Embedding Proteins within Spatially Controlled Hierarchical Nanoarchitectures for Ultrasensitive Immunoassay
作者：
Su, Dandan;Li, Hongxia;Zhou, Ri;Zhao, Lianjing;Li, Aixin;...
期刊：
Analytical Chemistry ,2022年94(16):6271-6280 ISSN：0003-2700
通讯作者：
Yan, Xu;Lu, GY;Zhu, CZ
作者机构：
[Yan, Xu; Liu, Xiaomin; Liu, Fangmeng; Wang, Chenguang; Sun, Peng; Lu, Geyu; Su, Dandan; Zhao, Lianjing; Yan, X; Li, Aixin; Zhou, Ri; Jia, Xiaoteng] Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Changchun 130012, Peoples R China.;[Li, Hongxia] Jilin Univ, Coll Food Sci & Engn, Dept Food Qual & Safety, Changchun 130062, Peoples R China.;[Zhu, Chengzhou; Zhu, CZ] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Yan, X; Lu, GY ] J;[Zhu, CZ ] C;Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Changchun 130012, Peoples R China.;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol Minist Educ, Wuhan 430079, Peoples R China.
摘要：
Modulating the precise self-assembly of functional biomacromolecules is a critical challenge in biotechnology. Herein, functional biomacromolecule-assembled hierarchical hybrid nanoarchitectures in a spatially controlled fashion are synthesized, achieving the biorecognition behavior and signal amplification in the immunoassay simultaneously. Biomacromolecules with sequential assembly on the scaffold through the biomineralization process show significantly enhanced stability, bioactivity, and utilization efficiency, allowing tuning of their functions by modifying their size and composition. The hierarchically hybrid nanoarchitectures show great potential in construction of ultrasensitive immunoassay platforms, achieving a three order-of-magnitude increase in sensitivity. Notably, the well-designed [email protected] nanoarchitectures allow for optical immunoassays with a detection range from picogram mL-1 to microgram mL-1 on demand, providing great promise for quantitative analysis of both low-abundance and high-residue targets for biomedical applications. © 2022 American Chemical Society.
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英文
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Recent advances in radical‐mediated transformations of 1,3‐dienes
作者：
Wang, Peng-Zi;Xiao, Wen-Jing;Chen, Jia-Rong
期刊：
催化学报 ,2022年43(3):548-557 ISSN：0253-9837
通讯作者：
Chen, JR
作者机构：
[Xiao, Wen-Jing; Chen, Jia-Rong; Wang, Peng-Zi; Chen, JR] Cent China Normal Univ, Coll Chem, CCNU uOttawa Joint Res Ctr, Key Lab Pesticides & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China.;[Chen, Jia-Rong; Chen, JR] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China.
通讯机构：
[Chen, JR ] C;Cent China Normal Univ, Coll Chem, CCNU uOttawa Joint Res Ctr, Key Lab Pesticides & Chem Biol,Minist Educ, Wuhan 430079, Hubei, Peoples R China.;Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China.
关键词：
1,3-Dienes;Photoredox catalysis;Radical difunctionalization;Radical transformations;Transition metal catalysis
摘要：
1,3-Dienes are a class of easily accessible and versatile feedstock chemicals that can participate in a wide range of reactions to facilitate the synthesis of various valuable allylic compounds. In the past decades, radical methodology has emerged as a powerful tool for organic synthesis by virtue of the fact that diverse highly reactive radical species can usually be generated under mild, neutral and controlled conditions, and allow for rapid generation of molecular complexity. In this review, we critically illustrate the recent advances in the field of radical-mediated transformations of 1,3-dienes based on the different radical precursors and working modes. Wherever possible, particular emphasis is also put on the related mechanistic studies and synthetic applications. © 2022 Dalian Institute of Chemical Physics, the Chinese Academy of Sciences
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英文
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Pd Metallene Aerogels with Single-Atom W Doping for Selective Ethanol Oxidation
作者：
Wang, Hengjia;Zheng, Huiling;Ling, Ling;Fang, Qie;Jiao, Lei;...
期刊：
ACS Nano ,2022年16(12):21266-21274 ISSN：1936-0851
通讯作者：
Zhu, Chengzhou(czzhu@ccnu.edu.cn);Song, Weiyu(songwy@cup.edu.cn)
作者机构：
[Fang, Qie; Qin, Ying; Luo, Zhen; Zhu, Chengzhou; Jiao, Lei; Gu, Wenling; Wang, Hengjia; Ling, Ling] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Key Lab Pesticides & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;[Zheng, Huiling] Taiyuan Univ Technol, State Key Lab Clean & Efficient Coal Utilizat, Taiyuan 030024, Peoples R China.;[Zheng, Lirong] Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Facil, Beijing 100049, Peoples R China.;[Song, Weiyu] China Univ Petr, State Key Lab Heavy Oil Proc, Beijing 102249, Peoples R China.
通讯机构：
[Weiyu Song] S;[Chengzhou Zhu] K;State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Beijing 102249, P. R. China<&wdkj&>Key Laboratory of Pesticides and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
关键词：
aerogels;metallene;single-atom doping;ethanol oxidation reaction;electrocatalysis
摘要：
The development of advanced electrocatalysts with satisfactory C1 pathway selectivity for the ethanol oxidation reaction (EOR) is critical. Herein, a bubbling CO-induced gelation method is developed in acetic acid at 50 °C to construct single-atom W-doped Pd metallene aerogels (denoted as SA W-Pd MAs) within 1 h. In light of the metallene structural advantages of noble metal aerogels and single-atom W decoration, the resultant SA W-Pd MAs exhibit an outstanding EOR performance with high C1 pathway selectivity. Density functional theory calculations validate that the SA W-Pd MAs greatly improve the formation of the CH3O intermediate and the transformation of poisonous CO species to CO2, thus resulting in high C1 pathway selectivity. Therefore, this work not only offers an effective gelation method to fabricate noble metal aerogels with atomic-scale building blocks but also presents guidance to develop high-efficiency EOR electrocatalysts. © 2022 American Chemical Society. All rights reserved.
