Dual-Channel Fluorescent Probe for Detecting Viscosity and ONOO-without Signal Crosstalk in Nonalcoholic Fatty Liver
作者：
Liu, Yijia;Feng, Shumin;Gong, Shengyi;Feng, Guoqiang
期刊：
Analytical Chemistry ,2022年94(50):17439-17447 ISSN：0003-2700
通讯作者：
Feng, Guoqiang(gf256@mail.ccnu.edu.cn)
作者机构：
[Feng, Guoqiang; Gong, Shengyi; Liu, Yijia; Feng, Shumin] Cent China Normal Univ, Coll Chem, Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Guoqiang Feng] K;Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, China
摘要：
Nonalcoholic fatty liver disease (NAFLD) is a global health issue. Peroxynitrite and liver viscosity have recently been found to be potential biomarkers of NAFLD. Therefore, it is of great significance to develop dual-response fluorescent probes for simultaneous detecting peroxynitrite and viscosity. We report herein a new probe (CQ) that can simultaneously detect peroxynitrite and viscosity at two independent fluorescent channels without signal crosstalk. CQ shows high selectivity, rapid response, good water solubility, low cytotoxicity, and mitochondrial localization properties. In particular, CQ responds sensitively to viscosity and peroxynitrite with off-on fluorescence changes at 710 and 505 nm, respectively. The wavelength gap between these two channels is more than 200 nm, ensuring that there is no signal crosstalk during detection. With this property, the probe was applied to simultaneously detect mitochondrial viscosity and peroxynitrite and image the changes of liver viscosity and peroxynitrite concentration during the pathogenesis of NAFLD. All results show that the CQ probe is a powerful tool for simultaneous detection of viscosity and peroxynitrite and provides a potential new diagnostic method for NAFLD. © 2022 American Chemical Society. All rights reserved.
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英文
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Iridium Single-Atomic Site Catalysts with Superior Oxygen Reduction Reaction Activity for Sensitive Monitoring of Organophosphorus Pesticides
作者：
Luo, Xin;Luo, Zhen;Wei, Xiaoqian;Jiao, Lei;Fang, Qie;...
期刊：
Analytical Chemistry ,2022年94(2):1390-1396 ISSN：0003-2700
通讯作者：
Zhu, CZ
作者机构：
[Luo, Zhen; Fang, Qie; Zhu, Chengzhou; Wei, Xiaoqian; Jiao, Lei; Zhu, CZ; Luo, Xin; Gu, Wenling; Wang, Hengjia] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;[Wang, Jinhua; Luo, Xin] Hubei Univ Technol, Hubei Res Ctr Food Fermentat Engn & Technol, Minist Educ,Natl 111 Ctr Cellular Regulat & Mol P, Hubei Prov Cooperat Innovat Ctr Ind Fermentat,Key, Wuhan 430068, Peoples R China.;[Hu, Liuyong] Wuhan Inst Technol, Sch Mat Sci & Engn, Hubei Key Lab Plasma Chem & Adv Mat, Wuhan 430205, Peoples R China.
通讯机构：
[Zhu, CZ ] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
摘要：
Tremendous efforts have been made in developing single-atomic site catalysts (SASCs) for oxygen reduction reaction (ORR), which is regarded as a pivotal cornerstone in electrochemical energy conversion. However, SASCs for ORR have not been explored for electrochemical sensing. Herein, a template-sacrificed strategy is reported for the synthesis of atomically dispersed Ir SASCs, serving as a sensing platform to detect organophosphorus pesticides (OPs) with high sensitivity and selectivity. Owing to abundant Ir single-atom active sites, Ir SASCs show excellent ORR activity and stability in a neutral medium. It is found that the ORR activity of Ir SASCs can be inhibited by thiocholine, which is the hydrolysate of acetylthiocholine. After being integrated with acetylcholinesterase (AChE), the AChE-Ir SASC-based electrochemical sensor is established and shows a superior sensitivity, which shows a wide detection range of 0.5–500 ng mL–1 with a low detection limit of 0.17 ng mL–1 for OPs. This work exhibits a broad application prospect of ORR for sensitive detection of biomolecules. © 2021 American Chemical Society
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英文
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Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor
作者：
Fu, Yi-Xuan;Guo, Wu-Yingzheng;Wang, Nan;Dai, Yi-Jie;Zhang, Zi-Ye;...
期刊：
Analytical Chemistry ,2022年94(50):17692-17699 ISSN：0003-2700
通讯作者：
Yang, Wen-Chao(tomyang@mail.ccnu.edu.cn)
作者机构：
[Yang, Guang-Fu; Wang, Nan; Yang, Wen-Chao; Dai, Yi-Jie; Guo, Wu-Yingzheng; Fu, Yi-Xuan; Zhang, Zi-Ye; Sun, Xin-Lin] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Wen-Chao Yang] K;Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan430079, P.R. China
摘要：
Plant diseases caused by bacteria have become one of the serious problems that threaten human food security, which led to the remarkable reduction of agricultural yields and economic loss. Nitroreductase (NTR), as an important biomarker, is highly expressed in bacteria, and the level of NTR is closely related to the progression of pathogen infection. Therefore, the design of small-molecule fluorescent sensors targeting NTR is of great significance for the detection and diagnosis of plant pathogenic bacteria. In this study, a new fluorescent sensor targeting NTR was discovered and then successfully applied to the imaging of zebrafish and pathogenic bacteria. Most importantly, the developed sensor achieved the real-time diagnosis of Brassica napus L. infected with bacteria, which provides a promising tool for examining the temporal and spatial infection of plant pathogens in precision agriculture. © 2022 American Chemical Society. All rights reserved.
