Controlled BSA Aggregation
作者：
Zhang, Ruiping;Chen, Xiaoya;Sun, Zhongyue;Chen, Sen;Gao, Jing;...
期刊：
Analytical Chemistry ,2019年91(9):6149-6154 ISSN：0003-2700
通讯作者：
Sun, Yao;Li, Haibing
作者机构：
[Zhang, Ruiping] Shanxi Med Univ, Affiliated Canc Hosp, Imaging Dept, Taiyuan 030001, Shanxi, Peoples R China.;[Chen, Sen; Li, Haibing; Sun, Zhongyue; Chen, Xiaoya; Sun, Yao; Sun, Y; Li, HB] Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Minist Educ,Coll Chem, Key Lab Pesticides & Chem Biol,Ctr Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Gao, Jing] Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Jiangsu Key Lab Med Opt, Suzhou 215163, Peoples R China.
通讯机构：
[Sun, Y; Li, HB] C;Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Minist Educ,Coll Chem, Key Lab Pesticides & Chem Biol,Ctr Chem Biol, Wuhan 430079, Hubei, Peoples R China.
摘要：
Hydrogen sulfide (H 2 S) is the third endogenous gaseous signal molecule in organisms that can directly increase the salt tolerance of plants by closing the K + channel. Inspired by the important role of H 2 S in nature, we have designed a H 2 S-responsive artificial nanochannel biosensor based on an azide reduction reaction strategy. This biomimetic device demonstrates an excellent H 2 S selective response owing to specific azide reduction by H 2 S inducing BSA aggregation on the channel with a high ion gating ratio. Furthermore, this H 2 S-responsive biosensor shows excellent reversibility and stability and a fast response rate, which will help us better understand the synergistic effect of H 2 S messengers in the ion channels of living organisms. © 2019 American Chemical Society.
语种：
英文
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A Chirality/Light Dual-Responsive Calixarene-Functionalized Gold Surface for the Separation of Naproxen Enantiomers
作者：
Xu, Pingping;Quan, Jiaxin;Chen, Wan;Zhang, Jin;Yan, Hewei;...
期刊：
ChemPlusChem ,2019年84(7):907-912 ISSN：2192-6506
通讯作者：
Li, Haibing;Yang, Guangfu
作者机构：
[Xu, Pingping; Zhang, Jin; Zeng, Xiangfei; Li, HB; Yang, GF; Liu, Yanxiang; Yang, Guangfu; Li, Haibing; Tan, Shiliang; Chen, Wan; Quan, Jiaxin; Yan, Hewei] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Psticide & Chem Biol CCNU, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Li, HB; Yang, GF] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Psticide & Chem Biol CCNU, Wuhan 430079, Hubei, Peoples R China.
关键词：
chirality;drugs;molecular recognition;photoswitching;surfaces
摘要：
Chiral and photo-responsive calix[4]arene (trans CAC4) host system that can be adsorbed onto gold surfaces was rationally designed and produced in quantitative yields. Chiral recognition through strong host–guest interaction between trans CAC4 and (R)-naproxen was confirmed by fluorescence titration and 1H NMR analysis. Functionalization of the gold surface with trans CAC4 was demonstrated by increased contact angle and XPS measurement. Photoswitching by trans-cis isomerization of CAC4 and CAC4-modified gold surfaces was confirmed by UV-vis spectroscopy and contact angle experiments. Trans CAC4-modified gold surfaces showed selective adsorption towards (R)-naproxen, while cis CAC4-modified gold surfaces did not show any distinctive interaction with (R)/(S)-naproxen. Langmuir isothermal plots and LSCM studies proved quantitative adsorption of (R)-naproxen by the trans CAC4-modified surface. This study demonstrated chiral recognition of a drug system by visual macroscopic changes, which may be used as a convenient methodology to separate bioactive enantiomers. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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英文
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Bioinspired γ-Cyclodextrin pseudorotaxane assembly nanochannel for selective amino acid Transport
作者：
Zhang, Xingrou;Zhang, Fan;Zhu, Fei;Zhang, Xiaoyan;Tian, Demei;...