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英文
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Controlled release of drug molecules by pillararene-modified nanosystems
作者：
Yang, Qinglin;Xu, Weiwei;Cheng, Ming;Zhang, Siyun;Kovaleva, Elena G.;...
期刊：
Chemical Communications ,2022年58(20):3255-3269 ISSN：1359-7345
通讯作者：
Cheng, Jing;Li, HB;Kovaleva, EG;Liang, F;Liu, JA;Abdelhameed, RM
作者机构：
[Xu, Weiwei; Cheng, Jing; Tian, Demei; Yang, Qinglin; Cheng, J; Cheng, Ming; Li, Haibing; Zhang, Siyun] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.;[Kovaleva, Elena G.] Ural Fed Univ, Dept Technol Organ Synth, Mira St 28, Ekaterinburg 620002, Russia.;[Liang, Feng; Liang, F] Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, State Key Lab Refractories & Met Coal Convers & N, Hubei Key Lab, Wuhan 430081, Peoples R China.;[Liu, Jun-an] Huazhong Agr Univ, Coll Sci, Dept Appl Chem, Wuhan 430070, Peoples R China.;[Abdelhameed, Reda M.; Abdelhameed, RM] Natl Res Ctr, Appl Organ Chem Dept, Chem Ind Res Div, 33 El Buhouth St,PO 12311, Dokki, Siza, Egypt.
通讯机构：
[Cheng, J; Li, HB ] C;[Liang, F ] W;[Liu, JA ] H;[Kovaleva, EG ] U;[Abdelhameed, RM ] N
摘要：
Stimuli-responsive nanosystems have attracted the interest of researchers due to their intelligent function of controlled release regulated by a variety of external stimuli and have been applied in biomedical fields. Pillar[n]arenes with the advantages of a rigid structure, electron holes and easy functionalization are considered as excellent candidates for the construction of host-guest nanosystems. In recent years, many pillararene modified nanosystems have been reported in response to different stimuli. In this feature article, we summarize the advance of stimuli-responsive pillararene modified nanosystems for controlled release of drugs from the perspectives of decomposition release and gated release, focusing on the control principles of these nanosystems. We expect that this review can enlighten and guide investigators in the field of stimuli-responsive controlled release. © The Royal Society of Chemistry
语种：
英文
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Monitoring the Dynamic Regulation of the Mitochondrial GTP-to-GDP Ratio with a Genetically Encoded Fluorescent Biosensor
作者：
Zhang, Meiqi;Yang, Bo;Zhang, Jiayuan;Song, Yuxin;Wang, Weibo;...
期刊：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION ,2022年61(33):e202201266- ISSN：1433-7851
通讯作者：
Wang, Jing(wangjingsioc@pku.edu.cn)
作者机构：
[Song, Yuxin; Zhang, Meiqi; Wang, Weibo; Yang, Bo; Li, Na; Wang, Yuan; Li, Wenzhe; Zhang, Jiayuan; Wang, Jing] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.;[Song, Yuxin; Zhang, Meiqi; Wang, Weibo; Yang, Bo; Li, Na; Wang, Yuan; Li, Wenzhe; Zhang, Jiayuan; Wang, Jing] Peking Univ, Dept Chem Biol, Sch Pharmaceut Sci, Beijing 100191, Peoples R China.;[Zhang, Jiayuan] Univ Oxford, Wellcome Ctr Human Genet, Roosevelt Dr, Oxford OX3 7BN, England.;[Wang, Weibo] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ,Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Wuhan 430079, Peoples R China.
通讯机构：
[Prof. Jing Wang] S;State Key Laboratory of Natural and Biomimetic Drugs and Department of Chemical Biology, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Peking University, Beijing, 100191 China
关键词：
Biosensor;GTP:GDP Ratio;Imaging;Metabolism;Mitochondria
摘要：
The interconversion of guanosine triphosphate (GTP) and guanosine diphosphate (GDP) is known to be integral to a wide variety of biological cellular activities, yet to date there are no analytical methods available to directly detect the ratio of intracellular GTP to GDP. Herein, we report GRISerHR, a genetically encoded fluorescent biosensor to monitor the GTP : GDP ratio in multiple cell types and in various organelles under metabolic perturbation. Additionally, we characterized the differential mitochondrial GTP : GDP ratios resulting from genetic modulation of two isoforms of a tricarboxylic acid (TCA) cycle enzyme (succinyl-CoA synthetase; SCS-ATP and SCS-GTP) and of a phosphoenolpyruvate (PEP) cycle enzyme (PEPCK-M). Thus, our GRISerHR sensor achieves spatiotemporally precise detection of dynamic changes in the endogenous GTP : GDP ratio in living cells and can help deepen our understanding about the energy metabolic contributions of guanosine nucleotides in biology. © 2022 Wiley-VCH GmbH.
语种：
英文
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Tetrasubstituted Carbon Stereocenters via Copper-Catalyzed Asymmetric Sonogashira Coupling Reactions with Cyclic gem-Dihaloketones and Tertiary α-Carbonyl Bromides
作者：
Mo, Xueling;Huang, Han;Zhang, Guozhu
期刊：
ACS CATALYSIS ,2022年12(16):9944-9952 ISSN：2155-5435
通讯作者：
Zhang, Guozhu(guozhuzhang@sioc.ac.cn)
作者机构：
[Zhang, Guozhu; Mo, Xueling] Cent China Normal Univ CCNU, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, CCNU uOttawa Joint Res Ctr,Key Lab Pesticides & Ch, Wuhan 430079, Hubei, Peoples R China.;[Zhang, Guozhu; Huang, Han] Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Chinese Acad Sci, Ctr Excellence Mol Synth,State Key Lab Organometal, Shanghai 200032, Peoples R China.