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英文
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Surface Boronizing Can Weaken the Excitonic Effects of BiOBr Nanosheets for Efficient O2Activation and Selective NO Oxidation under Visible Light Irradiation
作者：
Shi, Yanbiao;Yang, Zhiping;Shi, Lujia;Li, Hao;Liu, Xupeng;...
期刊：
Environmental Science & Technology ,2022年56(20):14478-14486 ISSN：0013-936X
通讯作者：
Li, Hao(hao_li@sjtu.edu.cn);Zhang, Lizhi(zhanglizhi@sjtu.edu.cn)
作者机构：
[Zhang, Lizhi; Shi, Yanbiao; Li, Hao] Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, Shanghai 200240, Peoples R China.;[Zhang, Lizhi; Liang, Chuan; Liu, Xupeng; Yang, Zhiping; Cheng, Jundi; Shi, Yanbiao; Guo, Furong; Zhang, Xu; Liu, Xiao; Ai, Zhihui; Cao, Shiyu; Shi, Lujia] Cent China Normal Univ, Coll Chem, Inst Environm & Appl Chem, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Hao Li; Lizhi Zhang] S;School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China<&wdkj&>Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Institute of Environmental & Applied Chemistry, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China<&wdkj&>School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China
关键词：
O2 activation;photocatalysis;excitonic effects;NO oxidation;surface boronizing
摘要：
The photocatalytic O2activation for pollutant removal highly depends on the controlled generation of desired reactive oxygen species (ROS). Herein, we demonstrate that the robust excitonic effect of BiOBr nanosheets, which is prototypical for singlet oxygen (1O2) production to partially oxidize NO into a more toxic intermediate NO2, can be weakened by surface boronizing via inducing a staggered band alignment from the surface to the bulk and simultaneously generating more surface oxygen vacancy (VO). The staggered band alignment destabilizes excitons and facilitates their dissociation into charge carriers, while surface VOtraps electrons and efficiently activates O2into a superoxide radical (•O2-) via a one-electron-transfer pathway. Different from 1O2 •O2-enables the complete oxidation of NO into nitrate with high selectivity that is more desirable for safe indoor NO remediation under visible light irradiation. This study provides a facile excitonic effect manipulating method for layered two-dimensional photocatalysts and sheds light on the importance of managing ROS production for efficient pollutant removal. © 2022 American Chemical Society. All rights reserved.
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英文
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Specific extraction of nucleic acids employing pillar[6]arene-functionalized nanochannel platforms
作者：
Li, Yu;Li, Wenjie;Xu, Weiwei;Huang, Jinmei;Sun, Zhongyue* ;...
期刊：
Chemical Communications ,2022年58(66):9278-9281 ISSN：1359-7345
通讯作者：
Sun, Zhongyue;Liao, Tangbin;Xu, Chuanlai;Cheng, Jing;Li, Haibing
作者机构：
[Li, Yu; Xu, Chuanlai; Li, Haibing; Cheng, Jing] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi, Jiangsu, Peoples R China.;[Li, Yu; Li, Wenjie; Huang, Jinmei; Li, Haibing; Xu, Weiwei; Cheng, Jing] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.;[Sun, Zhongyue] Hubei Univ Chinese Med, Sch Lab Med, Wuhan 430065, Peoples R China.;[Liao, Tangbin] Hubei Univ Chinese Med, Sch Pharm, Wuhan 430065, Peoples R China.;[Kovaleva, Elena G.] Ural Fed Univ, Dept Technol Organ Synth, Mira St 28, Ekaterinburg 620002, Russia.
通讯机构：
[Zhongyue Sun; Tangbin Liao; Chuanlai Xu; Jing Cheng; Haibing Li] S;School of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan 430065, P. R. China<&wdkj&>State Key Laboratory of Food Science and Technology, Jiangnan University, China<&wdkj&>School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, P. R. China<&wdkj&>State Key Laboratory of Food Science and Technology, Jiangnan University, China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
摘要：
The rapid extraction of high-purity nucleic acids from complex biological samples using conventional methods is complicated. Therefore, in this study, glycine-pillar[6]arene (Gly-P6)-functionalized tapered nanochannels were constructed using 32-mer single-stranded E. coli DNA (ssDNA) as a model sequence, which can selectively transport ssDNA by multiple noncovalent forces (transport flux of 2.65 nM cm−2 h−1) under the interference of amino acids and other substances. In view of these prospective results, the selective transport of nucleic acids with nanochannels could be applied in the design of nucleic acid enrichment and separation systems in the future. © 2022 The Royal Society of Chemistry.
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英文
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Rationally designed Ru(ii) metallacycles with tunable imidazole ligands for synergistical chemo-phototherapy of cancer
作者：
Tu, Le;Li, Chonglu;Liu, Chang;Bai, Suya;Yang, Jingfang;...
期刊：
Chemical Communications ,2022年58(65):9068-9071 ISSN：1359-7345
通讯作者：
Xu, Liying(aying0923@foxmail.com);Xiong, Xiaoxing(xiaoxingxiong@whu.edu.cn);Sun, Yao(sunyaogbasp@ccnu.edu.cn)
作者机构：
[Tu, Le; Xiong, Xiaoxing] Wuhan Univ, Remin Hosp, Dept Neurosurg, Wuhan 430079, Peoples R China.;[Zhang, Xian; Tu, Le; Bai, Suya; Sun, Yao; Li, Chonglu; Yang, Jingfang; Liu, Chang] Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Xu, Liying] Wuhan Univ, Zhongnan Hosp, Wuhan 430062, Peoples R China.