期刊：
ACS Applied Bio Materials ,2019年2(8):3607-3612 ISSN：2576-6422
通讯作者：
Johnson, Robert P.(RpJohnson@lincoln.ac.uk)
作者机构：
[Zhang, Xingrou; Zhang, Fan; Zhu, Fei; Zhang, Xiaoyan; Tian, Demei; Li, Haibing] Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan;430079, China;[Johnson, Robert P.] School of Chemistry, University of Lincoln, Brayford Pool, Lincoln;LN6 7TS, United Kingdom;[Zhang, Xingrou; Zhang, Fan; Zhu, Fei; Zhang, Xiaoyan; Tian, Demei; Li, Haibing] 430079, China
通讯机构：
[Robert P. Johnson] S;[Haibing Li] K;School of Chemistry, University of Lincoln, Brayford Pool, Lincoln LN6 7TS, United Kingdom<&wdkj&>Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, People’s Republic of China
关键词：
amino acid transport;chiral selectivity;host-guest system;nanochannel;nanosensor
摘要：
Amino acid metabolic abnormalities will cause serious diseases, which arise from the different biological effect of enantiomers. Therefore, it is necessary to design and construct an artificial chiral amino acid gated transport system, which can effectively recognize and selectively transport chiral amino acids. Herein, based on the host-guest interaction, a switchable chiral discrimination system for amino acid enantiomers is reported, and the biomimetic nanochannel was functionalized with N-(1-naphthyl) ethylenediamine (NEDA), which acts as the guest and γ-CD was used as the host. The artificial nanochannel performs highly chiral selective gating for l-phenylalanine and well regulates the process of amino acid transportation. Moreover, the channel can easily actualize the reversible switching under the influence of a pH change; thus, our biomimetic nanochannel with a host-guest assembly can be widely used in chiral detection and drug delivery. Copyright © 2019 American Chemical Society.
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英文
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A pyrophosphate-activated nanochannel inspired by a TRP ion channel
作者：
Zhu, Fei;Yang, Guanxing;Dhinakaran, Manivannan Kalavathi;Wang, Rui;Song, Miaomiao;...
期刊：
Chemical Communications ,2019年55(85):12833-12836 ISSN：1359-7345
通讯作者：
Li, Haibing
作者机构：
[Song, Miaomiao; Yang, Guanxing; Li, Haibing; Zhu, Fei; Dhinakaran, Manivannan Kalavathi; Wang, Rui] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Li, Haibing] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Hubei, Peoples R China.
摘要：
A pyrophosphate (PPi) selectively activated potassium channel was constructed via introducing the isoniazid functionalized calix[4]arene (C4NP) into a biomimetic nanochannel. The activation mechanism is mainly due to the changing of the inner surface charge and wettability of the nanochannel caused by PPi binding.
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英文
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Enantioselective Dynamic Self-Assembly of Histidine Droplets on Pillar[5]arene-Modified Interfaces.
作者：
Ma, Junkai;Yan, Hewei;Quan, Jiaxin;Bi, Jiahai;Tian, Demei;...
期刊：
ACS Applied Materials & Interfaces ,2019年11(1):1665-1671 ISSN：1944-8244
通讯作者：
Li, Haibing
作者机构：
[Ma, Junkai] Hubei Univ Med, Sch Pharm, Dept Chem, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan 442000, Hubei, Peoples R China.;[Li, Haibing; Quan, Jiaxin; Bi, Jiahai; Tian, Demei; Yan, Hewei] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Li, Haibing] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Hubei, Peoples R China.