通讯机构：
[Guozhu Zhang] C;CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticides & Chemical Biology Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health. College of Chemistry, Central China Normal University (CCNU), 152 Luoyu Road, Wuhan, Hubei 430079, P. R. China<&wdkj&>State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Center for Excellence in Molecular Synthesis, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China
关键词：
tertiary alkyl halides;copper-catalyzed;Sonogashira reaction;enantioselective;tetrasubstituted carbon stereocenters
摘要：
The construction of chiral tetrasubstituted carbon stereocenters is an ongoing challenge in synthetic organic chemistry due to its prevalence in multiple disciplines. One efficient approach is the catalytic asymmetric C-C coupling reactions of a readily available racemic tertiary alkyl electrophile by simple organic nucleophiles. While a variety of secondary alkyl halides succeeded in asymmetric Cu-catalyzed Sonogashira-type cross-coupling reactions with diverse alkynes, tertiary alkyl halides have rarely been used in this kind of coupling reaction. Herein, we demonstrate that tertiary bromides can serve as efficient coupling partners in copper/bisoxazoline phenyl amine (BOPA)-catalyzed asymmetric alkynylation, leading to synthetically and medicinally valuable tertiary C-F stereocenters and all-carbon quaternary stereocenters. © 2022 American Chemical Society.
语种：
英文
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CuO/TiO2Nanobelt with Oxygen Vacancies for Visible-Light-Driven Photocatalytic Bacterial Inactivation
作者：
Pan, Chuanqi;Shen, Huan;Liu, Guoli;Zhang, Xiang;Liu, Xiaoxuan;...
期刊：
ACS Applied Nano Materials ,2022年5(8):10980-10990 ISSN：2574-0970
通讯作者：
Guo, Yanbing(guoyanbing@mail.ccnu.edu.cn);Tian, Yuan(tianyuanlove1129@126.com)
作者机构：
[Zhang, Lizhi; Sun, Hongwei; Xu, Peiyan; Liu, Guoli; Guo, Yanbing; Zhang, Xiang; Chen, Wei; Liu, Xiaoxuan; Deng, Hongtao; Luo, Zhu; Shen, Huan; Pan, Chuanqi; Wang, Jinlong] Cent China Normal Univ, Inst Environm & Appl Chem, Coll Chem, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Liu, Huifeng; Tian, Yuan] Peoples Liberat Army Gen Hosp, Dept Comprehens Surg, Beijing 101149, Peoples R China.
通讯机构：
[Yuan Tian] D;[Yanbing Guo] K;Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Institute of Environmental and Applied Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China<&wdkj&>Department of Comprehensive Surgery, PLA General Hospital Jingdong Medical District, Beijing 101149, China
关键词：
photocatalytic;CuO/TiO2;nanomaterials;bacterial inactivation;oxygen vacancies
摘要：
Bacterial infection can induce a variety of deadly diseases that seriously threaten human life and health. TiO2 is extensively employed as a broad-spectrum antibacterial photocatalytic material for the inactivation of bacteria. However, a wide-band-gap nature has limited the effectiveness of TiO2 to only the UV-light range. In addition, photogenerated electrons and holes can recombine quickly, inducing low antibacterial efficiency. Here, we fabricated a CuO/TiO2 nanobelt by an impregnation method and introduced surface oxygen vacancies (Ov) to significantly improve their photocatalytic inactivation performance against Staphylococcus aureus. The CuO/TiO2-H2 catalyst contains more Ov and exhibits excellent antibacterial properties against S. aureus. The antibacterial efficiency is 32.2 and 99.4 times those of CuO/TiO2 and bare TiO2, respectively, under light irradiation. The photogenerated electron-hole pairs react with molecular oxygen (O2) and a surface hydroxyl group or water (OH- or H2O), resulting in the formation of an active hydroxyl radical (·OH) and a superoxide radical anion (·O2-). In addition, the surface Ov can effectively reduce the conduction band and act as an electron capture center, thereby promoting the adsorption and activation of O2 and generating more active ·O2- species. This work indicates the efficient antibacterial activity of a CuO/TiO2 nanobelt with Ov and provides a feasible approach for the development of highly efficient antibacterial nanomaterials in the medical field. © 2022 American Chemical Society.
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英文
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RBD conjugate vaccine with a built-in TLR1/2 agonist is highly immunogenic against SARS-CoV-2 and variants of concern
作者：
Zhou, Shi-Hao;Zhang, Ru-Yan;Zhang, Hai-Wei;Liu, Yan-Ling;Wen, Yu;...
期刊：
Chemical Communications ,2022年58(13):2120-2123 ISSN：1359-7345
通讯作者：
Yang, Guang-Fu;Guo, Jun;Gong, Rui
作者机构：
[Wang, Jian; Yang, Guang-Fu; Guo, J; Liu, Yan-Ling; Wen, Yu; Yin, Xu-Guang; Zhou, Shi-Hao; Li, Yu-Ting; Zhang, Ru-Yan; Guo, Jun; You, Zi-Wei] Cent China Normal Univ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Coll Chem,Key Lab Pesticide & Chem Bi, Wuhan 430079, Peoples R China.;[Gong, Rui; Zhang, Hai-Wei] Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, CAS Key Lab Special Pathogens & Biosafety, Wuhan 430071, Peoples R China.;[Qiu, Hong] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China.
通讯机构：
[Yang, GF; Guo, J; Gong, Rui] C;Cent China Normal Univ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Coll Chem,Key Lab Pesticide & Chem Bi, Wuhan 430079, Peoples R China.;Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, CAS Key Lab Special Pathogens & Biosafety, Wuhan 430071, Peoples R China.