通讯机构：
[Liying Xu] Z;[Xiaoxing Xiong] D;[Yao Sun] K;Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China<&wdkj&>Zhongnan Hospital of Wuhan University, Wuhan 430062, P. R. China<&wdkj&>Department of Neurosurgery, Remin Hospital of Wuhan University, Wuhan 430079, P. R. China
摘要：
Herein, we construct a series of Ru(ii) metallacycles with multimodal chemo-phototherapeutic properties, which exhibited much higher anticancer activity and better cancer-cell selectivity than cisplatin. The antitumor mechanism could be ascribed to the activation of caspase 3/7 and the resulting apoptosis. These results open new possibilities for Ru(ii) metallacycles in biomedicine. © 2022 The Royal Society of Chemistry.
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英文
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Pentacyclic and Hexacyclic Osmaarynes and Their Derivatives
作者：
Yang, Xiao Fei;Zhang, Ming-Xing;Fu, De Bin;Wang, Yang;Yin, Jun;...
期刊：
CHEMISTRY-A EUROPEAN JOURNAL ,2022年28(72) ISSN：0947-6539
通讯作者：
Hua Liu, Sheng(chshliu@mail.ccnu.edu.cn)
作者机构：
[Yang, Xiao Fei; Wang, Yang; Liu, Sheng Hua; Fu, De Bin; Yin, Jun; Zhang, Ming-Xing] Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.;[Zhang, Ming-Xing] Hubei Univ Educ, Coll Chem & Life Sci, Hubei Key Lab Purificat & Applicat Plant Anticanc, Wuhan 430205, Peoples R China.
通讯机构：
[Prof. Sheng Hua Liu] K;Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 430079 Wuhan, P. R. China
关键词：
aggregation-induced emission;near-infrared luminescence;osmium complexes;pentacyclic and hexacyclic osmaarynes;photothermal conversion
摘要：
Although osmabenzyne, osmanaphthalyne, osmaphenanthryne, and osmaanthracyne have been previously reported, the synthesis of polycyclic osmaarynes is still a challenge. Herein, we report the successful synthesis of the first pentacyclic osmaarynes (pyreno[b]osmabenzynes 1 a and 2 a) and hexacyclic osmaaryne (peryleno[b]osmabenzyne 3 a). Nucleophilic reaction of osmaarynes was used to obtain the corresponding pyreno[b]osmium complexes (1 and 2) and peryleno[b] osmium complex (3), which exhibited near-infrared luminescence and aggregation-induced emission (AIE) properties. Complexes 2 and 3 are resistant to photodegradation, and complex 2 has better photothermal conversion properties than 3. © 2022 Wiley-VCH GmbH.
语种：
英文
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Recent Advances on Dual-Band Electrochromic Materials and Devices
作者：
Zhai, Yanling;Li, Jiahui;Shen, Sophia;Zhu, Zhijun* ;Mao, Sui;...
期刊：
Advanced Functional Materials ,2022年32(17):2109848- ISSN：1616-301X
通讯作者：
Zhu, Zhijun;Lu, Xiaoquan;Chen, Jun
作者机构：
[Lu, Xiaoquan; Mao, Sui; Tang, Jianguo; Zhu, Zhijun; Lu, XQ; Li, Jiahui; Zhai, Yanling] Qingdao Univ, Coll Mat Sci & Engn, Inst Hybrid Mat, Coll Chem & Chem Engn,Inst Mol Metrol, Qingdao 266071, Peoples R China.;[Xiao, Xiao; Chen, Jun; Shen, Sophia] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA.;[Zhu, Chengzhou] Cent China Normal Univ, Coll Chem, Wuhan 430079, Peoples R China.;[Lu, Xiaoquan] Northwest Normal Univ, Coll Chem & Chem Engn, Key Lab Bioelectrochem & Environm Anal Gansu Prov, Lanzhou 730070, Peoples R China.
通讯机构：
[Zhu, ZJ; Lu, XQ] Q;[Chen, Jun] U;[Lu, Xiaoquan] N;Qingdao Univ, Coll Mat Sci & Engn, Inst Hybrid Mat, Coll Chem & Chem Engn,Inst Mol Metrol, Qingdao 266071, Peoples R China.;Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA.
关键词：
electrochromic devices;energy-saving;independent regulation;near-infrared;smart windows;visible light
摘要：
Dual-band electrochromism is a phenomenon where materials can independently regulate the transmittance of visible (VIS) and near-infrared (NIR) light. Owing to their bistability, low energy consumption, and independent control over VIS and NIR regions, dual-band electrochromic (EC) devices have been of great significance to fully harnessing VIS and NIR light and building an energy-saving society. The past several years have witnessed the efforts put in developing novel EC materials to improve their dual-band optical performance through altering their composition, structural, and physicochemical features, which determine the optical behavior of dual-band EC devices. In this review, the concept, significance, working principle, and key influence factors of dual-band electrochromism are briefly introduced. Next, the up-to-date progress of dual-band EC materials including inorganic, organic, and composites materials are summarized, with a focus on material design, device fabrication, and performance optimization. Finally, the challenges and perspectives of dual-band EC materials and devices are also presented. © 2022 Wiley-VCH GmbH.
语种：
英文
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Cell-Based Ambient Venturi Autosampling and Matrix-Assisted Laser Desorption Ionization Mass Spectrometric Imaging of Products
作者：
Shen, Baojie;Yang, Xiaoyu;Noll, Sarah Elizabeth;Yang, Xiaojie;Liu, Yanping;...