关键词：
amino acids;chiral recognition;macroscopic responsive;pillar[5]arene;self-assembly
摘要：
The self-assembly of macroscopic droplets on interfaces has attracted much attention and shown promising potential in the field of materials as a sensing or delivery system. Herein, we reported a new strategy to construct a d-tartaric acid-functionalized pillar[5]arene (d-TP5) interface for macroscopic differentiation of histidine enantiomers. At the molecular level, it has been proved that d-TP5 has the ability to distinguish between l-Histidine and d-Histidine (K L /K D = 4.6). Furthermore, a functional d-TP5 surface was constructed by a click reaction and characterized by contact angle measurements and attenuated total reflection-Fourier-transform infrared spectroscopy and X-ray photoelectron spectroscopy analyses. The d-TP5 surface exhibited the selective dynamic adhesion of l-His droplets on the tilted interface. It means that a d-TP5 surface can distinguish histidine enantiomers at a macrolevel. The amount of d/l-His absorbed by a d-TP5 surface and the morphology of His particles formed by removing the solvent have been investigated to prove that the self-assembly of His occurs on the d-TP5 surface. The possible mechanism has been discussed from host-guest interaction and chiral recognition. The proposed chiral material displays rapidly remarkable selectivity and is convenient to be utilized, which should be suitable for comprehending chiral recognition processing and applied to chiral recognition detection of histidine in a living body. © 2018 American Chemical Society.
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英文
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Fabrication of a Tyrosine-Responsive Liquid Quantum Dots Based Biosensor through Host-Guest Chemistry
作者：
Lu, Xiaoju;Zhan, Yibei;Ouyang, Qingying;Bai, Suya;Chen, Huan;...
期刊：
Analytical Chemistry ,2019年91(20):13285-13289 ISSN：0003-2700
通讯作者：
Sun, Yao
作者机构：
[Zhan, Yibei; Lu, Xiaoju] Hubei Polytech Univ, Sch Chem & Chem Engn, Huangshi 435003, Hubei, Peoples R China.;[Zheng, Yifu; Ouyang, Qingying; Li, Haibing; Chen, Huan; Bai, Suya; Sun, Yao] Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticides & Chem Biol, Minist Educ,Ctr Chem Biol,Coll Chem, Wuhan 430079, Hubei, Peoples R China.;[Yu, Yongliang] Northeastern Univ, Dept Chem, Coll Sci, Res Ctr Analyt Sci, Shenyang 110819, Liaoning, Peoples R China.;[Zheng, Yifu] Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, CAS Key Lab Nanobio Interface, Suzhou 215123, Peoples R China.
通讯机构：
[Sun, Yao] C;Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticides & Chem Biol, Minist Educ,Ctr Chem Biol,Coll Chem, Wuhan 430079, Hubei, Peoples R China.
摘要：
Design and fabrication of smart liquid quantum dots (LQDs) with high biomolecule selectivity and specificity remains a challenge. Herein, a multifunctional calix[4]arene derivative (PCAD) was rationally designed and applied to fabricate a Tyr-responsive CdSe-LQD system through host-guest chemistry. Such a biosensor displays an outstanding fluorescence/macroscopic response for Tyr and reversible fluidic features due to the hydrogen interaction between the PCAD of CdSe-LQDs and Tyr. These excellent results highlighted CdSe-LQDs as a promising platform for biological molecule recognition and separation in the future. © 2019 American Chemical Society.
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英文
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The chiral interfaces fabricated by d/l-alanine-pillar[5]arenes for selectively adsorbing ctDNA
作者：
Zhang, Jin;Wang, Zhenjun;Lv, Shuxin;Zeng, Xiangfei;Sun, Yao* ;...
期刊：
Chemical Communications ,2019年55(6):778-781 ISSN：1359-7345
通讯作者：
Zhang, Ruiping;Sun, Yao;Li, Haibing
作者机构：
[Zhang, Jin; Zhang, Ruiping; Wang, Zhenjun; Lv, Shuxin] Shanxi Med Univ, Affiliated Canc Hosp, Hosp 1, Taiyuan 030001, Shanxi, Peoples R China.;[Zhang, Jin; Zeng, Xiangfei; Li, Haibing; Sun, Yao; Sun, Y; Li, HB] Cent China Normal Univ, Key Lab Pesticide & Chem Biol CCNU, Int Joint Res Ctr Intelligent Biosensor Technol &, Minist Educ,Chem Biol Ctr,Coll Chem, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Zhang, Ruiping] S;[Sun, Y; Li, HB] C;Shanxi Med Univ, Affiliated Canc Hosp, Hosp 1, Taiyuan 030001, Shanxi, Peoples R China.;Cent China Normal Univ, Key Lab Pesticide & Chem Biol CCNU, Int Joint Res Ctr Intelligent Biosensor Technol &, Minist Educ,Chem Biol Ctr,Coll Chem, Wuhan 430079, Hubei, Peoples R China.