摘要：
The coronavirus 2019 (COVID-19) pandemic is causing serious impacts in the world, and safe and effective vaccines and medicines are the best methods to combat the disease. The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein plays a key role in interacting with the angiotensin-converting enzyme 2 (ACE2) receptor, and is regarded as an important target of vaccines. Herein, we constructed the adjuvant-protein conjugate Pam3CSK4-RBD as a vaccine candidate, in which the N-terminal of the RBD was site-selectively oxidized by transamination and conjugated with the TLR1/2 agonist Pam3CSK4. This demonstrated that the conjugation of Pam3CSK4 significantly enhanced the anti-RBD antibody response and cellular response. In addition, sera from the Pam3CSK4-RBD immunized group efficiently inhibited the binding of the RBD to ACE2 and protected cells from SARS-CoV-2 and four variants of concern (alpha, beta, gamma and delta), indicating that this adjuvant strategy could be one of the effective means for protein vaccine development. This journal is © The Royal Society of Chemistry
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英文
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Two Water-Soluble and Wash-Free Fluorogenic Probes for Specific Lighting Up Cancer Cell Membranes and Tumors
作者：
Feng, Shumin;Liu, Yijia;Li, Qianhua;Gui, Zhisheng;Feng, Guoqiang*
期刊：
Analytical Chemistry ,2022年94(3):1601-1607 ISSN：0003-2700
通讯作者：
Feng, Guoqiang
作者机构：
[Feng, Guoqiang; Li, Qianhua; Feng, GQ; Liu, Yijia; Gui, Zhisheng; Feng, Shumin] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
通讯机构：
[Feng, GQ ] C;Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
摘要：
The construction of microenvironment-sensitive probes with good cell membrane-targetability can reveal the fundamental properties of cell membranes. Herein, two polarity-sensitive probes, termed MEMs were reported for the first time to specifically light up cancer cell membranes. Both probes were designed with tetrahydroquinoxaline coumarin amide as the fluorophore, and quaternary ammonium groups were appended to increase water solubility and target cell membranes. In vitro studies showed that the fluorescence of both probes displayed strong polarity dependence and had a wide linear range to polarity (Δf). MEMs also displayed excellent cell membrane targeting ability and could long-term light up cell membranes with red fluorescence and a wash-free process. More excitingly, MEMs could specifically light up cancer cell membranes, revealing that cancer cells might have lower cell membrane polarity than normal cells. In vivo studies showed that MEMs could also effectively distinguish tumors from normal tissues. Overall, this work has not only developed two polarity-sensitive probes with good cell membrane targetability, but also provided new insights and methods for an in-depth understanding of cancer cells and cancer diagnosis. © 2022 American Chemical Society
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英文
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Design of a Metallacycle-Based Supramolecular Photosensitizer for In Vivo Image-Guided Photodynamic Inactivation of Bacteria
作者：
Xu, Yuling;Tuo, Wei;Yang, Liang;Sun, Yan;Li, Chonglu;...
期刊：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION ,2022年61(5):e202110048- ISSN：1433-7851
通讯作者：
Yang, Guangfu;Sun, Yao;Stang, Peter J.
作者机构：
[Xu, Yuling; Yang, Guangfu; Yang, Wenchao; Yang, GF; Sun, Yao] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticides & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;[Stang, Peter J.; Tuo, Wei; Sun, Yan] Univ Utah, Dept Chem, 315 South 1400 East,Room 2020, Salt Lake City, UT 84112 USA.;[Yang, Liang] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Radiol, Wuhan 430022, Peoples R China.;[Li, Chonglu] Guangxi Med Univ, Guangxi Key Lab High Incidence Tumor Prevent & Tr, Nanning 530021, Peoples R China.;[Chen, Xiaoqiang] Nanjing Univ Technol, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Peoples R China.
通讯机构：
[Yang, GF; Sun, Y] C;[Stang, Peter J.] U;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticides & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;Univ Utah, Dept Chem, 315 South 1400 East,Room 2020, Salt Lake City, UT 84112 USA.
关键词：
antimicrobial;metallacycle;photodynamic inactivation;supramolecule
摘要：
Bacterial infection is one of the greatest threats to public health. In vivo real-time monitoring and effective treatment of infected sites through non-invasive techniques, remain a challenge. Herein, we designed a PtII metallacycle-based supramolecular photosensitizer through the host-guest interaction between a pillar[5]arene-modified metallacycle and 1-butyl-4-[4-(diphenylamino)styryl]pyridinium. Leveraging the aggregation-induced emission supramolecular photosensitizer, we improved fluorescence performance and antimicrobial photodynamic inactivation. In vivo studies revealed that it displayed precise fluorescence tracking of S. aureus-infected sites, and in situ performed image-guided efficient PDI of S. aureus without noticeable side effects. These results demonstrated that metallacycle combined with host-guest chemistry could provide a paradigm for the development of powerful photosensitizers for biomedicine. © 2021 Wiley-VCH GmbH.
语种：
英文
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Single-Atom Iron Enables Strong Low-Triggering-Potential Luminol Cathodic Electrochemiluminescence
作者：
Gu, Wenling;Wang, Xiaosi;Xi, Mengzhen;Wei, Xiaoqian;Jiao, Lei;...
期刊：
Analytical Chemistry ,2022年94(26):9459-9465 ISSN：0003-2700
通讯作者：
Hu, Liuyong(huly@wit.edu.cn);Zhu, Chengzhou(czzhu@ccnu.edu.cn)
作者机构：
[Gu, Wenling; Wang, Xiaosi; Xi, Mengzhen; Wei, Xiaoqian; Jiao, Lei; Qin, Ying; Huang, Jiajia; Zhu, Chengzhou] Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan;430079, China;[Hu, Liuyong] Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan;430205, China;[Cui, Xiaowen; Zheng, Lirong] Institute of High Energy Physics, Chinese Academy of Sciences, Beijing
通讯机构：
[Liuyong Hu] H;[Chengzhou Zhu] K;Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China<&wdkj&>Hubei Key Laboratory of Plasma Chemistry and Advanced Materials, School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, China
摘要：
The conventional cathodic electrochemiluminescence (ECL) always requires a more negative potential to trigger strong emission, which inevitably damages the bioactivity of targets and decreases the sensitivity and specificity. In this work, iron single-atom catalysts (Fe-N-C SACs) were employed as an efficient co-reaction accelerator for the first time to achieve the impressively cathodic emission of a luminol-H2O2ECL system at an ultralow potential. Benefiting from the distinct electronic structure, Fe-N-C SACs exhibit remarkable properties for the activation of H2O2to produce massive reactive oxygen species (ROS) under a negative scanning potential from 0 to -0.2 V. The ROS can oxidize the luminol anions into luminol anion radicals, avoiding the tedious electrochemical oxidation process of luminol. Then, the in situ-formed luminol anion radicals will directly react with ROS for the strong ECL emission. As a proof of concept, sensitive detection of the carcinoembryonic antigen was realized by glucose oxidase-mediated ECL immunoassay, shedding light on the superiority of SACs to construct efficient cathodic ECL systems with low triggering potential. © 2022 American Chemical Society. All rights reserved.