期刊：
Analytical Chemistry ,2022年94(8):3456-3466 ISSN：0003-2700
通讯作者：
Zhong, HY
作者机构：
[Shen, Baojie; Yang, Xiaojie; Zheng, Shi; Zhong, Hongying; Liu, Yanping; Yang, Xiaoyu; Zhong, HY; Jia, Shanshan] Cent China Normal Univ, Minist Educ, Lab Mass Spectrometry, Coll Chem,Key Lab Pesticides & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;[Zhao, Jiaxing; Zhong, Hongying; Zhong, HY] Guangxi Univ, Coll Life Sci & Technol, State Key Lab Conservat & Utilizat Subtrop AgroBi, Nanning 530004, Guangxi, Peoples R China.;[Noll, Sarah Elizabeth; Zare, Richard N.] Stanford Univ, Dept Chem, Stanford, CA 94305 USA.
通讯机构：
[Zhong, HY ] C;Cent China Normal Univ, Minist Educ, Lab Mass Spectrometry, Coll Chem,Key Lab Pesticides & Chem Biol, Wuhan 430079, Hubei, Peoples R China.;Guangxi Univ, Coll Life Sci & Technol, State Key Lab Conservat & Utilizat Subtrop AgroBi, Nanning 530004, Guangxi, Peoples R China.
摘要：
A cell-based ambient Venturi autosampling device was established for the monitoring of dynamic cell secretions in response to chemical stimulations in real time with temporal resolution on the order of a second. Detection of secretory products of cells and screening of bioactive compounds are primarily performed on an ambient autosampling probe and matrix-assisted laser desorption ionization (MALDI) mass spectrometry. It takes advantage of the Venturi effect in which the fluid flowing through an inlet capillary tube is automatically fed into a parallel array of multiple outlet capillaries. Cells are incubated inside the inlet capillary tube that is connected with either a syringe pump or liquid chromatography (LC) for the transfer of single compounds or mixtures, respectively. Secretory products were continuously pushed into the outlet capillaries and then spotted into a compressed thin film of the matrix material 9-aminoacridine for MALDI mass spectrometric imaging. In physiological pH, without the use of high voltages and without the use of chemical derivatizations, this platform can be applied to the direct assay of neurotransmitters or other secretory products released from cells in response to the stimulation of individual compounds or LC-separated eluates of natural mixtures. It provides a new way to identify bioactive compounds with a detection limit down to 0.04 fmol/pixel. © 2022 American Chemical Society
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英文
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SERS Multiplex Profiling of Melanoma Circulating Tumor Cells for Predicting the Response to Immune Checkpoint Blockade Therapy
作者：
Li, Junrong;Wuethrich, Alain;Zhang, Zhen;Wang, Jing;Lin, Lynlee L.;...
期刊：
Analytical Chemistry ,2022年94(42):14573-14582 ISSN：0003-2700
通讯作者：
Wang, Jing(jing.wang@fjnu.edu.cn);Behren, Andreas(Andreas.Behren@onjcri.org.au);Wang, Yuling(yuling.wang@mq.edu.au);Trau, Matt(m.trau@uq.edu.au)
作者机构：
[Li, Junrong] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, R China, Wuhan 430079, Peoples R China.;[Wuethrich, Alain; Trau, Matt; Zhang, Zhen; Li, Junrong] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Ctr Personalized Nanomed, Brisbane, Qld 4072, Australia.;[Lin, Lynlee L.] Univ Queensland, Diamantina Inst, Dermatol Res Ctr, Brisbane, Qld 4102, Australia.;[Wang, Jing] Fujian Normal Univ, Key Lab OptoElect Sci & Technol Med, Fujian Prov Key Lab Photon Technol, Minist Educ, R China, Fuzhou 350007, Peoples R China.;[Behren, Andreas] La Trobe Univ, Oliva Newton John Canc Res Inst, Sch Canc Med, Heidelberg, Vic 3086, Australia.
通讯机构：
[Jing Wang] K;[Andreas Behren] O;[Yuling Wang] S;[Matt Trau] C;School of Natural Sciences, Faculty of Science and Engineering, Macquarie University, Sydney, NSW2109, Australia<&wdkj&>Centre for Personalized Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD4072, Australia<&wdkj&>School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD4072, Australia<&wdkj&>Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou350007, P. R. China<&wdkj&>Oliva Newton-John Cancer Research Institute, School of Cancer Medicine, La Trobe University, Heidelberg, VIC3086, Australia<&wdkj&>Department of Medicine, University of Melbourne, Heidelberg, VIC3010, Australia
摘要：
Immune checkpoint blockade (ICB) therapy has achieved remarkable success in many cancers including melanoma. However, ICB therapy benefits only a small proportion of patients and produces severe side effects for some patients. Thus, there is an urgent need to identify patients who are more likely to respond to ICB therapy to improve outcomes and minimize side effects. To predict ICB therapy responses, we design a surface-enhanced Raman scattering (SERS) assay for multiplex profiling of circulating tumor cells (CTCs) under basal and interferon-γ(IFN-γ) stimulation. Through simultaneous ensemble and single-cell measurements of CTCs, the SERS assay can reveal tumor heterogeneity and offer a comprehensive CTC phenotype for decision-making. Anisotropic gold-silver alloy nanoboxes are utilized as SERS plasmonic substrates for improved signal readouts of CTC surface biomarkers. By generating a unique CTC signature with four surface biomarkers, the developed assay enables the differentiation of CTCs from three different patient-derived melanoma cell lines. Significantly, in a cohort of 14 melanoma patients who received programmed cell death-1 blockade therapy, the changes of CTC signature induced by IFN-γstimulation to CTCs show the potential to predict responders. We expect that the SERS assay can help select patients for receiving ICB therapy in other cancers. © 2022 American Chemical Society. All rights reserved.