摘要：
In this paper, the d/l-AP5-interfaces are firstly fabricated by attaching d-alanine-pillar[5]arene and l-alanine-pillar[5]arene (d/l-AP5) onto the gold surface, and they exhibit a significantly different chiral influence on the morphology and the adsorption quantity of the adsorbed ctDNA molecules. The research provides an ideal chiral platform for investigating chiral phenomena in biological systems. © The Royal Society of Chemistry.
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英文
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A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host-guest systems
作者：
Sun, Yue;Zhang, Fan;Quan, Jiaxin;Zhu, Fei;Hong, Wei;...
期刊：
Nature Communications ,2018年9(1):2617 ISSN：2041-1723
通讯作者：
Li, Haibing
作者机构：
[Sun, Yue; Ma, Junkai; Li, Haibing; Pang, Huan; Hong, Wei; Zhu, Fei; Sun, Yao; Quan, Jiaxin; Zhang, Fan; Tian, Demei] Cent China Normal Univ, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Li, Haibing] C;Cent China Normal Univ, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Coll Chem, Wuhan 430079, Hubei, Peoples R China.
摘要：
Inspired by glucose-sensitive ion channels, herein we describe a biomimetic glucose-enantiomer-driven ion gate via the introduction of the chiral pillar[6]arene-based host-guest systems into the artificial nanochannels. The chiral nanochannels show a high chiral-driven ionic gate for glucose enantiomers and can be switched "off" by d-glucose and be switched "on" by l-glucose. Remarkably, the chiral nanochannel also exhibited a good reversibility toward glucose enantiomers. Further research indicates that the switching behaviors differed due to the differences in binding strength between chiral pillar[6]arene and glucose enantiomers, which can lead to the different surface charge within nanochannel. Given these promising results, the studies of chiral-driven ion gates may not only give interesting insight for the research of biological and pathological processes caused by glucose-sensitive ion channels, but also help to understand the origin of the high stereoselectivity in life systems. © 2018 The Author(s).
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英文
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Construction of a Switchable Nanochannel for Protein Transport via a Pillar[5]arene-Based Host-Guest System
作者：
Zhang, Fan;Ma, Junkai;Sun, Yue;Mei, Yuxiao;Chen, Xue;...
期刊：
Analytical Chemistry ,2018年90(13):8270-8275 ISSN：0003-2700
通讯作者：
Li, Haibing
作者机构：
[Sun, Yue; Ma, Junkai; Wang, Wenqian; Li, Haibing; Mei, Yuxiao; Zhang, Fan; Chen, Xue] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Li, Haibing] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Hubei, Peoples R China.
摘要：
Modulating protein selective translocation is a significant process, which has great potential for mimicking and understanding complex biological activities. As such, how to construct a nanochannel that can accomplish well gating protein transport is vital and challenge. Herein, inspired by nature, we presented a robust strategy to construct a switchable nanochannel by introducing a pH responsive binary host-guest system into a nanochannel. Benefiting from the novel design of the pillar[5]arene as gatekeeper, the functional nanochannel can well facilitate histone transport. Under pH regulation, the host-guest assembled nanochannel is capable of switching "on" and "off" to manipulate the histone translocation process. This study exemplifies the importance of molecular switch mediated protein transport in this process and provides a new theoretical model for biological research, which will open a new avenue for better understanding of some physiological and pathological behaviors. © Copyright 2018 American Chemical Society.
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