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英文
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Oxygen and Chlorine Dual Vacancies Enable Photocatalytic O2Dissociation into Monatomic Reactive Oxygen on BiOCl for Refractory Aromatic Pollutant Removal
作者：
Yang, Zhiping;Shi, Yanbiao;Li, Hao* ;Mao, Chengliang;Wang, Xiaobing;...
期刊：
Environmental Science & Technology ,2022年56(6):3587-3595 ISSN：0013-936X
通讯作者：
Liu, Xiao;Zhang, LZ;Li, Hao
作者机构：
[Zhang, Lizhi; Liu, Xiao; Yang, Zhiping; Mao, Chengliang; Liu, Xiufan; Wang, Xiaobing; Zhang, LZ] Cent China Normal Univ, Inst Environm Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Zhang, Lizhi; Shi, Yanbiao; Li, Hao; Li, H; Zhang, LZ] Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, Shanghai 200240, Peoples R China.
通讯机构：
[Liu, X; Zhang, LZ ] C;[Li, H] S;Cent China Normal Univ, Inst Environm Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, Shanghai 200240, Peoples R China.
关键词：
BiOCl;O2 dissociation;dual anionic vacancies;monatomic reactive oxygen;photocatalysis
摘要：
Room-temperature molecular oxygen (O2) dissociation is challenging toward chemical reactions due to its triplet ground-state and spin-forbidden characteristic. Herein, we demonstrate that BiOCl of oxygen and chlorine dual vacancies can photocatalytically dissociate O2 into monatomic reactive oxygen (•O-) for the ring opening of aromatic refractory pollutants toward deep oxidation. The electron-rich and geometry-flexible dual vacancies of oxygen and chlorine remarkably lengthen the O-O bond of adsorbed O2 from 1.21 to 2.74 Å, resulting in the rapid O2 dissociation and the subsequent •O- formation. During the photocatalytic degradation of sulfamethazine, the in situ-formed •O- plays an indispensable role in breaking the critical intermediate of pyrimidine containing a stubborn aromatic heterocyclic ring, thus facilitating the overall mineralization. More importantly, BiOCl of oxygen and chlorine dual vacancies is also superior to its monovacancy counterparts on the degradation of other refractory pollutants containing conjugated six-membered rings, including p-chlorophenol, p-chloronitrobenzene, p-hydroxybenzoic acid, and p-nitrobenzoic acid. This study sheds light on the importance of sophisticated defects for regulating the O2 activation manner and deliveries a novel O2 activation approach for environmental remediation with solar energy. © 2022 American Chemical Society.
语种：
英文
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In-situ forming Sub-2 nm hydrous iron oxide particles in MOFs for deep-treatment and high anti-interference in arsenic removal
作者：
Chen, Tian;Ji, Min;Wen, Lili;Guo, Taolian;Pan, Siyuan;...
期刊：
Chemical Engineering Journal ,2022年431:133813 ISSN：1385-8947
通讯作者：
Lu, ZD;Pan, BC;Lu, Zhenda
作者机构：
[Lu, Zhenda; Ji, Min; Chen, Tian] Nanjing Univ, Coll Engn & Appl Sci, State Key Lab Analyt Chem Life Sci, Nanjing 210093, Peoples R China.;[Lu, Zhenda; Ji, Min; Chen, Tian] Nanjing Univ, Jiangsu Key Lab Artificial Funct Mat, Nanjing 210093, Peoples R China.;[Wen, Lili; Guo, Taolian] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.;[Pan, Siyuan; Cheng, Sikai; Pan, Bingcai; Pan, BC] Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China.;[Lu, Zhenda; Pan, Bingcai; Pan, BC] Nanjing Univ, Res Ctr Environm Nanotechnol ReCENT, Nanjing 210023, Peoples R China.
通讯机构：
[Lu, ZD; Lu, ZD ; Pan, BC ] N;Nanjing Univ, Coll Engn & Appl Sci, State Key Lab Analyt Chem Life Sci, Nanjing 210093, Peoples R China.;Nanjing Univ, Jiangsu Key Lab Artificial Funct Mat, Nanjing 210093, Peoples R China.;Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China.;Nanjing Univ, Res Ctr Environm Nanotechnol ReCENT, Nanjing 210023, Peoples R China.
关键词：
Anti-interference;Arsenic removal;Deep-treatment;Hydrous iron oxide nanoparticles;MOFs;Water treatment
摘要：
An adsorbent with deep-treatment ability and high selectivity for arsenic removal is strongly in need in water treatment. A new composite structure combining ultrasmall (sub-2 nm) nanoparticles (NPs) with metal–organic frameworks (MOFs) has been prepared here. In this structure, ultrasmall (sub-2 nm) hydrous ferric oxide nanoparticles (HFeO) were in-situ generated inside a Fe-based MOF (MIL-100) through a room-temperature reduction process. The structure, denoted as HFeO@MIL-100, demonstrates extraordinary adsorption ability for As (V), with a high capacity and more than 20 times faster kinetics than that of MIL-100. More importantly, it can deeply treat As (V) in contaminated water from 3900 μgL−1 to 5 μg L−1, directly meeting the WHO drinking water standard (<10 μg L−1). And due to the size-exclusion effect of uniform micropores originated from MOFs, the structure performs high anti-interference ability in As (V) adsorption, maintaining more than 97% capacity even within abundant competitive ions or species, such as humic acid, silicate and sulfate ions. © 2021 Elsevier B.V.
语种：
英文
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Atomically thin bismuthene nanosheets for sensitive electrochemical determination of heavy metal ions
作者：
Zhang, Yu;Qin, Ying;Jiao, Lei;Wang, Hengjia;Wu, Zhichao;...