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英文
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Iron Single-Atom Catalysts Boost Photoelectrochemical Detection by Integrating Interfacial Oxygen Reduction and Enzyme-Mimicking Activity
作者：
Qin, Ying;Wen, Jing;Wang, Xiaosi;Jiao, Lei;Wei, Xiaoqian;...
期刊：
ACS Nano ,2022年16(2):2997-3007 ISSN：1936-0851
通讯作者：
Gu, Wenling;Zhu, CZ;Hu, LY
作者机构：
[Qin, Ying; Zhu, Chengzhou; Li, Jinli; Jiao, Lei; Gu, Wenling; Liu, Mingwang; Wang, Xiaosi; Wei, Xiaoqian; Gu, WL; Zhu, CZ; Wang, Hengjia] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;[Wen, Jing; Hu, Liuyong] Wuhan Inst Technol, Hubei Engn Technol Res Ctr Optoelect & New Energy, Hubei Key Lab Plasma Chem & Adv Mat, Wuhan 430205, Peoples R China.;[Zheng, Lirong] Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China.
通讯机构：
[Hu, LY ] W;[Gu, WL; Zhu, CZ ] C;Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;Wuhan Inst Technol, Hubei Engn Technol Res Ctr Optoelect & New Energy, Hubei Key Lab Plasma Chem & Adv Mat, Wuhan 430205, Peoples R China.
关键词：
photoelectrochemical analysis;single-atom catalysts;nanozymes;oxygen reduction reaction;signal amplification
摘要：
The investigations on the generation, separation, and interfacial-redox-reaction processes of the photoinduced carriers are of paramount importance for realizing efficient photoelectrochemical (PEC) detection. However, the sluggish interfacial reactions of the photogenerated carriers, combined with the need for appropriate photoactive layers for sensing, remain challenges for the construction of advanced PEC platforms. Here, as a proof of concept, well-defined Fe single-atom catalysts (Fe SACs) were integrated on the surface of semiconductors, which amplified the PEC signals via boosting oxygen reduction reaction. Besides, Fe SACs were evidenced with efficient peroxidase-like activity, which depresses the PEC signals through the Fe SACs-mediated enzymatic precipitation reaction. Harnessing the oxygen reduction property and peroxidase-like activity of Fe SACs, a robust PEC sensing platform was successfully constructed for the sensitive detection of acetylcholinesterase activity and organophosphorus pesticides, providing guidelines for the employment of SACs for sensitive PEC analysis. © 2022 American Chemical Society
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英文
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Fabrication of Redox-Controllable Bioinspired Nanochannels for Precisely Regulating Protein Transport
作者：
Tu, Le;Qiu, Sheng;Li, Yuntao;Chen, Xiaoya;Li, Junrong;...
期刊：
ACS Applied Materials & Interfaces ,2022年14(23):27421-27426 ISSN：1944-8244
通讯作者：
Xiong, Xiaoxing(xiaoxingxiong@whu.edu.cn);Sun, Yao(sunyaogbasp@ccnu.edu.cn);Li, Junrong(junrong.li@ccnu.edu.cn)
作者机构：
[Tu, Le; Li, Haibing; Li, Junrong; Sun, Yao] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Minist Educ, Wuhan 430079, Peoples R China.;[Tu, Le; Xiong, Xiaoxing; Qiu, Sheng; Li, Yuntao] Zhejiang Univ, Sch Med, Huzhou Cent Hosp, Affiliated Huzhou Hosp,Dept Neurosurg, Huzhou 313099, Peoples R China.;[Xiong, Xiaoxing; Li, Yuntao] Wuhan Univ, Remin Hosp, Dept Neurosurg, Wuhan 430079, Peoples R China.;[Chen, Xiaoya] Guilin Med Univ, Guangxi Key Lab Brain & Cognit Neurosci, Guilin 541199, Peoples R China.;[Han, Yunfeng] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430074, Peoples R China.
通讯机构：
[Junrong Li; Yao Sun] K;[Xiaoxing Xiong] D;Department of Neurosurgery, The Affiliated Huzhou Hospital, Zhejiang University School of Medicine (Huzhou Central Hospital), Huzhou 313099, P.R. China<&wdkj&>Department of Neurosurgery, Remin Hospital of Wuhan University, Wuhan 430079, P. R. China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
关键词：
bioinspired nanochannel;protein transport;redox driven;pillar[5]arene;gating ratio
摘要：
Redox regulation is an inherent feature of nature and plays a crucial role in the transport of ions/small molecules. However, whether redox status affects the biomolecule transport remains largely unknown. To explore the effects of redox status on biomolecule transport, herein, we constructed a glutathione/glutathione disulfide (GSH/GSSG)-driven and pillar[5]arene (P5)-modified artificial nanochannel for protein transport. The results indicate that hemoglobin (Hb) protein is selectively and effectively transported across the GSH-driven P5-modified nanochannel, which suggests that the redox status of the nanochannel could affect the process of protein transport. Therefore, this redox-driven nanochannel could provide a potential application for biomolecule detection and redox-controllable biomolecular drug release. © 2022 American Chemical Society. All rights reserved.
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英文
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Singlet Oxygen and Mobile Hydroxyl Radicals Co-operating on Gas-Solid Catalytic Reaction Interfaces for Deeply Oxidizing NOx
作者：
Li, Qian;Zhao, Jingjing;Shang, Huan;Ma, Zhong;Cao, Haiyan;...