期刊：
Analytica Chimica Acta ,2022年1235:340510 ISSN：0003-2670
通讯作者：
Zhu, Chengzhou(czzhu@ccnu.edu.cn);Gu, Wenling(wlgu@ccnu.edu.cn)
作者机构：
[Qin, Ying; Zhu, Chengzhou; Wu, Yu; Zhang, Yu; Wei, Xiaoqian; Wu, Nannan; Jiao, Lei; Gu, Wenling; Wang, Hengjia; Wu, Zhichao] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;[Hu, Liuyong] Wuhan Inst Technol, Hubei Engn Technol Res Ctr Optoelect & New Energy, Hubei Key Lab Plasma Chem & Adv Mat, Wuhan 430205, Peoples R China.;[Zhong, Hong] Chongqing Univ, Coll Mat Sci & Engn, Chongqing 400030, Peoples R China.
通讯机构：
[Wenling Gu; Chengzhou Zhu] K;Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China
关键词：
Atomic scale materials;Electrocatalysis;Electrochemical sensors;Heavy metal ions;Metallene
摘要：
Developing effective electrocatalysts to achieve highly sensitive and selective detection of heavy metal ions is one of the challenges in the field of environmental monitoring. Herein, bismuth (Bi) metallene (Bi-ene) in atomic thickness is successfully synthesized and applied as a conceptual application in electrochemical sensors for the detection of lead ion (Pb2+) and cadmium ion (Cd2+) both individually and simultaneously, exhibiting superior sensitivity and anti-interference performance. Density functional theory (DFT) calculations reveal that the Bi-ene has a stronger adsorption capability for Pb and Cd than that of Bi nanosheets (Bi-NSs). This work not only achieves Bi-ene-based catalytic signal amplification for sensitive detection of heavy metal ions but also holds promising application of atomic scale materials in environmental monitoring. © 2022 Elsevier B.V.
语种：
英文
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Construction of Long-Wavelength Emissive Organic Nanosonosensitizer Targeting Mitochondria for Precise and Efficient In Vivo Sonotherapy
作者：
Zhang, Xiangqian;Li, Chonglu;Zhang, Yi;Guan, Xiaofang;Mei, Longcan;...
期刊：
Advanced Functional Materials ,2022年32(40):2207259- ISSN：1616-301X
通讯作者：
Sun, Yao(sunyaogbasp@ccnu.edu.cn)
作者机构：
[Feng, Huili; Zhang, Xiangqian; Deng, Ganzhen] Huazhong Agr Univ, Coll Anim Sci & Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China.;[Feng, Guoqiang; Tu, Le; Zhang, Yi; Guan, Xiaofang; Mei, Longcan; Sun, Yao; Li, Chonglu] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Minist Educ,Key Lab Pesticides & Chem Biol, Wuhan 430079, Peoples R China.;[Li, Jie] Nanjing Univ, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Peoples R China.;[Tu, Le] Southeast Univ, State Key Lab Bioelect, Nanjing 210096, Peoples R China.
通讯机构：
[Yao Sun] K;Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan, 430079 China
关键词：
cancer therapy;mitochondria-targeted;NIR-II region;organic nanosonosensitizer;sonodynamic therapy
摘要：
As a modern biomedical therapeutic modality, sonodynamic therapy (SDT) presents unique advantages, including superior tissue penetration capability, temporal–spatial controllability, and negligible side effects. However, the bottlenecks of most organic sonosensitizers are their short emission wavelengths, strong phototoxicity, and unsatisfactory SDT effect, which undermines the precise fluorescence imaging-guided SDT in vivo. Here, a long-wavelength emissive and mitochondria-targeted organic nanosonosensitizer, named CCNU980 nanoparticles (NPs), is rationally designed, which possesses deep-tissue optical penetration (up to 6mm), depth-activated ROS production (up to 8cm), high photostability, and low phototoxicity. In vitro studies verify CCNU980 NPs selectively enriches in cancer cells with the ability to target the mitochondria and induce mitochondria-mediated apoptosis using abundant 1O2 under US irradiation. Notably, CCNU980 NPs enables precise in vivo NIR-II fluorescence imaging-guided SDT, accompanied by the suppression of the bilateral 4T1 tumor growth with minimal side effects. The current work can inspire a general strategy for the design of organic nanosonosensitizers with long-wavelength emission and new thoughts for precision medicine. © 2022 Wiley-VCH GmbH.
语种：
英文
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Solar light-induced injection of hot electrons and photocarriers for synergistically enhanced photothermocatalysis over Cu-Co/SrTiO3 catalyst towards boosting CO hydrogenation into C2–C4 hydrocarbons
作者：
Ning, Shangbo;Sun, Yanhui;Ouyang, Shuxin;Qi, Yuhang;Ye, Jinhua
期刊：
Applied Catalysis B: Environmental ,2022年310:121063 ISSN：0926-3373
通讯作者：
Ouyang, Shuxin(oyxs@mail.ccnu.edu.cn);Ye, Jinhua(jinhua.ye@nims.go.jp)
作者机构：
[Ning, Shangbo; Qi, Yuhang; Ye, Jinhua; Sun, Yanhui] Tianjin Univ, Sch Mat Sci & Engn, TJU NIMS Int Collaborat Lab, 92 Weijin Rd, Tianjin 300072, Peoples R China.;[Ouyang, Shuxin] Cent China Normal Univ, Coll Chem, 152 Luoyu Rd, Wuhan 430079, Peoples R China.;[Ye, Jinhua] Natl Inst Mat Sci NIMS, Int Ctr Mat Nanoarchitecton WPI MANA, 1-1 Namiki, Tsukuba, Ibaraki 3050047, Japan.
通讯机构：
[Ouyang, S.] C;[Ye, J.] T;College of Chemistry, No. 152, Luoyu Road, China;TJU-NIMS International Collaboration Laboratory, No. 92 Weijin Road, Nankai District, China
关键词：
Solar light;Photocatalysis;Photothermocatalysis;Synergistically enhanced effect;
Cu, Co co-loaded SrTiO3
摘要：
Solar light-driven catalysis provides a viable approach for solar-to-chemical energy conversion, but it is difficult to maximize the conversion efficiency of solar energy through individual photocatalysis or photothermocatalysis. Herein, we construct a light-induced photo- and thermal-synergistic catalysis based on an adjacent Co and Cu nanoparticles co-loading on SrTiO3 nanoparticles. Under the irradiation of concentrated solar light, the SrTiO3 support is excited by ultraviolet light to induce photocatalytic effect to generate photocarriers; meanwhile, the localized surface plasma resonance-active Cu nanoparticles mainly absorb the visible-infrared light to produce hot electrons which are either quenched to generate heat or transported to active sites; finally, the active-phase Co nanoparticles converge the electrons and heat to drive CO hydrogenation into C2–C4 hydrocarbons. This study demonstrates that a rationally-designed catalyst can effectively convert solar energy to photocarriers/hot electrons and heat, and importantly, can couple them to regulate reaction pathways towards the production of value-added chemicals. © 2022 Elsevier B.V.
语种：
英文
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Highly-efficient solution-processed organic light-emitting diodes using cationic iridium complexes with a pyridine-imidazole type ancillary ligand as the dopants
作者：
Zhang, Ke;Meng, Xianwen;He, Lei
期刊：
Dyes and Pigments ,2022年207:110758 ISSN：0143-7208
通讯作者：
He, Lei(helei@ccnu.edu.cn)
作者机构：
[Zhang, Ke; Meng, Xianwen; He, Lei] Cent China Normal Univ, Key Lab Pesticide Chem Biol, Minist Educ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Wuhan 430079, Peoples R China.;[He, Lei] South China Univ Technol, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Peoples R China.
通讯机构：
[Lei He] K;Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, College of Chemistry, Central China Normal University, Wuhan, 430079, People's Republic of China<&wdkj&>State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510640, PR China
关键词：
Cationic iridium complex;Organic light -emitting diode;Solution -process;Phosphorescence;Ancillary ligand
摘要：
Phosphorescent cationic iridium complexes have emerged as promising dopants for solution-processed OLEDs, but further enhancing their device performances to the level achieved by neutral iridium complexes has remained challenging. Herein, we report a series of cationic iridium complexes, namely [Ir(ppz)2(Mepyim)]PF6 (1), [Ir(Mephtz)2(Mepyim)]PF6 (2), [Ir(tPhTAZ)2(Mepyim)]PF6 (3) and [Ir(CF3-dPhTAZ)2(Mepyim)]PF6 (4) for highly-efficient solution-processed OLEDs, which use 1-phenyl-1H-pyrazole (ppz), 1,3-dimethyl-5-phenyl-1H-1,2,4-triazole (Mephtz), 3,4,5-triphenyl-4H-1,2,4-triazole (tPhTAZ), and 3,4-diphenyl-5-(trifluoromethyl)-4H-1,2,4-triazole (CF3-dPhTAZ) as the cyclometalating (C^N) ligands, respectively, and 2-(1-methyl-1H-imidazole-2-yl)pyridine (Mepyim) as the ancillary (N^N) ligand. Their chemical structures have been verified by X-ray crystallography and their photophysical and electrochemical properties have been comprehensively characterized. In lightly doped poly(methylmethacrylate) films, complexes 1–4 afford green-blue to sky-blue emission, with high phosphorescent efficiencies at 0.75–0.98; in particular, complex 2 exhibits not only a near-unity phosphorescent efficiency (0.98) but also a short triplet lifetime (1.19 μs), because of its rather high radiative decay rate (8.2 × 105 s−1). Theoretical calculations reveal that the emission originates from either charge-transfer states (Ir/C^N → N^N) or C^N/N^N-centered 3π−π* states. By using complexes 1–4 as the dopants, solution-processed OLEDs with a simple double-layer structure afford efficient green-blue to sky-blue electroluminescence, with external quantum efficiencies (EQEs) at 6.8%–18.9%. In particular, the green-blue OLED based on complex 2 shows not only a high peak EQE of 18.9% but also a small efficiency roll-off (EQE = 16.5% at 1000 cd m−2), which is the best-performing device based on cationic iridium complex reported so far. © 2022 Elsevier Ltd
语种：
英文
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Hypoxia-Activatable Nanovesicles as In Situ Bombers for Combined Hydrogen-Sulfide-Mediated Respiration Inhibition and Photothermal Therapy
作者：
Yu, Qi;Tu, Le;Zhu, Ting;Zhu, Hongda;Liu, Shujuan;...
期刊：
ACS Applied Materials & Interfaces ,2022年14(45):50637-50648 ISSN：1944-8244
通讯作者：
Yu, Qi(iamqyu@outlook.com);Sun, Yao(sunyaogbasp@mail.ccnu.edu.cn);Zhao, Qiang(iamqzhao@njupt.edu.cn)
作者机构：
[Zhu, Hongda; Yu, Qi] Hubei Univ Technol, Natl Ctr Cellular Regulat & Mol Pharmaceut 111, Sch Food & Biol Engn, Key Lab Fermentat Engn,Minist Educ,Hubei Key Lab I, Wuhan 430068, Peoples R China.;[Tu, Le; Sun, Yao] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.;[Zhao, Qiang; Zhu, Ting; Liu, Shujuan] Nanjing Univ Posts & Telecommun NUPT, State Key Lab Organ Elect & Informat Displays, Nanjing 210023, Peoples R China.;[Zhao, Qiang; Zhu, Ting; Liu, Shujuan] Nanjing Univ Posts & Telecommun NUPT, Inst Adv Mat IAM, Jiangsu Key Lab Biosensors, Nanjing 210023, Peoples R China.;[Zhao, Qiang; Zhu, Ting; Liu, Shujuan] Nanjing Univ Posts & Telecommun NUPT, Inst Flexible Elect Future Technol, Nanjing 210023, Peoples R China.