期刊：
Environmental Science & Technology ,2022年56(9):5830-5839 ISSN：0013-936X
通讯作者：
Zhang, Dieqing(dqzhang@shnu.edu.cn)
作者机构：
[Li, Qian; Cao, Haiyan; Zhao, Jingjing; Li, Hexing; Zhang, Dieqing; Li, Guisheng; Zhou, Yue] Shanghai Normal Univ, Shanghai Frontiers Sci Ctr Biomimet Catalysis, Key Lab Resource Chem, Joint Int Res Lab Resource Chem,Minist Educ, Shanghai 200234, Peoples R China.;[Li, Qian; Cao, Haiyan; Zhao, Jingjing; Li, Hexing; Zhang, Dieqing; Li, Guisheng; Zhou, Yue] Shanghai Normal Univ, Shanghai Frontiers Sci Ctr Biomimet Catalysis, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China.;[Shang, Huan] Cent China Normal Univ, Coll Chem, Inst Environm & Appl Chem, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;[Ma, Zhong] Univ Waterloo, Dept Chem Engn, Waterloo, ON N2L 3G1, Canada.;[Ma, Zhong] Univ Waterloo, Waterloo Inst Nanotechnol WIN, Waterloo, ON N2L 3G1, Canada.
通讯机构：
[Dieqing Zhang] T;The Education Ministry Key Lab of Resource Chemistry, Joint International Research Laboratory of Resource Chemistry, Ministry of Education, and Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Frontiers Science Center of Biomimetic Catalysis, Shanghai Normal University, Shanghai 200234, P. R. China
关键词：
NOx oxidation;hydroxyl radicals;photocatalysis;singlet oxygen;synergistic effect
摘要：
Learning from the important role of porphyrin-based chromophores in natural photosynthesis, a bionic photocatalytic system based on tetrakis (4-carboxyphenyl) porphyrin-coupled TiO2was designed for photo-induced treating low-concentration NOxindoor gas (550 parts per billion), achieving a high NO removal rate of 91% and a long stability under visible-light (λ ≥ 420 nm) irradiation. Besides the great contribution of the conventional •O2-reactive species, a synergic effect between a singlet oxygen (1O2) and mobile hydroxyl radicals (•OHf) was first illustrated for removing NOxindoor gas (1O2+ 2NO → 2NO2, NO2+ •OHf→ HNO3), inhibiting the production of the byproducts of NO2. This work is helpful for understanding the surface mechanism of photocatalytic NOxoxidation and provides a new perspective for the development of highly efficient air purification systems. © 2022 American Chemical Society. All rights reserved.
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英文
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Sustainable electrochemical dehydrogenative C(sp3)–H mono/di-alkylations
作者：
He, Jin-Yu;Qian, Wei-Feng;Wang, Yan-Zhao;Yao, Chaochao;Wang, Nana;...
期刊：
Green Chemistry ,2022年24(6):2483-2491 ISSN：1463-9262
通讯作者：
Zhu, Cuiju;Xu, H
作者机构：
[Wang, Yan-Zhao; Xu, Hao; Qian, Wei-Feng; Liu, Huilin; Xu, H; He, Jin-Yu; Yao, Chaochao; Zhu, Cuiju; Zhu, CJ; Zhong, Bing; Wang, Nana] Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Xu, H ; Zhu, CJ] C;Cent China Normal Univ, Coll Chem, Key Lab Pesticides & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China.
摘要：
Catalyst-free, direct electrooxidative phenol derivatives C(sp3)-H mono- and di-alkylation reaction have been developed. In contrast to previous typical oxidative and electrochemical coupling, this electrosynthetic approach enables selective mono- and di-alkylations through metal- and external oxidant-free mild conditions via easily available electrodes. Advances of this strategy were proven by an unparalleled broad substrate scope for efficient C-C, C-N, C-O bond formation as well as excellent site- and regioselectivity. The electrochemical selective alkylations were devoid of additional electrolytes, could be conducted on a gram scale, and provided the enone products by cascade electrooxidative dehydrogenation, which highlight a notable potential for further late-stage diversification. Detailed mechanistic studies allowed to delineate the exact profile of the generation of the mono- and di-alkylation events. © 2022 the Owner Societies.
语种：
英文
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Ultra-Low Content Bismuth-Anchored Gold Aerogels with Plasmon Property for Enhanced Nonenzymatic Electrochemical Glucose Sensing
作者：
Fang, Qie;Qin, Ying;Wang, Hengjia;Xu, Weiqing;Yan, Hongye;...
期刊：
Analytical Chemistry ,2022年94(31):11030-11037 ISSN：0003-2700
通讯作者：
Zhu, Chengzhou(czzhu@ccnu.edu.cn)
作者机构：
[Qin, Ying; Zhu, Chengzhou; Yan, Hongye; Li, Jinli; Jiao, Lei; Gu, Wenling; Xu, Weiqing; Fang, Qie; Liu, Mingwang; Wei, Xiaoqian; Luo, Xin; Wang, Hengjia; Hu, Liuyong] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol &, Key Lab Pesticides, Wuhan 430079, Peoples R China.
通讯机构：
[Chengzhou Zhu] K;Key Laboratory of Pesticides and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, P.R. China
摘要：
Effective glucose surveillance provides a strong guarantee for the high-quality development of human health. Au nanomaterials possess compelling applications in nonenzymatic electrochemical glucose biosensors owing to superior catalytic performances and intriguing biocompatibility properties. However, it has been a grand challenge to accurately control the architecture and composition of Au nanomaterials to optimize their optical, electronic, and magnetic properties for further improving the performance of electrocatalytic sensing. Herein, ultra-low content Bi-anchored Au aerogels are synthesized via a one-step reduction strategy. Benefiting from the unique structure of aerogels as well as the synergistic effect between Au and Bi, the optimized Au200Bi aerogels greatly boost the activity of glucose oxidation compared with Au aerogels. Under plasmon resonance excitation, bimetallic Au200Bi aerogels with wider photics-dependent properties further show plasmon-promoted glucose electro-oxidation activity, which is derived from the photothermal and photoelectric effects caused by the local surface plasmon resonance. Thanks to the enhanced performance, a nonenzymatic electrochemical glucose biosensor is constructed to detect glucose with high sensitivity. This plasmon-promoted electrocatalytic activity through the synergetic strategy of bimetallic aerogels has potential applications in various research fields. © 2022 American Chemical Society. All rights reserved.
语种：
英文
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Engineering of coordination environment in bioinspired laccase-mimicking catalysts for monitoring of pesticide poisoning
作者：
Yan, Xu;Li, Hongxia;Wang, Tuhui;Li, Aixin;Zhu, Chengzhou;...
期刊：
Chemical Engineering Journal ,2022年446:136930 ISSN：1385-8947
通讯作者：
Yan, Xu(yanx@jlu.edu.cn)
作者机构：
[Yan, Xu; Wang, Tuhui; Li, Hongxia; Li, Aixin; Lu, Geyu] Jilin Univ, Coll Elect Sci & Engn, State Key Lab Integrated Optoelect, Key Lab Adv Gas Sensors, 2699 Qianjin St, Changchun 130012, Peoples R China.;[Li, Hongxia] Jilin Univ, Coll Food Sci & Engn, Dept Food Qual & Safety, Changchun 130062, Peoples R China.;[Zhu, Chengzhou] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.
通讯机构：
[Xu Yan; Geyu Lu] S;[Chengzhou Zhu] K;State Key Laboratory of Integrated Optoelectronics, Key Laboratory of Advanced Gas Sensors, Jilin Province, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun 130012, PR China<&wdkj&>Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, PR China
关键词：
Coordination environments;Enzyme-mimicking activity;Immunoassay;Nanomaterials;Pesticide poisoning
摘要：
Developing enzyme-mimicking catalysts with high catalytic activity and specificity has been a long-standing challenge. Herein we report efficient laccase-mimicking catalysts (His-Cys-Cu) that consist of atomic Cu active centers and dipeptide-organized electron transfer pathway by simulating the catalytic process of natural enzymes, exhibiting high catalytic activity and robust stability. In particular, chloride ion (bromide ions) anchored on the surface of His-Cys-Cu as recognition antenna enhances the catalytic activity and recognition specificity by regulating reaction rate and adsorption affinity toward the substrate. By harnessing the characteristic of His-Cys-Cu, stimuli-responsive hydrogel-based portable kits and chromogenic immunosensors are fabricated for monitoring pesticide biomarkers via combining high-affinity biorecognition elements. As a result, the biosensor based on His-Cys-Cu improves the limit of detection by up to 150-fold and enhances the robustness of bioapplication for on-site testing. We envision that such a modular approach provides a versatile platform for rapid profiling of a diverse range of targets by exploiting their specific enzymatic signatures. © 2022 Elsevier B.V.
语种：
英文
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Through-space charge-transfer emitters featuring high radiative decay rates for efficient organic light-emitting diodes
作者：
Ren, Hao;Song, Yongjun;Yu, Renyou;Tian, Mingxing;He, Lei
期刊：
Dyes and Pigments ,2022年204:110389 ISSN：0143-7208
通讯作者：
He, Lei(helei@ccnu.edu.cn)
作者机构：
[Ren, Hao; Tian, Mingxing; Song, Yongjun; He, Lei; Yu, Renyou] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ,Hubei Int Sci & Technol Cooperat Base, Wuhan 430079, Peoples R China.
通讯机构：
[Lei He] K;Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, College of Chemistry, Central China Normal University, Wuhan, 430079, People's Republic of China
关键词：
Donor-acceptor systems;Through-space charge-transfer;Thermally-activated delayed fluorescence;Radiative decays;Organic light-emitting diodes
摘要：
Through-space charge-transfer (TSCT) emitters with high radiative decay rates are very important for their use in electroluminescent devices but have rarely been reported. Here, three TSCT emitters 1–3 with high radiative decay rates of over 107 s−1 are developed by using 4-methyl-9H-xanthene (MeXT) as the rigid linker, 10-phenyldihydroacridine (PhDMAC) as the donor, and 2,4,6-triphenyltriazine (1), 2,4,6-triphenylpyrimidine (2) and 2,4-di-tert-butyl-6-phenyl-1,3,5-triazine (3) as the acceptors. Single-crystal structures and theoretical calculations reveal that the donor fixed by the spiro-structure in MeXT and the acceptor located nearby the donor are arranged into a very close, cofacial packing with strong through-space electronic interactions, which promotes TSCT and the radiative decay of charge-transfer state. In degassed toluene solution, 1–3 show blue emission centered at 479, 458 and 455 nm, respectively, and afford high radiative decay rates (kr,s) of up to 1.6 × 107 s−1, which are the highest for TSCT emitters reported so far. In the doped films, 1–3 show high kr,s values of up to 1.3 × 107 s−1 and high photoluminescent efficiencies (ΦPL) of up to 0.95. Organic light-emitting diodes using 1–3 as the emitters afford blue emission with high external quantum efficiencies of up to 22.6%. The work reveals that TSCT emitters with similar emission characteristics (high ΦPL and high kr,s) to through-bond charge-transfer emitters are achievable by arranging the donor and acceptor units into a very close, cofacial packing. © 2022 Elsevier Ltd
语种：
英文
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Photoredox-Enabled Chromium-Catalyzed Alkene Diacylations
作者：
Liu, Jing;Lu, Liang-Qiu;Luo, Yixin;Zhao, Wei;Sun, Peng-Chao;...