通讯机构：
[Qi Yu; Yao Sun] K;[Qiang Zhao] S;Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P.R. China<&wdkj&>Key Laboratory of Fermentation Engineering (Ministry of Education), National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Hubei Key Laboratory of Industrial Microbiology, School of Food and Biological Engineering, Hubei University of Technology, Wuhan 430068, P.R. China<&wdkj&>State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM) & Institute of Flexible Electronics (Future Technology), Nanjing University of Posts and Telecommunications (NUPT), Nanjing 210023, P.R. China
关键词：
hypoxic environment;hydrogen sulfide;mitochondria respiration inhibition;nanovesicles;photothermal therapy
摘要：
Photothermal therapy (PTT) has emerged as a promising alternative or supplement to cancer treatments. While PTT induces the ablation of solid tumors, its efficiency is hampered by self-recovery within impaired cancer cells through glycolysis and respiration metabolism. Based on this, the introduction of hydrogen sulfide (H2S)-mediated respiration inhibition is a good choice to make up for the PTT limitation. Herein, nanovesicles (NP1) are integrated by a hypoxia-responsive conjugated polymer (P1), polymetric H2S donor (P2), and near-infrared (NIR) light-harvesting aza-BODIPY dye (B1) for the delivery of H2S and synergistic H2S gas therapy/PTT. The scaffold of NP1 undergoes disassembly in the hypoxic environments, thus triggering the hydrolysis of P2 to continuously long-term release H2S. Dependent on the superior photothermal ability of B1, NP1 elicits high photothermal conversion efficiency (η = 19.9%) under NIR light irradiation for PTT. Moreover, NP1 serves as in situ H2S bombers in the hypoxic tumor environment and suppresses the mitochondrial respiration through inhibiting expression of cytochrome c oxidase (COX IV) and cutting off the adenosine triphosphate (ATP) generation. Both in vitro and in vivo results demonstrate good antitumor efficacy of H2S gas therapy/PTT, which will be recommended as an advanced strategy for cancer therapeutics. © 2022 American Chemical Society.
语种：
英文
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Fabrication of molecularly imprinted nanochannel membrane for ultrasensitive electrochemical detection of triphenyl phosphate
作者：
Cheng, Jing* ;Huang, Xiaolan;Chen, Linfeng;Yan, Ling;Zhu, Fei;...
期刊：
Analytica Chimica Acta ,2022年1192:339374 ISSN：0003-2670
通讯作者：
Cheng, Jing;Li, Haibing
作者机构：
[Huang, Xiaolan; Yan, Ling; Li, Haibing; Cheng, Jing; Li, HB; Chen, Linfeng; Zhu, Fei] Cent China Normal Univ, Coll Chem, Inst Environm Chem, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Cheng, J; Li, HB] C;Cent China Normal Univ, Coll Chem, Inst Environm Chem, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
关键词：
Artificial nanochannel membrane;Molecularly imprinted polymer;Surface grafting technique;Triphenyl phosphate;Ultra-sensitive electrochemical sensor
摘要：
Driven by the urgent need for the determination of trace level triphenyl phosphate (TPhP) present in environment, a simple, rapid and ultrasensitive sensor has been fabricated for detection of TPhP by directly measuring transmembrane current. The transmembrane containing artificial nanochannel named polyethylene terephthalate (PET) nanochannel membrane is designed to be grafted by TPhP molecularly imprinted polymers (TPhP-MIPs) on its outer surface and inner surface of nanochannel. After the fabricated membrane banded TPhP, the transmembrane current decreased. The rate of current change is linearly proportional to the logarithm value of TPhP concentrations in the range of 0.001 ng mL−1 -800 ng mL−1. Meanwhile, the limit of detection (LOD) was 0.0003 ng mL−1. This LOD value is much lower than most results acquired by using chromatography-mass spectrometry and electrochemistry (EC) sensor based on the functionalization of electrode, whereas the cost of our fabricated EC sensor is much lower. The newly developed sensor is suitable for real-time or field detection of TPhP. The interference of analogs and non-analogs with similar structure of TPhP can be effectively avoided. The sensor not only exhibits high selectivity for TPhP, but also shows ultrasensitive assay for measuring TPhP in real environmental water. © 2021 Elsevier B.V.
语种：
英文
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Single Atom Ru Monolithic Electrode for Efficient Chlorine Evolution and Nitrate Reduction
作者：
Yao, Yancai;Zhao, Long;Dai, Jie;Wang, Jiaxian;Fang, Chuyang;...
期刊：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION ,2022年61(41):e202208215- ISSN：1433-7851
通讯作者：
Zhang, Lizhi(zhanglizhi@sjtu.edu.cn)
作者机构：
[Wang, Jiaxian; Zhang, Lizhi; Dai, Jie; Hou, Wei; Yao, Yancai; Zheng, Qian; Zhao, Long] Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, Shanghai 200240, Peoples R China.;[Zhang, Lizhi; Fang, Chuyang; Zhan, Guangming] Cent China Normal Univ, Coll Chem, Inst Appl & Environm Chem, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Prof. Lizhi Zhang] S;School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240 P. R. China<&wdkj&>Key Laboratory of Pesticide & Chemical Biology of Ministry of Education Institute of Applied & Environmental Chemistry College of Chemistry, Central China Normal University, Wuhan, 430079 P. R. China
关键词：
Bifunctionality;Chlorine Evolution Reaction;Inherent Oxide Anchoring Strategy;Nitrate Reduction Reaction;Single Atom Monolithic Electrode
摘要：
Fabricating single-atom electrodes via atomic dispersion of active metal atoms into monolithic metal supports is of great significance to advancing the lab-to-fab translation of the electrochemical technologies. Here, we report an inherent oxide anchoring strategy to fasten ligand-free isolated Ru atoms on the amorphous layer of monolithic Ti support by regulating the electronic metal-support interactions. The prepared Ru single atom electrode exhibited exceptional electrochemical chlorine evolution activity, three orders of magnitude higher mass activity than that of commercial dimensionally stable anode, and also selectively reduced nitrate to ammonia with an unprecedented ammonia yield rate of 22.2 mol g−1 h−1 at −0.3 V. Furthermore, the Ru single atom monolithic electrode can be scaled up from 2×2 cm to 25×15 cm at least, thus demonstrating great potential for industrial electrocatalytic applications. © 2022 Wiley-VCH GmbH.
语种：
英文
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