期刊：
ACS CATALYSIS ,2022年12(3):1879-1885 ISSN：2155-5435
通讯作者：
Cheng, Ying;Xiao, Wen-Jing;Qi, Xiaotian
作者机构：
[Zhao, Wei; Cheng, Ying; Lu, Liang-Qiu; Liu, Jing; Xiao, Wen-Jing; Xiao, WJ] Cent China Normal Univ, Coll Chem, CCNU uOttawa Joint Res Ctr, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;[Lu, Liang-Qiu] Chinese Acad Sci, Lanzhou Inst Chem Phys LICP, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China.;[Qi, Xiaotian; Luo, Yixin; Qi, XT] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China.;[Sun, Peng-Chao; Jin, Weiwei] Xinjiang Univ, Coll Chem,Urumqi Key Lab Green Catalysis & Synth, State Key Lab Chem & Utilizat Carbon Based Energy, Key Lab Oil & Gas Fine Chem,Minist Educ & Xinjian, Urumqi 830046, Peoples R China.
通讯机构：
[Cheng, Y; Xiao, WJ ] C;[Qi, XT ] W;Cent China Normal Univ, Coll Chem, CCNU uOttawa Joint Res Ctr, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China.;Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China.
关键词：
visible light;photoredox;chromium catalysis;alkene diacylations;diones
摘要：
Transition-metal-catalyzed cross-coupling reactions are a powerful tool to construct carbon-carbon bonds in modern synthetic chemistry. Chromium catalysis is much less developed compared with the widely used palladium and nickel catalysis. Herein, we reported an efficient and flexible chromium-catalyzed radical diacylation of alkenes with the help of visible-light photoredox catalysis, giving access to valuable 1,4-, 1,6-, and 1,7-diones under mild conditions. The synthetic utility of this methodology was proven by converting diones to diverse heterocycles. Furthermore, the same dual catalysis system can be successfully applied to dienes and vinyl cyclopropanes. A possible mechanism of alkene diacylation via dual photoredox/chromium catalysis was proposed according to control experiments and DFT calculations. ©
语种：
英文
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iNKT cell agonists as vaccine adjuvants to combat infectious diseases
作者：
Li, Ya-Qian;Yan, Cheng;Luo, Rui;Liu, Zheng
期刊：
Carbohydrate Research ,2022年513:108527 ISSN：0008-6215
通讯作者：
Liu, Zheng(liuz1118@ccnu.edu.cn);Luo, Rui(luorui@mail.hzau.edu.cn)
作者机构：
[Luo, Rui; Li, Ya-Qian] Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China.;[Yan, Cheng; Liu, Zheng] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ,Hubei Int Sci & Technol Cooperat Base, Wuhan 430079, Hubei, Peoples R China.
通讯机构：
[Rui Luo] S;[Zheng Liu] K;State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, 430070, PR China<&wdkj&>Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, College of Chemistry, Central China Normal University, Wuhan, Hubei, 430079, PR China
关键词：
Adjuvant;Formulation;Infectious disease;iNKT cell;Mucosal immunity;α-galactosylceramide
摘要：
iNKT cells are a special type of T cell that acts as a link between the innate and adaptive immune systems, with the capacity to stimulate a wide range of cell types. The glycolipid α-galactosylceramide (αGC) is a robust agonist of iNKT cells and induces the secretion of Th1- and Th2-type cytokines. αGC and its analogs are widely used as adjuvants to enhance immune responses against viral, parasitic, and bacterial pathogens. This review first discusses the challenges of using free αGC as a vaccine adjuvant to treat infectious diseases. We next present strategies to realize the potential of the adjuvant effect of iNKT cell glycolipids, including (1) the use of Th1- or Th2-biasing αGC analogs, (2) covalent conjugation of glycolipid with antigen, (3) particulate vehicle-assisted delivery of glycolipid, (4) glycolipid-loaded cellular systems, (5) glycolipid combination with other immunostimulants, and (6) usage as mucosal adjuvants. Finally, we discuss future approaches for the development of iNKT cell agonists used as vaccine adjuvants against infectious diseases. © 2022 Elsevier Ltd
语种：
英文
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单原子材料类酶催化及生物医学应用研究进展
作者：
Sha Meng;Xu Weiqing;Wu Zhichao;Gu Wenling;Zhu Chengzhou
期刊：
高等学校化学学报 ,2022年43(5):212-227 ISSN：0251-0790
通讯作者：
Zhu, Chengzhou(czzhu@ccnu.edu.cn)
作者机构：
[Sha Meng; Zhu Chengzhou; Xu Weiqing; Gu Wenling; Wu Zhichao] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensing Technol, Minist Educ,Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China.
关键词：
单原子材料;类酶催化;纳米酶;生物医学应用
摘要：
纳米酶因其经济、稳定、性质可调和可循环利用等诸多优势,成功地克服了天然酶在实际应用中的不足.单原子材料的出现使得对纳米酶的研究迈入原子水平,其较高的原子利用率、独特的配位环境和较强的金属-载体相互作用为揭示纳米酶构效关系及调控类酶活性提供了可能.本文总结了近年来单原子材料类酶催化的研究进展,重点讨论了单原子材料类酶活性的调控策略和催化机理,概述了单原子类酶材料在癌症治疗、抗氧化治疗、抗菌以及生物传感等方面的应用,并对单原子类酶材料的发展前景进行了展望.
语种：
中文
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